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Botulinum neurotoxin type A for the treatment of pain: not just in migraine and trigeminal neuralgia

Background Despite their huge epidemiological impact, primary headaches, trigeminal neuralgia and other chronic pain conditions still receive suboptimal medical approach, even in developed countries. The limited efficacy of current pain-killers and prophylactic treatments stands among the main reasons for this phenomenon. Botulinum neurotoxin (BoNT) represents a well-established ...

The FAST D protocol: a simple method to rule out traumatic vascular injuries of the lower extremities

Background The aim of this study is to assess the accuracy of a Fast Doppler protocol for the examination of an injured lower limb, namely 2-Point Fast Doppler (2PFD), in order to rapidly triage arterial lesions after penetrating trauma. Methods The presence of flow and the aspects of the Doppler waveform of the dorsalis pedis artery (DPA) and posterior tibial artery (PTA) of the ...

Dynamic political contexts and power asymmetries: the cases of the Blue Nile and the Yarmouk Rivers

This paper explores the evolving patterns of hydropolitical relations in the dynamic contexts of Yarmouk and Blue Nile Rivers in comparison. The analysis aims at shedding light over the complex implications that recent political and social changes have aroused for the water disputes between Jordan and Syria on the one hand, and Ethiopia and Egypt on the other. In both basins, ...

Hyaluronan coating improves liver engraftment of transplanted human biliary tree stem/progenitor cells

Background Cell therapy of liver diseases with human biliary tree stem cells (hBTSCs) is biased by low engraftment efficiency. Coating the hBTSCs with hyaluronans (HAs), the primary constituents of all stem cell niches, could facilitate cell survival, proliferation, and, specifically, liver engraftment given that HAs are cleared selectively by the liver. Methods We developed a fast ...

From protein-protein interactions to protein co-expression networks: a new perspective to evaluate large-scale proteomic data

The reductionist approach of dissecting biological systems into their constituents has been successful in the first stage of the molecular biology to elucidate the chemical basis of several biological processes. This knowledge helped biologists to understand the complexity of the biological systems evidencing that most biological functions do not arise from individual molecules; ...

Combined photographic and ultrasonographic measurement of the ANB angle: a pilot study

Objective This study was performed to evaluate the feasibility of noninvasive measurement of the ANB angle using photographic and ultrasonographic methods. Methods Twenty consecutive orthodontic patients were evaluated. The ANB angle and soft tissue thickness covering the N, A, and B cephalometric points were measured by lateral teleradiography; these measurements were made by two ...

Microscopic and ultrastructural evidences in human skin following calcium hydroxylapatite filler treatment

This study uses light and electron microscopes to gain a better knowledge of the interactions of calcium hydroxylapatite filler with the connective tissue of the skin and the modifications of the human deep dermis, after 2 months of treatment. Some morphological evidences of this observational study of filler treated tissue support-specific mechanism involved in the structural ...

Cultural Constellations: Burckhardtsource.org

Burckhardtsource.org hosts a corpus of over 1,000 documents forming the correspondence of more than 300 different authors with Swiss historian of art and culture Jacob Burckhardt (1818–1897). Dr. Susanne Müller and Dr. Costanza Giannaccini, who collaborated on the creation of the platform and on the critical digital edition of the letters to Burckhardt, discuss the guiding ...

Environmental exposure to arsenic and chromium in an industrial area

Arsenic and chromium are widespread environmental contaminants that affect global health due to their toxicity and carcinogenicity. To date, few studies have investigated exposure to arsenic and chromium in a population residing in a high-risk environmental area. The aim of this study is to evaluate the exposure to arsenic and chromium in the general population with no occupational ...

Facility location with double-peaked preferences

We study the problem of locating a single facility on a real line based on the reports of self-interested agents, when agents have double-peaked preferences, with the peaks being on opposite sides of their locations. We observe that double-peaked preferences capture real-life scenarios and thus complement the well-studied notion of single-peaked preferences. As a motivating ...

Characteristics and outcomes of ureteroscopic treatment in 2650 patients with impacted ureteral stones

Purpose To describe stone-free rates and complications of ureteroscopic treatment for impacted compared with non-impacted ureteral stones and evaluate predictive variables for impaction. Methods The Clinical Research Office of the Endourological Society prospectively collected 1 consecutive year of data from 114 centers worldwide. Patients eligible for inclusion were patients ...

A theoretical model of the relationship between the h-index and other simple citation indicators

Of the existing theoretical formulas for the h-index, those recently suggested by Burrell (J Informetr 7:774–783, 2013b) and by Bertoli-Barsotti and Lando (J Informetr 9(4):762–776, 2015) have proved very effective in estimating the actual value of the h-index Hirsch (Proc Natl Acad Sci USA 102:16569–16572, 2005), at least at the level of the individual scientist. These approaches ...

Explaining Conflicting Results in Research on the Heterogeneous Effects of Parental Separation on Children’s Educational Attainment According to Social Background

In recent years, researchers have become increasingly interested in how the effects of parental separation on children’s educational attainment vary with social background. On the one hand, parents with more resources might be better able to prevent possible adverse events like separation to affect their children’s outcomes. On the other hand, children from higher social ...

Time takes space: selective effects of multitasking on concurrent spatial processing

Many everyday activities require coordination and monitoring of complex relations of future goals and deadlines. Cognitive offloading may provide an efficient strategy for reducing control demands by representing future goals and deadlines as a pattern of spatial relations. We tested the hypothesis that multiple-task monitoring involves time-to-space transformational processes, and ...

Impulsivity and Stress Response in Pathological Gamblers During the Trier Social Stress Test

Gambling has been associated with increased sympathetic nervous system output and stimulation of the hypothalamic–pituitary–adrenal axis. However it is unclear how these systems are affected in pathological gambling. This study aimed to investigate the effect of the Trier Social Stress Test (TSST) on cortisol and on cardiac interbeat intervals in relation to impulsivity, in a ...

Economics of cultural tourism: issues and perspectives

The special issue aims at exploring, with an economic perspective, the interconnections between cultural participation, in all its expressions, and tourism organization and patterns with the purpose of understanding economic effects, emerging trends and policy implications. The expanding notion of the cultural consumption of tourists makes the definition of cultural tourism ...

Improvements in Reading Comprehension Performance After a Training Program Focusing on Executive Processes of Working Memory

Reading comprehension is a complex cognitive task crucial to success in formal education and everyday life activities. Working memory (WM) and associated executive processes have been shown to be implicated in reading comprehension abilities. The aim of the present study was to assess the efficacy of a program for improving reading comprehension skills based on reading activities ...