Advanced search    

Search: *

49,487 papers found. Showing first 1,000 results.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Detecting protein variants by mass spectrometry: a comprehensive study in cancer cell-lines

Background Onco-proteogenomics aims to understand how changes in a cancer’s genome influences its proteome. One challenge in integrating these molecular data is the identification of aberrant protein products from mass-spectrometry (MS) datasets, as traditional proteomic analyses only identify proteins from a reference sequence database. Methods We established proteomic workflows ...

Critical Exponents on Fortuin–Kasteleyn Weighted Planar Maps

In this paper we consider random planar maps weighted by the self-dual Fortuin–Kasteleyn model with parameter \({q \in (0,4)}\). Using a bijection due to Sheffield and a connection to planar Brownian motion in a cone we obtain rigorously the value of the annealed critical exponent associated with the length of cluster interfaces, which is shown to be $$\frac{4}{\pi} \arccos \left( ...

Rheological behavior of cold recycled asphalt materials with different contents of recycled asphalt pavements

In Québec, for more than 20 years, cold in-place recycling (CIR) and full-depth reclamation (FDR) have been reliable rehabilitation techniques; restoring pavement condition at an affordable cost with a lower footprint on the environment. Experience reveals that CIR and FDR interventions effectively address the issues of reflective cracking and respect Québec’s Ministry of ...

Diagnosis of rare diseases under focus: impacts for Canadian patients

This paper presents an in-depth qualitative analysis of the impact of diagnosis on the lives of rare disease (RD) patients. While diagnosis may be described as a watershed step for RD patients, no extensive account of non-medical outcomes following a RD diagnosis exists within the literature. This study aims to fill this knowledge gap through an analysis of the impact of diagnosis ...

Copper (II) complexes of bidentate ligands exhibit potent anti-cancer activity regardless of platinum sensitivity status

Insensitivity to platinum, either through inherent or acquired resistance, is a major clinical problem in the treatment of many solid tumors. Here, we explored the therapeutic potential of diethyldithiocarbamate (DDC), pyrithione (Pyr), plumbagin (Plum), 8-hydroxyquinoline (8-HQ), clioquinol (CQ) copper complexes in a panel of cancer cell lines that differ in their sensitivity to ...

Mental Health Perceptions and Practices of a Cree Community in Northern Ontario: A Qualitative Study

This project is a qualitative study of the mental health perceptions and practices of one Aboriginal community in the northern Ontario James and Hudson Bay region. Despite a shared history of trauma and oppression with the other five Cree communities in this area, as well as an added trauma of natural disaster and subsequent relocation, this community has been reported to have ...

Optimizing Infill Drilling Decisions Using Multi-Armed Bandits: Application in a Long-Term, Multi-Element Stockpile

Mining operations face a decision regarding additional drilling several times during their lifetime. The two questions that always arise upon making this decision are whether more drilling is required and, if so, where the additional drill holes should be located. The method presented in this paper addresses both of these questions through an optimization in a multi-armed bandit ...

Analysis of Big Data in Gait Biomechanics: Current Trends and Future Directions

The increasing amount of data in biomechanics research has greatly increased the importance of developing advanced multivariate analysis and machine learning techniques, which are better able to handle “big data”. Consequently, advances in data science methods will expand the knowledge for testing new hypotheses about biomechanical risk factors associated with walking and running ...

Team communication patterns in emergency resuscitation: a mixed methods qualitative analysis

Background In order to enhance patient safety during resuscitation of critically ill patients, we need to optimize team communication and enhance team situational awareness but little is known about resuscitation team communication patterns. The objective of this study is to understand how teams communicate during resuscitation; specifically to assess for a shared mental model ...

Attributing extreme fire risk in Western Canada to human emissions

Canada is expected to see an increase in fire risk under future climate projections. Large fires, such as that near Fort McMurray, Alberta in 2016, can be devastating to the communities affected. Understanding the role of human emissions in the occurrence of such extreme fire events can lend insight into how these events might change in the future. An event attribution framework is ...