Advanced search    

Search: *

42,456 papers found. Showing first 1,000 results.
Use AND, OR, NOT, +word, -word, "long phrase", (parentheses) to fine-tune your search.

Effect of Levothyroxine Treatment on Incident Dementia in Adults with Atrial Fibrillation and Hypothyroidism

Background and ObjectiveThe possible adverse or positive effects of levothyroxine treatment among patients with atrial fibrillation have been debated. Atrial fibrillation, levothyroxine treatment, and dementia are common among older adults, yet little is known about the effects of levothyroxine on the development of dementia.MethodsThe study population included all adults (n = 12...

Onboard experiment investigating metal leaching of fresh hydrothermal sulfide cores into seawater

We observed the initial release rate of metals from four fresh (i.e., without long time exposure to the atmosphere) hydrothermal sulfide cores into artificial seawater. The sulfide samples were collected by seafloor drilling from the Okinawa Trough by D/V Chikyu, powdered under inert gas, and immediately subjected to onboard metal-leaching experiments at different temperatures (5...

Design, synthesis and biological activity of hydroxybenzoic acid ester conjugates of phenazine-1-carboxylic acid

We prepared 16 novel hydroxybenzoic acid ester conjugates of phenazine-1-carboxylic acid (PCA) and investigated their biological activity. Most of the synthesized conjugates displayed some level of fungicidal activities in vitro against five phytopathogenic fungi. Nine conjugates 5b, 5c, 5d, 5e, 5h, 5i, 5m, 5n and 5o (EC50 between 3.2 μg/mL and 14.1 μg/mL) were more active than...

Nonlocal evolution inclusions under weak conditions

We study evolution inclusions given by multivalued perturbations of m-dissipative operators with nonlocal initial conditions. We prove the existence of solutions. The commonly used Lipschitz hypothesis for the perturbations is weakened to one-sided Lipschitz ones. We prove an existence result for the multipoint problems that cover periodic and antiperiodic cases. We give examples...

Trend prediction of the 3D thermocline’s lateral boundary based on the SVR method

In recent years, with the use of the float-based wireless sensor network in the Argo project, a large amount of ocean data has been obtained. These data can be applied to analyze the oceanic thermocline, and the forecasting trend of the thermocline through the SVR method in machine learning is presented in this paper. Firstly, this paper refines the spatial resolution with the...

The fundamental solution matrix and relative stable maps

Givental’s Lagrangian cone \({\mathscr {L}}_X\) is a Lagrangian submanifold of a symplectic vector space which encodes the genus-zero Gromov–Witten invariants of X. Building on work of Braverman, Coates has obtained the Lagrangian cone as the push-forward of a certain class on the moduli space of stable maps to Open image in new window . This provides a conceptual description for...

ILFCS: an intelligent learning fuzzy-based channel selection framework for cognitive radio networks

Cognitive radio networks (CRNs) have been introduced as a promising solution to optimize the use of available radio-frequency spectrum. The key idea in CRNs is the proper selection of available sensed channels. In this paper, an intelligent distributed channel selection strategy is proposed for cognitive radio ad-hoc networks aiming to assist them in selecting the best channel...

Collaborative organizational forms: on communities, crowds, and new hybrids

In this article, I examine collaborative organizational forms in terms of their institutional properties and the mechanisms by which they solve the universal problems of organizing. Based on three ideal forms—markets, hierarchies, and communities—I propose a framework for analyzing and mapping organizational forms. The framework expands our understanding of the ideal forms and...

Adaptations to Concurrent Training in Combination with High Protein Availability: A Comparative Trial in Healthy, Recreationally Active Men

BackgroundWe implemented a high-protein diet (2 g·kg−1·d−1) throughout 12 weeks of concurrent exercise training to determine whether interferences to adaptation in muscle hypertrophy, strength and power could be attenuated compared to resistance training alone.MethodsThirty-two recreationally active males (age: 25 ± 5 years, body mass index: 24 ± 3 kg·m−2; mean ± SD) performed 12...

Two Glucose-Lowering Mechanisms of Canagliflozin Depending on Body Weight Changes in Drug-Naïve Subjects with Type 2 Diabetes

ObjectivesThe aim of this study was to investigate the relations between the changes in body weight and those of glycemic and non-glycemic parameters in drug-naïve subjects with type 2 diabetes mellitus (T2DM) treated with canagliflozin monotherapy.MethodsSubjects received 50–100 mg/day canagliflozin monotherapy for 3 months (n = 36), and were then divided into two groups: (1...

The Economic Burden of Pediatric Asthma in the United States: Literature Review of Current Evidence

Asthma is a chronic respiratory disease that is widespread throughout the US population and disproportionately affects children. This literature review aimed to identify recent information regarding the economic burden of pediatric asthma in the US. MEDLINE, EMBASE, Econlit, and PsycINFO databases and gray literature sources were searched from January 2012 to January 2018 to...

Hybrid scheme to enable DTN routing protocols to efficiently exploit stable MANET contacts

Disaster communication is still challenging due to the unpredictable nature and high variance in possible scenarios. Hybrid networking solutions that integrate principles from mobile ad hoc networks (MANETs) and delay tolerant networks (DTN) have been suggested to guarantee a certain robustness for the communication service in case of partial or complete failure of infrastructure...

The Janus face of HMGB1 in heart disease: a necessary update

High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein involved in transcription regulation, DNA replication and repair and nucleosome assembly. HMGB1 is passively released by necrotic tissues or actively secreted by stressed cells. Extracellular HMGB1 acts as a damage-associated molecular pattern (DAMPs) molecule and gives rise to several redox forms that by binding...

Consensus on management of castration-resistant prostate cancer on behalf of the Urological Tumours Working Group (URONCOR) of the Spanish Society of Radiation Oncology

BackgroundThe knowledge in the field of castration-resistant prostate cancer (CRPC) is developing rapidly, with emerging new therapies and advances in imaging. Nonetheless, in multiple areas there is still a lack of or very limited evidence, and clear guidance from clinicians regarding optimal strategy is required.MethodsA modified Delphi method, with 116 relevant questions...

Impaired Renal Function May Not Negate the Efficacy of Tolvaptan in the Treatment of Cirrhotic Patients with Refractory Ascites

Background and ObjectiveTolvaptan, an oral vasopressin V2 receptor antagonist, has been widely used for the treatment of patients with cirrhosis and ascites. However, its efficacy in patients with renal dysfunction remains unknown. The objective of this study was to investigate the efficacy and safety of tolvaptan in patients with decompensated cirrhosis and severe chronic kidney...

Hierarchical complexity control algorithm for HEVC based on coding unit depth decision

The next-generation High Efficiency Video Coding (HEVC) standard reduces the bit rate by 44% on average compared to the previous-generation H.264 standard, resulting in higher encoding complexity. To achieve normal video coding in power-constrained devices and minimize the rate distortion degradation, this paper proposes a hierarchical complexity control algorithm for HEVC on the...

Assessment of Medication Safety Using Only Dispensing Data

Purpose of ReviewThe purpose of this review is to provide an overview of the published studies that have been used to generate evidence on the safety of medicine use when only medication dispensing data are available.Recent FindingsMedication dispensing databases are increasingly available for research on large populations, particularly in countries that provide universal...

Experiments and assessments of a 3-DOF haptic device for interactive operation

Haptic devices have been applied in interactive operation to perform contact tasks. To explore the haptic perception characteristics of typical push-pull and rotation operation, an experimental system was built by incorporating a three degrees of freedom (3-DOF) haptic device and the virtual environment. In this system, the haptic device is used to provide motion commands to...

Conjunctive uses of the geothermal water resources from lower cretaceous formations in the Mogilno–Lodz trough, Poland

The geothermal energy sector continues to develop dynamically in the world. Within this work, preliminary feasibilities of different geothermal applications were presented for the Lower Cretaceous formations for wider geothermal uses’ development in the Mogilno–Lodz trough, Central Poland. The Lower Cretaceous formations are one of the most prospective geothermal reservoirs in...

Against ‘immigrant integration’: for an end to neocolonial knowledge production

This paper, written on invitation by the editors of Comparative Migration Studies, is intended as a provocation piece for invited commentators, and more broadly for those working with, or concerned about, the field of immigrant integration research. It outlines an argument put forward in Imagined Societies. A Critique of Immigrant Integration in Western Europe (Cambridge...