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Macular Hole Development After Vitrectomy for Floaters: A Case Report

Introduction The purpose of this report is to describe a case of macular hole development after vitrectomy for floaters with induction of posterior vitreous detachment. Case Report A 44-year-old otherwise healthy man presented with visually debilitating floaters in his right eye; these had been present for more than 2 years. Preoperative examination was unremarkable in both eyes, ...

A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies

Mutations rapidly accumulate in the HIV-1 genome after infection. Some of those mutations are selected by host immune responses and often cause viral fitness losses. This study is to investigate whether strongly selected mutations that are not associated with immune responses result in fitness losses. Strongly selected mutations were identified by analyzing 5′-half HIV-1 genome ...

Customized microscale approach for optimizing two-phase bio-oxidations of alkanes with high reproducibility

Numerous challenges remain to achieve industrially competitive space–time yields for bio-oxidations. The ability to rapidly screen bioconversion reactions for characterization and optimization is of major importance in bioprocess development and biocatalyst selection; studies at conventional lab scale are time consuming and labor intensive with low experimental throughput. The ...

Behavioral testing of minipigs transgenic for the Huntington gene—A three-year observational study

Background Large animal models of Huntington’s disease (HD) may increase the reliability of translating preclinical findings to humans. Long live expectancy offers opportunities particularly for disease modifying approaches, but also challenges. The transgenic (tg) HD minipig model assessed in this study exhibits a high genetic homology with humans, similar body weight, and ...

Recurrence analysis of ant activity patterns

In this study, we used recurrence quantification analysis (RQA) and recurrence plots (RPs) to compare the movement activity of individual workers of three ant species, as well as a gregarious beetle species. RQA and RPs quantify the number and duration of recurrences of a dynamical system, including a detailed quantification of signals that could be stochastic, deterministic, or ...

Interpretation of Offshore Crustal Movements Following the 2011 Tohoku-Oki Earthquake by the Combined Effect of Afterslip and Viscoelastic Stress Relaxation

On the 11th March 2011, a megathrust event, called the Tohoku-oki earthquake, occurred at the North American-Pacific plate interface off northeast Japan. Transient crustal movements following this earthquake were clearly observed by a dense GPS network (GEONET) on land and a sparse GPS/Acoustic positioning network on seafloor. The observed crustal movements are in accordance with ...

Design, Perception and Behavior in the Innovation Era: Revisiting the Concept of Interdependence

The innovation era has seen firms adopting a variety of organization designs with autonomous teams as their basic building blocks. Such organization designs have confronted firms with the challenge of managing complex task interdependence configurations. The predominant assumption within the organization design field for decades has been that task interdependence given by design ...