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Japan’s English-medium instruction initiatives and the globalization of higher education

This article analyzes a recent initiative of Japan’s Ministry of Education, which aims to internationalize higher education in Japan. The large-investment project “Top Global University Project” (TGUP) has emerged to create globally oriented universities, to increase the role of foreign languages in higher education, and to foster global human resources. The TGUP identifies 37 ...

Stage IV pleomorphic carcinoma of the lung without recurrence for 6 years: a case report

Background Pleomorphic carcinoma is a rare primary lung carcinoma that occurs at a rate of about 0.3%. Even with complete resection, the tumor usually recurs aggressively, resulting in a poor prognosis. Herein, we report a case of advanced pleomorphic carcinoma of the lung who had a long survival time after resection of the primary and metastatic sites. Case presentation A ...

Spontaneous torsion of the right upper lung lobe: a case report

Background Pulmonary torsion is usually caused by thoracic surgery or trauma. Spontaneous pulmonary torsion caused by tumor and pleural effusion is very rare. Case presentation A 76-year-old Asian male with a chronic cough and suspected lung or pleural tumor presented with sudden dyspnea. Computed tomography showed that the right upper lung lobe contained a large tumor in the ...

Research on urban landscape design using the interactive genetic algorithm and 3D images

Background Generally, there are different optimal solutions with regard to urban landscape planning depending on the area and the opinions and characteristics of community residents. Furthermore, when considering urban landscape and/or city-planning regulations, it is important to include residents’ opinions based on voluntary activities like participation in town development on a ...

Molecular recircumscription of Broussonetia (Moraceae) and the identity and taxonomic status of B. kaempferi var. australis

Background Despite being a relatively small genus, the taxonomy of the paper mulberry genus Broussonetia remains problematic. Much of the controversy is related to the identity and taxonomic status of Broussonetia kaempferi var. australis, a name treated as a synonym in the floras of Taiwan and yet accepted in the floras of China. At the generic level, the monophyly of Corner (Gard ...

Solitary choroidal metastasis from gastric adenocarcinoma: a case report

Background Metastatic choroidal carcinomas that originated from the gastrointestinal tract are extremely rare. We report a case of suspected solitary choroidal metastasis from gastric adenocarcinoma. Case presentation The patient was a 60-year-old man who had undergone laparoscopic distal gastrectomy with D1+ lymphadenecetomy for gastric cancer. The clinical stage was T1bN0M0 (TNM ...

Liver resection for HER2-enriched breast cancer metastasis: case report and review of the literature

Liver metastasis from breast cancer usually results in the development of systemic metastasis. We report a breast cancer patient with an early isolated liver recurrence who survived more than 7 years with no recurrence. She was treated with aggressive HER2-directed chemotherapy and hepatic metastasectomy. Local hepatectomy with effective medical oncological therapy with curative ...

Waste prevention for sustainable resource and waste management

Although the 2Rs (reduce and reuse) are considered high-priority approaches, there has not been enough quantitative research on effective 2R management. The purpose of this paper is to provide information obtained through the International Workshop in Kyoto, Japan, on 11–13 November 2015, which included invited experts and researchers in several countries who were in charge of 3R ...

Complementary function of two transketolase isoforms from Moniliella megachiliensis in relation to stress response

Two transketolase isogenes, MmTKL1 and MmTKL2, isolated from Moniliella megachiliensis were investigated for their roles in stress response and erythritol biosynthesis. The encoded proteins were highly homologous in amino acid sequence and domain structure. Two stress response elements (STREs) were found upstream of MmTKL1, while no STRE was found upstream of MmTKL2. In contrast, ...

Online detection of continuous changes in stochastic processes

We are concerned with detecting continuous changes in stochastic processes. In conventional studies on non-stationary stochastic processes, it is often assumed that changes occur abruptly. By contrast, we assume that they take place continuously. The proposed scheme consists of an efficient algorithm and rigorous theoretical analysis under the assumption of continuity. The ...

Radical resection of a primary unresectable duodenal cancer after chemotherapy using S-1 and cisplatin: report of a case

Background Therapeutic outcomes and prognosis of primary unresectable duodenal cancer remains unsatisfactory, because effective chemotherapy is not established. Case presentation A 71-year-old male diagnosed with unresectable duodenal carcinoma with distant lymph node metastases was judged inoperable (cT3N2M1 cStage in UICC7th). Duodenal obstruction developed due to tumor growth, ...

Mont Terri rock laboratory, 20 years of research: introduction, site characteristics and overview of experiments

Geologic repositories for radioactive waste are designed as multi-barrier disposal systems that perform a number of functions including the long-term isolation and containment of waste from the human environment, and the attenuation of radionuclides released to the subsurface. The rock laboratory at Mont Terri (canton Jura, Switzerland) in the Opalinus Clay plays an important role ...

Ascending colon cancer with synchronous external iliac and inguinal lymph node metastases but without regional lymph node metastasis: a case report and brief literature review

Lymph node metastasis to the iliac or inguinal region of colon cancer is extremely rare. We experienced a case of ascending colon cancer with synchronous isolated right external iliac and inguinal lymph node metastases but without any regional lymph node metastasis. An 83-year-old woman was admitted to our hospital due to anemia. Colonoscopy and computed tomography revealed an ...

Corrosion of carbon steel in clay environments relevant to radioactive waste geological disposals, Mont Terri rock laboratory (Switzerland)

Carbon steel is widely considered as a candidate material for the construction of spent fuel and high-level waste disposal canisters. In order to investigate corrosion processes representative of the long term evolution of deep geological repositories, two in situ experiments are being conducted in the Mont-Terri rock laboratory. The iron corrosion (IC) experiment, aims to measure ...

NC-6004 Phase I study in combination with gemcitabine for advanced solid tumors and population PK/PD analysis

Objectives This study was an open-label phase I study to confirm the safety and tolerability of NC-6004 in combination with gemcitabine in Japanese patients with advanced solid tumors and to assess the PK effects of NC-6004 monotherapy. Methods This phase I study used a 3 + 3 design to determine the maximum tolerated dose (MTD) and recommended dose of NC-6004 combined with ...

Serum albumin level adjusted with C-reactive protein predicts hemodialysis patient survival

Background Malnutrition-related conditions such as protein energy wasting are affecting poor outcome of the dialysis population. The serum albumin level is often used as a marker of wasting and malnutrition. However, the serum albumin level can be affected by the presence of inflammation as well as by nutritional status. We investigated associations between serum albumin values ...

Antithrombin use and 28-day in-hospital mortality among severe-burn patients: an observational nationwide study

Background Previous studies have suggested that antithrombin may be beneficial for treating coagulopathy in patients with severe burns. However, robust evidence for this idea is lacking. We examined the hypothesis that antithrombin may be effective in treating patients with severe burns. Methods We performed propensity score-matched analyses of the nationwide administrative ...

License and Entry Strategies for an Outside Innovator Under Duopoly

In Proposition 4 of Kamien and Tauman (Q J Econ 101:471–492, 1986), assuming linear demand and cost functions with fixed fee licensing it was argued that for the outside innovating firm under oligopoly when the number of firms is small (or very large), strategy to enter the market with license of its cost-reducing technology to the incumbent firm (entry with license strategy) is ...

Energy levels of natural sensitizers extracted from rengas (Gluta spp.) and mengkulang (Heritiera elata) wood for dye-sensitized solar cells

Dye-sensitized solar cells (DSSCs) are fabricated using natural sensitizers extracted from rengas (Gluta spp.) and mengkulang (Heritieraelata) wood. The natural sensitizers are extracted using a cold extraction and the Soxhlet extraction methods. This paper presents the results of the analysis of the optical characteristics of the sensitizers via ultraviolet–visible ...