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Linking the knowledge and reasoning of dissenting actors fosters a bottom-up design of agroecological viticulture

Wine growing has a high economic value globally, and vineyards, with their centenarian grape varieties, are an integral part of our societies. Yet with the use of spraying to control pathogens and weeds, mainstream viticulture has become a big pesticide consumer. Criticism of this conventional type of viticulture and its environmental/health impacts is increasing strongly ...

G.A.M.E.: GPU-accelerated mixture elucidator

GPU acceleration is useful in solving complex chemical information problems. Identifying unknown structures from the mass spectra of natural product mixtures has been a desirable yet unresolved issue in metabolomics. However, this elucidation process has been hampered by complex experimental data and the inability of instruments to completely separate different compounds. ...

A review of parameters and heuristics for guiding metabolic pathfinding

Recent developments in metabolic engineering have led to the successful biosynthesis of valuable products, such as the precursor of the antimalarial compound, artemisinin, and opioid precursor, thebaine. Synthesizing these traditionally plant-derived compounds in genetically modified yeast cells introduces the possibility of significantly reducing the total time and resources ...

Formation of amides: one-pot condensation of carboxylic acids and amines mediated by TiCl4

A general procedure for the synthesis of amides via the direct condensation of carboxylic acids and amines in the presence of TiCl4 is reported. The amidation reaction was performed in pyridine at 85 °C with a wide range of substrates providing the corresponding amide products in moderate to excellent yields and high purity. The reaction proceeds with low yields when both the ...

The environmental sustainability of insects as food and feed. A review

With a growing world population, increasingly demanding consumers, and a limited amount of agricultural land, there is an urgent need to find alternatives to conventional meat products. Livestock production is, moreover, a leading cause of anthropogenic-induced climate change. To mediate this, more sustainable diets are needed, with reduced meat consumption or the use of ...

Polytechnic engineering mathematics: assessing its relevance to the productivity of industries in Uganda

Background The main objective of the study was to examine the relevance of engineering mathematics to the emerging industries. The level of abstraction, the standard of rigor, and the depth of theoretical treatment are necessary skills expected of a graduate engineering technician to be derived from mathematical knowledge. The question of whether these skills are imparted to ...

Channel quantization-based physical-layer network coding for two-way relay STBC system

Wireless multiple-input multiple-output (MIMO) two-way relay systems have received increasing attention recently. In a simple two-hop relay system, physical-layer network coding (PNC) is an effective scheme for relay to map the transmitted symbols from two terminal nodes into the network coded symbol. This paper considers a two-hop two-way relay system which uses the Alamouti ...

Early assessment of response to induction therapy in acute myeloid leukemia using 18F-FLT PET/CT

Background We evaluated the suitability of 18F-fluorodeoxythymidine (18F-FLT) positron emission tomography (PET)/computed tomography (CT) for assessment of the early response to induction therapy and its value for predicting clinical outcome in patients with acute myeloid leukemia (AML). Adult patients who had histologically confirmed AML and received induction therapy were ...

Effect of forest fire on tree diversity and regeneration potential in a tropical dry deciduous forest of Mudumalai Tiger Reserve, Western Ghats, India

Introduction The study was conducted in Mudumalai Tiger Reserve, in the Western Ghats to understand the effect of a single fire event on tree diversity and regeneration status. Four forest patches were selected which were unburned, 2-year-old burn, 5-year-old burn, and 15-year-old burn. Three 0.1 ha square plots were laid randomly in all four patches and analyzed for tree ...

Compilation of a regionally extended inter-country input–output table and its application to global value chain analyses

Studies on the rise of global value chains (GVCs) have attracted a great deal of interest in the recent economics literature. However, due to statistical and methodological challenges, most existing researches ignore domestic regional heterogeneity in assessing the impact of joining GVCs. GVCs are supported not only directly by domestic regions that export goods and services to the ...

Assessment of glucose regulation in pregnancy after gastric bypass surgery

Aims/hypothesis Roux-en-Y gastric bypass (RYGB) surgery is characterised by glycaemic variability. Prospective studies of glucose metabolism in pregnancy after RYGB are not available, therefore this study aimed to evaluate physiological alterations in glucose metabolism in pregnancy following RYGB. Methods Sixty-three pregnant women (25 who underwent RYGB, 19 non-operated obese ...

Chronic Traumatic Encephalopathy: Connecting Mechanisms to Diagnosis and Treatment

Chronic traumatic encephalopathy is a progressive neurodegenerative disease that has been linked to the incidence of repetitive mild traumatic brain injuries. As chronic traumatic encephalopathy has no formal diagnosis or treatment, current research is striving to better understand its neuropathology in order to develop effective diagnostic and treatment strategies. This review ...

Transitioning to Minimal Footwear: a Systematic Review of Methods and Future Clinical Recommendations

Background Recent interest in barefoot running has led to the development of minimalist running shoes that are popular in distance runners. A careful transition to these shoes has been suggested and examined in the literature. However, no guidelines based on systematic evidence have been presented. The purpose of this review is to systematically examine the methods employed in the ...

Silverland: the Realm of Compounds of Divalent Silver—and Why They are Interesting

In this personal account, the author takes readers on the journey to “Silverland,” i.e., the emerging field of electronic and magnetic materials based on divalent silver (Ag2+). He blends historical background with the reasons which led him to become involved in this research, as well as to proposing (with Roald Hoffmann, 2001) that high-T C superconductivity might ultimately be ...

Sequential estimation of intrinsic activity and synaptic input in single neurons by particle filtering with optimal importance density

This paper deals with the problem of inferring the signals and parameters that cause neural activity to occur. The ultimate challenge being to unveil brain’s connectivity, here we focus on a microscopic vision of the problem, where single neurons (potentially connected to a network of peers) are at the core of our study. The sole observation available are noisy, sampled voltage ...

Therapeutic Potential of Optogenetic Treatment for Individuals with Multiple Sclerosis

Multiple Sclerosis (MS) is a chronic neuroautoimmune condition characterized by neurodegeneration and demyelination throughout the central nervous system. While the pathology of MS is largely unknown, its symptoms are well defined. Current MS therapies such as intravenous corticoid injection, disease modifying treatments (DMTs) and neuro-rehabilitation exist; however most are ...

Handpad: a virtual mouse for controlling laptops in a smart home

This study investigates the possibilities of equipping fixed furniture with touch screens to control laptops or other smart home devices, to create a holistic smart home control system. Although multi-touch screens have recently been integrated into desktop use, most users prefer a classical mouse for desktop input. This study introduces Handpad, which is a new indirect touch input ...