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Pharmacokinetic modeling of [11C]flumazenil kinetics in the rat brain

Background Preferred models for the pharmacokinetic analysis of [11C]flumazenil human studies have been previously established. However, direct translation of these models and settings to animal studies might be sub-optimal. Therefore, this study evaluates pharmacokinetic models for the quantification of [11C]flumazenil binding in the rat brain. Dynamic (60 min) [11C]flumazenil ...

Design and pharmacodynamics of recombinant NZ2114 histidine mutants with improved activity against methicillin-resistant Staphylococcus aureus

NZ2114 is a promising candidate for therapeutic application owing to its potent activity to Staphylococcus aureus. Our objective was to identify NZ2114 derivatives with improved activity through substitution of His16 and His18 with residues Arginine and Lysine. Eight mutants were designed and expressed in Pichia pastoris X-33 via pPICZαA. Five of them exhibited strong antimicrobial ...

Purification and characterization of a novel ubiquitin-like antitumour protein with hemagglutinating and deoxyribonuclease activities from the edible mushroom Ramaria botrytis

A novel ubiquitin-like antitumour protein (RBUP) was isolated from fruiting bodies of the edible mushroom Ramaria botrytis. The protein was isolated with a purification protocol involving ion exchange chromatography on DEAE-Sepharose fast flow and gel filtration on Sephadex G-75. SDS-PAGE, Native-PAGE and ultracentrifugation analysis disclosed that RBUP was a monomeric protein with ...

The Oxygen Reduction Electrocatalytic Activity of Cobalt and Nitrogen Co-doped Carbon Nanocatalyst Synthesized by a Flat Template

The design of noble-metal-free catalysts for oxygen reduction reaction (ORR) is very important to the commercialization of fuel cells. Here, we use a Co-modified montmorillonite (Co-MMT) as a flat template to prepare Co- and N-doped nanocarbon ORR catalysts derived from carbonization of polyaniline at controlled temperatures. The use of flat template can hinder the agglomeration of ...

Genetics and genomics of dilated cardiomyopathy and systolic heart failure

Heart failure is a major health burden, affecting 40 million people globally. One of the main causes of systolic heart failure is dilated cardiomyopathy (DCM), the leading global indication for heart transplantation. Our understanding of the genetic basis of both DCM and systolic heart failure has improved in recent years with the application of next-generation sequencing and ...

Predictive value of sperm deoxyribonucleic acid (DNA) fragmentation index in male infertility

Background Recently, damage to the sperm DNA has been studied as it is associated with reduced fertilization rates, embryo quality, and pregnancy rates, also higher rates of spontaneous miscarriage. Objective To develop a diagnostic method in predicting male infertility. Material and Methods The design of this study is cross-sectional. Data were retrieved from medical records of ...

Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells

Background Magnesium is essential for numerous physiological functions. Magnesium exists mostly in bone and the amount is dynamically regulated by skeletal remodeling. Accelerating bone mass loss occurs when magnesium intake is insufficient; whereas high magnesium could lead to mineralization defects. However, the underlying magnesium regulatory mechanisms remain elusive. In the ...

Enhanced Photovoltage Response of Hematite-X-Ferrite Interfaces (X = Cr, Mn, Co, or Ni)

High-fluorescent p-X-ferrites (XFe2O4; XFO; X = Fe, Cr, Mn, Co, or Ni) embedded in n-hematite (Fe2O3) surfaces were successfully fabricated via a facile bio-approach using Shewanella oneidensis MR-1. The results revealed that the X ions with high/low work functions modify the unpaired spin Fe2+–O2− orbitals in the XFe2O4 lattices to become localized paired spin orbitals at the ...

A new method for treating fecal incontinence by implanting stem cells derived from human adipose tissue: preliminary findings of a randomized double-blind clinical trial

Background Anal sphincter defects are a major cause of fecal incontinence causing negative effects on daily life, social interactions, and mental health. Because human adipose-derived stromal/stem cells (hADSCs) are easier and safer to access, secrete high levels of growth factor, and have the potential to differentiate into muscle cells, we investigated the ability of hADSCs to ...

Synergistic Enhancement of the Percolation Threshold in Hybrid Polymeric Nanocomposites Based on Carbon Nanotubes and Graphite Nanoplatelets

Synergistic effect causes significant decreasing of the percolation threshold in the ternary polymer composites filled with carbon nanotubes (CNT) and graphite nanoplatelets (GNP) in comparison with binary ones. Enhancement of the percolation threshold strongly depends only on the relative aspect ratios of the filler particles due to the formation of the bridges between puddles of ...

Depression and anxiety behaviour in a rat model of chronic migraine

Background Epidemiological and clinical studies have demonstrated comorbidity between migraine and affective disorders. However, it is unclear whether chronic migraine can lead to affective disorders in other animals. Methods A classical chronic migraine rat model (repeated dura mater inflammatory soup [IS] infusion) was used to evaluate depression and anxiety behaviour via weight, ...

Synthesis and Characterization of Pure Ni and Ni-Sn Intermetallic Nanoparticles

The present research focused on the synthesis of Ni and Ni-Sn nanoparticles via a chemical reduction method using hydrazine hydrate. The syntheses were performed applying highly purified water or diethylene glycol as solvent. The produced nanoparticles were characterized by scanning electron microscopy and powder X-ray diffraction. The as-synthesized Ni-Sn nanoparticles with ...

Don’t forget the porpoise: acoustic monitoring reveals fine scale temporal variation between bottlenose dolphin and harbour porpoise in Cardigan Bay SAC

Populations of bottlenose dolphin and harbour porpoise inhabit Cardigan Bay, which was designated a Special Area of Conservation (SAC), with bottlenose dolphin listed as a primary feature for its conservation status. Understanding the abundance, distribution and habitat use of species is fundamental for conservation and the implementation of management. Bottlenose dolphin and ...

Novel approaches to the energy load unbalance forecasting in the Italian electricity market

In the present paper we study the statistical properties of the Italian daily electricity load market, by mean of different statistical methods, such, e.g., the exponential smoothing model, the ARMA-ARIMA model and the ARIMA-GARCH model, also providing results about the goodness of each of the proposed approaches. Moreover, we show how the aforementioned models behave if exogenous ...

The English National Screening Programme for diabetic retinopathy 2003–2016

The aim of the English NHS Diabetic Eye Screening Programme is to reduce the risk of sight loss amongst people with diabetes by the prompt identification and effective treatment if necessary of sight-threatening diabetic retinopathy, at the appropriate stage during the disease process. In order to achieve the delivery of evidence-based, population-based screening programmes, it was ...

The discovery of novel LPMO families with a new Hidden Markov model

Background Renewable biopolymers, such as cellulose, starch and chitin are highly resistance to enzymatic degradation. Therefore, there is a need to upgrade current degradation processes by including novel enzymes. Lytic polysaccharide mono-oxygenases (LPMOs) can disrupt recalcitrant biopolymers, thereby enhancing hydrolysis by conventional enzymes. However, novel LPMO families are ...

Structural, Optical, and Magnetic Properties of Zn-Doped CoFe2O4 Nanoparticles

The effect of Zn-doping in CoFe2O4 nanoparticles (NPs) through chemical co-precipitation route was investigated in term of structural, optical, and magnetic properties. Both XRD and FTIR analyses confirm the formation of cubic spinel phase, where the crystallite size changes with Zn content from 46 to 77 nm. The Scherrer method, Williamson-Hall (W-H) analysis, and size-strain plot ...