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Pharmacokinetic modeling of [11C]flumazenil kinetics in the rat brain

Background Preferred models for the pharmacokinetic analysis of [11C]flumazenil human studies have been previously established. However, direct translation of these models and settings to animal studies might be sub-optimal. Therefore, this study evaluates pharmacokinetic models for the quantification of [11C]flumazenil binding in the rat brain. Dynamic (60 min) [11C]flumazenil ...

Design and pharmacodynamics of recombinant NZ2114 histidine mutants with improved activity against methicillin-resistant Staphylococcus aureus

NZ2114 is a promising candidate for therapeutic application owing to its potent activity to Staphylococcus aureus. Our objective was to identify NZ2114 derivatives with improved activity through substitution of His16 and His18 with residues Arginine and Lysine. Eight mutants were designed and expressed in Pichia pastoris X-33 via pPICZαA. Five of them exhibited strong antimicrobial ...

Purification and characterization of a novel ubiquitin-like antitumour protein with hemagglutinating and deoxyribonuclease activities from the edible mushroom Ramaria botrytis

A novel ubiquitin-like antitumour protein (RBUP) was isolated from fruiting bodies of the edible mushroom Ramaria botrytis. The protein was isolated with a purification protocol involving ion exchange chromatography on DEAE-Sepharose fast flow and gel filtration on Sephadex G-75. SDS-PAGE, Native-PAGE and ultracentrifugation analysis disclosed that RBUP was a monomeric protein with ...

Don’t forget the porpoise: acoustic monitoring reveals fine scale temporal variation between bottlenose dolphin and harbour porpoise in Cardigan Bay SAC

Populations of bottlenose dolphin and harbour porpoise inhabit Cardigan Bay, which was designated a Special Area of Conservation (SAC), with bottlenose dolphin listed as a primary feature for its conservation status. Understanding the abundance, distribution and habitat use of species is fundamental for conservation and the implementation of management. Bottlenose dolphin and ...

Novel approaches to the energy load unbalance forecasting in the Italian electricity market

In the present paper we study the statistical properties of the Italian daily electricity load market, by mean of different statistical methods, such, e.g., the exponential smoothing model, the ARMA-ARIMA model and the ARIMA-GARCH model, also providing results about the goodness of each of the proposed approaches. Moreover, we show how the aforementioned models behave if exogenous ...

Decline of Jakar sheep population in pastoral communities of Bhutan: A consequence of diminishing utility, alternate income opportunities and increasing challenges

Jakar sheep population in Bhutan is declining at unprecedented rate (44.4% per annum), and current population is little over 1,700. This study attempts to understand the current status of Jakar sheep and investigate the causes and drivers behind the rapid decline in population. The utility of sheep and wool in particular for clothing by herders is also declining. Sheep farming is ...

Development of a prototype 16S rRNA gene-based microarray for monitoring planktonic actinobacteria in shrimp ponds

Many reports have shown that the composition of the bacterioplankton community can serve as a biological indicator to evaluate the occurrence of shrimp diseases. However, the distribution, diversity, and function of planktonic actinobacteria in shrimp ponds are still poorly understood. In this study, a prototype of a 16S rRNA gene-based taxonomic microarray was developed and ...

Performance improvement of a passive solar still in a water desalination

Using a solar energy in water desalination system is regarded as one of the most effective ways to resolve the problem of freshwater shortages in this world. Experimental and theoretical approaches were carried out to design and test multistage solar still. The experimental tests were conducted for five months in the city of Kirkuk, north of Iraq, at 43.39° longitudinal and 35.17° ...

Microbial flora and resistance in ophthalmology: a review

Antibiotic resistance in systemic infection is well-researched and well-publicized. Much less information is available on the resistance of normal ocular microbiome and that of ophthalmic infections. An understanding of the distribution of ocular microorganisms may help us in tailoring our empiric treatment, as well as in choosing effective pre-, peri- and postoperative management, ...

Stage IV pleomorphic carcinoma of the lung without recurrence for 6 years: a case report

Background Pleomorphic carcinoma is a rare primary lung carcinoma that occurs at a rate of about 0.3%. Even with complete resection, the tumor usually recurs aggressively, resulting in a poor prognosis. Herein, we report a case of advanced pleomorphic carcinoma of the lung who had a long survival time after resection of the primary and metastatic sites. Case presentation A ...

Application of multivariate statistical technique for hydrogeochemical assessment of groundwater within the Lower Pra Basin, Ghana

Multivariate statistical technique and hydrogeochemical approach were employed for groundwater assessment within the Lower Pra Basin. The main objective was to delineate the main processes that are responsible for the water chemistry and pollution of groundwater within the basin. Fifty-four (54) (No) boreholes were sampled in January 2012 for quality assessment. PCA using Varimax ...

Spontaneous torsion of the right upper lung lobe: a case report

Background Pulmonary torsion is usually caused by thoracic surgery or trauma. Spontaneous pulmonary torsion caused by tumor and pleural effusion is very rare. Case presentation A 76-year-old Asian male with a chronic cough and suspected lung or pleural tumor presented with sudden dyspnea. Computed tomography showed that the right upper lung lobe contained a large tumor in the ...

ADCY5-related dyskinesia presenting as familial myoclonus-dystonia

We describe a family with an autosomal dominant familial dyskinesia resembling myoclonus-dystonia associated with a novel missense mutation in ADCY5, found through whole-exome sequencing. A tiered analytical approach was used to analyse whole-exome sequencing data from an affected grandmother-granddaughter pair. Whole-exome sequencing identified 18,000 shared variants, of which 46 ...