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Non-invasive Photodynamic Therapy in Brain Cancer by Use of Tb3+-Doped LaF3 Nanoparticles in Combination with Photosensitizer Through X-ray Irradiation: A Proof-of-Concept Study

The use of photodynamic therapy (PDT) in the treatment of brain cancer has produced exciting results in clinical trials over the past decade. PDT is based on the concept that a photosensitizer exposed to a specific light wavelength produces the predominant cytotoxic agent, to destroy tumor cells. However, delivering an efficient light source to the brain tumor site is still a ...

Evaluation of surgical treatment for incidental gallbladder carcinoma diagnosed during or after laparoscopic cholecystectomy: single center results

Background Laparoscopic cholecystectomy (LC) is the accepted standard management for benign gallbladder disease. LC rarely results in a diagnosis of incidental gallbladder carcinoma (IGBC). The aim of our study was to report our experience with IGBC diagnosed during or following LC. Methods Between January 2008 and January 2015, 352 patients underwent LC at Iwakuni Clinical Center. ...

Postoperative delirium after pharyngolaryngectomy with esophagectomy: a role for ramelteon and suvorexant

Background Postoperative delirium is common after extensive surgery, and is known to be associated with sleeping medications. In this study, we aimed to investigate the relationships between sleeping medications and postoperative delirium after pharyngolaryngectomy with esophagectomy. Methods We performed a retrospective analysis of 65 patients who underwent pharyngolaryngectomy ...

A model for multi-directional cyclic shear-induced pore water pressure and settlement on clays

An estimation method for earthquake-induced pore water pressure and the post-earthquake settlement of soft clay was developed by focusing on its Atterberg’s limits and the direction of cyclic shearing. To clarify the fundamental characteristics of clays with different Atterberg’s limits under multi-directional cyclic shear, normally consolidated specimens of Kaolinite clay, Tokyo ...

Huge mediastinal liposarcoma resected by clamshell thoracotomy: a case report

Background Liposarcoma is the single most common soft tissue sarcoma. Because mediastinal liposarcomas often grow rapidly and frequently recur locally despite adjuvant chemotherapy and radiotherapy, they require complete excision. Therefore, the feasibility of achieving complete surgical excision must be carefully considered. We here report a case of a huge mediastinal liposarcoma ...

Multiple metastatic malignant phyllodes tumor of the breast with tonsillar metastasis: a case report

Background Tonsillar metastasis is very rare and accounts for only 0.8% of tonsillar tumors. And phyllodes tumor of the breast with tonsillar metastasis is very rare. Case presentation A 57-year-old Japanese woman received surgery (partial mastectomy) of malignant phyllodes tumor. Seven months after initial surgery, pharyngeal pain, swelling, and a feeling of dyspnea developed, and ...

Transcatheter closure of an atrial septal defect with high risk of erosion using a Figulla Flex II atrial septal defect occluder

An 85-year-old man with a high risk for open heart surgery underwent a percutaneous closure of an atrial septal defect that lacked adequate aortic and superior rims. To avoid the risk for erosion, a Figulla Flex II ASD occluder was selected for the procedure. Implantation was successful, and no complications were observed during the 6 months of follow-up.

Seismicity-permeability coupling in the behavior of gas shales, CO2 storage and deep geothermal energy

Contemporary methods of energy conversions that reduce carbon intensity include sequestering CO2, fuel switching to lower-carbon sources, such as from gas shales, and recovering deep geothermal energy via EGS. In all of these endeavors, either maintaining the low permeability and integrity of caprocks or in controlling the growth of permeability in initially very-low-permeability ...

Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny

Background Epidemiological studies suggest that hyponutrition during the fetal period increases the risk of mental disorders such as attention deficit hyperactivity disorder and autism-spectrum disorder, which has been experimentally supported using animal models. However, previous experimental hyponutrition or protein-restricted (PR) diets affected stages other than the fetal ...

Rapid and selective simultaneous quantitative analysis of modified nucleosides using multi-column liquid chromatography-tandem mass spectrometry

Background The profiles of modified nucleosides could act as useful biomarkers for cancer and cellular stress-induced diseases. However, there are no reports of high throughput and simultaneous quantitative methods for using biomarker evaluation and discovery at the bedside. Methods Modified nucleosides were separated on two CAPCELL PAK ADME S3 (100 mm × 2.1 mm i.d.; 3-μm particle ...

Stepwise addition of genetic changes correlated with histological change from “well-differentiated” to “sarcomatoid” phenotypes: a case report

Background Sarcomatoid cancer is defined by the World Health Organization as a category of non-small cell lung cancers with sarcoma or sarcoma-like differentiation. They are characterized by poor prognosis and resistance to conventional chemotherapy. However, the mutational profile of sarcomatoid cancer remains yet to be elucidated. Sarcomatoid cancers are usually biphasic tumors ...

Clinical significance of soluble CD163 in polymyositis-related or dermatomyositis-related interstitial lung disease

Background Macrophage activation is involved in the pathogenesis of polymyositis (PM)/dermatomyositis (DM). CD163, a scavenger receptor expressed on the surface of activated macrophages, mediates anti-inflammatory functions. This study aimed to evaluate the clinical significance of soluble CD163 (sCD163) in PM/DM-related interstitial lung disease (ILD). Methods The main subjects ...

Epithelioid schwannoma of the skin displaying unique histopathological features: a teaching case giving rise to diagnostic difficulties on a morphological examination of a resected specimen, with a brief literature review

Background Epithelioid schwannoma as a rare variant poses a challenge to all pathologists, as this uncommon entity is extremely difficult to conclusively diagnose by morphological analyses on a resected sample alone owing to its unique histopathological features. However, few papers have described the detailed clinicopathological characteristics of epithelioid schwannoma. Case ...

Genetic structure in the Sherpa and neighboring Nepalese populations

Background We set out to describe the fine-scale population structure across the Eastern region of Nepal. To date there is relatively little known about the genetic structure of the Sherpa residing in Nepal and their genetic relationship with the Nepalese. We assembled dense genotype data from a total of 1245 individuals representing Nepal and a variety of different populations ...

Inactivity periods and postural change speed can explain atypical postural change patterns of Caenorhabditis elegans mutants

Background With rapid advances in genome sequencing and editing technologies, systematic and quantitative analysis of animal behavior is expected to be another key to facilitating data-driven behavioral genetics. The nematode Caenorhabditis elegans is a model organism in this field. Several video-tracking systems are available for automatically recording behavioral data for the ...

The association between fear of falling and smoothness of lower trunk oscillation in gait varies according to gait speed in community-dwelling older adults

Background Fear of falling (FoF) is common in community-dwelling older adults. FoF and increased walking speed are associated with lower trunk oscillation during gait in older adults. We hypothesized that older adults with FoF would struggle to walk safely when instructed to walk faster than usual. Methods Participants included 260 community-dwelling older adults aged over 65 years ...

Increased amygdala reactivity following early life stress: a potential resilience enhancer role

Background Amygdala hyper-reactivity is sometimes assumed to be a vulnerability factor that predates depression; however, in healthy people, who experience early life stress but do not become depressed, it may represent a resilience mechanism. We aimed to test these hypothesis examining whether increased amygdala activity in association with a history of early life stress (ELS) was ...

Meeting report: the 5th International expert symposium in Fukushima on radiation and health

Background The symposium entitled “Chernobyl +30, Fukushima +5: Lessons and Solutions for Fukushima’s Thyroid Question” was held in September, 2016 in Fukushima. The aim of the Symposium was to revisit and recapitulate evidence from the studies in Chernobyl in order to share multidisciplinary opinions and views on the likely reason for the high rate of thyroid cancer detected by ...