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Next-gen cancer research

manipulated to enhance hematopoietic stem cell transplantation therapies [ 3 ]. The quality of these reviews by three up-andcoming young investigators bodes well for the next generation of cancer research. 1

Retractions in cancer research: a systematic survey

until 2015 for retracted journal publications related to cancer research. For each article, the reason for retraction was categorized as plagiarism, duplicate publication, fraud, error, authorship issues ... Offices, Hamilton, ON L8V 1C3 , Canada Conclusions: Retractions in cancer research are increasing in frequency at a similar rate to all biomedical research retractions. Cancer retractions are largely due

Epidemiologic paradigms for progress in ovarian cancer research

approaches, survival has not substantially improved, in part due to the late stage at diagnosis in most patients. This decade has marked a very exciting time in ovarian cancer research with the paradigm ... recommendations for public and private sector efforts that could facilitate progress in reducing the incidence of and the morbidity and mortality from ovarian cancer,” with an emphasis on advancing research on

Causality in cancer research: a journey through models in molecular epidemiology and their philosophical interpretation

In the last decades, Systems Biology (including cancer research) has been driven by technology, statistical modelling and bioinformatics. In this paper we try to bring biological and philosophical ... link between the macro‑ and the micro‑environment In order to causally link the micro- and macro-environments, omic technologies provide a key set of instruments in cancer research: these allow us to

Top classic citations in pancreatic cancer research

to explore the top classic citations in pancreatic cancer (PC) research. Methods A computerized literature search was conducted using the database, the Science Citation Index Expanded. The top 100 ... - Background Currently, pancreatic cancer (PC) remains a fatal disease with poor prognosis [1]. In recent decades, significant growth has been seen in the field of pancreatic cancer research. Though these

Lost in translation: returning germline genetic results in genome-scale cancer research

Background The return of research results (RoR) remains a complex and well-debated issue. Despite the debate, actual data related to the experience of giving individual results back, and the impact ... , Sydney , Australia 2 Austin Hospital , 145 Studley Road, Heidelberg, VIC 3084 , Australia 3 Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow , Garscube Estate

Choosing the right cell line for renal cell cancer research

Cell lines are still a tool of choice for many fields of biomedical research, including oncology. Although cancer is a very complex disease, many discoveries have been made using monocultures of ... research had a major impact on the development of cancer treatment allowing an innumerable amount of effective drugs to be introduced into practice [1]. Cancer cell lines, especially those in NCI-60 panel

YM500v3: a database for small RNA sequencing in human cancer research

We previously presented the YM500 database, which contains >8000 small RNA sequencing (smRNA-seq) data sets and integrated analysis results for various cancer miRNome studies. In the updated YM500v3 ... , Taiwan 2 Institute of Biomedical Informatics, National Yang-Ming University , Taipei 11221 , Taiwan 3 Center for Infectious Disease and Cancer Research, Kaohsiung Medical University , Kaohsiung 80708

UK Breast Cancer Research Symposium 2016: Submitted Abstracts

may be a ‘‘Goldilocks level’’ of ESR1 expression for breast cancer protection. The Institute of Cancer Research, London Cancer-associated fibroblasts (CAFs) are non-malignant cells prominently found ... , Sophia Karagiannis1,2, Andrew Tutt1 1Breast Cancer Now Research Unit, Division of Cancer Studies, Faculty of Life Sciences and Medicine, King’s College London SE1 9RT, UK; 2Skin Science, Division of

African Organization for Research and Training in Cancer: position and vision for cancer research on the African Continent

The African Organization for Research and training in Cancer (AORTIC) bases the following position statements on a critical appraisal of the state on cancer research and cancer care in Africa ... Africa; Diagnosis of cancer; Access to healthcare; Cancer research - Background Cancer is a major public health concern In Africa Cancer is a leading cause of death worldwide. About half of the annual

African Organization for Research and Training in Cancer: position and vision for cancer research on the African Continent

The African Organization for Research and training in Cancer (AORTIC) bases the following position statements on a critical appraisal of the state on cancer research and cancer care in Africa ... Africa; Diagnosis of cancer; Access to healthcare; Cancer research - Background Cancer is a major public health concern In Africa Cancer is a leading cause of death worldwide. About half of the annual

Patient-derived xenograft in zebrafish embryos: a new platform for translational research in gastric cancer

translational research and personalized treatment on GC. Gastric cancer; Zebrafish; Patient-derived xenograft; Microinjection; Translational research Background Gastric cancer (GC) remains a major health ... burden across the globe. According to the 2012 statistics of the International Agency for Research on Cancer (IARC), GC was the fifth most common malignancy and the third leading cause of cancer death

Cancer Research in Low- and Middle-Income Countries: Consortiums, Implementation Science and Healthcare Delivery

colleagues describe the formation of a successful cancer research consortium in sub-Saharan Africa 1 Departments of Surgery and Global Health Medicine, University of Washington , Seattle, WA 2 Drawing on their ... Sloan Kettering Cancer Center in the US, the investigators delineate steps and key factors needed for establishing a successful collaborative cancer research consortium. The group delineated four initial

A Librarian by Any Other Name: The Role of the Informationist on a Clinical Research Team

informationist is serving as a member of the research team on the grant, “Promoting Breast Cancer Screening in Non-Adherent Women” (R01 CA-132935, National Cancer Institute, National Institutes of Health), working ... Informationist on a Clinical Research Team Sally A. Gore University of Massachusetts Medical School, Worcester, MA, USA In 2012, the Lamar Soutter Library (LSL), University of Massachusetts Medical School (UMMS

Patterns in target-directed breast cancer research

We undertake an analysis of ongoing BC targeted therapy trials registered to CT.gov to describe patterns of ongoing clinical research, highlight gaps in current research programs and identify ways of ... (DeSantis et  al. 2013; Canadian Cancer Society’s Steering Committee on Cancer Statistics 2013) . Over 600 million dollars are invested in BC research in the United States (US) each year by, the National

NMR-Based Metabolomics and Its Application in Drug Metabolism and Cancer Research

Purpose of Review In this review, the contribution of NMR to the metabolomics field will be discussed—particularly as it relates to cancer and drug metabolism research. An overview of the typical NMR ... investigation of complex biological samples [9]. In this review, the NMR-based metabolomic approach will be highlighted and its application in cancer and drug metabolism research. As a primary tool for the

Decision trees in epidemiological research

55455 , USA 3 Division of Applied Research, Allina Health , 2925 Chicago Ave, Minneapolis, MN 55407 , USA Background: In many studies, it is of interest to identify population subgroups that are ... advocate the use of the newer CTree technique due to its simplicity and ease of interpretation. Decision trees; Subgroup heterogeneity; Predictors Background The framing of medical research hypotheses and

Multidimensional phenotyping of breast cancer cell lines to guide preclinical research

Purpose Cell lines are extremely useful tools in breast cancer research. Their key benefits include a high degree of control over experimental variables and reproducibility. However, the advantages ... ) and xenografts (PDX) can model this complexity fairly accurately and are becoming more prevalent in preclinical research. While PDCL/PDX are in many ways ‘better’ models of breast cancer, established

Journal of Experimental & Clinical Cancer Research reviewer acknowledgement 2015

Contributing reviewers The editors of Journal of Experimental & Clinical Cancer Research would like to thank all our reviewers who have contributed their time and expertise to the journal in Volume

Specificity of Genetic Biomarker Studies in Cancer Research: A Systematic Review

As genetic information becomes more readily available, there is increasing demand from both patients and providers to develop personalized approaches to cancer care. Investigators are increasingly ... medical literature [ 6 ]. However, it is not clear how well this knowledge has been disseminated amongst the basic research community. Many cancer patients are at high risk of competing causes of death