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Longitudinal strain assessed by cardiac magnetic resonance correlates to hemodynamic findings in patients with severe aortic stenosis and predicts positive remodeling after transcatheter aortic valve replacement

Aims To assess left-ventricular strain parameters before and after transcatheter aortic valve replacement (TAVR) by feature tracking cardiac magnetic resonance imaging (FT CMR) and to correlate the findings to hemodynamic state and left-ventricular remodeling. Methods and results Patients with symptomatic AS underwent FT CMR before and after TAVR. Patients were carefully evaluated ...

Water properties in pâtés enriched with potato juice

Freshly squeezed potato juice was used in the traditional European folk medicine. Potato juice can be introduced into food products both in its fresh as well as in thermally preserved form as a component of functional food. An attempt was made to analyse the impact of potato juice supplementation on qualitative and quantitative parameters characterising water bonds in poultry meat ...

Low-dose tolvaptan PK/PD: comparison of patients with hyponatremia due to syndrome of inappropriate antidiuretic hormone secretion to healthy adults

Purpose Tolvaptan (TLV) is indicated to treat hyponatremia due to syndrome of inappropriate diuretic hormone (SIADH) in Europe. Treatment is to be initiated at 15 mg QD but post-approval reporting indicates increasing use of 7.5 mg as the starting dose. Physicians believe 7.5 mg is effective and has a lower incidence of overly rapid correction of serum sodium. Methods Single TLV ...

Alpha-synuclein oligomers: a new hope

Alpha-synuclein is a protein implicated in Parkinson’s disease and thought to be one of the main pathological drivers in the disease, although it remains unclear how this protein elicits its neurotoxic effects. Recent findings indicate that the assembly of toxic oligomeric species of alpha-synuclein may be one of the key processes for the pathology and spread of the disease. The ...

Das AMDS-System zur Dokumentation von Schmerzbefunden

Die Autoren stellen als Arbeitsgemeinschaft für Methodik und Dokumentation von Schmerzbefunden (AMDS) ein System zur Befunderhebung vor. Dieses lehnt sich in seiner Struktur an das AMDP-System (System der Arbeitsgemeinschaft für Methodik und Dokumentation in der Psychiatrie) zur Dokumentation psychiatrischer Befunde an. Die vorgeschlagenen Merkmale wurden in einem Stufenprozess aus ...

The use of aortic balloon occlusion in traumatic shock: first report from the ABO trauma registry

Purpose Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a technique for temporary stabilization of patients with non-compressible torso hemorrhage. This technique has been increasingly used worldwide during the past decade. Despite the good outcomes of translational studies, clinical studies are divided. The aim of this multicenter-international study was to ...

Neurosecretion: what can we learn from chromaffin cells

Many of the molecular players in the stimulus-secretion chain are similarly active in neurosecretion and catecholamine release. Therefore, studying chromaffin cells uncovered many details of the processes of docking, priming, and exocytosis of vesicles. However, morphological specializations at synapses, called active zones (AZs), confer extra speed of response and another layer of ...

Phase 1 study of darolutamide (ODM-201): a new-generation androgen receptor antagonist, in Japanese patients with metastatic castration-resistant prostate cancer

Purpose This trial assessed the safety, pharmacokinetics, and efficacy of darolutamide (ODM-201), a new-generation nonsteroidal androgen receptor antagonist, in Japanese patients with metastatic castration-resistant prostate cancer (mCRPC). Methods In this open-label, nonrandomized, two-cohort, dose-escalating phase 1 study, Japanese patients with mCRPC were enrolled after a ...

Expression patterns of key Sonic Hedgehog signaling pathway components in the developing and adult mouse midbrain and in the MN9D cell line

The temporal dynamic expression of Sonic Hedgehog (SHH) and signaling during early midbrain dopaminergic (mDA) neuron development is one of the key players in establishing mDA progenitor diversity. However, whether SHH signaling is also required during later developmental stages and in mature mDA neurons is less understood. We study the expression of SHH receptors Ptch1 and Gas1 ...

Does competition in the housing market cause transport poverty? Interrelations of residential location choice and mobility

Introduction This contribution examines the impact of the housing market on daily mobility and is based on the assumption that, in a supply-dominated housing market, as availability and affordability decline, many people must compromise, particularly on accessibility-related decision criteria when searching for a residential location. This applies even more to households with low ...

Community-based knowledge towards rangeland condition, climate change, and adaptation strategies: the case of Afar pastoralists

Introduction Pastoral communities have a comprehensive knowledge of their environments. This knowledge was acquired through extensive observation of the local environment and continuous herding practices. Pastoralists’ wisdom about their local environment and adaptation strategies to climate change is essential for sustainable development. Thus, appreciation of pastoralists’ ...

Classification of Westminster Parliamentary constituencies using e-petition data

In a representative democracy it is important that politicians have knowledge of the desires, aspirations and concerns of their constituents. Opportunities to gauge these opinions are however limited and, in the era of novel data, thoughts turn to what alternative, secondary, data sources may be available to keep politicians informed about local concerns. One such source of data ...

Levofloxacin is phytotoxic and modifies the protein profile of lupin seedlings

The toxicity of levofloxacin to yellow lupin plants was evaluated in this study. Recommended indexes of plant (roots and shoots) growth were determined and new indexes were proposed which better characterise the phytotoxicity of levofloxacin. These were, in particular, the activity of antioxidative enzymes, the content of free radicals, as well as the root protein content and the ...