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Evaluation of compaction parameters of fine-grained soils using standard and modified efforts

Compaction characteristics of the soil have the great importance for practically achieving the desired strength, permeability and compressibility of soil during the construction. Standard compaction test (SCT) and modified compaction test (MCT) are two very famous laboratory test methods to determine the compaction characteristics of soils worldwide. Modest efforts have been made...

Conceptual model for the health technology assessment of current and novel interventions in rheumatoid arthritis

The objective of this study was to evaluate current approaches to economic modeling in rheumatoid arthritis (RA) and propose a new conceptual model for evaluation of the cost-effectiveness of RA interventions. We followed recommendations from the International Society of Pharmacoeconomics and Outcomes Research-Society of Medical Decision Making (ISPOR-SMDM) Modeling Good Research...

Cosmopolitanism without a World? David Mitchell’s Cloud Atlas

This article argues that David Mitchell’s 2004 novel Cloud Atlas equivocates between an optimistic articulation of a global public sphere and a more pessimistic inability to offer its readers a vision in which this public sphere can be realised. I attribute this equivocation to two competing imaginaries within the novel. The first—a cosmopolitan imaginary—wishes to dispense with...

James MacMillan's Mass of Blessed John Henry Newman and the Culture of Liturgical Music-Making in the Scottish Catholic Church

James MacMillan composed his Mass of Blessed John Henry Newman as a congregational setting for the visit of Pope Benedict XVI to the United Kingdom in 2010. The work was heralded as the first setting of the new English Missal translation, and MacMillan expressed hope that it would make a longer-term contribution to music-making in the Roman Catholic Anglosphere. However, in...

Sensorimotor expectations and the visual field

Sensorimotor expectations concern how visual experience covaries with bodily movement. Sensorimotor theorists argue from such expectations to the conclusion that the phenomenology of vision is constitutively embodied: objects within the visual field are experienced as 3-D because sensorimotor expectations partially constitute our experience of such objects. Critics argue that...

Pilot capability evaluation of a feedback electronic imaging system prototype for in-process monitoring in electron beam additive manufacturing

Electron beam additive manufacturing (EBAM) is an additive manufacturing (AM) technique increasingly used by many industrial sectors, including medical and aerospace industries. The application of this technology is still, however, challenged by many technical barriers. One of the major issues is the lack of process monitoring and control system to monitor process repeatability...

Only giving orders? An experimental study of the sense of agency when giving or receiving commands

In human societies, agents are assumed to experience being the author of their own actions. These basic motoric experiences of action are influenced by social hierarchies, leading to surprising and morally significant results. Here we ask whether, under coercion, the sense of agency and responsibility pass from the person who receives orders to the person who gives them...

Relationship between endotoxin core, staphylococcal and varicella antibody levels and outcome following aortic valve replacement surgery: a prospective observational study

BackgroundMorbidity and mortality following cardiac valve surgery is high. Immunity is an important contributor to outcome. This study examines the relationship of staphylococcal and endotoxin antibody levels to outcome following cardiac surgery.MethodsUsing enzyme-linked immunosorbent assays (ELISA), we measured pre-operative levels of antibodies to endotoxin core (EndoCAb); 3...

Novel Concepts in Psoriatic Arthritis Management: Can We Treat to Target?

Purpose of reviewPsoriatic arthritis (PsA) is a chronic inflammatory spondyloarthritis that can cause progressive joint damage and irreversible disability. Advances in modern therapies, now mean a target of remission is an achievable goal in PsA. There is strong and consistent evidence that a treat-to-target (T2T) approach to PsA management results in better patient outcomes...

Translational molecular imaging in exocrine pancreatic cancer

Effective treatment for pancreatic cancer remains challenging, particularly the treatment of pancreatic ductal adenocarcinoma (PDAC), which makes up more than 95% of all pancreatic cancers. Late diagnosis and failure of chemotherapy and radiotherapy are all too common, and many patients die soon after diagnosis. Here, we make the case for the increased use of molecular imaging in...

In-hospital care, complications, and 4-month mortality following a hip or proximal femur fracture: the Spanish registry of osteoporotic femur fractures prospective cohort study

SummaryWe have characterised 997 hip fracture patients from a representative 45 Spanish hospitals, and followed them up prospectively for up to 4 months. Despite suboptimal surgical delays (average 59.1 hours), in-hospital mortality was lower than in Northern European cohorts. The secondary fracture prevention gap is unacceptably high at 85%.PurposeTo characterise inpatient care...

Can Population Modelling Principles be Used to Identify Key PBPK Parameters for Paediatric Clearance Predictions? An Innovative Application of Optimal Design Theory

PurposePhysiologically-based pharmacokinetic (PBPK) models are essential in drug development, but require parameters that are not always obtainable. We developed a methodology to investigate the feasibility and requirements for precise and accurate estimation of PBPK parameters using population modelling of clinical data and illustrate this for two key PBPK parameters for hepatic...

Food cue-induced craving in individuals with bulimia nervosa and binge-eating disorder

Individuals with bulimia nervosa (BN) or binge-eating disorder (BED) experience more frequent and intense food cravings than individuals without binge eating. However, it is currently unclear whether they also show larger food cue-induced increases in craving (i.e., food cue reactivity) than those without binge eating, as suggested by conditioning theories of binge eating. A...

Mind Matters: Treatment Concerns Predict the Emergence of Antiretroviral Therapy Side Effects in People with HIV

The aim of this analysis of historical data was to determine whether patients’ pre-treatment beliefs about antiretroviral therapy (ART) predict the subsequent reporting of side effects. Data were collected as part of a prospective, 12-month follow-up study. Of 120 people starting ART, 76 completed follow-up assessments and were included in the analyses. Participants completed...

The 1831 eruption of Babuyan Claro that never happened: has the source of the one of the largest volcanic climate forcing events of the nineteenth century been misattributed?

The 1831 eruption of Babuyan Claro in the Philippines is regarded as one of the most significant volcanic climate forcing events of the nineteenth century. Modern databases have assigned the eruption a VEI of 4? and Magnitude of 4.7. Our analysis of historical sources, however, suggests that there was no such eruption in 1831 and that this date is the result of a...

Mosaic Turner syndrome shows reduced penetrance in an adult population study

PurposeMany women with X chromosome aneuploidy undergo lifetime clinical monitoring for possible complications. However, ascertainment of cases in the clinic may mean that the penetrance has been overestimated.MethodsWe characterized the prevalence and phenotypic consequences of X chromosome aneuploidy in a population of 244,848 women over 40 years of age from UK Biobank, using...

Heat kernel asymptotics of the subordinator and subordinate Brownian motion

For a class of Laplace exponents, we consider the transition density of the subordinator and the heat kernel of the corresponding subordinate Brownian motion. We derive explicit approximate expressions for these objects in the form of asymptotic expansions: via the saddle point method for the subordinator’s transition density and via the Mellin transform for the subordinate heat...

Cross-laboratory evaluation of multiplex bead assays including independent common reference standards for immunological monitoring of observational and interventional human studies

Background Multiplex assays are increasingly applied to analyze multicomponent signatures of human immune responses, including the dynamics of cytokine and chemokine production, in observational as well as interventional studies following treatment or vaccination. However, relatively limited information is available on the performance of the different available multiplex kits...

The Chronic Effects of Copper and Cadmium on Life History Traits Across Cladocera Species: A Meta-analysis

The effect of sublethal concentrations of heavy metals on cladoceran growth and reproduction is a cornerstone of modern ecotoxicology. However, the literature contains assays across numerous concentrations, on numerous species and genotypes, and conditions are far from consistent. We undertook a systematic review of the sublethal effects of copper and cadmium concentrations on...

Three-dimensional representation of the many-body quantum state

Using the trajectory conception of state, we give a simple demonstration that the quantum state of a many-body system may be expressed as a set of states in three-dimensional space, each associated with a different particle. It follows that the many-body wavefunction may be derived from a set of waves in 3-space. Entanglement is represented in the trajectory picture by the mutual...