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Methodology for Determining Dwell Times Consistent with Passenger Flows in the Case of Metro Services

The importance of a mobility system based on railway technology as the backbone of public transport is now widely acknowledged. Indeed, rail systems are green, high performing, smart and able to ensure a high degree of safety. Therefore, modal split should be steered towards rail transport by increasing the attractiveness of this transport mode. In this context, a key element is ...

The inhibition of FGF receptor 1 activity mediates sorafenib antiproliferative effects in human malignant pleural mesothelioma tumor-initiating cells

Background Malignant pleural mesothelioma is an aggressive cancer, characterized by rapid progression and high mortality. Persistence of tumor-initiating cells (TICs, or cancer stem cells) after cytotoxic drug treatment is responsible for tumor relapse, and represents one of the main reasons for the poor prognosis of mesothelioma. In fact, identification of the molecules affecting ...

Maxillary resection for cancer, zygomatic implants insertion, and palatal repair as single-stage procedure: report of three cases

Background Oronasal/antral communication, loss of teeth and/or tooth-supporting bone, and facial contour deformity may occur as a consequence of maxillectomy for cancer. As a result, speaking, chewing, swallowing, and appearance are variably affected. The restoration is focused on rebuilding the oronasal wall, using either flaps (local or free) for primary closure, either ...

Functional models and extending strategies for ecological networks

Complex network analysis is rising as an essential tool to understand properties of ecological landscape networks, and as an aid to land management. The most common methods to build graph models of ecological networks are based on representing functional connectivity with respect to a target species. This has provided good results, but the lack of a model able to capture general ...

Digital breast tomosynthesis (DBT): recommendations from the Italian College of Breast Radiologists (ICBR) by the Italian Society of Medical Radiology (SIRM) and the Italian Group for Mammography Screening (GISMa)

This position paper, issued by ICBR/SIRM and GISMa, summarizes the evidence on DBT and provides recommendations for its use. In the screening setting, DBT in adjunct to digital mammography (DM) increased detection rate by 0.5–2.7‰ and decreased false positives by 0.8–3.6% compared to DM alone in observational and double-testing experimental studies. The reduction in recall rate ...

Magmatic gas percolation through the old lava dome of El Misti volcano

The proximity of the major city of Arequipa to El Misti has focused attention on the hazards posed by the active volcano. Since its last major eruption in the fifteenth century, El Misti has experienced a series of modest phreatic eruptions and fluctuating fumarolic activity. Here, we present the first measurements of the compositions of gas emitted from the lava dome in the summit ...

Impact of event landslides on road networks: a statistical analysis of two Italian case studies

Despite abundant information on landslides, and on landslide hazard and risk, in Italy, little is known on the direct impact of event landslides on road networks and on the related economic costs. We investigated the physical and economic damage caused by two rainfall-induced landslide events in Central and Southern Italy, to obtain road restoration cost statistics. Using a ...

CPANNatNIC software for counter-propagation neural network to assist in read-across

Background CPANNatNIC is software for development of counter-propagation artificial neural network models. Besides the interface for training of a new neural network it also provides an interface for visualisation of the results which was developed to aid in interpretation of the results and to use the program as a tool for read-across. Results The work presents the details of the ...

Neighbors-Aware Proportional Fair scheduling for future wireless networks with mixed MAC protocols

In this paper, we consider a beyond-5G scenario, where two types of users, denoted as scheduled and uncoordinated nodes, coexist on the same set of radio resources for sending data to a base station. Scheduled nodes rely solely on a centralized scheduler within the base station for the assignment of resources, while uncoordinated nodes use an unslotted Carrier Sense Multiple Access ...

The Partial Visibility Representation Extension Problem

For a graph G, a function \(\psi \) is called a bar visibility representation of G when for each vertex \(v \in V(G)\), \(\psi (v)\) is a horizontal line segment (bar) and \(uv \in E(G)\) if and only if there is an unobstructed, vertical, \(\varepsilon \)-wide line of sight between \(\psi (u)\) and \(\psi (v)\). Graphs admitting such representations are well understood (via simple ...

Communication on Safety of Medicines in Europe: Current Practices and General Practitioners’ Awareness and Preferences

Introduction National competent authorities (NCAs) for medicines coordinate communication relating to the safety of medicines in Europe. The effectiveness of current communication practices has been questioned, particularly with regard to reaching general practitioners (GPs). Objective The aim of this study was to assess current European NCA safety communication practices and to ...

Transcranial Direct Current Stimulation (tDCS) of the Anterior Prefrontal Cortex (aPFC) Modulates Reinforcement Learning and Decision-Making Under Uncertainty: a Double-Blind Crossover Study

Reinforcement learning refers to the ability to acquire information from the outcomes of prior choices (i.e. positive and negative) in order to make predictions on the effect of future decision and adapt the behaviour basing on past experiences. The anterior prefrontal cortex (aPFC) is considered to play a key role in the representation of event value, reinforcement learning and ...

Pituitary dysfunction in granulomatosis with polyangiitis

Purpose Granulomatosis with polyangiitis (GPA) is a multisystem disease, characterized by necrotizing small-vessel vasculitis, which mainly affects the respiratory tract and the kidneys. Pituitary involvement in GPA is rare, present in about 1% of all cases of GPA. To date, only case reports or small case series have been published. Herein we report clinical features, imaging ...

Soft tissue-based surgical techniques for treatment of posterior shoulder instability

Posterior shoulder instability is a rare clinical condition that encompasses different degrees of severity including various possible pathologies involving the labrum, capsule, bony lesions, and even locked posterior dislocation. When focusing on soft tissue involvement, the diagnosis of posterior instability may be difficult to make because frequently patients report vague ...