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Cauda Equina Syndrome: presentation, outcome, and predictors with focus on micturition, defecation, and sexual dysfunction

Background Even though micturition, defecation, and sexual function are substantially affected in cauda equina syndrome (CES), data on outcome are scarce. Methods Medical files of patients operated on lumbar herniated disc were screened for CES and retrospectively analyzed for baseline characteristics, outcome of micturition, defecation, and sexual function and possible predictors. ...

Understanding diversity: a Dutch case study on teachers’ attitudes towards their diverse student population

Background In the Netherlands, there has been a strong increase in diversity among students in recent decades. Even though access for previously underrepresented groups based on economic status, ethnicity or culture has been realised to a certain extent, differences in student performance between groups persist. Research shows that teacher performance influences student achievement ...

Diagnostic impact of [18F]flutemetamol PET in early-onset dementia

Background Early-onset dementia patients often present with atypical clinical symptoms, hampering an accurate clinical diagnosis. The purpose of the present study was to assess the diagnostic impact of the amyloid-positron emission tomography (PET) imaging agent [18F]flutemetamol in early-onset dementia patients, in terms of change in (confidence in) diagnosis and patient ...

Temperament Traits and Psychopathology in Young Clinically Referred Children Compared to a General Population Sample

Evidence from general population studies shows the contribution of various temperament traits to the development of child psychopathology. Little is known about which traits are associated with internalizing and externalizing problems in young clinically referred children. The current study assessed temperament and internalizing and externalizing problems in 216 referred children ...

Differences in Cortical Sources of the Event-Related P3 Potential Between Young and Old Participants Indicate Frontal Compensation

The event-related P3 potential, as elicited in auditory signal detection tasks, originates from neural activity of multiple cortical structures and presumably reflects an overlap of several cognitive processes. The fact that the P3 is affected by aging makes it a potential metric for age-related cognitive change. The P3 in older participants is thought to encompass frontal ...

Tyrosine Kinase Inhibitors and Proton Pump Inhibitors: An Evaluation of Treatment Options

Tyrosine kinase inhibitors (TKIs) have rapidly become an established factor in oncology, and have been shown to be effective in a wide variety of solid and hematologic malignancies. Use of the oral administration route of TKIs offers flexibility and is convenient for the patient; however, despite these advantages, the oral route of administration also causes a highly relevant new ...

Music Preferences, Friendship, and Externalizing Behavior in Early Adolescence: A SIENA Examination of the Music Marker Theory Using the SNARE Study

Music Marker Theory posits that music is relevant for the structuring of peer groups and that rock, urban, or dance music preferences relate to externalizing behavior. The present study tested these hypotheses, by investigating the role of music preference similarity in friendship selection and the development of externalizing behavior, while taking the effects of friends’ ...

Post-stroke dementia – a comprehensive review

Post-stroke dementia (PSD) or post-stroke cognitive impairment (PSCI) may affect up to one third of stroke survivors. Various definitions of PSCI and PSD have been described. We propose PSD as a label for any dementia following stroke in temporal relation. Various tools are available to screen and assess cognition, with few PSD-specific instruments. Choice will depend on purpose of ...

Shifting patterns of mild weather in response to projected radiative forcing

Climate change has been shown to impact the mean climate state and climate extremes. Though climate extremes have the potential to disrupt society, extreme conditions are rare by definition. In contrast, mild weather occurs frequently and many human activities are built around it. We provide a global analysis of mild weather based on simple criteria and explore changes in response ...

Effects of a genetically modified potato on a non-target aphid are outweighed by cultivar differences

Insect–plant interactions may be unintentionally affected when introducing genetically modified (GM) crops into an agro-ecosystem. Our aim was to test the non-target effects of a late blight-resistant GM potato on Myzus persicae in greenhouse and climate room experiments and understand how position and number of R gene insertions can affect non-targets in GM events. We also aimed ...

World Governance and Leadership Designs for the Future

An expanding globalization causes global failures, similar to economy failures encountered in the national economic system. Global failures take other forms and are likely to be more severe in the future because of the entry in the world scene of leading countries that have distinctly different economic systems (for instance, China, India) from leading incumbents (US, EU), and ...

The Effect of Religiosity on Life Satisfaction in a Secularized Context: Assessing the Relevance of Believing and Belonging

The positive relationship between religiosity and life satisfaction is well-established. This relationship is, however, likely to vary across cultural contexts and different religious affiliations. Furthermore, research is needed to uncover why religion is relevant for life satisfaction. Addressing these issues, we investigate what dimensions of being religious play a role in the ...

Basics of Joule–Thomson Liquefaction and JT Cooling

This paper describes the basic operation of Joule–Thomson liquefiers and Joule–Thomson coolers. The discussion is based on the first law of thermodynamics mainly using hT-diagrams. It is limited to single-component fluids. A nitrogen liquefier and a helium cooler are discussed as important examples.

New players in entrepreneurial finance and why they are there

The landscape for entrepreneurial finance has changed strongly over the last years. Many new players have entered the arena. This editorial introduces and describes the new players and compares them along the four dimensions: debt or equity, investment goal, investment approach, and investment target. Following this, we discuss the factors explaining the emergence of the new ...

Contrast in Terahertz Images of Archival Documents—Part I: Influence of the Optical Parameters from the Ink and Support

This study aims to objectively inform curators when terahertz time-domain (TD) imaging set in reflection mode is likely to give well-contrasted images of inscriptions in a complex archival document and is a useful non-invasive alternative to current digitisation processes. To this end, the dispersive refractive indices and absorption coefficients from various archival materials are ...

Renal function in patients with non-dialysis chronic kidney disease receiving intravenous ferric carboxymaltose: an analysis of the randomized FIND-CKD trial

Background Preclinical studies demonstrate renal proximal tubular injury after administration of some intravenous iron preparations but clinical data on renal effects of intravenous iron are sparse. Methods FIND-CKD was a 56-week, randomized, open-label, multicenter study in which patients with non-dialysis dependent chronic kidney disease (ND-CKD), anemia and iron deficiency ...

Analytical method for calculation of deviations from intended dosages during multi-infusion

Background In this paper, a new method is presented that combines mechanical compliance effects with Poiseuille flow and push-out effects (“dead volume”) in one single mathematical framework for calculating dosing errors in multi-infusion set-ups. In contrast to existing numerical methods, our method produces explicit expressions that illustrate the mathematical dependencies of the ...

Effectiveness of medication review: a systematic review and meta-analysis of randomized controlled trials

Background Medication review is often recommended to optimize medication use. In clinical practice it is mostly operationalized as an intervention without co-interventions during a short term intervention period. However, most systematic reviews also included co-interventions and prolonged medication optimization interventions. Furthermore, most systematic reviews focused on ...