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The relationship between target joints and direct resource use in severe haemophilia

Objectives Target joints are a common complication of severe haemophilia. While factor replacement therapy constitutes the majority of costs in haemophilia, the relationship between target joints and non drug-related direct costs (NDDCs) has not been studied. Methods Data on haemophilia patients without inhibitors was drawn from the ‘Cost of Haemophilia across Europe – a ...

Evaluation of Hirst-type spore traps in outdoor Aspergillaceae monitoring during large demolition work in hospital

Demolition can generate fungal spore suspensions in association with various adverse health effects, such as high risk of invasive aspergillosis in immunocompromised patients. One block of Edouard Herriot Hospital was entirely demolished. The aim of the present study was to evaluate Hirst-type spore traps utility in monitoring outdoor Aspergillaceae (Aspergillus spp. + Penicillium ...

The farnesoid X receptor agonist obeticholic acid upregulates biliary excretion of asymmetric dimethylarginine via MATE-1 during hepatic ischemia/reperfusion injury

Background We previously showed that increased asymmetric dimethylarginine (ADMA) biliary excretion occurs during hepatic ischemia/reperfusion (I/R), prompting us to study the effects of the farnesoid X receptor (FXR) agonist obeticholic acid (OCA) on bile, serum and tissue levels of ADMA after I/R. Material and methods Male Wistar rats were orally administered 10mg/kg/day of OCA ...

Proliferation and survival of human amniotic epithelial cells during their hepatic differentiation

Stem cells derived from placental tissues are an attractive source of cells for regenerative medicine. Amniotic epithelial cells isolated from human amnion (hAECs) have desirable and competitive characteristics that make them stand out between other stem cells. They have the ability to differentiate toward all three germ layers, they are not tumorigenic and they have ...

Association between PM10, PM2.5, NO2, O3 and self-reported diabetes in Italy: A cross-sectional, ecological study

Introduction Air pollution represents a serious threat to health on a global scale, being responsible for a large portion of the global burden of disease from environmental factors. Current evidence about the association between air pollution exposure and Diabetes Mellitus (DM) is still controversial. We aimed to evaluate the association between area-level ambient air pollution and ...

Thromboelastography-based anticoagulation management during extracorporeal membrane oxygenation: a safety and feasibility pilot study

Background There is no consensus on the management of anticoagulation during extracorporeal membrane oxygenation (ECMO). ECMO is currently burdened by a high rate of hemostatic complications, possibly associated with inadequate monitoring of heparin anticoagulation. This study aims to assess the safety and feasibility of an anticoagulation protocol for patients undergoing ECMO ...

On the Methodological Framework of Composite Indices: A Review of the Issues of Weighting, Aggregation, and Robustness

In recent times, composite indicators have gained astounding popularity in a wide variety of research areas. Their adoption by global institutions has further captured the attention of the media and policymakers around the globe, and their number of applications has surged ever since. This increase in their popularity has solicited a plethora of methodological contributions in ...

Reconstructing normality following the diagnosis of a childhood chronic disease: does “rare” make a difference?

Living with a childhood chronic disease can be challenging, especially if the diagnosis involves a rare condition. This study sought to elucidate how the diagnosis of a rare disease, as compared to a common, chronic condition, may influence maternal experiences of childhood illness. We conducted face-to-face, semi-structured interviews with 26 mothers of children treated in a ...

CT imaging of primary pancreatic lymphoma: experience from three referral centres for pancreatic diseases

Purpose To describe CT characteristics of primary pancreatic lymphoma (PPL), a rare disease with features in common with adenocarcinoma. Materials and methods Fourteen patients were enrolled. CT: unenhanced scan, contrast-enhanced pancreatic and venous phases. Image analysis: tumour location; peri-pancreatic vessel encasement; necrosis; enlarged lymph nodes; fat stranding; enlarged ...

Fusarium ershadii sp. nov., a Pathogen on Asparagus officinalis and Musa acuminata

Two Fusarium strains, isolated from Asparagus in Italy and Musa in Vietnam respectively, proved to be members of an undescribed clade within the Fusarium solani species complex based on phylogenetic species recognition on ITS, partial RPB2 and EF-1α gene fragments. Macro- and micro-morphological investigations followed with physiological studies done on this new species: Fusarium ...

Peripheral Blood Brain-Derived Neurotrophic Factor as a Biomarker of Alzheimer’s Disease: Are There Methodological Biases?

Mounting evidence that alterations in brain-derived neurotrophic factor (BDNF) levels and signaling may be involved in the etiopathogenesis of Alzheimer’s disease (AD) has suggested that its blood levels could be used as a biomarker of the disease. However, higher, lower, or unchanged circulating BDNF levels have all been described in AD patients compared to healthy controls. ...

Dynamics of transcendental Hénon maps

The dynamics of transcendental functions in the complex plane has received a significant amount of attention. In particular much is known about the description of Fatou components. Besides the types of periodic Fatou components that can occur for polynomials, there also exist so-called Baker domains, periodic components where all orbits converge to infinity, as well as wandering ...

Life history traits and demographic parameters in the Keratella cochlearis (Rotifera, Monogononta) species complex

A recent study based on DNA taxonomy indicated that the widespread rotifer Keratella cochlearis comprises several evolutionarily significant units (ESUs). Identification of ESUs based on DNA taxonomy alone is problematic and usually requires morphological, demographic, and/or ecological evidence. We isolated three haplotypes belonging to two ESUs of K. cochlearis and conducted life ...

For an inclusive innovation. Healing the fracture between the human and the technological in the hypercomplex society

Hurled into hypercomplexity, we are facing a complex process of anthropological transformation, of a shift in paradigms, models and codes, other than an irreversible synthesis of new value systems and criteria for judgment. Our extraordinary scientific discoveries and technological innovations not only open dizzily onto as yet unimaginable horizons and scenarios, but show, ever ...

Discussion of “The power of monitoring: how to make the most of a contaminated multivariate sample”

We contribute to the discussion of an article where Andrea Cerioli, Marco Riani, Anthony Atkinson and Aldo Corbellini review the advantages of analyzing multivariate data by monitoring how the estimated model parameters change as the estimation parameters vary. The focus is on robust methods and their sensitivity to the nominal efficiency and breakdown point. In congratulating with ...

Adaptive independent sticky MCMC algorithms

Monte Carlo methods have become essential tools to solve complex Bayesian inference problems in different fields, such as computational statistics, machine learning, and statistical signal processing. In this work, we introduce a novel class of adaptive Monte Carlo methods, called adaptive independent sticky Markov Chain Monte Carlo (MCMC) algorithms, to sample efficiently from any ...

Prevalence, risk factors and molecular evaluation of hepatitis E virus infection among pregnant women resident in the northern shores of Persian Gulf, Iran

Background Although Iran is reported to be an endemic country for hepatitis E virus (HEV), data on the prevalence of HEV infection among pregnant women are scarce and the epidemiology of HEV is unknown in most parts of the country. Therefore, this study was conducted to elucidate the prevalence, risk factors and genotypic pattern of HEV infection among pregnant women resident in ...

The efficacy of a porcine collagen matrix in keratinized tissue augmentation: a 5-year follow-up study

Background When keratinized tissue width around dental implants is poorly represented, the clinician could resort to autogenous soft tissue grafting. Autogenous soft tissue grafting procedures are usually associated with a certain degree of morbidity. Collagen matrices could be used as an alternative to reduce morbidity and intra-operatory times. The aim of this study was to assess ...