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The universe of ANA testing: a case for point-of-care ANA testing

Testing for total antinuclear antibodies (ANA) is a critical tool for diagnosis and management of autoimmune diseases at both the primary care and subspecialty settings. Repurposing of ANA from a test for lupus to a test for any autoimmune condition has driven the increase in ANA requests. Changes in ANA referral patterns include early or subclinical autoimmune disease detection in ...

Instrumental approach toward understanding nano-pollutants

Nano-pollutants (NPLTs) have recently raised global concerns due to their possible harmful impact on environment and human health. However, until date, information on the occurrence, fate and toxicity of NPLTs in environment is scant. The knowledge gap can be attributed to the lack of advanced and sophisticated methodologies for the precise detection and characterization of NPLTs ...

Data completion in building information management: electrical lines from range scans and photographs

Background The concept of building information management (BIM) is based on its holistic nature. This idea pays off, if all relevant information is fused into one consistent data set. As a consequence, the completeness of data is vital and the research question on how to complete data automatically remains open. Methods In this article we present a data completion technique based ...

Barriers and facilitators for BIM use among Swedish medium-sized contractors - “We wait until someone tells us to use it”

Background The pace of diffusion of BIM (Building Information Modelling) use is considered to increase with governmental initiatives in which public clients in countries like Finland, Singapore, United Kingdom, and Sweden begin requiring BIM as a part of the project delivery. Currently, larger contractor firms use BIM to a certain extent. However, BIM use by mid-sized contractor ...

A facile synthesis and anticancer activity of some novel thiazoles carrying 1,3,4-thiadiazole moiety

Background Thiazoles and 1,3,4-thiadiazoles have been reported to possess various pharmacological activities. Results A novel series of thiazoles carrying 1,3,4-thiadiazole core were designed and prepared via the reaction of the 2-(4-methyl-2-phenylthiazole-5-carbonyl)-N-phenylhydrazinecarbo-thioamide with the appropriate hydrazonoyl chlorides. The structures of the newly ...

Efficient method of two-dimensional DOA estimation for coherent signals

An effective decoherence method called the fourth-order cumulants-based improved Toeplitz matrices reconstruction (FOC-ITMR) is addressed for two-dimensional (2-D) direction-of-arrival (DOA) estimation of coherent signals. To avoid the loss of the array’s physical aperture, the FOC-ITMR method fully utilizes the information of received data from the whole two parallel uniform ...

Prognostic Value of Computed Tomography: Measured Parameters of Body Composition in Primary Operable Gastrointestinal Cancers

Background Previous reports suggest that body composition parameters can be used to predict outcomes for patients with gastrointestinal (GI) cancers. However, evidence for an association with long-term survival is conflicting, with much of the data derived from patients with advanced disease. This study examined the effect of body composition on survival in primary operable GI ...

Multi-resolution privacy-enhancing technologies for smart metering

The availability of individual load profiles per household in the smart grid end-user domain combined with non-intrusive load monitoring to infer personal data from these load curves has led to privacy concerns. Privacy-enhancing technologies have been proposed to address these concerns. In this paper, the extension of privacy-enhancing technologies by wavelet-based ...

The civic turn of immigrant integration policies in the Scandinavian welfare states

This special issue addresses the question of how to understand the civic turn within immigrant integration in the West towards programs and instruments, public discourses and political intentions, which aim to condition, incentivize, and shape through socialization immigrants into ‘citizens’. Empirically, it focuses on the less studied Scandinavian cases of Sweden, Norway, and ...

Interaction of marijuana and alcohol on fatal motor vehicle crash risk: a case–control study

Background Concurrent use of marijuana and alcohol in drivers is of increasing concern but its role in crash causation has not been well understood. Methods Using a case–control design, we assessed the individual and joint effects of marijuana and alcohol use on fatal crash risk. Cases (n = 1944) were drivers fatally injured in motor vehicle crashes in the United States at specific ...

Global hydrogen reservoirs in basement and basins

Background Hydrogen is known to occur in the groundwaters of some ancient cratons. Where associated gases have been dated, their age extends up to a billion years, and the hydrogen is assumed also to be very old. These observations are interpreted to represent the radiolysis of water and hydration reactions and migration of hydrogen into fracture systems. A hitherto untested ...

From working collections to the World Germplasm Project: agricultural modernization and genetic conservation at the Rockefeller Foundation

This paper charts the history of the Rockefeller Foundation’s participation in the collection and long-term preservation of genetic diversity in crop plants from the 1940s through the 1970s. In the decades following the launch of its agricultural program in Mexico in 1943, the Rockefeller Foundation figured prominently in the creation of world collections of key economic crops. ...

From protein-protein interactions to protein co-expression networks: a new perspective to evaluate large-scale proteomic data

The reductionist approach of dissecting biological systems into their constituents has been successful in the first stage of the molecular biology to elucidate the chemical basis of several biological processes. This knowledge helped biologists to understand the complexity of the biological systems evidencing that most biological functions do not arise from individual molecules; ...

Nudge management: applying behavioural science to increase knowledge worker productivity

Knowledge worker productivity is essential for competitive strength in the digital century. Small interventions based on insights from behavioural science makes it possible for knowledge workers to be more productive. In this point of view article, we outline and discuss a new management style which we label nudge management.

A novel architecture for parallel multi-view HEVC decoder on mobile device

The multi-view HEVC (MV-HEVC) extension was finalized in July of 2014 by the Moving Picture Experts Group and the Video Coding Experts Group. Recently, multi-view videos based on stereo representations are becoming widely popular. Also, a variety of multimedia contents are now available for mobile devices. A real-time multi-view video decoder is therefore needed. In mobile devices, ...

Hybrid wireless networks with FIB-based Named Data Networking

In Named Data Networking (NDN) architecture, packets carry data names rather than source or destination addresses. To realize this paradigm, each NDN router maintains three data structures CS, PIT, FIB in the forwarding plane. Designing a quick enough forwarding plane with high capacity is a major challenge within the overall NDN research area. In this paper, we present a novel ...

The association of catastrophizing with quality-of-life outcomes in patients with irritable bowel syndrome

Background Catastrophizing is a cognitive process characterized by a propensity to concentrate on and magnify the value of an actual or anticipated painful stimulus and negatively assesses one’s ability to cope. Catastrophizing is an important predictor of pain-related outcomes. A cornerstone symptom of irritable bowel syndrome (IBS) is abdominal pain or discomfort. Also ...

HSV-1 interaction to 3-O-sulfated heparan sulfate in mouse-derived DRG explant and profiles of inflammatory markers during virus infection

The molecular mechanism of herpes simplex virus (HSV) entry and the associated inflammatory response in the nervous system remain poorly understood. Using mouse-derived ex vivo dorsal root ganglia (DRG) explant model and single cell neurons (SCNs), in this study, we provided a visual evidence for the expression of heparan sulfate (HS) and 3-O-sulfated heparan sulfate (3-OS HS) ...

How to bail out your local club: the application of the State aid rules to professional football clubs in financial difficulty

This article analyzes the decisions involving State aid granted to professional football clubs in financial difficulty, namely Willem II, MVV Maastricht, NEC Nijmegen, FC Den Bosch and Valencia CF. The decisions are fundamentally different in one very important aspect: the aid granted to the Dutch clubs was declared compatible aid, whereas the aid granted to Valencia CF was ...

Revisiting CDK Inhibitors for Treatment of Glioblastoma Multiforme

Despite extensive efforts and continual progress in research and medicine, outcomes for patients with high-grade glioma remain exceptionally poor. Over the past decade, research has revealed a great deal about the complex biology behind glioma development, and has brought to light some of the major barriers preventing successful treatment. Glioblastoma multiforme (GBM) (stage 4 ...