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Linking the knowledge and reasoning of dissenting actors fosters a bottom-up design of agroecological viticulture

Wine growing has a high economic value globally, and vineyards, with their centenarian grape varieties, are an integral part of our societies. Yet with the use of spraying to control pathogens and weeds, mainstream viticulture has become a big pesticide consumer. Criticism of this conventional type of viticulture and its environmental/health impacts is increasing strongly ...

Oxidized low-density lipoprotein (oxLDL) affects load-free cell shortening of cardiomyocytes in a proprotein convertase subtilisin/kexin 9 (PCSK9)-dependent way

Recent studies have documented that oxidized low-density lipoprotein cholesterol (oxLDL) levels directly impact myocardial structure and function. However, the molecular mechanisms by which oxLDL affects cardiac myocytes are not well established. We addressed the question whether oxLDL modifies load-free cell shortening, a standardized readout of cardiac cellular function, and ...

Investigation of a real-time location system of corneal astigmatic axis

Background To construct a real-time computerized location system (RCLS) to analyze and display the axis of corneal astigmatism and to compare its accuracy with the Scheimpflug method. Methods Fifty-seven eyes of 39 volunteers with corneal astigmatism more than 1.00 diopter (D) were recruited. The RCLS was composed of a circular light-emitting diode (LED) light source, surgical ...

Diet has independent effects on the pace and shape of aging in Drosophila melanogaster

Studies examining how diet affects mortality risk over age typically characterise mortality using parameters such as aging rates, which condense how much and how quickly the risk of dying changes over time into a single measure. Demographers have suggested that decoupling the tempo and the magnitude of changing mortality risk may facilitate comparative analyses of mortality ...

Potential Effect of Prolonged Sevoflurane Anesthesia on the Kinetics of [11C]Raclopride in Non-human Primates

Purpose Positron emission tomography (PET) in non-human primates (NHP) is commonly performed under anesthesia, with sevoflurane being a widely used inhaled anesthetic. PET measurement in NHP can be repeated, and a difference in radioligand kinetics has previously been observed between the first and second PET measurement on the same day using sevoflurane anesthesia. In this study, ...

High-resolution infrared thermography: a new tool to assess tungiasis-associated inflammation of the skin

Background Tungiasis is highly prevalent in low- and middle-income countries but remains often under diagnosed and untreated eventually leading to chronic sequels. The objective of the study was to assess whether tungiasis-associated inflammation can be detected and quantified by high-resolution infrared thermography (HRIT) and whether after removal of the parasite inflammation ...

Concurrent wing and high-lift system aerostructural optimization

A method is presented for concurrent aerostructural optimization of wing planform, airfoil and high lift devices. The optimization is defined to minimize the aircraft fuel consumption for cruise, while satisfying the field performance requirements. A coupled adjoint aerostructural tool, that couples a quasi-three-dimensional aerodynamic analysis method with a finite beam element ...

No Interpretation of Probability

I argue that none of the usual interpretations of probability provide an adequate interpretation of probabilistic theories in science. Assuming that the aim of such theories is to capture noisy relationships in the world, I suggest that we do not have to give them classical truth-conditional content at all: their probabilities can remain uninterpreted. Indirectly, this account ...

Land Use Alters the Drought Responses of Productivity and CO2 Fluxes in Mountain Grassland

Climate extremes and land-use changes can have major impacts on the carbon cycle of ecosystems. Their combined effects have rarely been tested. We studied whether and how the abandonment of traditionally managed mountain grassland changes the resilience of carbon dynamics to drought. In an in situ common garden experiment located in a subalpine meadow in the Austrian Central Alps, ...

Mosquito Mapper: a phone application to map urban mosquitoes

This paper presents mosquito mapper: an android phone application created with the goal of giving science-driven citizens the means to monitor mosquito populations in an urban environment. Mosquito mapper allows the recording of mosquito encounters as well as conditions surrounding the encounter. It also features a rudimentary identification tool. The goal of the application is to ...

Measurement of cortisol in saliva: a comparison of measurement error within and between international academic-research laboratories

Objective Hundreds of scientific publications are produced annually that involve the measurement of cortisol in saliva. Intra- and inter-laboratory variation in salivary cortisol results has the potential to contribute to cross-study inconsistencies in findings, and the perception that salivary cortisol results are unreliable. This study rigorously estimates sources of measurement ...

Positive equilibria of a class of power-law kinetics

This paper studies a class of power-law kinetics, PL-ILK, for whose subset, PL-TIK, analogues of the Deficiency Zero Theorem and the Deficiency One Theorem (DOT) for mass action systems are valid. The DOT also includes the necessary and sufficient condition of Boros for uniqueness in the non-weakly reversible case. To our knowledge, this is the first set of kinetics beyond mass ...

Successive Release of Tissue Inhibitors of Metalloproteinase-1 Through Graphene Oxide-Based Delivery System Can Promote Skin Regeneration

The purpose of this study was to testify the hypothesis that graphene oxide (GO) could act as an appropriate vehicle for the release of tissue inhibitors of metalloproteinase-1 (TIMP-1) protein in the context of skin repair. GO characteristics were observed by scanning electron microscopy, atomic force microscopy, and thermal gravimetric analysis. After TIMP-1 absorbing GO, the ...

Wetting of Sn-Zn-Ga and Sn-Zn-Na Alloys on Al and Ni Substrate

Wetting of Al and Ni substrate by Sn-Zn eutectic-based alloys with 0.5 (wt.%) of Ga and 0.2 (wt.%) of Na was studied using the sessile drop method in the presence of ALU33® flux. Spreading tests were performed for 60 s, 180 s, and 480 s of contact, at temperatures of 503 K, 523 K and 553 K (230°C, 250°C, and 280°C). After cleaning the flux residue from solidified samples, the ...