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Minimally interrupted novel oral anticoagulant versus uninterrupted vitamin K antagonist during atrial fibrillation ablation

PurposeThe safety and efficacy of a minimally interrupted novel oral anticoagulant (NOAC) strategy at the time of atrial fibrillation (AF) ablation is uncertain. The purpose of this study was to compare rates of bleeding and thromboembolic events between minimally interrupted NOAC and uninterrupted vitamin K antagonist (VKA) in patients undergoing AF ablation.MethodsThis was a...

Skin mucosome activity as an indicator of Batrachochytrium salamandrivorans susceptibility in salamanders

Recently emerged fungal diseases, Batrachochytrium dendrobatidis (Bd) and Batrachochytrium salamandrivorans (Bsal) are an increasing threat to amphibians worldwide. In Europe, the threat of Bsal to salamander populations is demonstrated by the rapid decline of fire salamander populations in Germany, the Netherlands and Belgium. Although most European urodelans are susceptible to...

A standardized protocol for quantification of saccadic eye movements: DEMoNS

Objective Quantitative saccadic testing is a non-invasive method of evaluating the neural networks involved in the control of eye movements. The aim of this study is to provide a standardized and reproducible protocol for infrared oculography measurements of eye movements and analysis, which can be applied for various diseases in a multicenter setting. Methods Development of a...

The Netherlands’ Physical Society, NNV, a vibrant community of 4000 physicists

It was a lively conference, the annual meeting of the Netherlands’ Physical Society (Nederlandse Natuurkundige Vereniging, NNV) on April 10 at Eindhoven University of Technology. In addition to the plenary morning sessions and six parallel sessions in the afternoon, there were award ceremonies for the Teacher of the year and for the best Bachelor thesis, a Young Speakers Contest...

An eye-witness report on how the CD came about

The Compact Disc was a smashing success. It pushed the traditional 45 and 33 RPM vinyl records off the market in an astonishingly short period of time. But the struggle to develop the CD and to get it on the market was just as fascinating.

The golden hour of sepsis: An in-depth analysis of sepsis-related maternal mortality in middle-income country Suriname

Background Sepsis was the main cause of maternal mortality in Suriname, a middle-income country. Objective of this study was to perform a qualitative analysis of the clinical and management aspects of sepsis-related maternal deaths with a focus on the ‘golden hour’ principle of antibiotic therapy. Methods A nationwide reproductive age mortality survey was performed from 2010 to...

HappyTools: A software for high-throughput HPLC data processing and quantitation

High-performance liquid chromatography (HPLC) is widely used for absolute quantitation. The advent of new columns and HPLC technology has enabled higher sample throughput, and hence, larger scale studies that perform quantitation on different sample types (e.g. healthy controls vs. patients with rheumatoid arthritis) using HPLC are becoming feasible. However, there remains a lack...

On K3 double planes covering Enriques surfaces

The moduli space of nodal Enriques surfaces is irreducible of dimension 9. A nodal Enriques surface is shown to be the quotient of a double cover of the plane by a lift of the Cremona involution. We also show that this gives a straightforward proof of the known description of the automorphism group for the generic such surface.

Compte-rendu de la 3e conférence internationale sur les glucosinolates « Glucosinolates and beyond »

La 3e conférence internationale sur les glucosinolates, intitulée « Glucosinolates and beyond », a rassemblé plus d’une centaine de participants à Wageningen aux Pays-Bas, du 12 au 15 Octobre 2014. Le programme a été organisé en quatre sessions couvrant la recherche fondamentale sur l’origine et la biosynthèse des glucosinolates au cours de l’évolution, et les applications concr...

Lifshitz entanglement entropy from holographic cMERA

Abstract We study entanglement entropy in free Lifshitz scalar field theories holographically by employing the metrics proposed by Nozaki, Ryu and Takayanagi in [1] obtained from a continuous multi-scale entanglement renormalisation ansatz (cMERA). In these geometries we compute the minimal surface areas governing the entanglement entropy as functions of the dynamical exponent z...

Drag resolution of a PIV wake rake for transiting models

The accuracy of the “PIV wake rake” method to measure the drag of transiting objects is evaluated. Tomographic particle image velocimetry measurements are conducted on a sphere towed at different speeds, within a Reynolds number range where the drag coefficient is constant. In contrast to PIV wake rake application on steady models in wind tunnels, where the upstream conditions...

How farmers’ characteristics influence spontaneous spreading of stone bunds in the highlands of Ethiopia: a case study in the Girar Jarso woreda

This study aims to identify key differences between farmers who spontaneously implement stone bunds (i.e. farmers implementing stone bunds by their own initiative) and farmers who do not. Data were collected in the Girar Jarso woreda in the central highlands of Ethiopia, through a household survey with 80 farmers: 40 with spontaneously implemented stone bunds and 40 without...

Genomic approaches for the elucidation of genes and gene networks underlying cardiovascular traits

Genome-wide association studies have shed light on the association between natural genetic variation and cardiovascular traits. However, linking a cardiovascular trait associated locus to a candidate gene or set of candidate genes for prioritization for follow-up mechanistic studies is all but straightforward. Genomic technologies based on next-generation sequencing technology...

Plant breeding and diversity: A troubled relationship?

Plant breeding collects, induces and rearranges genetic diversity followed by selection. Breeding may contribute to diversity in farmers’ fields or significantly reduce it. History has numerous examples of both. The diversity of many crops have gone through domestication, dispersal and modernization bottlenecks. Between these major decreasing processes, diversity has picked up...

Instantaneous wave-free ratio and fractional flow reserve in clinical practice

ObjectivesTo compare fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) measurements in an all-comer patient population with moderate coronary artery stenoses.BackgroundVisual assessment of the severity of coronary artery stenoses is often discordant in moderate lesions. FFR allows reliable functional severity assessment in these cases but requires adenosine...

Introgressive Hybridization in Potato Revealed by Novel Cytogenetic and Genomic Technologies

Potato is the third most important food crop in the world and is crucial to ensure food security. However, increasing biotic and abiotic stresses jeopardize its stable production. Fortunately, breeders count on a rich pool of wild relatives that provide sources for disease resistance and tolerance to environmental stresses. To use such traits effectively, breeders require tools...

A decrease in vitamin D levels is associated with methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia

PurposeChildren with acute lymphoblastic leukemia (ALL) are at increased risk of vitamin D deficiency, which might make them more susceptible to developing adverse events. Previous studies showed that low vitamin D levels were associated with an increased inflammatory mucosal state and impaired mucosal tissue barriers. We examined the prevalence of vitamin D deficiency and...