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Alamandine attenuates hypertension and cardiac hypertrophy in hypertensive rats

Oral administration of the peptide alamandine has antihypertensive and anti-fibrotic effects in rats. This work aimed to determine whether subcutaneous alamandine injection would attenuate hypertension and cardiac hypertrophy, and improve the function of a major target of hypertension-related damage, the left ventricle (LV), in spontaneously hypertensive rats (SHRs). This was...

On the Influence of Nb/Ti Ratio on Environmentally-Assisted Crack Growth in High-Strength Nickel-Based Superalloys

The effect of Nb/Ti ratio on environmentally-assisted crack growth of three prototype Ni-based superalloys is studied. For these alloys, the yield strength is unaltered with increasing Nb/Ti ratio due to an increase in grain size. This situation has allowed the rationalization of the factors influencing damage tolerance at 700 °C. Primary intergranular cracks have been...

Optically Active Plasmonic Metasurfaces based on the Hybridization of In-Plane Coupling and Out-of-Plane Coupling

Plasmonic metasurfaces have attracted much attention in recent years owing to many promising prospects of applications such as polarization switching, local electric field enhancement (FE), near-perfect absorption, sensing, slow-light devices, and nanoantennas. However, many problems in these applications, like only gigahertz switching speeds of electro-optical switches, low...

The Vaiont landslide: re-assessment of the evidence leads to rejection of the consensus

There appears to be a clear general consensus in the literature regarding four critical issues that define the problem of the October 1963 Vaiont landslide and its behaviour that are central to the disaster: (1) the 1963 failure was a reactivation of an ancient landslide; (2) failure took place along thin clay seams (already at residual strength); (3) the sliding surface had a...

Diffusion tensor MRI of the healthy brachial plexus

Introduction Diffusion Tensor MRI (DT-MRI) is a promising tool for the evaluation of brachial plexus pathology. Therefore, we introduce and evaluate a fast DT-MRI protocol (8min33s scanning with 5–10 min postprocessing time) for the brachial plexus. Materials and methods Thirty healthy volunteers within three age-groups (18–35, 36–55, and > 56) received DT-MRI of the brachial...

Probing compressed mass spectra in electroweak supersymmetry with Recursive Jigsaw Reconstruction

AbstractThe lack of evidence for the production of colored supersymmetric particles at the LHC has increased interest in searches for superpartners of the electroweak SM gauge bosons, namely the neutralinos and charginos. These are challenging due to the weak nature of the production process, and the existing discovery reach has significant gaps in due to the difficulty of...

New Avenues for Nanoparticle-Related Therapies

Development of nanoparticle-based drug delivery systems has been attempted for the treatment of cancer over the past decade. The enhanced permeability and retention (EPR) effect is the major mechanism to passively deliver nanodrugs to tumor tissue. However, a recent systematic review demonstrated limited success of these studies, with the clearance of nanoparticles by the...

Predicting user demographics from music listening information

Online activities such as social networking, online shopping, and consuming multi-media create digital traces, which are often analyzed and used to improve user experience and increase revenue, e. g., through better-fitting recommendations and more targeted marketing. Analyses of digital traces typically aim to find user traits such as age, gender, and nationality to derive...

Daylighting performance in UAE traditional buildings used as museums

This article investigates how daylight performs in traditional UAE buildings that were turned into museums with specific focus on museum lighting requirements and effect on artefacts. The study used several methods such as on-site measurements, data collection and analysis, and computer simulation. It depended on the climate-based daylighting metric daylighting autonomy. The...

Detection of false data injection attacks using unscented Kalman filter

It has recently been shown that state estimation (SE), which is the most important real-time function in modern energy management systems (EMSs), is vulnerable to false data injection attacks, due to the undetectability of those attacks using standard bad data detection techniques, which are typically based on normalized measurement residuals. Therefore, it is of the utmost...

The relationships between soil chemical properties and vegetation succession in the aspect of changes of distance from the glacier forehead and time elapsed after glacier retreat in the Irenebreen foreland (NW Svalbard)

AimsThe aim of this study was to determine relationships between soil chemical parameters (i.e. content of total organic carbon, total nitrogen, total sulphur, soil pH) and vegetation development in relation to distance from the current glacier forehead and time elapsed after glacier retreat in the Irenebreen foreland.MethodsThree transects were designated along the foreland...

Combining gray matter volume in the cuneus and the cuneus-prefrontal connectivity may predict early relapse in abstinent alcohol-dependent patients

Background Developing more effective strategies to prevent relapse remains one of the major challenges of treating substance dependence. Previous studies have identified brain abnormalities in abstinent alcoholics. However, whether these persistent brain deficits in abstinence could predict early relapse to alcohol use has not been well established. This study aimed to identify...

Behavioural biomarkers and mobile mental health: a new paradigm

Over recent decades, the field of psychiatry has allocated a vast amount of resources and efforts to make available more accurate and objective methods to diagnose, assess and monitor treatment outcomes in psychiatric disorders. Despite the optimism and some significant progress in biological markers, it has become increasingly evident that they are failing to meet initial...