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Application of Genome Editing Techniques in Immunology

The idea of using the effector immune cells to specifically fight cancer has recently evolved into an exciting concept of adoptive cell therapies. Indeed, genetically engineered T cells expressing on their surface recombinant, cancer-targeted receptors have been shown to induce promising response in oncological patients. However, in addition to exogenous expression of such ...

Drivers of seasonal return patterns in German stocks

Using a data set of German stocks that includes the financial crisis, this paper identifies market liquidity as the main driver of return seasonality. In comparison, the economic significance of order flow imbalance is markedly weaker. Applying panel regressions and controlling for unobserved effects, we investigate the effects of both variables simultaneously, together with ...

Observations on the dynamics and fate of dissolved organic phosphorus in lake water and a new model of eplimnetic P cycling

Phosphorus (P) in lake water is commonly partitioned into particulate P and dissolved P by membrane filtration, and dissolved P is then fractionated into soluble reactive P (SRP, reactive with molybdate) and dissolved unreactive or organic P (DOP). Much of what is known about DOP is derived from radiotracer studies using gel chromatography, and summarized by a kinetic model (Lean, ...

Evaluation of hot mix asphalt made with recycled aggregates from demolition waste (RADW) coated with bitumen emulsion

Several researches and studies were done in the field of using the recycled aggregates (RA) in hot mix asphalt (HMA), especially the recycled concrete aggregates (RCA). In this study, we investigated the possibility of using the recycled aggregates from all types of the demolition waste not only the recycled aggregates from concrete RCA. In the previous researches, the RCA were ...

Study on concrete with rice husk ash

Rice husk ash (RHA) possesses high pozzolanic activities and very suitable as partial replacement of cement in concrete. This paper presents a comparative study on use of RHA as partial replacement of cement in concrete specimens. Review of the researches on physical, mechanical and structural properties of concrete containing RHA as partial replacement of ordinary Portland cement ...

Digital Obeya Room: exploring the synergies between BIM and lean for visual construction management

Industrial construction management increasingly needs to integrate processes, technologies, and people to support strategic objectives and seeks to eliminate waste to achieve more efficient results. From this, the synergistic use of building information modeling (BIM) and lean construction (LC) principles can bring continuous improvements to the construction industry. This paper ...

Evidence and Opportunities for Integrating Landscape Ecology into Natural Resource Planning across Multiple-Use Landscapes

Enhancing natural resource management has been a focus of landscape ecology since its inception, but numerous authors argue that landscape ecology has not yet been effective in achieving the underlying goal of planning and designing sustainable landscapes. We developed nine questions reflecting the application of fundamental research topics in landscape ecology to the landscape ...

ENCP: a new Energy-efficient Nonlinear Coverage Control Protocol in mobile sensor networks

The node deployment in mobile sensor networks (MSNs) is mostly performed in a random method. However, a large number of redundant nodes may exist due to the randomness. As a result, severe data congestion may be caused and the quality of coverage (QoC) is undermined. In order to solve this QoC problem, we propose an Energy-efficient Nonlinear Coverage Control Protocol (ENCP). This ...

Author Correction: Ouabain attenuates ovalbumin-induced airway inflammation

In the original publication, author missed to include the financial support from CAPES/PROCAD-2013. The complete funding text should read as follows.

The Šariš Transitional Zone, revealing interactions between Pieniny Klippen Belt, Outer Carpathians and European platform

The Pieniny Klippen Belt (PKB) is a narrow structure delineating the boundary between the Central and Outer Carpathians. It is built of nappes stacked during the Cretaceous and Paleocene and then re-folded in the Miocene during the formation of the Outer Carpathian overthrusts. The internal structure of the PKB at the Polish/Slovakian border first formed during northward nappe ...

Smart container monitoring using custom-made WSN technology: from business case to prototype

This paper reports on the development of a prototype solution for tracking and monitoring shipping containers. Deploying wireless sensor networks (WSNs) in an operational environment remains a challenging task. We strongly believe that standardized methodologies and tools could enhance future WSN deployments and enable rapid prototype development. Therefore, we choose to use a ...

VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis

Regulation of cell division requires the integration of signals implicated in chromatin reorganization and coordination of its sequential changes in mitosis. Vaccinia-related kinase 1 (VRK1) and Aurora B (AURKB) are two nuclear kinases involved in different steps of cell division. We have studied whether there is any functional connection between these two nuclear kinases, which ...

Current Approaches and New Developments in the Pharmacological Management of Tourette Syndrome

Tourette syndrome (TS) is a neurodevelopmental disorder of unknown etiology characterized by spontaneous, involuntary movements and vocalizations called tics. Once thought to be rare, TS affects 0.3–1% of the population. Tics can cause physical discomfort, emotional distress, social difficulties, and can interfere with education and desired activities. The pharmacologic treatment ...

Inter- and intracellular colonization of Arabidopsis roots by endophytic actinobacteria and the impact of plant hormones on their antimicrobial activity

Many actinobacteria live in close association with eukaryotes such as fungi, insects, animals and plants. Plant-associated actinobacteria display (endo)symbiotic, saprophytic or pathogenic life styles, and can make up a substantial part of the endophytic community. Here, we characterised endophytic actinobacteria isolated from root tissue of Arabidopsis thaliana (Arabidopsis) ...

Life-Threatening Reaction with Topical 5-Fluorouracil

A 67-year-old man developed a suspected adverse drug reaction during treatment with topical 5-fluorouracil (5-FU) for multiple actinic keratosis of the face, neck, and forearms. The man received topical 5-FU at a dosage of 0.5% for the actinic keratoses. After 1 week, he developed extreme lethargy, fatigue, fever, and mouth erosions. Several days later, and after discontinuation of ...

Biotic interactions enhance survival and fitness in the caddisfly Micropterna sequax (Trichoptera: Limnephilidae)

Patches of coarse particulate organic matter in lowland streams are inhabited by many different macroinvertebrate species, yet knowledge of interactions among the members of these assemblages is scarce. In a mesocosm experiment we aimed to determine the effect of interspecific interactions on species survival and fitness of two caddisfly species. It was hypothesized that, as a ...

The experiences and beliefs of older people in Scottish very sheltered housing about using multi-compartment compliance aids

Background Multi-compartment compliance aids (MCAs) are promoted as a potential solution to medicines non-adherence despite the absence of high quality evidence of effectiveness of MCA use impacting medicines adherence or any clinical outcomes. Furthermore, there is a lack of qualitative research which focuses on the perspectives of older people receiving MCAs. Objectives To ...

Life history traits and demographic parameters in the Keratella cochlearis (Rotifera, Monogononta) species complex

A recent study based on DNA taxonomy indicated that the widespread rotifer Keratella cochlearis comprises several evolutionarily significant units (ESUs). Identification of ESUs based on DNA taxonomy alone is problematic and usually requires morphological, demographic, and/or ecological evidence. We isolated three haplotypes belonging to two ESUs of K. cochlearis and conducted life ...

Characterization of the Pharmacokinetics of Vilaprisan: Bioavailability, Excretion, Biotransformation, and Drug–Drug Interaction Potential

Background and objectives In-vitro data suggest that clearance of vilaprisan is mediated by cytochrome P450 3A4 (oxidation) and aldoketoreductases (reduction). To fully understand the elimination and biotransformation pathways of vilaprisan, a selective progesterone receptor modulator, and to quantify the impact of cytochrome P450 3A4 inhibition on the pharmacokinetics of ...