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Benzene poisoning, clinical and blood abnormalities in two Brazilian female gas station attendants: two case reports

Background Brazilian gas station workers are chronically exposed to benzene, toluene, xylene (BTX) during their working time. Describe below two cases of latin female gas station workers with benzene poisoning symptoms and miscarriage history. Case presentation In both cases were identified complex chromosomal rearrangements (CCR) with fluorescence in situ hybridization, applied to ...

Tissue is the issue and tissue competition. Re-biopsy for mutation T790: where and why?

Lung cancer is still the leading cause of death among all cancers. During the last 15 years, pharmacogenomics of lung cancer have established targeted therapy with tyrosine kinase inhibitors (TKIs) for epidermal growth factor receptor (EGFR) positive patients in adenocarcinoma or mixed adenosquamus lung cancer patients. However; while novel drugs are released in the market, at the ...

[64Cu]NOTA-pentixather enables high resolution PET imaging of CXCR4 expression in a preclinical lymphoma model

Background The chemokine receptor 4 (CXCR4) is an important molecular target for both visualization and therapy of tumors. The aim of the present study was the synthesis and preclinical evaluation of a 64Cu-labeled, CXCR4-targeting peptide for positron emission tomography (PET) imaging of CXCR4 expression in vivo. Methods For this purpose, 1,4,7-triazacyclononane,1-glutaric ...

Cognitive Enhancement of Numerical and Arithmetic Capabilities: a Mini-Review of Available Transcranial Electric Stimulation Studies

Arithmetic capabilities are complex cognitive skills essential for handling requirements of the modern world. At the same time, educational institutions are challenged with math-related problems, e.g., developmental dyscalculia and math anxiety, and also with less severe difficulties of arithmetic understanding. Thus, non-invasive techniques for cognitive enhancement have attracted ...

SPH propagation back-analysis of Baishuihe landslide in south-western China

Background Landslides and landslide dams are a major natural hazard causing high socioeconomic risk in inhabited mountainous areas. This is also true for vast parts of south-western China, which are highly prone to slope failures due to several factors, such as a humid climate with high precipitation in the summer months, geological predisposing factors with highly weathered ...

Key factors and challenges of research-informed policy making in ECEC: examples from longitudinal studies

In this commentary, we draw on examples from the thematic issue ‘Longitudinal studies in ECEC—challenges of translating research results into policy actions’ to discuss how research from longitudinal studies in ECEC can potentially inform policy making. Thereby, we point out the challenges in the relationship between research and policy and suggest three key factors that can ...

Quantitative assessment of angiogenesis and pericyte coverage in human cell-derived vascular sprouts

Background Pericytes, surrounding the endothelium, fulfill diverse functions that are crucial for vascular homeostasis. The loss of pericytes is associated with pathologies, such as diabetic retinopathy and Alzheimer’s disease. Thus, there exists a need for an experimental system that combines pharmacologic manipulation and quantification of pericyte coverage during sprouting ...

On the interdependence of ambulatory and hospital care in the German health system

For some considerable time now the interface between ambulatory and hospital care has been mooted as a cause of inefficiencies in the German health system and there have been calls for a softening of the strict separation between the two sectors. This debate emphasizes the need for detailed empirical information on the interdependence between the two sectors. Using extensive ...

Eslicarbazepine acetate: its effectiveness as adjunctive therapy in clinical trials and open studies

Eslicarbazepine acetate (ESL) is a once-daily antiepileptic drug that is approved as adjunctive therapy in adults with focal-onset seizures. Following oral administration, ESL is rapidly metabolized to its active metabolite, eslicarbazepine, which acts primarily by enhancing slow inactivation of voltage-gated sodium channels. The efficacy and safety/tolerability of ESL in the ...

Early postoperative tumor progression predicts clinical outcome in glioblastoma—implication for clinical trials

Molecular markers define the diagnosis of glioblastoma in the new WHO classification of 2016, challenging neuro-oncology centers to provide timely treatment initiation. The aim of this study was to determine whether a time delay to treatment initiation was accompanied by signs of early tumor progression in an MRI before the start of radiotherapy, and, if so, whether this influences ...

Maternal Parenting and Child Behaviour: An Observational Study of Childhood Social Anxiety Disorder

Etiological models of social anxiety disorder (SAD) suggest parenting is involved in the development of SAD. However, previous studies have often neglected potential contributions of child behaviour to parenting behaviour. Further, parent–child interaction has often been assessed in artificial laboratory settings thereby impairing ecological validity. Children (aged 9–13 years) ...

Functional responses can unify invasion ecology

We contend that invasion ecology requires a universal, measurable trait of species and their interactions with resources that predicts key elements of invasibility and ecological impact; here, we advocate that functional responses can help achieve this across taxonomic and trophic groups, among habitats and contexts, and can hence help unify disparate research interests in invasion ...

Post-stroke dementia – a comprehensive review

Post-stroke dementia (PSD) or post-stroke cognitive impairment (PSCI) may affect up to one third of stroke survivors. Various definitions of PSCI and PSD have been described. We propose PSD as a label for any dementia following stroke in temporal relation. Various tools are available to screen and assess cognition, with few PSD-specific instruments. Choice will depend on purpose of ...

LIVIVO – the Vertical Search Engine for Life Sciences

The explosive growth of literature and data in the life sciences challenges researchers to keep track of current advancements in their disciplines. Novel approaches in the life science like the One Health paradigm require integrated methodologies in order to link and connect heterogeneous information from databases and literature resources. Current publications in the life sciences ...

Carrier transfer between confined and localized states in type II InAs/GaAsSb quantum wells

Temperature-resolved photoluminescence studies were performed on tensely-strained AlSb/InAs/GaAsSb W-shaped type II quantum wells. They revealed two emission bands: one at lower energy of localized origin resulting from carrier trapping states at interfaces and dominates at low-temperature; and one corresponding to the fundamental optical transition in the type II quantum well. ...