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Effect of cardiovascular risk factors and time of hospital presentation on mortality of maintenance hemodialysis patients presenting with acute pulmonary edema

Background Acute pulmonary edema (APE) has a poor prognosis in the general population. Mortality associated with APE in patients with end-stage renal disease (ESRD) is especially high, although specific predictors are not well understood. This study aimed to determine the potential predictive factors of outcome in patients with ESRD presenting with APE. Methods Sixty-eight patients ...

Laparoscopic anterior gastropexy for type III/IV hiatal hernia in elderly patients

Introduction Large esophageal hiatal hernias occur most commonly in elderly patients with comorbidities, in whom even an elective surgery cannot be performed without high risks. Although fundoplication is recommended for esophageal hiatal hernia repair, we prefer not to limit our options to fundoplication, as obstruction is a frequent main complaint. We favor an anterior gastropexy ...

Uncommon features of surgically resected ALK-positive cavitary lung adenocarcinoma: a case report

Some features found on chest computed tomography (CT), such as central tumor location, large pleural effusion, and the absence of a pleural tail, and a patient age of less than 60 years, have been suggested to be useful in predicting anaplastic lymphoma kinase (ALK) rearrangement in patients with non-small cell lung cancer (NSCLC). A 68-year-old female patient with a history of ...

Efficacy and safety of golimumab 52-week maintenance therapy in Japanese patients with moderate to severely active ulcerative colitis: a phase 3, double-blind, randomized, placebo-controlled study-(PURSUIT-J study)

Background The global phase 3 studies of golimumab [PURSUIT-SC and PURSUIT-maintenance (M)], an anti-tumor necrosis factor-α (anti-TNFα) antibody, have demonstrated clinical efficacy and safety as induction and maintenance therapies in patients with moderate to severely active ulcerative colitis (UC). This study aimed to evaluate the efficacy and safety of golimumab as maintenance ...

Sex Differences in the Blood Concentration of Tacrolimus in Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients with CYP3A5*3/*3

The purpose of this study was to describe the impact of sex and cytochrome P450 3A5 (CYP3A5) variant on the blood concentration of tacrolimus in patients with systemic lupus erythematosus or rheumatoid arthritis. The blood concentration of tacrolimus (ng/mL) divided by the daily dose of tacrolimus (mg/day) and the patient’s weight (kg) (C/D) was obtained from 55 patients. The C/D ...

Lusutrombopag increases hematocytes in a compensated liver cirrhosis patient

A 56-year-old Japanese man with liver cirrhosis (LC) due to hepatitis C virus was admitted to our hospital for radiofrequency ablation of residual tumor following lusutrombopag administration. Laboratory tests revealed thrombocytopenia and leukopenia. The patient’s LC was managed, and he was classified as Child–Pugh A. After admission, lusutrombopag was administered for 7 days. The ...

Comorbidities according to airflow limitation severity: data from comprehensive health examination in Japan

Objectives The present study aimed to investigate the relationship between airflow limitation (AL) severity and comorbidities in comprehensive health examination. Methods This cross-sectional study included 6661 men and 6044 women aged 40–89 who underwent a lung function test during medical checkups. AL was defined as forced expiratory volume in 1 s/forced vital capacity of < 0.7. ...

Occupation exposed to road-traffic emissions and respiratory health among Congolese transit workers, particularly bus conductors, in Kinshasa: a cross-sectional study

Objectives Road-traffic emissions (RTE) induce adverse health effects, notably respiratory symptoms and respiratory diseases, as a result of pollutants deposited into the respiratory tract. The aim of this study was to evaluate the association between occupation groups of Congolese transit workers exposed to RTE, particularly bus conductors and respiratory health, in Kinshasa. ...

Four-year maintenance treatment with adalimumab in Japanese patients with moderately to severely active ulcerative colitis

Background The 52-week safety and efficacy of adalimumab in Japanese patients with moderately to severely active ulcerative colitis were demonstrated in a placebo-controlled phase 2/3 trial. Data from patients who enrolled in the open-label extension study are presented. Methods Remission and response per the full Mayo score (FMS) and the partial Mayo score (PMS), remission per the ...

Joint universality for dependent L-functions

We prove that, for arbitrary Dirichlet L-functions \(L(s;\chi _1),\ldots ,L(s;\chi _n)\) (including the case when \(\chi _j\) is equivalent to \(\chi _k\) for \(j\ne k\)), suitable shifts of type \(L(s+i\alpha _jt^{a_j}\log ^{b_j}t;\chi _j)\) can simultaneously approximate any given set of analytic functions on a simply connected compact subset of the right open half of the ...

A new peptide vaccine OCV-501: in vitro pharmacology and phase 1 study in patients with acute myeloid leukemia

Wilms’ tumor 1 (WT1) is a promising target of new immunotherapies for acute myeloid leukemia (AML) as well as for other cancers. OCV-501 is a helper peptide derived from the WT1 protein. OCV-501 induced OCV-501-specific Type 1 T-helper (Th1) responses dose-dependently and stimulated helper activity of the specific Th1 cells in peripheral blood mononuclear cells from healthy donors. ...

Characteristics and outcomes of ureteroscopic treatment in 2650 patients with impacted ureteral stones

Purpose To describe stone-free rates and complications of ureteroscopic treatment for impacted compared with non-impacted ureteral stones and evaluate predictive variables for impaction. Methods The Clinical Research Office of the Endourological Society prospectively collected 1 consecutive year of data from 114 centers worldwide. Patients eligible for inclusion were patients ...

PD-L1 expression in pancreatic ductal adenocarcinoma is a poor prognostic factor in patients with high CD8+ tumor-infiltrating lymphocytes: highly sensitive detection using phosphor-integrated dot staining

Background Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis. For the development of more effective immunotherapies, it is first necessary to elucidate the immunological escape mechanisms. In this study, we applied our recently developed highly sensitive immunostaining method employing fluorescent phosphor-integrated dot (PID) nanoparticles to evaluate the ...

Effect of Engine Output on Maneuverability of a VLCC in Still Water and Adverse Weather Conditions

In this study, an MMG-based maneuvering simulation method (Yasukawa and Yoshimura, J Mar Sci Technol 20(1):37–52, 1) was used to investigate the maneuverability of a VLCC in still water and adverse weather conditions. Specifically, the investigation involved a situation where the engine output of a VLCC was significantly reduced owing to advances in energy-saving technology. First, ...

An estimation of water origins in the vicinity of a tropical cyclone’s center and associated dynamic processes

To clarify the time evolution of water origins in the vicinity of a tropical cyclone (TC)’s center, we have simulated Typhoon Man-yi (July 2007) in our case study, using an isotopic regional spectral model. The model results confirm that the replacement of water origins occurs successively as the TC develops and migrates northward over the western North Pacific. It is confirmed ...

Hepatotoxicity and Drug/Chemical Interaction Toxicity of Nanoclay Particles in Mice

Nanomaterials are relatively new and unconventional materials with many useful properties, but their effects on biological systems are poorly understood. Nanoclay is a general term for layered mineral silicate nanoparticles that are ideally suited for use in clay-based nanocomposites. The potential biological hazards of nanoclays have not been addressed, however. Therefore, we ...