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Effect of Victimization on Impulse Control and Binge Drinking among Serious Juvenile Offenders from Adolescence to Young Adulthood

A vast literature has found longitudinal effects of early life stress on substance use and self-regulatory processes. These associations may vary by period-specific development among youth involved in the juvenile justice system. The current study used an accelerated longitudinal design and auto-regressive latent trajectory with structure residuals (ALT-SR) model to examine the ...

DNA methylation age-acceleration is associated with disease duration and age at onset in C9orf72 patients

The repeat expansion in C9orf72 is the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. C9orf72 patients present with a wide range in disease duration and age of onset. The strongest risk factor for both syndromes is aging, which was linked to DNA methylation (DNAm) age based on the cumulative assessment of the methylation levels of 353 CpGs included ...

What do Key Stakeholders Think About HIV Self-Testing in Canada? Results from a Cross-Sectional Survey

Human immunodeficiency virus (HIV) self-testing presents an empowering alternative to facility-based testing for reaching undiagnosed HIV infected individuals, but is not currently available in Canada. We surveyed stakeholders (clinical providers, public health professionals, researchers) engaged in HIV testing initiatives nationwide to identify the concerns, opportunities and ...

Can experienced surgeons predict the additional value of a CT scan in patients with displaced intra-articular distal radius fractures?

There are no clear guidelines when an additional CT scan should be obtained for the treatment of displaced intra-articular distal radius fractures (DRF). This study aimed to investigate whether surgeons can predict the usefulness of CT scans to facilitate choice of treatment plan and/or pre-operative planning for DRF. Four surgeons evaluated 51 patients with displaced DRF. The ...

A modern congestion pricing policy for urban traffic: subsidy plus toll

Congestion pricing is seen as an effective policy to address traffic congestion. In such policies where money, people and authorities are involved, the success generally hinges upon two factors: equity (being fair) and acceptability (to both people and authorities). The primary concern is the equity, for which “tradable credit scheme (TCS)” has been introduced and extensively ...

Are genetic markers of interest for economic research?

The idea that genetic differences may explain a multitude of individual-level outcomes studied by economists is far from controversial. Since more datasets now contain measures of genetic variation, it is reasonable to postulate that incorporating genomic data in economic analyses will become more common. However, there remains much debate among academics as to, first, whether ...

Complex problems and unchallenged solutions: Bringing ecosystem governance to the forefront of the UN sustainable development goals

Sustainable development aims at addressing economic, social, and environmental concerns, but the current lack of responsive environmental governance hinders progress. Short-term economic development has led to limited actions, unsustainable resource management, and degraded ecosystems. The UN Sustainable Development Goals (SDGs) may continue to fall short of achieving significant ...

Western classical music development: a statistical analysis of composers similarity, differentiation and evolution

This paper proposes a statistical analysis that captures similarities and differences between classical music composers with the eventual aim to understand why particular composers ‘sound’ different even if their ‘lineages’ (influences network) are similar or why they ‘sound’ alike if their ‘lineages’ are different. In order to do this we use statistical methods and measures of ...

An observational time and motion study of denosumab subcutaneous injection and zoledronic acid intravenous infusion in patients with metastatic bone disease: results from three European countries

Purpose Denosumab (administered via subcutaneous injection) demonstrated superior efficacy versus the intravenously administered zoledronic acid in the prevention of skeletal-related events in an integrated analysis of three head-to-head phase III trials in patients with bone metastases secondary to solid tumors. To date, no studies have evaluated treatment administration duration ...

Hydrogen production and microbial kinetics of Clostridium termitidis in mono-culture and co-culture with Clostridium beijerinckii on cellulose

Cellulose utilization by hydrogen producers remains an issue due to the low hydrogen yields reported and the pretreatment of cellulose prior to fermentation requires complex and expensive steps. Clostridium termitidis is able to breakdown cellulose into glucose and produce hydrogen. On the other hand, Clostridium beijerinckii is not able to degrade cellulose but is adept at ...

Cord blood hematopoietic cells from preterm infants display altered DNA methylation patterns

Background Premature infants are highly vulnerable to infection. This is partly attributable to the preterm immune system, which differs from that of the term neonate in cell composition and function. Multiple studies have found differential DNA methylation (DNAm) between preterm and term infants’ cord blood; however, interpretation of these studies is limited by the confounding ...

A Statistical Approach for Analyzing Residential Isolation and its Determinants for Immigrant Communities: an Application to the Montréal Metropolitan Region

The aim of this paper is to measure the net propensity to live in isolation for Montréal’s main immigrant communities and to identify specific profiles that are particularly isolated. For that purpose, a statistical approach is used based on individual determinants to compute standardized isolation indexes that take into account the socioeconomic composition of the different ...

Are multiple-trial experiments appropriate for eyewitness identification studies? Accuracy, choosing, and confidence across trials

Eyewitness identification experiments typically involve a single trial: A participant views an event and subsequently makes a lineup decision. As compared to this single-trial paradigm, multiple-trial designs are more efficient, but significantly reduce ecological validity and may affect the strategies that participants use to make lineup decisions. We examined the effects of a ...

Darting Primates: Steps Toward Procedural and Reporting Standards

Darting, a common method of capturing wild primates, poses risks to the individuals that must be appropriately minimized. A recent article in the International Journal of Primatology by Cunningham et al. (International Journal of Primatology, 36(5), 894–915, 2015) presented a literature review of the reporting of darting procedures in primatology and anonymously surveyed ...

Emerging Use of Early Health Technology Assessment in Medical Product Development: A Scoping Review of the Literature

Early health technology assessment is increasingly being used to support health economic evidence development during early stages of clinical research. Such early models can be used to inform research and development about the design and management of new medical technologies to mitigate the risks, perceived by industry and the public sector, associated with market access and ...

Correlation of carotid blood flow and corrected carotid flow time with invasive cardiac output measurements

Background Non-invasive measures that can accurately estimate cardiac output may help identify volume-responsive patients. This study seeks to compare two non-invasive measures (corrected carotid flow time and carotid blood flow) and their correlations with invasive reference measurements of cardiac output. Consenting adult patients (n = 51) at Massachusetts General Hospital ...

A Review on the Safety and Efficacy of Inhaled Corticosteroids in the Management of Asthma

Asthma is a chronic inflammatory disease characterized by symptoms of cough, dyspnea, chest tightness, and wheeze. Inhaled corticosteroids (ICS) have been recommended as initial therapy in the treatment of persistent asthma in all guidelines, as they have been shown to reduce morbidity and mortality. However, high-dose regimens and long-term use of ICS may be associated with a ...