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Acute hyperventilation increases the central venous-to-arterial PCO2 difference in stable septic shock patients

Background To evaluate the effects of acute hyperventilation on the central venous-to-arterial carbon dioxide tension difference (∆PCO2) in hemodynamically stable septic shock patients. Methods Eighteen mechanically ventilated septic shock patients were prospectively included in the study. We measured cardiac index (CI), ∆PCO2, oxygen consumption (VO2), central venous oxygen ...

Prognosis of cirrhotic patients admitted to intensive care unit: a meta-analysis

Background The best predictors of short- and medium-term mortality of cirrhotic patients receiving intensive care support are unknown. Methods We conducted meta-analyses from 13 studies (2523 cirrhotics) after selection of original articles and response to a standardized questionnaire by the corresponding authors. End-points were in-ICU, in-hospital, and 6-month mortality in ICU ...

A CPN/B method transformation framework for railway safety rules formal validation

This paper presents a “CPN/B method” based process for railway systems safety analysis. Achieving interoperability through the European Rail Traffic Management System (ERTMS/ETCS) is facing difficulties in railway safety assessment due to the interaction of national and European operating specifications. These specifications have been modeled using several formalisms, which makes ...

Benefit of Rare-Earth “Smart Doping” and Material Nanostructuring for the Next Generation of Er-Doped Fibers

Erbium-doped fiber amplifiers (EDFAs) for harsh environments require to develop specific fabrication methods of Er 3+-doped fibers (EDFs) so as to limit the impact of radiation-induced absorption. In this context, a compromise has to be found between the concentration of Erbium and the glass composition. On the one hand, high concentration of Er 3+ ions helps to reduce the length ...

Sepsis risk factors in infants with congenital diaphragmatic hernia

Background Congenital diaphragmatic hernia (CDH) is a rare congenital anomaly and remains among the most challenging ICU-managed disease. Beside severe pulmonary hypertension, lung hypoplasia and major abdominal surgery, infective complications remain major determinants of outcome. However, the specific incidence of sepsis as well as associated risk factors is unknown. Methods This ...

Lung adenocarcinoma with thyroid metastasis: a case report

Background The metastases of a primary lung cancer over the thyroid gland are extremely rare. We report on an unusual presentation of thyroid metastasis of lung cancer in order to improve the management of similar cases. Case presentation Three years ago, a Moroccan male 59-year-old was admitted for dyspnea, dry cough, and chest pain. He had smoked about 30 cigarette packs a year. ...

Reduction of relative centrifugal forces increases growth factor release within solid platelet-rich-fibrin (PRF)-based matrices: a proof of concept of LSCC (low speed centrifugation concept)

Purpose The present study evaluated the platelet distribution pattern and growth factor release (VEGF, TGF-β1 and EGF) within three PRF (platelet-rich-fibrin) matrices (PRF, A-PRF and A-PRF+) that were prepared using different relative centrifugation forces (RCF) and centrifugation times. Materials and methods immunohistochemistry was conducted to assess the platelet distribution ...

Lessons learned from additional research analyses of unsolved clinical exome cases

Background Given the rarity of most single-gene Mendelian disorders, concerted efforts of data exchange between clinical and scientific communities are critical to optimize molecular diagnosis and novel disease gene discovery. Methods We designed and implemented protocols for the study of cases for which a plausible molecular diagnosis was not achieved in a clinical genomics ...

Occupation exposed to road-traffic emissions and respiratory health among Congolese transit workers, particularly bus conductors, in Kinshasa: a cross-sectional study

Objectives Road-traffic emissions (RTE) induce adverse health effects, notably respiratory symptoms and respiratory diseases, as a result of pollutants deposited into the respiratory tract. The aim of this study was to evaluate the association between occupation groups of Congolese transit workers exposed to RTE, particularly bus conductors and respiratory health, in Kinshasa. ...

Heavy-Tailed Random Walks on Complexes of Half-Lines

We study a random walk on a complex of finitely many half-lines joined at a common origin; jumps are heavy-tailed and of two types, either one-sided (towards the origin) or two-sided (symmetric). Transmission between half-lines via the origin is governed by an irreducible Markov transition matrix, with associated stationary distribution \(\mu _k\). If \(\chi _k\) is 1 for one-sided ...

Depression Risk in Patients with Rheumatoid Arthritis in the United Kingdom

Introduction Rheumatoid arthritis (RA) is one of the most common chronic inflammatory diseases. The goal of this study was to analyze the risk of depression in patients diagnosed with RA and treated by general practitioners in the UK. Methods The present study included patients first diagnosed with RA between 2000 and 2014 (index date). Individuals were excluded if they had also ...

Cultural Constellations: Burckhardtsource.org

Burckhardtsource.org hosts a corpus of over 1,000 documents forming the correspondence of more than 300 different authors with Swiss historian of art and culture Jacob Burckhardt (1818–1897). Dr. Susanne Müller and Dr. Costanza Giannaccini, who collaborated on the creation of the platform and on the critical digital edition of the letters to Burckhardt, discuss the guiding ...

The risk and clinical outcome of candidemia depending on underlying malignancy

Purpose To assess the risk factors and outcomes associated with fungemia caused by the six most commonly occurring Candida species in patients with and without malignancies. Methods Analysis of the episodes of fungemia due to common Candida species in adults, based on an active hospital-based surveillance program (Paris area, France, 2002 to 2014). Results Of the 3417 patients ...

The Hypernetted Chain Equations for Periodic Systems

Starting from the general inhomogeneous Fermi hypernetted chain equations, the equations for periodic systems are derived by simple Fourier transform. It is shown how the symmetry reduces the size of the involved quantities. First results for a one-dimensional (1D) model system are presented. The results allow a reliable estimation of the numerical demand even for realistic 3D ...

Numerical analysis of side airbags deployment in out-of-position situations

Side-impact collisions represent the second greatest cause of fatality in motor vehicle accidents. Side-impact airbags have been installed in recent model year vehicle due to its effectiveness in reducing passengers’ injuries and fatality rates. In meeting these requirements, simulations of folding and deploying airbags are very useful and are widely used. The paper presents a ...