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The relationship between target joints and direct resource use in severe haemophilia

Objectives Target joints are a common complication of severe haemophilia. While factor replacement therapy constitutes the majority of costs in haemophilia, the relationship between target joints and non drug-related direct costs (NDDCs) has not been studied. Methods Data on haemophilia patients without inhibitors was drawn from the ‘Cost of Haemophilia across Europe – a ...

Impacts of glyphosate-based herbicides on disease resistance and health of crops: a review

Based on experimental data from laboratory and field, numerous authors have raised concern that exposure to glyphosate-based herbicides (GBHs) may pre-dispose crops to damage by microbial pathogens. In this review, we distinguish and evaluate two principal pathways by which GBHs may affect the susceptibility of crops to disease: pathway 1—via disruptions to rhizosphere microbial ...

Rising up: Fertility trends in Egypt before and after the revolution

In 2014, Egypt’s Demographic and Health Survey (EDHS) documented an increase in the total fertility rate (TFR) to 3.5, up from a low of 3.0 recorded by the 2008 EDHS. The increase has been anecdotally attributed to the social upheaval following Egypt’s January 2011 revolution, but little is known about when fertility first began to increase and among which sub-groups of women. ...

Reliability of plasma polar metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry

Background Cohort studies with metabolomics data are becoming more widespread, however, large-scale studies involving 10,000s of participants are still limited, especially in Asian populations. Therefore, we started the Tsuruoka Metabolomics Cohort Study enrolling 11,002 community-dwelling adults in Japan, and using capillary electrophoresis-mass spectrometry (CE-MS) and liquid ...

Cognitive distortions and gambling near-misses in Internet Gaming Disorder: A preliminary study

Increased cognitive distortions (i.e. biased processing of chance, probability and skill) are a key psychopathological process in disordered gambling. The present study investigated state and trait aspects of cognitive distortions in 22 individuals with Internet Gaming Disorder (IGD) and 22 healthy controls. Participants completed the Gambling Related Cognitions Scale as a trait ...

Sodium bicarbonate supplementation improves severe-intensity intermittent exercise under moderate acute hypoxic conditions

Acute moderate hypoxic exposure can substantially impair exercise performance, which occurs with a concurrent exacerbated rise in hydrogen cation (H+) production. The purpose of this study was therefore, to alleviate this acidic stress through sodium bicarbonate (NaHCO3) supplementation and determine the corresponding effects on severe-intensity intermittent exercise performance. ...

Measuring management’s perspective of data quality in Pakistan’s Tuberculosis control programme: a test-based approach to identify data quality dimensions

Background Data quality is core theme of programme’s performance assessment and many organizations do not have any data quality improvement strategy, wherein data quality dimensions and data quality assessment framework are important constituents. As there is limited published research about the data quality specifics that are relevant to the context of Pakistan’s Tuberculosis ...

The behavioural phenotype of Potocki-Lupski syndrome: a cross-syndrome comparison

Background Potocki-Lupski syndrome (PTLS) and Smith-Magenis syndrome (SMS) are related genomic disorders, as duplication 17p11.2 (associated with PTLS) is the reciprocal recombination product of the SMS microdeletion. While SMS has a relatively well-delineated behavioural phenotype, the behavioural profile in PTLS is less well defined, despite purported associations with autism ...

Community heterogeneity of aquatic macroinvertebrates in urban ponds at a multi-city scale

Purpose Urbanisation is a leading cause of biotic homogenisation in urban ecosystems. However, there has been little research examining the effect of urbanisation and biotic homogenisation on aquatic communities, and few studies have compared findings across different urban landscapes. We assessed the processes that structure aquatic macroinvertebrate diversity within five UK ...

Examining human paragonimiasis as a differential diagnosis to tuberculosis in The Gambia

Objective Paragonimiasis is a foodborne trematode infection of the lungs caused by Paragonimus spp., presenting clinically with similar symptoms to active tuberculosis (TB). Worldwide, an estimated 20.7 million people are infected with paragonimiasis, but relatively little epidemiological data exists for Africa. Given a recently reported case, we sought to establish whether ...

On the Methodological Framework of Composite Indices: A Review of the Issues of Weighting, Aggregation, and Robustness

In recent times, composite indicators have gained astounding popularity in a wide variety of research areas. Their adoption by global institutions has further captured the attention of the media and policymakers around the globe, and their number of applications has surged ever since. This increase in their popularity has solicited a plethora of methodological contributions in ...

Specialized attachment structure of the fish pathogenic oomycete Saprolegnia parasitica

The secondary cysts of the fish pathogen oomycete Saprolegnia parasitica possess bundles of long hooked hairs that are characteristic to this economically important pathogenic species. Few studies have been carried out on elucidating their specific role in the S. parasitica life cycle and the role they may have in the infection process. We show here their function by employing ...

Morphometric characterisation of human tracheas: focus on cartilaginous ring variation

Purpose Details regarding tracheal anatomy are currently lacking, with existing literature focussing mainly on the cricoid-tracheal region or the carina. External gross anatomy and internal morphology throughout the entire trachea is important for normal physiological functioning and various clinical applications such as designs for tracheal implants or endotracheal devices. ...

HIGHEST WEIGHT VECTORS AND TRANSMUTATION

Let G = GL n be the general linear group over an algebraically closed field k, let \( \mathfrak{g}={\mathfrak{gl}}_n \) be its Lie algebra and let U be the subgroup of G which consists of the upper uni-triangular matrices. Let \( k\left[\mathfrak{g}\right] \)be the algebra of polynomial functions on \( \mathfrak{g} \) and let \( k{\left[\mathfrak{g}\right]}^G \) be the algebra of ...

Mediating National History and Personal Catastrophe: Televising Holocaust Memorial Day Commemoration

This article explores the rhetoric and mass mediation of the national Holocaust Memorial Day (HMD) commemoration ceremony, as broadcast on British television. Following the recommendation of the Stockholm International Forum, since 2001, Britain has commemorated victims of the Holocaust and subsequent genocides on 27 January. The national commemoration has been broadcast on ...

Introspecting knowledge

If we use “introspection” just as a label for that essentially first-person way we have of knowing about our own mental states, then it’s pretty obvious that if there is such a thing as introspection, we know on that basis what we believe, and want, and intend, at least in many ordinary cases. I assume there is such a thing as introspection. So I think the hard question is how it ...

Changes in balance and joint position sense during a 12-day high altitude trek: The British Services Dhaulagiri medical research expedition

Postural control and joint position sense are essential for safely undertaking leisure and professional activities, particularly at high altitude. We tested whether exposure to a 12-day trek with a gradual ascent to high altitude impairs postural control and joint position sense. This was a repeated measures observational study of 12 military service personnel (28±4 years). ...

Submodular unsplittable flow on trees

We study the Unsplittable Flow problem (\(\mathsf {UFP}\)) on trees with a submodular objective function. The input to this problem is a tree with edge capacities and a collection of tasks, each characterized by a source node, a sink node, and a demand. A subset of the tasks is feasible if the tasks can simultaneously send their demands from the source to the sink without violating ...

A reassessment of the Montmaurin-La Niche mandible (Haute Garonne, France) in the context of European Pleistocene human evolution

We here present a comparative study of the Montmaurin-LN Middle Pleistocene mandible (Haute-Garonne, France). This mandible, of which its right and left molar series are preserved in situ, was found in La Niche cave (Montmaurin’s karst system) in 1949, and was first attributed to the ‘Mindel-Riss’ interglacial (= MIS 9 to 11) based on its geological context. Later studies based on ...