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G.A.M.E.: GPU-accelerated mixture elucidator

GPU acceleration is useful in solving complex chemical information problems. Identifying unknown structures from the mass spectra of natural product mixtures has been a desirable yet unresolved issue in metabolomics. However, this elucidation process has been hampered by complex experimental data and the inability of instruments to completely separate different compounds. ...

A review of parameters and heuristics for guiding metabolic pathfinding

Recent developments in metabolic engineering have led to the successful biosynthesis of valuable products, such as the precursor of the antimalarial compound, artemisinin, and opioid precursor, thebaine. Synthesizing these traditionally plant-derived compounds in genetically modified yeast cells introduces the possibility of significantly reducing the total time and resources ...

Formation of amides: one-pot condensation of carboxylic acids and amines mediated by TiCl4

A general procedure for the synthesis of amides via the direct condensation of carboxylic acids and amines in the presence of TiCl4 is reported. The amidation reaction was performed in pyridine at 85 °C with a wide range of substrates providing the corresponding amide products in moderate to excellent yields and high purity. The reaction proceeds with low yields when both the ...

Polytechnic engineering mathematics: assessing its relevance to the productivity of industries in Uganda

Background The main objective of the study was to examine the relevance of engineering mathematics to the emerging industries. The level of abstraction, the standard of rigor, and the depth of theoretical treatment are necessary skills expected of a graduate engineering technician to be derived from mathematical knowledge. The question of whether these skills are imparted to ...

Transitioning to Minimal Footwear: a Systematic Review of Methods and Future Clinical Recommendations

Background Recent interest in barefoot running has led to the development of minimalist running shoes that are popular in distance runners. A careful transition to these shoes has been suggested and examined in the literature. However, no guidelines based on systematic evidence have been presented. The purpose of this review is to systematically examine the methods employed in the ...

Sequential estimation of intrinsic activity and synaptic input in single neurons by particle filtering with optimal importance density

This paper deals with the problem of inferring the signals and parameters that cause neural activity to occur. The ultimate challenge being to unveil brain’s connectivity, here we focus on a microscopic vision of the problem, where single neurons (potentially connected to a network of peers) are at the core of our study. The sole observation available are noisy, sampled voltage ...

Effect of drying–wetting cycles on aggregate breakdown for yellow–brown earths in karst areas

Background Drying and rewetting process, frequently occurred during climatic changes, is an important process in soil aggregate slacking and dissolution. The severer interference of human activities on global climate makes the extreme climate scenarios like drought and rainstorm occur frequently. Therefore, there is necessity to further our understanding on the impact of the ...

The Young Innovators Program at the Eshelman Institute for Innovation: a case study examining the role of a professional pharmacy school in enhancing STEM pursuits among secondary school students

Background Professional schools, such as schools of pharmacy, are rarely involved with promoting STEM interests among secondary school students. To address this shortcoming, the Young Innovators Program (YIP) was created to provide local secondary school students a summer immersive experiential program at the UNC Eshelman School of Pharmacy. The objective of this study was to ...

Approximate equiangular tight frames for compressed sensing and CDMA applications

Performance guarantees for recovery algorithms employed in sparse representations, and compressed sensing highlights the importance of incoherence. Optimal bounds of incoherence are attained by equiangular unit norm tight frames (ETFs). Although ETFs are important in many applications, they do not exist for all dimensions, while their construction has been proven extremely ...

Discrete Schrödinger equations in the nonperiodic and superlinear cases: homoclinic solutions

Using variational methods, we study the existence and multiplicity of homoclinic solutions for a class of discrete Schrödinger equations in infinite m-dimensional lattices with nonlinearities being superlinear at infinity. Our results generalize some existing results in the literature by using some weaker conditions.

Mathematical modeling of infectious disease transmission in macroalgae

Understanding the infectious diseases outbreak of algae can provide significant knowledge for disease control intervention and/or prevention. We consider here a disease caused by highly pathogenic organisms that can result in the death of algae. Even though a great deal of understanding about diseases of algae has been reached, studies concerning effects of the outbreak at the ...

Qualitative behaviors of the high-order Lorenz-Stenflo chaotic system arising in mathematical physics describing the atmospheric acoustic-gravity waves

The boundedness of chaotic systems plays an important role in investigating the stability of the equilibrium, estimating the Lyapunov dimension of attractors, the Hausdorff dimension of attractors, the existence of periodic solutions, chaos control, and chaos synchronization. However, as far as the authors know, there are only a few papers dealing with bounds of high-order chaotic ...

SParticle, an algorithm for the analysis of filamentous microorganisms in submerged cultures

Streptomycetes are filamentous bacteria that produce a plethora of bioactive natural products and industrial enzymes. Their mycelial lifestyle typically results in high heterogeneity in bioreactors, with morphologies ranging from fragments and open mycelial mats to dense pellets. There is a strong correlation between morphology and production in submerged cultures, with small and ...

Streamflow Changes in the Vicinity of Seismogenic Fault After the 1999 Chi–Chi Earthquake

Changes in streamflow have been observed at 23 stream gauges in central Taiwan after the 1999 M W 7.6 Chi–Chi earthquake. Post-earthquake increases, ranging from 58 to 833% in discharge, were recorded at 22 gauges on four rivers and their tributaries. The streamflow increase typically peaked in 2–3 days and followed by a slow decay for a month or more. An increased groundwater ...

Health-related quality of life and its determinants in patients with metastatic renal cell carcinoma

Purpose Based on improvements of progression-free survival (PFS), new agents for metastatic renal cell carcinoma (mRCC) have been approved. It is assumed that one of the benefits is a delay in health-related quality of life (HRQoL) deterioration as a result of a delay in progression of disease. However, little data are available supporting this relationship. This study aims to ...

The Role of Intra-Session Exercise Sequence in the Interference Effect: A Systematic Review with Meta-Analysis

Background There is a necessity for numerous sports to develop strength and aerobic capacity simultaneously, placing a significant demand upon the practice of effective concurrent training methods. Concurrent training requires the athlete to perform both resistance and endurance exercise within a training plan. This training paradigm has been associated with an ‘interference ...

Positive equilibria of a class of power-law kinetics

This paper studies a class of power-law kinetics, PL-ILK, for whose subset, PL-TIK, analogues of the Deficiency Zero Theorem and the Deficiency One Theorem (DOT) for mass action systems are valid. The DOT also includes the necessary and sufficient condition of Boros for uniqueness in the non-weakly reversible case. To our knowledge, this is the first set of kinetics beyond mass ...

Rearing river lamprey Lampetra fluviatilis (L.) larvae under controlled conditions as a tool for restitution of endangered populations

A method for actively protecting river lamprey and increasing the number of river lamprey populations is presented as protocol of rearing stocking material. The objective of the study was to accommodate lamprey larvae during the most critical life period under controlled conditions until they reach a sufficient size, which will increase their chances to survive in the natural ...