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Heat transfer rates in sheared beds of inertial particles at high Biot numbers

We investigate heat conduction rates through the contact network of sheared granular materials that consist of particles with a density much larger than that of the ambient fluid. The tool ParScale, a finite difference solver for intra-particle transport processes, is coupled to the discrete element method solver LIGGGHTS to carry out the simulations. Heat transfer to the ...

Cross-sectional examination of musculoskeletal conditions and multimorbidity: influence of different thresholds and definitions on prevalence and association estimates

Background Multimorbidity and musculoskeletal conditions create substantial burden for people and health systems. Quantifying the extent of co-occurring conditions is hampered by conceptual heterogeneity, imprecision and/or indecision about how multimorbidity is defined. The purpose of this study is to examine the influence of different ways of operationalising multimorbidity on ...

Impurity Location-Dependent Relaxation Dynamics of Cu:CdS Quantum Dots

Various types of 2% Cu-incorporated CdS (Cu:CdS) quantum dots (QDs) with very similar sizes have been prepared via a water soluble colloidal method. The locations of Cu impurities in CdS host nanocrystals have been controlled by adopting three different synthetic ways of doping, exchange, and adsorption to understand the impurity location-dependent relaxation dynamics of charge ...

Assessment of regional pulmonary blood flow using 68Ga-DOTA PET

Background In vivo determination of regional pulmonary blood flow (PBF) is a valuable tool for the evaluation of many lung diseases. In this study, the use of 68Ga-DOTA PET for the in vivo quantitative determination of regional PBF is proposed. This methodology was implemented and tested in healthy pigs and validated using fluorescent microspheres. The study was performed on young ...

Benzene poisoning, clinical and blood abnormalities in two Brazilian female gas station attendants: two case reports

Background Brazilian gas station workers are chronically exposed to benzene, toluene, xylene (BTX) during their working time. Describe below two cases of latin female gas station workers with benzene poisoning symptoms and miscarriage history. Case presentation In both cases were identified complex chromosomal rearrangements (CCR) with fluorescence in situ hybridization, applied to ...

Effective Particles in Quantum Field Theory

The concept of effective particles is introduced in the Minkowski space-time Hamiltonians in quantum field theory using a new kind of the relativistic renormalization group procedure that does not integrate out high-energy modes but instead integrates out the large changes of invariant mass. The new procedure is explained using examples of known interactions. Some applications in ...

Big Systems Versus Stocky Tangles: It Can Matter to the Details

Wolfgang Spohn’s Frege prize lecture, like the work on which it is based, is a tour de force of rich, elegant, coherent argument about how the projected world that we experience is constructed. But we do not live in this projected world nor reason about it. The things Spohn constructs are there from the start—or so my Stanford School pragmatism teaches. This paper explores a deep ...

Arranging blood for elective thyroid surgeries: dilemma continues in the developing world

Background Cross matched blood is frequently ordered based on a subjective anticipation of blood loss for a procedure. Excessive blood arrangement and wastage overburdens the blood bank in terms of work load and storage of blood, increases cost of medical care and results in injudicious use of a limited resource. The aim of this short report is to assess the current practice for ...

Ophthalmic examination as a means to diagnose Subacute Sclerosing Panencephalitis: an optical coherence tomography and ultrawide field imaging evaluation

Background Subacute sclerosing panencephalitis (SSPE) is a potentially fatal complication of measles. The authors report a case of recurrent myoclonic jerks under investigation, whose ophthalmic examination pointed to the diagnosis. Case presentation A 12-year-old boy with recurrent episodes of myoclonic jerks was found to have optic disc pallor and an irregular macular scar with ...

Dental implants and grafting success remain high despite large variations in maxillary sinus mucosal thickening

Background Although mucosal thickening is the most common radiographic finding observed regarding sinus pathology, the knowledge regarding its clinical significance on the outcomes of dental implants and grafting in the maxillary sinuses is still limited. We hypothesized that mucosal thickening would not alter the predictability for sinus floor augmentation and dental implant ...

Tissue is the issue and tissue competition. Re-biopsy for mutation T790: where and why?

Lung cancer is still the leading cause of death among all cancers. During the last 15 years, pharmacogenomics of lung cancer have established targeted therapy with tyrosine kinase inhibitors (TKIs) for epidermal growth factor receptor (EGFR) positive patients in adenocarcinoma or mixed adenosquamus lung cancer patients. However; while novel drugs are released in the market, at the ...

A cognitive electrophysiological signature differentiates amnestic mild cognitive impairment from normal aging

Background Noninvasive and effective biomarkers for early detection of amnestic mild cognitive impairment (aMCI) before measurable changes in behavioral performance remain scarce. Cognitive event-related potentials (ERPs) measure synchronized synaptic neural activity associated with a cognitive event. Loss of synapses is a hallmark of the neuropathology of early Alzheimer’s disease ...

Severe community-acquired adenovirus pneumonia treated with oral ribavirin: a case report

Background Adenovirus is a common pathogen of acute upper respiratory infection in children and is generally self-limiting. Severe adenovirus infections have been reported in immunocompromised hosts especially bone marrow transplantation recipients due to hematologic malignancy. Severe adenovirus pneumonia in immunocompetent hosts has rarely been reported and optimal treatment has ...

The antineoplastic drug, trastuzumab, dysregulates metabolism in iPSC-derived cardiomyocytes

Background The targeted ERBB2 therapy, trastuzumab, has had a tremendous impact on management of patients with HER2+ breast cancer, leading to development and increased use of further HER2 targeted therapies. The major clinical side effect is cardiotoxicity but the mechanism is largely unknown. On the basis that gene expression is known to be altered in multiple models of heart ...

Transient Uncertainty Analysis in Solar Thermal System Modeling

Complex, dynamic, computational models are routinely used to evaluate and optimize the design and performance of solar thermal systems. As models become more complex, performing uncertainty analysis on such models can be quite challenging and computationally expensive. This paper presents an effective approach to quantify uncertainties associated with transient simulation results ...

Rapid and selective simultaneous quantitative analysis of modified nucleosides using multi-column liquid chromatography-tandem mass spectrometry

Background The profiles of modified nucleosides could act as useful biomarkers for cancer and cellular stress-induced diseases. However, there are no reports of high throughput and simultaneous quantitative methods for using biomarker evaluation and discovery at the bedside. Methods Modified nucleosides were separated on two CAPCELL PAK ADME S3 (100 mm × 2.1 mm i.d.; 3-μm particle ...

A bibliometric analysis of two decades of aromatherapy research

Background Quantitative data are lacking on the profile of published research in aromatherapy. The objective of the study was to investigate the profile of original and review articles under the topic aromatherapy using bibliometric analysis. Methods Articles on aromatherapy, published between 1995 and 2014, were retrieved from the Science Citation Index-Expanded database from the ...

Experimental Study of Three-Nucleon Dynamics in the Dp Breakup Collisions Using the WASA Detector

Until recently, all calculations of breakup observables were carried out in a non-relativistic regime. The relativistic treatment of the breakup reaction in 3 N system is quite a new achievement. The detailed study of various aspects of few-nucleon system dynamics in medium energy region, with a particular emphasis on investigation of relativistic effects and their interplay with ...