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Role of myeloid regulatory cells (MRCs) in maintaining tissue homeostasis and promoting tolerance in autoimmunity, inflammatory disease and transplantation

Myeloid cells play a pivotal role in regulating innate and adaptive immune responses. In inflammation, autoimmunity, and after transplantation, myeloid cells have contrasting roles: on the one hand they initiate the immune response, promoting activation and expansion of effector T-cells, and on the other, they counter-regulate inflammation, maintain tissue homeostasis, and...

Combined explanations of B-physics anomalies: the sterile neutrino solution

Abstract In this paper we provide a combined explanation of charged- and neutral-current B-physics anomalies assuming the presence of a light sterile neutrino NR which contributes to the B → D(*)τν processes. We focus in particular on two simplified models, where the mediator of the flavour anomalies is either a vector leptoquark U 1 μ ∼ (3, 1, 2/3) or a scalar leptoquark S1...

A PET-positive rapidly growing mass of the abdominal wall after cesarean section with an unexpected diagnosis of vernix caseosa granuloma: a case report

BackgroundAbdominal wall tumors are rare and include heterogeneous diseases. Among them, desmoid tumors are the most frequent and are often diagnosed in young women during or early after pregnancy; inflammatory response after trauma or microtrauma, such as after cesarean section, may favor their growth.ResultsA 37-year-old woman presented with a progressive mass in the abdominal...

Seasonal changes in dry matter yield from Karst pastures as influenced by morphoclimatic features

Pastures are strongly affected by local environmental variables in terms of their species richness, plant composition and herbage production. A multi-site monitoring study was conducted over three years to investigate the influence of morphoclimatic factors on the seasonal variations in dry matter (DM) yield from Karst pastures. Seven sites located on the Italian and Slovenian...

Mutational and copy number asset of primary sporadic neuroendocrine tumors of the small intestine

Small intestine neuroendocrine tumors (SI-NETs) represent the most common histotype among small intestine neoplasms, and metastatic disease is usually present at diagnosis. A retrospective series of 52 sporadic primary surgically resected SI-NETs, which were metastatic at diagnosis, was analyzed by high-coverage target sequencing (HCTS) for the mutational status of 57 genes and...

Pharmacologic rescue of hyperammonemia-induced toxicity in zebrafish by inhibition of ornithine aminotransferase

Hyperammonemia is the common biochemical hallmark of urea cycle disorders, activating neurotoxic pathways. If untreated, affected individuals have a high risk of irreversible brain damage and mortality. Here we show that acute hyperammonemia strongly enhances transamination-dependent formation of osmolytic glutamine and excitatory glutamate, thereby inducing neurotoxicity and...

Animal-Assisted Activity at A. Meyer Children's Hospital: A Pilot Study

The authors systematically studied the introduction of animal-assisted activity into a children's hospital in Italy. This pilot study examined the reactions of children, their parents and the hospital staff and the hospital-wide infection rate before and after the introduction of animals. The SAM (self-assessment manikin), three behavioral scales, analysis of children's graphic...

Anatomy of the Episodic Buffer: A Voxel-Based Morphometry Study in Patients with Dementia

In 2000 Baddeley proposed the existence of a new component of working memory, the episodic buffer, which should contribute to the on-line maintenance of integrated memory traces. The author assumed that this component should be critical for immediate recall of a short story that exceeds the capacity of the phonological store. Accordingly, patients with Alzheimer’s dementia (AD...

Rh System and Intrauterine Growth. Interaction with Season of Birth

Based on the hypothesis that maternal-fetal genetic differences in membrane transport and signal transduction may influence intrauterine development, the recent acquisition on transport function of Rh protein prompted us to study the relationship between joint maternal-fetal Rh phenotype and birth weight. Considering that metabolic effect of maternal-fetal competition could be...

On boundary value problems for degenerate differential inclusions in Banach spaces

We consider the applications of the theory of condensing set-valued maps, the theory of set-valued linear operators, and the topological degree theory of the existence of mild solutions for a class of degenerate differential inclusions in a reflexive Banach space. Further, these techniques are used to obtain the solvability of general boundary value problems for a given class of...

Positive solutions for singular discrete boundary value problems

We study the existence of zero-convergent solutions for the second-order nonlinear difference equation Δ(anΦp(Δxn))=g(n,xn

Protein carbonyl group content in patients affected by familiar chronic nail candidiasis

Familiar chronic nail candidiasis (FCNC) is a rare disorder characterized by early-onset infections caused by different species of Candida, restricted to the nail of the hands and feet, and associated with a low serum concentration of intercellular adhesion molecule 1. Host defense mechanisms against candidiasis require the cooperation of many immune cells through several...

Bifidobacterium bifidum PRL2010 alleviates intestinal ischemia/reperfusion injury

Mesenteric ischemia/reperfusion is a clinical emergency with high morbidity and mortality due to the transient reduction of blood supply to the bowel. In recent years, the critical contribution of gut microbiome to human health and proper gastrointestinal functions has gradually emerged. In the current study, we investigated the protective effects of five days supplementation...

Rivoluzioni visuali, in forma di cosa: cronaca di un evento (in)tempestivo

Simposio internazionale Poesia in forma di cosa. Concretismo e Visualità in Italia e Belgio negli anni Sessanta e Settanta – Istituto Italiano di Cultura di Bruxelles, 24-25 maggio 2018.

Chromosome numbers for the Italian flora: 5

In this contribution new chromosome data obtained on material collected in Italy are presented. It includes 7 chromosome counts for Centaurea (Asteraceae).

The lichens of the Alps – an annotated checklist

This is the first attempt to provide an overview of the lichen diversity of the Alps, one of the biogegraphically most important and emblematic mountain systems worldwide. The checklist includes all lichenised species, plus a set of non- or doubtfully lichenised taxa frequently treated by lichenologists, excluding non-lichenised lichenicolous fungi. Largely based on recent...

The traditional food use of wild vegetables in Apulia (Italy) in the light of Italian ethnobotanical literature

In this work, we present a summary of an ethnobotanical research carried out in the whole Administrative Region of Apulia (southern Italy). The main topic of the investigation is the traditional knowledge about wild plants, focusing on their common names, on which parts were used in cooking and how they were used. The main aim was to establish a botanical knowledge about these...

A new species of Rhodocybe sect. Rufobrunnea (Entolomataceae, Agaricales) from Italy

Rhodocybe fumanellii is described from Italy as a new species based both on morphological and molecular nrITS/nrLSU data. It belongs in sect. Rufobrunnea and is characterised by massive tricholomatoid basidiomata with reddish-brown tinges, adnate and crowded lamellae, an enlarged stipe base with long rhizomorphs, long sinuose slender cheilocystidia, ellipsoid basidiospores and...

Arteriovenous Malformation Pulmonary (AVM) in a Post-Cesarean Woman: Intensive Care and Urgent Surgery Operation

The AVM is a rare congenital disease that often affects the brain and only rarely we find in other organs. In this pathology there is an alteration of the vascular system, with the arteries discharging directly into the veins, bypassing the capillary system; this puts the patient at high risk of sudden hemorrhage. Today we present the case of a young woman suffering from unknown...

23rd International Colloquium on Animal Cytogenetics and Genomics (23 ICACG) June 9–12, 2018, Saint-Petersburg, Russia

In memory of Ingemar Gustavsson 23rd International Colloquium on Animal Cytogenetics and Genomics (23 ICACG) took place in June 9–12, 2018 in Saint-Petersburg, Russia. Organized biennially, the Colloquium runs from 1970. From its very start this meeting is associated with the name of Ingemar Gustavsson to whom we dedicated the Colloquium 2018. The long and productive career of...