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Prone positioning in acute respiratory distress syndrome after abdominal surgery: a multicenter retrospective study

Background The recent demonstration of prone position’s strong benefit on patient survival has rendered proning a major therapeutic intervention in severe ARDS. Uncertainties remain as to whether or not ARDS patients in the postoperative period of abdominal surgery should be turned prone because of the risk of abdominal complications. Our aim was to investigate the prevalence of ...

Calcipotriol Plus Betamethasone Dipropionate Aerosol Foam in Patients with Moderate-to-Severe Psoriasis: Sub-Group Analysis of the PSO-ABLE Study

Background Fixed-combination calcipotriol 50 μg/g plus betamethasone 0.5 mg/g (Cal/BD) aerosol foam is a new topical treatment for psoriasis. Although moderate-to-severe psoriasis is typically treated with systemic/biologic therapies, a topical treatment that is efficacious in these patients may be a significant cost-saving alternative to systemic therapy. Objective The objective ...

Gene expression signature for early prediction of late occurring pancytopenia in irradiated baboons

Based on gene expression changes measured in the peripheral blood within the first 2 days after irradiation, we predicted a pancytopenia in a baboon model. Eighteen baboons were irradiated with 2.5 or 5 Gy. According to changes in blood cell counts, the surviving baboons (n = 17) exhibited a hematological acute radiation syndrome (HARS) either with or without a pancytopenia. We ...

Impact of the electron donor on in situ microbial nitrate reduction in Opalinus Clay: results from the Mont Terri rock laboratory (Switzerland)

At the Mont Terri rock laboratory (Switzerland), an in situ experiment is being carried out to examine the fate of nitrate leaching from nitrate-containing bituminized radioactive waste, in a clay host rock for geological disposal. Such a release of nitrate may cause a geochemical perturbation of the clay, possibly affecting some of the favorable characteristics of the host rock. ...

Natural gas extraction and artificial gas injection experiments in Opalinus Clay, Mont Terri rock laboratory (Switzerland)

Two experiments have been installed at Mont Terri in 2004 and 2009 that allowed gas circulation within a borehole at a pressure between 1 and 2 bar. These experiments made it possible to observe the natural gases that were initially dissolved in pore-water degassing into the borehole and to monitor their content evolution in the borehole over several years. They also allowed for ...

An avoidable cause of thymoglobulin anaphylaxis

Background Thymoglobulin® (anti-thymocyte globulin [rabbit]) is a purified pasteurised, gamma immune globulin obtained by immunisation of rabbits with human thymocytes. Anaphylactic allergic reactions to a first injection of thymoglobulin are rare. Case presentation We report a case of serious anaphylactic reaction occurring after a first intraoperative injection of thymoglobulin ...

Amphibian decline, pond loss and reduced population connectivity under agricultural intensification over a 38 year period

Habitat loss, together with less obvious land-use changes such as intensified farming practice, can have significant adverse impacts on biodiversity. An important factor in determining the ability of species to cope with such changes is their potential to sustain a populations network by dispersal across the landscape. Habitat quality and structure are particularly important for ...

Quantitative morphological analysis of 2D images of complex-shaped branching biological growth forms: the example of branching thalli of liverworts

Background Many organisms such as plants can be characterized as complex-shaped branching forms. The morphological quantification of the forms is a support for a number of areas such as the effects of environmental factors and species discrimination. To date, there is no software package suitable for our dataset representing the forms. We therefore formulate methods for extracting ...

How to Diagnose Early 5-Azacytidine-Induced Pneumonitis: A Case Report

Interstitial pneumonitis is a classical complication of many drugs. Pulmonary toxicity due to 5-azacytidine, a deoxyribonucleic acid methyltransferase inhibitor and cytotoxic drug, has rarely been reported. We report a 67-year-old female myelodysplastic syndrome patient treated with 5-azacytidine at the conventional dosage of 75 mg/m2 for 7 days. One week after starting she ...

Stem cell mechanical behaviour modelling: substrate’s curvature influence during adhesion

Recent experiments hint that adherent cells are sensitive to their substrate curvature. It is already well known that cells behaviour can be regulated by the mechanical properties of their environment. However, no mechanisms have been established regarding the influence of cell-scale curvature of the substrate. Using a numerical cell model, based on tensegrity structures theory and ...

Current Care and Investigational Therapies in Achondroplasia

Purpose of Review The goal of this review is to evaluate the management options for achondroplasia, the most common non-lethal skeletal dysplasia. This disease is characterized by short stature and a variety of complications, some of which can be quite severe. Recent Findings Despite several attempts to standardize care, there is still no widely accepted consensus. This is in part ...

Mont Terri rock laboratory, 20 years of research: introduction, site characteristics and overview of experiments

Geologic repositories for radioactive waste are designed as multi-barrier disposal systems that perform a number of functions including the long-term isolation and containment of waste from the human environment, and the attenuation of radionuclides released to the subsurface. The rock laboratory at Mont Terri (canton Jura, Switzerland) in the Opalinus Clay plays an important role ...

Nilotinib first-line therapy in patients with Philadelphia chromosome-negative/BCR-ABL-positive chronic myeloid leukemia in chronic phase: ENEST1st sub-analysis

Purpose The ENEST1st sub-analysis presents data based on Philadelphia chromosome (Ph) status, i.e., Ph+ and Ph−/BCR-ABL1 + chronic myeloid leukemia. Methods Patients received nilotinib 300 mg twice daily, up to 24 months. Results At screening, 983 patients were identified as Ph+ and 30 patients as Ph−/BCR-ABL + based on cytogenetic and RT-PCR assessment; 76 patients had unknown ...

Corrosion of carbon steel in clay environments relevant to radioactive waste geological disposals, Mont Terri rock laboratory (Switzerland)

Carbon steel is widely considered as a candidate material for the construction of spent fuel and high-level waste disposal canisters. In order to investigate corrosion processes representative of the long term evolution of deep geological repositories, two in situ experiments are being conducted in the Mont-Terri rock laboratory. The iron corrosion (IC) experiment, aims to measure ...