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Risky decision-making and affective features of impulse control disorders in Parkinson’s disease

Impulse control disorders (ICDs) in Parkinson’s disease (PD) are considered dopaminergic treatment side effects. Cognitive and affective factors may increase the risk of ICD in PD. The aim is to investigate risky decision-making and associated cognitive processes in PD patients with ICDs within a four-stage conceptual framework. Relationship between ICDs and affective factors was ...

Sex differences in the characteristics and short-term prognosis of patients presenting with acute symptomatic pulmonary embolism

Background We sought to examine sex-related differences in the characteristics and outcome in patients presenting with acute symptomatic pulmonary embolism (PE). Methods We conducted a retrospective cohort study of 2,096 patients diagnosed with acute PE. The characteristics were recorded at presentation. Treatment was at the discretion of patients’ physicians. The primary study ...

A real time metabolomic profiling approach to detecting fish fraud using rapid evaporative ionisation mass spectrometry

Introduction Fish fraud detection is mainly carried out using a genomic profiling approach requiring long and complex sample preparations and assay running times. Rapid evaporative ionisation mass spectrometry (REIMS) can circumvent these issues without sacrificing a loss in the quality of results. Objectives To demonstrate that REIMS can be used as a fast profiling technique ...

Measurement of the triple-differential dijet cross section in proton-proton collisions at \(\sqrt{s}=8\,\text {TeV} \) and constraints on parton distribution functions

A measurement is presented of the triple-differential dijet cross section at a centre-of-mass energy of 8\(\,\text {TeV}\) using 19.7\(\,\text {fb}^\text {-1}\) of data collected with the CMS detector in proton-proton collisions at the LHC. The cross section is measured as a function of the average transverse momentum, half the rapidity separation, and the boost of the two leading ...

Lactobacillus reuteri suppresses E. coli O157:H7 in bovine ruminal fluid: Toward a pre-slaughter strategy to improve food safety?

The bovine gastrointestinal tract (GIT) is the main reservoir for enterohaemorrhagic Escherichia coli (EHEC) responsible for food-borne infections. Therefore, it is crucial to develop strategies, such as EHEC suppression by antagonistic microorganisms, to reduce EHEC survival in the GIT of cattle and to limit shedding and food contamination. Most human-derived Lactobacillus reuteri ...

Hormonal contraceptives and risk of ischemic stroke in women with migraine: a consensus statement from the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC)

Several data indicate that migraine, especially migraine with aura, is associated with an increased risk of ischemic stroke and other vascular events. Of concern is whether the risk of ischemic stroke in migraineurs is magnified by the use of hormonal contraceptives. As migraine prevalence is high in women of reproductive age, it is common to face the issue of migraine and hormonal ...

Measurements of the associated production of a Z boson and b jets in pp collisions at \({\sqrt{s}} = 8\,\text {TeV} \)

Measurements of the associated production of a \(\mathrm{Z}\) boson with at least one jet originating from a b quark in proton–proton collisions at \(\sqrt{s} = 8\,\text {TeV} \) are presented. Differential cross sections are measured with data collected by the CMS experiment corresponding to an integrated luminosity of 19.8\(\,\text {fb}^{-1}\). \(\mathrm{Z}\) bosons are ...

Peripheral blood HIV-1 DNA dynamics in antiretroviral-treated HIV/HCV co-infected patients receiving directly-acting antivirals

Background Aim was to determine the dynamics of peripheral blood mononuclear cells (PBMC)- associated total HIV-1 DNA in successfully ART-treated HIV/HCV co-infected patients receiving DAA treatment and to explore possible virological hypotheses underlying the phenomenon. Methods Longitudinal, single-centre study measuring total HIV-1 DNA before the start of DAA, at the end of ...

Preclinical effects of APOE ε4 on cerebrospinal fluid Aβ42 concentrations

Background From earlier studies it is known that the APOE ε2/ε3/ε4 polymorphism modulates the concentrations of cerebrospinal fluid (CSF) beta-amyloid1–42 (Aβ42) in patients with cognitive decline due to Alzheimer’s disease (AD), as well as in cognitively healthy controls. Here, in a large cohort consisting solely of cognitively healthy individuals, we aimed to evaluate how the ...

Genuine participation in participant-centred research initiatives: the rhetoric and the potential reality

The introduction of Web 2.0 technology, along with a population increasingly proficient in Information and Communications Technology (ICT), coupled with the rapid advancements in genetic testing methods, has seen an increase in the presence of participant-centred research initiatives. Such initiatives, aided by the centrality of ICT interconnections, and the ethos they propound ...

Multi-nest high-resolution model of submesoscale circulation features in the Gulf of Taranto

Recent oceanographic field measurements and high-resolution numerical modelling studies have revealed intense, transient, submesoscale motions characterised by a horizontal length scale of 100–10,000 m. This submesoscale activity increases in the fall and winter when the mixed layer (ML) depth is at its maximum. In this study, the submesoscale motions associated with a large-scale ...

Metabolic syndrome and Chronic Obstructive Pulmonary Disease (COPD): The interplay among smoking, insulin resistance and vitamin D

Background A close relationship between Metabolic Syndrome (MetS) and Chronic Obstructive Pulmonary Disease (COPD) has been described, but the exact nature of this link remains unclear. Current epidemiological data refer exclusively to the MetS prevalence among patients with COPD and data about the prevalence of COPD in MetS patients are still unavailable. Aim of the study To ...

A Multi-Arm Phase I Study of the PI3K/mTOR Inhibitors PF-04691502 and Gedatolisib (PF-05212384) plus Irinotecan or the MEK Inhibitor PD-0325901 in Advanced Cancer

Background This phase I, four-arm, open-label study (NCT01347866) evaluated the PI3K/mTOR inhibitors PF-04691502 (arms A, B) and gedatolisib (PF-05212384; arms C, D) in combination with the MEK inhibitor PD-0325901 (arm A, D) or irinotecan (arm B, C) in patients with advanced solid tumors. Objectives Primary endpoint was dose-limiting toxicity with each combination. Secondary ...

Musicians have better memory than nonmusicians: A meta-analysis

Background Several studies have found that musicians perform better than nonmusicians in memory tasks, but this is not always the case, and the strength of this apparent advantage is unknown. Here, we conducted a meta-analysis with the aim of clarifying whether musicians perform better than nonmusicians in memory tasks. Methods Education Source; PEP (WEB)—Psychoanalytic Electronic ...

Spatial variation of reef fishes and the relative influence of biotic and abiotic habitat traits

Patterns of distribution of reef fishes were examined across three spatial scales and related to habitat traits along 25 km of the northern Portuguese coast. Response variables included the multivariate assemblage structure, the total number of taxa and individuals, and the abundance of single groups categorized according to their preference for the benthic, proximo-benthic or ...

Monitoring multiple myeloma by idiotype-specific peptide binders of tumor-derived exosomes

Tumor-derived exosomes (TDEs) play a pivotal role in tumor establishment and progression, and are emerging biomarkers for tumor diagnosis in personalized medicine. To date, there is a lack of efficient technology platforms for exosome isolation and characterization. Multiple myeloma (MM) is an incurable B-cell malignancy due to the rapid development of drug-resistance. MM-released ...