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Potentially Harmful Medication Use and Decline in Health-Related Quality of Life among Community-Dwelling Older Adults

Background Several scales to quantify the impact of potentially harmful medications (PHMs) have been shown to predict mortality and functional decline; however, the effect of PHMs on quality of life (QoL) has not been well-studied. Objective The aims of this study were to investigate an association between PHM use and change in health-related QoL among community-dwelling older ...

Discovering co-location patterns with aggregated spatial transactions and dependency rules

Co-location pattern mining focuses on finding associations among spatial features. Existing co-location pattern mining techniques mainly rely on frequency based thresholds which discard the rare patterns and find the noisy patterns. This could be avoided by evaluating co-location patterns based on their statistical significance. Recent studies focused on association rule mining ...

Research on modulation recognition with ensemble learning

Modulation scheme recognition occupies a crucial position in the civil and military application. In this paper, we present boosting algorithm as an ensemble frame to achieve a higher accuracy than a single classifier. To evaluate the effect of boosting algorithm, eight common communication signals are yet to be identified. And five kinds of entropy are extracted as the training ...

On fractional Hahn calculus

In this paper, the new concepts of Hahn difference operators are introduced. The properties of fractional Hahn calculus in the sense of a forward Hahn difference operator are introduced and developed.

Measurement versus prediction in the construction of patient-reported outcome questionnaires: can we have our cake and eat it?

Background Two important goals when using questionnaires are (a) measurement: the questionnaire is constructed to assign numerical values that accurately represent the test taker’s attribute, and (b) prediction: the questionnaire is constructed to give an accurate forecast of an external criterion. Construction methods aimed at measurement prescribe that items should be reliable. ...

Presenting comparative study PRO results to clinicians and researchers: beyond the eye of the beholder

Purpose Patient-reported outcome (PRO) results from clinical trials can inform clinical care, but PRO interpretation is challenging. We evaluated the interpretation accuracy and perceived clarity of various strategies for displaying clinical trial PRO findings. Methods We conducted an e-survey of oncology clinicians and PRO researchers (supplemented by one-on-one clinician ...

Environmental noise reduces predation rate in an aquatic invertebrate

Noise is one of a wide range of disturbances associated with human activities that have been shown to have detrimental impacts on a wide range of species, from montane regions to the deep marine environment. Noise may also have community-level impacts via predator–prey interactions, thus jeopardising the stability of trophic networks. However, the impact of noise on freshwater ...

Pomalidomide with Dexamethasone for Treating Relapsed and Refractory Multiple Myeloma Previously Treated with Lenalidomide and Bortezomib: An Evidence Review Group Perspective of an NICE Single Technology Appraisal

The National Institute for Health and Care Excellence (NICE), as part of the institute’s single technology appraisal (STA) process, invited the manufacturer of pomalidomide (POM; Imnovid®, Celgene) to submit evidence regarding the clinical and cost effectiveness of the drug in combination with dexamethasone (POM + LoDEX) for the treatment of relapsed and refractory multiple myeloma ...

Genetic redundancy in the catabolism of methylated amines in the yeast Scheffersomyces stipitis

The catabolism of choline as a source of nitrogen in budding yeasts is thought to proceed via the intermediates trimethylamine, dimethylamine and methylamine before the release of ammonia. The present study investigated the utilisation of choline and its downstream intermediates as nitrogen sources in the yeast Scheffersomyces stipitis using a reverse genetics approach. Six genes ...

Taxation and agency conflicts between firm owners and managers: a review

When analyzing the influence of taxation on agency conflicts between firm owners and managers, one can draw on theoretical principal–agent literature from various research fields. In recent years, this interdisciplinary research has grown significantly covering research with regards to optimal compensation, investment decisions, tax avoidance and transfer pricing while analyzing ...

Effects of freshwater flow and phytoplankton biomass on growth, reproduction, and spatial subsidies of the estuarine copepod Pseudodiaptomus forbesi

We examined how freshwater flow and phytoplankton biomass affected abundance and population dynamics of the introduced subtropical copepod Pseudodiaptomus forbesi in brackish and freshwater regions of the San Francisco Estuary, California, USA. This copepod is key prey for the endangered and food-limited delta smelt, Hypomesus transpacificus, in low-salinity water during ...

Glacier Calving in Greenland

In combination, the breakaway of icebergs (calving) and submarine melting at marine-terminating glaciers account for between one third and one half of the mass annually discharged from the Greenland Ice Sheet into the ocean. These ice losses are increasing due to glacier acceleration and retreat, largely in response to increased heat flux from the oceans. Behaviour of Greenland’s ...

Autologous Cell Seeding in Tracheal Tissue Engineering

Purpose of Review There is no consensus on the best technology to be employed for tracheal replacement. One particularly promising approach is based upon tissue engineering and involves applying autologous cells to transplantable scaffolds. Here, we present the reported pre-clinical and clinical data exploring the various options for achieving such seeding. Recent Findings Various ...

Learning topic description from clustering of trusted user roles and event models characterizing distributed provenance networks: a reinforcement learning approach

This paper proposes a reinforcement learning based message transfer model for transferring news report messages through a selected path in a trusted provenance network with the objective of maximizing the reward values based on trust or importance based and network congestion or utility based cost measures. The reward values are calculated along a dynamically defined policy path ...

The Adherence Rate Threshold is Drug Specific

Introduction Patient adherence to a medication regimen is usually expressed as an adherence rate, defined as the proportion of prescribed doses actually taken. An adherence rate threshold, above which the therapeutic effect is maintained, is typically assigned an arbitrary value, commonly 0.8. Objective Here, we determined the value of the adherence rate threshold objectively in ...

Plasma modification of microporous polymer membranes for application in biomimetic dissolution studies

Biorelevant dissolution is an indispensable tool utilized during formulation development and optimization for the prediction of in vivo bioavailability of pharmaceutical agents. Within that framework, membrane-permeation dissolution methodologies are widely used to model drug absorption. The current work evaluates polymer membrane surface modifications for production of biomimetic ...