Advanced search    

Search: *

279,665 papers found. Showing first 1,000 results.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Non-isothermal stability by linear heating: a fast method for preformulation stability screening of drugs at the discovery and development interface

The non-isothermal method for prediction of chemical stability of pharmaceuticals has been discussed in the literature for almost half a century but it has not yet been systematically evaluated. The purpose of this study was to carry out a comprehensive experimental evaluation of the non-isothermal method against the conventional isothermal method for a fast preformulation ...

The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer’s pathology

Background Insulin resistance (IR) has previously been associated with an increased risk of developing Alzheimer’s disease (AD), although the relationship between IR and AD is not yet clear. Here, we examined the influence of IR on AD using plasma and cerebrospinal fluid (CSF) biomarkers related to IR and AD in cognitively healthy men. We also aimed to characterise the shared ...

Vibration-Induced Property Change in the Melting and Solidifying Process of Metallic Nanoparticles

Tuning material properties in the 3-D printing process of metallic parts is a challenging task of current interests. Much research has been conducted to understand the effects of controlling parameters such as the particle geometry (size and shape), heating, and cooling ways on the outcome of the printing process. However, nothing has been done to explore the system vibration ...

Memory is preserved in older adults taking AT1 receptor blockers

Background Prior work suggests that some but not all antihypertensive treatments may benefit cognition and risk for Alzheimer’s disease, independent of stroke. Angiotensin II receptor blockers (ARBs) have been highlighted as one antihypertensive drug class that may confer greatest benefit. Methods The participants comprised 1626 nondemented adults, aged 55–91 years, recruited from ...

Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes

Background The growth factor receptor network (GFRN) plays a significant role in driving key oncogenic processes. However, assessment of global GFRN activity is challenging due to complex crosstalk among GFRN components, or pathways, and the inability to study complex signaling networks in patient tumors. Here, pathway-specific genomic signatures were used to interrogate GFRN ...

Human virus and microbial indicator occurrence in public-supply groundwater systems: meta-analysis of 12 international studies

Groundwater quality is often evaluated using microbial indicators. This study examines data from 12 international groundwater studies (conducted 1992–2013) of 718 public drinking-water systems located in a range of hydrogeological settings. Focus was on testing the value of indicator organisms for identifying virus-contaminated wells. One or more indicators and viruses were present ...

GIS-based visualization of integrated highway maintenance and construction planning: a case study of Fort Worth, Texas

Background This paper reports on a case study of the use of visualization of geospatial data that is distributed across data sets and requires integration over time and space to aid decision makers. Like many State Highway Agencies (SHAs) in the United States, the Texas Department of Transportation (TxDOT) is organized along the traditional functional lines of planning, design, ...

Mining and Environmental Health Disparities in Native American Communities

Purpose of Review More than a century of hard rock mining has left a legacy of >160,000 abandoned mines in the Western USA that are home to the majority of Native American lands. This article describes how abrogation of treaty rights, ineffective policies, lack of infrastructure, and a lack of research in Native communities converge to create chronic exposure, ill-defined risks, ...

Song Ci (1186–1249), “Father of World Legal Medicine”: History, Science, and Forensic Culture in Contemporary China

Song Ci (1186–1249) was an official of the Southern Song Dynasty best known for authoring the Collected Writings on the Washing Away of Wrongs (Xiyuan jilu), a work often hailed as the world's first systematic treatise on forensic medicine. While biographical details about his life were known in local history writings during the late imperial period, Song had garnered relatively ...

The Case of the Suzhou Hospital of National Medicine (1939–41): War, Medicine, and Eastern Civilization

This article explores the founding of the Suzhou Hospital of National Medicine in 1939 during the Japanese occupation of Suzhou. We argue that the hospital was the culmination of a period of rich intellectual exchange between traditional Chinese and Japanese physicians in the early twentieth century and provides important insights into the modern development of medicine in both ...

Current Concepts in Noninvasive Prenatal Screening (NIPS)

Noninvasive prenatal screening (NIPS) represents a significant advance in prenatal screening for trisomy 21 and other conditions. Like any new and rapidly developing technology, it is important for healthcare providers to keep up to date with current and developing issues to help ensure that users of tests such as NIPS are well informed. This review intends to outline and explain ...