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Load–settlement response of shallow foundations resting on granular soil

Proper estimation of settlement of shallow foundations resting on granular soil deposits has a significant role in the design and construction of buildings and other related structures. While several procedures are available in the literature, discrepancies still exist between the predicted and observed responses. Furthermore, there is a decoupling between bearing capacity and ...

Digitally translated Self-Administered Gerocognitive Examination (eSAGE): relationship with its validated paper version, neuropsychological evaluations, and clinical assessments

Background The original paper Self-Administered Gerocognitive Examination (SAGE) is a valid and reliable cognitive assessment tool used to identify individuals with mild cognitive impairment (MCI) or early dementia. We evaluated identical test questions in a digital format (eSAGE) made for tablet use with the goals of calibrating it against SAGE and establishing its association ...

A large-scale behavior change intervention to prevent Nipah transmission in Bangladesh: components and costs

Background Nipah virus infection (NiV) is a bat-borne zoonosis transmitted to humans through consumption of NiV-contaminated raw date palm sap in Bangladesh. The objective of this analysis was to measure the cost of an NiV prevention intervention and estimate the cost of scaling it up to districts where spillover had been identified. Methods We implemented a behavior change ...

International Economic Integration and Human Development: Informing the Debate in Favour or Against Formal Integration and Migration

Recently, some leaders in different countries have promoted positions towards immigration and formal international economic integration that contest policy recommendations resting on predominant microeconomic and international economics theories. The cases of Brexit, the new presidency in the United States of America, and election processes in countries such as Germany and France ...

Populism in Search of its Model

This article makes the case that populism needs to be understood in the context of a model. The key argument formulated in this article is that the phenomenon of populism does not lend itself to taut theoretical formulations. Consequently, the explanatory and the inferential reaches of populism are largely descriptive. However, “mere description” within the context of a model is ...

The “Enemy” Complex of Populism in American Ethnic Politics and Its Implications to Trump’s Foreign Policy

In the two types of American nationalism, while the culture-based nationalism finds its origins in the American settlerism tradition, the belief-based nationalism finds its roots in the American liberal tradition; while the former type of American nationalism can result in a closed and exclusive society, the later one an open and inclusive society. Hence, there is the “enemy” ...

Structure elucidation of metabolite x17299 by interpretation of mass spectrometric data

Introduction A major bottleneck in metabolomic studies is metabolite identification from accurate mass spectrometric data. Metabolite x17299 was identified in plasma as an unknown in a metabolomic study using a compound-centric approach where the associated ion features of the compound were used to determine the true molecular mass. Objectives The aim of this work is to elucidate ...

Human adipose tissue mesenchymal stromal cells and their extracellular vesicles act differentially on lung mechanics and inflammation in experimental allergic asthma

Background Asthma is a chronic inflammatory disease that can be difficult to treat due to its complex pathophysiology. Most current drugs focus on controlling the inflammatory process, but are unable to revert the changes of tissue remodeling. Human mesenchymal stromal cells (MSCs) are effective at reducing inflammation and tissue remodeling; nevertheless, no study has evaluated ...

The effect of membrane exposure on lateral ridge augmentation: a case-controlled study

Background The effect of membrane exposure on guided bone regeneration (GBR) for lateral ridge augmentation has been poorly addressed. This case-controlled study aimed to investigate potential effect of membrane exposure lateral ridge augmentation and subsequent implant placement. Methods A total of 14 patients that did receive lateral ridge augmentation procedure using allogeneic ...

How Adaptation Makes Low Firing Rates Robust

Low frequency firing is modeled by Type 1 neurons with a SNIC, but, because of the vertical slope of the square-root-like f–I curve, low f only occurs over a narrow range of I. When an adaptive current is added, however, the f–I curve is linearized, and low f occurs robustly over a large I range. Ermentrout (Neural Comput. 10(7):1721-1729, 1998) showed that this feature of ...

CMV immune evasion and manipulation of the immune system with aging

Human cytomegalovirus (HCMV) encodes numerous proteins and microRNAs that function to evade the immune response and allow the virus to replicate and disseminate in the face of a competent innate and acquired immune system. The establishment of a latent infection by CMV, which if completely quiescent at the level of viral gene expression would represent an ultimate in immune evasion ...

Age and intraspecific diversity of resilient Acropora communities in Belize

The corals Acropora palmata and A. cervicornis are important Caribbean reef-builders that have faced significant mortality in recent decades. While many studies have focused on the recent demise of these species, data from areas where Acropora spp. have continued to thrive are limited. Understanding the genetic diversity, recruitment, and temporal continuity of healthy populations ...