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Stochastic integer programming for multi-disciplinary outpatient clinic planning

Scheduling appointments in a multi-disciplinary clinic is complex, since coordination between disciplines is required. The design of a blueprint schedule for a multi-disciplinary clinic with open access requirements requires an integrated optimization approach, in which all appointment schedules are jointly optimized. As this currently is an open question in the literature, our ...

Update of the Dutch manual for costing studies in health care

Objectives Dutch health economic guidelines include a costing manual, which describes preferred research methodology for costing studies and reference prices to ensure high quality studies and comparability between study outcomes. This paper describes the most important revisions of the costing manual compared to the previous version. Methods An online survey was sent out to ...

Nationwide claims data validated for quality assessments in acute myocardial infarction in the Netherlands

Introduction Since health insurance is compulsory in the Netherlands, the centrally registered medical claims data might pose a unique opportunity to evaluate quality of (cardiac) care on a national level without additional collection of data. However, validation of these claims data has not yet been assessed. Design Retrospective cohort study. Methods National claims data ...

The effect of tranexamic acid on blood loss and maternal outcome in the treatment of persistent postpartum hemorrhage: A nationwide retrospective cohort study

Background Recent results show a protective effect of tranexamic acid on death due to bleeding in patients with postpartum hemorrhage in low- and middle-resource countries. We quantify the association between early administration of tranexamic acid compared to late or no administration and severe acute maternal morbidity and blood loss among women suffering from persistent severe ...

A methodology for least-squares local quasi-geoid modelling using a noisy satellite-only gravity field model

The paper is about a methodology to combine a noisy satellite-only global gravity field model (GGM) with other noisy datasets to estimate a local quasi-geoid model using weighted least-squares techniques. In this way, we attempt to improve the quality of the estimated quasi-geoid model and to complement it with a full noise covariance matrix for quality control and further data ...

Knowledge and practice on prevention of diabetes mellitus among Diabetes mellitus family members, in suburban cities in Ethiopia

Background Diabetes mellitus (DM) is one of the serious non communicable diseases worldwide. Presence of DM patient in a family may be considered as risk factor for other family members to acquire the disease, due to DM inheritance nature and/or similar life style pattern among family members. This paper assessed awareness of DM patients’ family members (DMPFMs) about DM occurrence ...

Anti-carbamylated protein antibodies precede disease onset in monkeys with collagen-induced arthritis

Rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) and anti-carbamylated protein (anti-CarP) antibodies are rheumatoid arthritis (RA)-associated autoantibodies. Besides their presence in human serum, anti-CarP antibodies have also been described in rodent models of arthritis, while ACPA are not consistently detectable. Data on these RA-associated autoantibodies in ...

Raw pet food as a risk factor for shedding of extended-spectrum beta-lactamase-producing Enterobacteriaceae in household cats

Background Close contact between pets and owners provides the opportunity for transmission of antimicrobial resistant organisms like extended-spectrum beta-lactamase (ESBL)/AmpC beta-lactamase (AmpC)-producing Enterobacteriaceae, posing a risk to public health. Objectives To investigate whether raw feed is a risk factor for household cats to shed ESBL-producing Enterobacteriaceae, ...

Measurement versus prediction in the construction of patient-reported outcome questionnaires: can we have our cake and eat it?

Background Two important goals when using questionnaires are (a) measurement: the questionnaire is constructed to assign numerical values that accurately represent the test taker’s attribute, and (b) prediction: the questionnaire is constructed to give an accurate forecast of an external criterion. Construction methods aimed at measurement prescribe that items should be reliable. ...

Ouderen en ict

De nederlandse zorg vergrijst. de zorgverleners zijn gemiddeld ouder, de patiënten en cliënten zijn ouder, hun zorgvraag is complexer. Ook netwerken rondom oudere patiënten veranderen. Kinderen die mantelzorg verlenen, wonen steeds verder bij hun ouders vandaan.

Verzin een list

Kort geleden bezocht ik de nachtopvang - die tegenwoordig overdag ook vol is - van het Leger des Heils. Daar sprak ik een bezoeker die verstrikt was geraakt in de regelingen van de Nederlandse gezondheidszorg en sociale zekerheid. Hij had recht op een bijstandsuitkering maar kreeg die niet, omdat hij geen adres had.

Hormonal contraceptives and risk of ischemic stroke in women with migraine: a consensus statement from the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC)

Several data indicate that migraine, especially migraine with aura, is associated with an increased risk of ischemic stroke and other vascular events. Of concern is whether the risk of ischemic stroke in migraineurs is magnified by the use of hormonal contraceptives. As migraine prevalence is high in women of reproductive age, it is common to face the issue of migraine and hormonal ...

Pomalidomide with Dexamethasone for Treating Relapsed and Refractory Multiple Myeloma Previously Treated with Lenalidomide and Bortezomib: An Evidence Review Group Perspective of an NICE Single Technology Appraisal

The National Institute for Health and Care Excellence (NICE), as part of the institute’s single technology appraisal (STA) process, invited the manufacturer of pomalidomide (POM; Imnovid®, Celgene) to submit evidence regarding the clinical and cost effectiveness of the drug in combination with dexamethasone (POM + LoDEX) for the treatment of relapsed and refractory multiple myeloma ...

Evaluation of vascular features of vocal cords proposed by the European Laryngological Society

A newly proposed classification by the European Laryngological Society (ELS) of glottic lesions by narrow-band imaging (NBI) divides their vascular patterns into longitudinal and perpendicular ones. The latter are further subdivided into the wide and narrow patterns. The longitudinal, wide, and narrow patterns are characteristic of benign disease, papilloma, and malignancy, ...

The effect of sodium/glucose cotransporter 2 (SGLT2) inhibition on the urinary proteome

Treatment with empagliflozin, an inhibitor of the sodium/glucose cotransporter 2 (SGLT2), is associated with slower progression of diabetic kidney disease. In this analysis, we explored the hypothesis that empagliflozin may have an impact on urinary peptides associated with chronic kidney disease (CKD). In this post-hoc, exploratory analysis, we investigated urine samples obtained ...

Proteomics in asthma: the clinicians were right after all, were not they?

Clinical disease phenotypes with underlying information of molecular and biological signatures for the same, is a prerequisite for improving medical care and developing more effective, stratified management strategies. This commentary reviews the research carried out by Cao et al. to unravel biological networks associated with different clinical categories of asthma. It finally ...

The Needs of Foster Children and How to Satisfy Them: A Systematic Review of the Literature

Family foster care deeply influences the needs of children and how these are satisfied. To increase our knowledge of foster children’s needs and how these are conceptualized, this paper presents a systematic literature review. Sixty-four empirical articles from six databases were reviewed and categorized (inter-rater agreement K = .78) into four categories: medical, belongingness, ...

Corrections to: Use of the BOADICEA Web Application in clinical practice: appraisals by clinicians from various countries

The article “Use of the BOADICEA Web Application in clinical practice: appraisals by clinicians from various countries” written by Anne Brédart · Jean‑Luc Kop · Antonis C. Antoniou · Alex P. Cunningham · Antoine De Pauw ·Marc Tischkowitz · Hans Ehrencrona · Sylvie Dolbeault · Léonore Robieux · Kerstin Rhiem ·Douglas F. Easton · Peter Devilee · Dominique Stoppa‑Lyonnet· Rita ...