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Update of the activity of telavancin against a global collection of Staphylococcus aureus causing bacteremia, including endocarditis (2011–2014)

The efficacy and safety of telavancin is under evaluation for the treatment of subjects with complicated Staphylococcus aureus bacteremia and S. aureus right-sided infective endocarditis. This study evaluated the telavancin activity against a global collection of S. aureus causing bloodstream infections (BSI), including endocarditis, to support the development of ...

Gradient (elevation) vs. disturbance (agriculture) effects on primary cloud forest in Ecuador: floristics and physical structure

Background Cloud forests are common in the Neotropics and an important part of its hydrological cycle. An investigation on how elevation and recovery from agriculture affects cloud forest floristics and physical structure in Ecuador was undertaken. Methods Species and diameter at a specified height (dsh) of trees were sampled in large plots in Maquipucuna and Yanacocha cloud ...

Sibsonian and non-Sibsonian natural neighbour interpolation of the total electron content value

In radioastronomy the interferometric measurement between radiotelescopes located relatively close to each other helps removing ionospheric effects. Unfortunately, in case of networks such as LOw Frequency ARray (LOFAR), due to long baselines (currently up to 1500 km), interferometric methods fail to provide sufficiently accurate ionosphere delay corrections. Practically it means ...

Synergistic Development of Biochips and Cell Preservation Methodologies: a Tale of Converging Technologies

Purpose of the Review Over the past several decades, cryopreservation has been widely used to preserve cells during long-term storage, but advances in stem cell therapies, regenerative medicine, and miniaturized cell-based diagnostics and sensors are providing new targets of opportunity for advancing preservation methodologies. The advent of microfluidic-based devices is an ...

Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease

Diffuse intrinsic pontine glioma (DIPG) is a rare and deadly childhood malignancy. After 40 years of mostly single-center, often non-randomized trials with variable patient inclusions, there has been no improvement in survival. It is therefore time for international collaboration in DIPG research, to provide new hope for children, parents and medical professionals fighting DIPG. In ...

Pattern recognition of spectral entropy features for detection of alcoholic and control visual ERP’s in multichannel EEGs

This paper presents a novel ranking method to select spectral entropy (SE) features that discriminate alcoholic and control visual event-related potentials (ERP’S) in gamma sub-band (30–55 Hz) derived from a 64-channel electroencephalogram (EEG) recording. The ranking is based on a t test statistic that rejects the null hypothesis that the group means of SE values in alcoholics and ...

Synergism of spectra averaging and extrapolation for quantification of in vivo MRS time signals encoded from the ovary

The fast Padé transform (FPT) is further optimized for encoded in vivo MRS time signals. This is achieved by a judicious combination of spectra averaging and time signal extrapolation. The motivation is in strengthening suppression of the over-sensitivity of signal processing to changes in model order K. Implementation is carried out in the FPT variant \(\hbox {FPT}^{(+)}\) which, ...

Chronic Wound Healing: A Review of Current Management and Treatments

Wound healing is a complex, highly regulated process that is critical in maintaining the barrier function of skin. With numerous disease processes, the cascade of events involved in wound healing can be affected, resulting in chronic, non-healing wounds that subject the patient to significant discomfort and distress while draining the medical system of an enormous amount of ...

Transcriptional Regulation of Stem Cell and Cancer Stem Cell Metabolism

Purpose of Review Metabolism is increasingly recognized as a major player in control of stem cell function and fate. How stem cell metabolism is established, maintained, and regulated is a fundamental question of biology and medicine. In this review, we discuss major metabolic programs in stem cells and cancer stem cells, with a focus on key transcription factors that shape the ...

The Effect of Superparamagnetic Iron Oxide Nanoparticle Surface Charge on Antigen Cross-Presentation

Magnetic nanoparticles (NPs) of superparamagnetic iron oxide (SPIO) have been explored for different kinds of applications in biomedicine, mechanics, and information. Here, we explored the synthetic SPIO NPs as an adjuvant on antigen cross-presentation ability by enhancing the intracellular delivery of antigens into antigen presenting cells (APCs). Particles with different chemical ...

Permanent draft genome of Thiobacillus thioparus DSM 505T, an obligately chemolithoautotrophic member of the Betaproteobacteria

Thiobacillus thioparus DSM 505T is one of first two isolated strains of inorganic sulfur-oxidising Bacteria. The original strain of T. thioparus was lost almost 100 years ago and the working type strain is Culture CT (=DSM 505T = ATCC 8158T) isolated by Starkey in 1934 from agricultural soil at Rutgers University, New Jersey, USA. It is an obligate chemolithoautotroph that ...

Genotype- and sex-dependent effects of altered Cntnap2 expression on the function of visual cortical areas

Background Autism spectrum disorder (ASD) is a heritable, heterogeneous neurodevelopmental disorder that is four times more likely to affect males than females. Despite this overt sex bias, it is unclear how genetic mutations associated with ASD alter cortical circuitry to produce the behavioral phenotypes by which ASD is diagnosed. Contactin-associated protein-like 2 (CNTNAP2) is ...

Maxillary segmental osteoperiosteal flap with simultaneous placement of dental implants: case report of a novel technique

Dental restorative space from the opposing dentition requires adequate distance for restorative material for an acceptable restoration. Typically, long-standing edentulous alveolar ridges will have vertical and or horizontal defects that require alveolar ridge augmentation for ideal dental implant restorations. Along with these defects, one will see the opposing dentition supra ...

Differential correlation for sequencing data

Background Several methods have been developed to identify differential correlation (DC) between pairs of molecular features from –omics studies. Most DC methods have only been tested with microarrays and other platforms producing continuous and Gaussian-like data. Sequencing data is in the form of counts, often modeled with a negative binomial distribution making it difficult to ...

Normative Differences in Chinese and European Discourses on Global Security: Obstacles and Opportunities for Cooperation

This article attempts to provide an answer to the puzzle of how to account for the variations in levels and effectiveness of security cooperation between the EU and China, particularly given the apparently structural nature of the main factors affecting their security relationship. The hypothesis put forward in this study is that normative differences and overlaps could hold ...