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Factors associated with poor treatment outcome of tuberculosis in Debre Tabor, northwest Ethiopia

Objective Directly observed treatment short course has been implemented as part of the national tuberculosis control program in Ethiopia. The strategy, as evidenced by different studies, has improved the survival and treatment success rate of tuberculosis patients. However, some patients failed to complete their treatments and the factors for this failure were not assessed in the ...

Measuring management’s perspective of data quality in Pakistan’s Tuberculosis control programme: a test-based approach to identify data quality dimensions

Background Data quality is core theme of programme’s performance assessment and many organizations do not have any data quality improvement strategy, wherein data quality dimensions and data quality assessment framework are important constituents. As there is limited published research about the data quality specifics that are relevant to the context of Pakistan’s Tuberculosis ...

The geographical distribution of dialysis services in Ghana

Background Chronic kidney disease (CKD) is an important global health challenge with increasing burden worldwide. CKD and acute kidney injury (AKI) may require renal replacement therapy (RRT) at some stages of the disease. Ghana currently has no renal transplant program. Dialysis services still remain a mirage to many chronic kidney disease patients in Ghana due to cost and paucity ...

Estimating the proportion of clinically diagnosed infectious and non-infectious animal diseases in Ganta Afeshum woreda, Eastern Tigray zone, Ethiopia

Objective This study was performed with the objective of identifying the proportion of emerging and endemic livestock diseases using cross sectional survey. Result A total of 285 clinically diseased animals were presented to a veterinary clinic and diagnosed tentatively based on history, clinical sign, and simple laboratory diagnostics and from the study, actinomycosis (15.83%), ...

The behavioural phenotype of Potocki-Lupski syndrome: a cross-syndrome comparison

Background Potocki-Lupski syndrome (PTLS) and Smith-Magenis syndrome (SMS) are related genomic disorders, as duplication 17p11.2 (associated with PTLS) is the reciprocal recombination product of the SMS microdeletion. While SMS has a relatively well-delineated behavioural phenotype, the behavioural profile in PTLS is less well defined, despite purported associations with autism ...

Nonmedical prescription opioid use and illegal drug use: initiation trajectory and related risks among people who use illegal drugs in Vancouver, Canada

Objective We investigated the prevalence of and risk factors associated with initiating nonmedical prescription opioid use (NMPOU) before and after illegal drugs using data from two linked cohort studies of street youth and adults who use illegal drugs in Vancouver, Canada. All participants who attended a study visit between 2013 and 2016 were eligible for the primary analyses. ...

Infantile hypertrophic pyloric stenosis: a 4-year experience from two tertiary care centres in Cameroon

Objective This study aimed to describe the clinical characteristics of patients with infantile hypertrophic stenosis, management and its outcome in two tertiary care centres in Cameroon. Results A total of 21 patients were included from the two centres. The mean age at presentation was 5.2 ± 1.2 weeks, predominantly male with a male-to-female ratio of 4.25:1. The triad of vomiting, ...

Publication rate of abstracts presented at Japan Geriatrics Society Annual Meetings (2011–2012): a retrospective observational study

Objective We aimed to determine the publication rate of abstracts presented at Japan Geriatrics Society Annual Meetings. Publication rates were determined by searching for full-text publications up to September 2017 in the MEDLINE database. Factors associated with publication were determined. Results In total, 618 abstracts presented at Japan Geriatrics Society Annual Meetings ...

Examining human paragonimiasis as a differential diagnosis to tuberculosis in The Gambia

Objective Paragonimiasis is a foodborne trematode infection of the lungs caused by Paragonimus spp., presenting clinically with similar symptoms to active tuberculosis (TB). Worldwide, an estimated 20.7 million people are infected with paragonimiasis, but relatively little epidemiological data exists for Africa. Given a recently reported case, we sought to establish whether ...

Increased whole blood FFA2/GPR43 receptor expression is associated with increased 30-day survival in patients with sepsis

Objective Sepsis is a condition associated with a dysregulated inflammatory response to infection with significant morbidity. Recent advances have elucidated the vital role that the short chain fatty acid glycoprotein receptor 43 (FFA2/GPR43) plays in inflammatory and immunomodulatory pathways. We hypothesized that elevated whole blood GPR43 RNA expression would be associated with ...

Profile of epigenetic mechanisms in lung tumors of patients with underlying chronic respiratory conditions

Background Chronic lung diseases such as chronic obstructive pulmonary disease (COPD) and epigenetic events underlie lung cancer (LC) development. The study objective was that lung tumor expression levels of specific microRNAs and their downstream biomarkers may be differentially regulated in patients with and without COPD. Methods In lung specimens (tumor and non-tumor), microRNAs ...

Autophagy is required for human umbilical cord mesenchymal stem cells to improve spatial working memory in APP/PS1 transgenic mouse model

Background Recent studies have shown that autophagy plays a central role in mesenchymal stem cells (MSCs), and many studies have shown that human umbilical cord MSCs (huMSCs) can treat Alzheimer’s disease (AD) through a variety of mechanisms. However, no studies have looked at the effects of autophagy on neuroprotective function of huMSCs in the AD mouse model. Thus, in this study ...

Morphometric characterisation of human tracheas: focus on cartilaginous ring variation

Purpose Details regarding tracheal anatomy are currently lacking, with existing literature focussing mainly on the cricoid-tracheal region or the carina. External gross anatomy and internal morphology throughout the entire trachea is important for normal physiological functioning and various clinical applications such as designs for tracheal implants or endotracheal devices. ...

Quality of life in mucopolysaccharidoses: construction of a specific measure using the focus group technique

Objective To describe the perceptions of patients, their caregivers, and their healthcare providers to the development of a new specific instrument for assessment of the quality of life (QoL) in patients with mucopolysaccharidoses (MPS) using a qualitative focus group (FG) design. FGs were held in two Brazilian states (Rio Grande do Sul and Rio de Janeiro). Results Three versions ...

Bioinformatics-based identification of miR-542-5p as a predictive biomarker in breast cancer therapy

Background Tamoxifen is the first-line hormone therapy for estrogen receptor alpha positive (ERα+) breast cancer. However, about 40% of patients with ERα + breast cancer who receive tamoxifen therapy eventually develop resistance resulting in a poor prognosis. The aim of this study was to mine available data sets in the Gene Expression Omnibus (GEO) database, including in vitro ...

The role of smoking in the relationship between intimate partner violence and age at natural menopause: a mediation analysis

Background Age at natural menopause (ANM) is considered as a biologic marker of health and ageing. The relationship between intimate partner violence (IPV) and ANM is currently unknown, and whether smoking plays a role in this relationship is unclear. The aim of this study was to examine the association between IPV and ANM and to quantify the effect mediated through smoking. ...

Treatment outcome of anti-angiogenesis through VEGF-pathway in the management of gastric cancer: a systematic review of phase II and III clinical trials

Objectives Advanced gastric cancer poses a therapeutic challenge worldwide. In randomised clinical trials, anti-VEGF has been reported as an essential agent for the treatment of advanced gastric cancer. This review aims at assessing the treatment outcome of anti-angiogenesis therapy through the VEGF pathway in the management of patients with advanced gastric cancer. Results During ...

Aberrant expression and DNA methylation of lipid metabolism genes in PCOS: a new insight into its pathogenesis

Background Polycystic ovary syndrome (PCOS), whose etiology remains uncertain, is a highly heterogenous and genetically complex endocrine disorder. The aim of this study was to identify differentially expressed genes (DEGs) in granulosa cells (GCs) from PCOS patients and make epigenetic insights into the pathogenesis of PCOS. Results Included in this study were 110 women with PCOS ...

Newborn follow-up after discharge from a tertiary care hospital in the Western Cape region of South Africa: a prospective observational cohort study

Background Current practice in the Western Cape region of South Africa is to discharge newborns born in-hospital within 24 h following uncomplicated vaginal delivery and two days after caesarean section. Mothers are instructed to bring their newborn to a clinic after discharge for a health assessment. We sought to determine the rate of newborn follow-up visits and the potential ...

Draft genome sequence of Streptomyces hyaluromycini MB-PO13T, a hyaluromycin producer

Streptomyces hyaluromycini MB-PO13T (=NBRC 110483T = DSM 100105T) is type strain of the species, which produces a hyaluronidase inhibitor, hyaluromycin. Here, we report the draft genome sequence of this strain together with features of the organism and generation, annotation and analysis of the genome sequence. The 11.5 Mb genome of Streptomyces hyaluromycini MB-PO13T encoded ...