Advanced search    

Search: *

111,566 papers found. Showing first 1,000 results.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

The burden of headache disorders in Ethiopia: national estimates from a population-based door-to-door survey

Background Headache disorders are the third-highest cause of disability worldwide, with migraine and medication-overuse headache (MOH) the major contributors. In Ethiopia we have shown these disorders to be highly prevalent: migraine 17.7%, TTH 20.6%, probable MOH (pMOH) 0.7%, any headache yesterday (HY) 6.4%. To inform local health policy, we now estimate disability and other ...

Report on potential sampling biases in the LaMEVE database of global volcanism

We investigate whether the disproportionate contribution of individual volcanoes in the Large Magnitude Explosive Volcanic Eruption database (LaMEVE) potentially compromises the treatment of LaMEVE as a globally representative database of volcanic activity. We find that 41% of volcanoes which contribute at least one eruption to LaMEVE only contribute one eruption (10% of all ...

Designing in between Local Government and the Public – Using Institutional Analysis in Interventions on Civic Infrastructures

Adapting and changing the systems and technologies involved in civic engagement with local government is among the key challenges of collaborative technologies for political participation. In such contexts, both existing sets of technologies and ingrained, often formalised practices, the ‘rules of the game’, constrain any opportunity for intervention. Additionally, ‘civic’ and ...

Macrophage-derived interleukin-1beta promotes human breast cancer cell migration and lymphatic adhesion in vitro

Lymphovascular invasion (LVI), encompassing blood and lymphatic vessel invasion, is an important event in tumourigenesis. Macrophages within the tumour microenvironment are linked to the presence of LVI and angiogenesis. This study investigates the role of macrophage-derived, caspase-1-dependent interleukin-1beta (IL-1β) in an in vitro model of LVI. IL-1β significantly augmented ...

Improving care for people with heart failure in Uganda: serial in-depth interviews with patients’ and their health care professionals

Background The short prognosis of patients with advanced heart failure (HF) and the associated multidimensional distress as illustrated in literature from high income countries necessitates the integration of palliative care into the care of advanced HF patients to address these needs and improve their quality of life. These needs, which are subjective, have not been described from ...

The inhibition of FGF receptor 1 activity mediates sorafenib antiproliferative effects in human malignant pleural mesothelioma tumor-initiating cells

Background Malignant pleural mesothelioma is an aggressive cancer, characterized by rapid progression and high mortality. Persistence of tumor-initiating cells (TICs, or cancer stem cells) after cytotoxic drug treatment is responsible for tumor relapse, and represents one of the main reasons for the poor prognosis of mesothelioma. In fact, identification of the molecules affecting ...

Estimation bias under model selection for distance sampling detection functions

Many simulation studies have examined the properties of distance sampling estimators of wildlife population size. When assumptions hold, if distances are generated from a detection model and fitted using the same model, they are known to perform well. However, in practice, the true model is unknown. Therefore, standard practice includes model selection, typically using model ...

Combined uncertainty factor for sampling and analysis

Measurement uncertainty that arises from primary sampling can be expressed as an uncertainty factor, which recognises its sometimes approximately log-normal probability distribution. By contrast, uncertainty arising from chemical analysis is usually expressed as relative uncertainty, based upon the assumptions of its approximately normal distribution. A new method is proposed that ...

Neuro-oncology family caregivers’ view on keeping track of care issues using eHealth systems: it’s a question of time

Primary brain tumors (PBTs) are rare but have a great impact on both patient and family caregiver wellbeing. Supporting caregivers can help them to continue their caregiving activities to maintain the patients’ best possible level of quality of life. Efforts to improve PBT caregiver wellbeing should take into account country- or culture-specific differences in care issues and ...

European Criminal Law After Brexit

The victory for the ‘Brexit’ vote in the referendum last June has sent shockwaves around Europe. The initial shock has given way for some to the realisation of the legal and constitutional complexity of untangling the UK’s relationship with the EU and re-engineering this relationship for a post-Brexit era, an era when the UK will be a third country for the EU. The legal challenges ...

Tactile feedback is an effective instrument for the training of grasping with a prosthesis at low- and medium-force levels

Grasping is a complex task routinely performed in an anticipatory (feedforward) manner, where sensory feedback is responsible for learning and updating the internal model of grasp dynamics. This study aims at evaluating whether providing a proportional tactile force feedback during the myoelectric control of a prosthesis facilitates learning a stable internal model of the ...

“Daring to Care”: Challenging Corporate Environmentalism

Corporate engagements with pressing environmental challenges focus on expanding the role of the market, seeking opportunities for growth and developing technologies to manage better environmental resources. Such approaches have proved ineffective. I suggest that a lack of meaningful response to ecological degradation and climate change is inevitable within a capitalist system ...

Characteristics associated with quality of life among people with drug-resistant epilepsy

Quality of Life (QoL) is the preferred outcome in non-pharmacological trials, but there is little UK population evidence of QoL in epilepsy. In advance of evaluating an epilepsy self-management course we aimed to describe, among UK participants, what clinical and psycho-social characteristics are associated with QoL. We recruited 404 adults attending specialist clinics, with at ...

Electronic lab notebooks: can they replace paper?

Despite the increasingly digital nature of society there are some areas of research that remain firmly rooted in the past; in this case the laboratory notebook, the last remaining paper component of an experiment. Countless electronic laboratory notebooks (ELNs) have been created in an attempt to digitise record keeping processes in the lab, but none of them have become a ‘key ...

Autism Spectrum Disorder in Anorexia Nervosa: An Updated Literature Review

Purpose of Review There is growing interest in the relationship between anorexia nervosa (AN) and autism spectrum disorder (ASD). This review aimed to synthesise the most recent research on this topic to identify gaps in current knowledge, directions for future research and reflect on implications for treatment. Recent Findings Eight studies assessing the presence of ASD in AN were ...

Multilevel genomics of colorectal cancers with microsatellite instability—clinical impact of JAK1 mutations and consensus molecular subtype 1

Background Approximately 15% of primary colorectal cancers have DNA mismatch repair deficiency, causing a complex genome with thousands of small mutations—the microsatellite instability (MSI) phenotype. We investigated molecular heterogeneity and tumor immunogenicity in relation to clinical endpoints within this distinct subtype of colorectal cancers. Methods A total of 333 primary ...

Factors affecting hedgehog (Erinaceus europaeus) attraction to rural villages in arable landscapes

Although residential areas are often unfavourable for wildlife, some species can take advantage of the available shelter and anthropogenic sources of food such as supplementary feeding. The European hedgehog (Erinaceus europaeus) is increasingly associated with gardens and villages and less so with arable farmland. Suggested drivers for this include the following: hedgehogs’ ...

Quantitative analysis of dynamic 18F-FDG PET/CT for measurement of lung inflammation

Background An inflammatory reaction in the airways and lung parenchyma, comprised mainly of neutrophils and alveolar macrophages, is present in some patients with chronic obstructive pulmonary disease (COPD). Thoracic fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) has been proposed as a promising imaging biomarker to assess this inflammation. We sought to introduce ...

Novel maximum likelihood approach for passive detection and localisation of multiple emitters

In this paper, a novel target acquisition and localisation algorithm (TALA) is introduced that offers a capability for detecting and localising multiple targets using the intermittent “signals-of-opportunity” (e.g. acoustic impulses or radio frequency transmissions) they generate. The TALA is a batch estimator that addresses the complex multi-sensor/multi-target data association ...