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Comparison of response patterns in different survey designs: a longitudinal panel with mixed-mode and online-only design

Background Increasing availability of the Internet allows using only online data collection for more epidemiological studies. We compare response patterns in a population-based health survey using two survey designs: mixed-mode (choice between paper-and-pencil and online questionnaires) and online-only design (without choice). Methods We used data from a longitudinal panel, the ...

Validation of α-Synuclein as a CSF Biomarker for Sporadic Creutzfeldt-Jakob Disease

The analysis of cerebrospinal fluid (CSF) biomarkers gains importance in the differential diagnosis of prion diseases. However, no single diagnostic tool or combination of them can unequivocally confirm prion disease diagnosis. Electrochemiluminescence (ECL)-based immunoassays have demonstrated to achieve high diagnostic accuracy in a variety of sample types due to their high ...

Nudge management: applying behavioural science to increase knowledge worker productivity

Knowledge worker productivity is essential for competitive strength in the digital century. Small interventions based on insights from behavioural science makes it possible for knowledge workers to be more productive. In this point of view article, we outline and discuss a new management style which we label nudge management.

Patients’ perspective of disease and medication adherence for type 2 diabetes in an urban area in Bangladesh: a qualitative study

Background Patients’ perspective of diabetes and adherence to its prescribed medications is a significant predictor of glycemic control and overall management of the disease. However, there is a paucity of such information in Bangladesh. This study aimed to explore patients’ perspective of diabetes, their experience of taking oral hypoglycemic medications and explore factors that ...

Reduction of relative centrifugal forces increases growth factor release within solid platelet-rich-fibrin (PRF)-based matrices: a proof of concept of LSCC (low speed centrifugation concept)

Purpose The present study evaluated the platelet distribution pattern and growth factor release (VEGF, TGF-β1 and EGF) within three PRF (platelet-rich-fibrin) matrices (PRF, A-PRF and A-PRF+) that were prepared using different relative centrifugation forces (RCF) and centrifugation times. Materials and methods immunohistochemistry was conducted to assess the platelet distribution ...

Feasibility of in vivo 18F-florbetaben PET/MR imaging of human carotid amyloid-β

Purpose Amyloid-beta (Aβ) peptides are involved in the inflammatory pathology of atherosclerosis. 18F-Florbetaben is a PET tracer for clinical imaging of cerebral Aβ plaques in Alzheimer’s disease (AD). We sought to determine whether specific uptake of 18F-florbetaben in the carotid arteries can be identified using a fully integrated hybrid PET/MRI system and whether this uptake is ...

Lessons learned from additional research analyses of unsolved clinical exome cases

Background Given the rarity of most single-gene Mendelian disorders, concerted efforts of data exchange between clinical and scientific communities are critical to optimize molecular diagnosis and novel disease gene discovery. Methods We designed and implemented protocols for the study of cases for which a plausible molecular diagnosis was not achieved in a clinical genomics ...

Impingement-Syndrom des oberen Sprunggelenks

Das Impingement-Syndrom des oberen Sprunggelenks (OSG) ist eine klinische Diagnose und entsteht posttraumatisch, überlastungsbedingt durch wiederholte mechanische Belastungen oder durch anatomische Varianten. Es zeichnet sich durch chronisch-rezidivierende Schmerzen und/oder einen eingeschränkten Bewegungsumfang aus. Aufgrund eines pathologischen Engpasses werden Knochen- und/oder ...

Detection of tetrabromobisphenol A and its mono- and dimethyl derivatives in fish, sediment and suspended particulate matter from European freshwaters and estuaries

An analytical method was developed for the determination of tetrabromobisphenol A (TBBPA), 3,3′,5,5′-tetrabromobisphenol-A-monomethyl ether (MM-TBBPA) and 3,3′,5,5′-tetrabromobisphenol-A-dimethyl ether (DM-TBBPA), and its valid application on fish muscle matrix (bream and sole), suspended particulate matter (SPM) and surface sediment layer samples, using only 0.5 g sample material, ...

Maximal Interaction Two-Mode Clustering

Most classical approaches for two-mode clustering of a data matrix are designed to attain homogeneous row by column clusters (blocks, biclusters), that is, biclusters with a small variation of data values within the blocks. In contrast, this article deals with methods that look for a biclustering with a large interaction between row and column clusters. Thereby an aggregated, ...

Four-year maintenance treatment with adalimumab in Japanese patients with moderately to severely active ulcerative colitis

Background The 52-week safety and efficacy of adalimumab in Japanese patients with moderately to severely active ulcerative colitis were demonstrated in a placebo-controlled phase 2/3 trial. Data from patients who enrolled in the open-label extension study are presented. Methods Remission and response per the full Mayo score (FMS) and the partial Mayo score (PMS), remission per the ...

Positive emotion impedes emotional but not cognitive conflict processing

Cognitive control enables successful goal-directed behavior by resolving a conflict between opposing action tendencies, while emotional control arises as a consequence of emotional conflict processing such as in irony. While negative emotion facilitates both cognitive and emotional conflict processing, it is unclear how emotional conflict processing is affected by positive emotion ...

Depression Risk in Patients with Rheumatoid Arthritis in the United Kingdom

Introduction Rheumatoid arthritis (RA) is one of the most common chronic inflammatory diseases. The goal of this study was to analyze the risk of depression in patients diagnosed with RA and treated by general practitioners in the UK. Methods The present study included patients first diagnosed with RA between 2000 and 2014 (index date). Individuals were excluded if they had also ...