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Relationship between regulatory pattern of gene expression level and gene function

regulated structurally, not arbitrarily, according to the gene function. This funding is indicative of a systematic control of transcription processes at the whole-cell level. ... ±regulated geneº pairs. All the scatter diagrams were classified into four types depending on the regulatory mechanisms. We also characterized each type in terms of gene function and found that the regulatory

Combinatorial selection for replicable RNA by Qβ replicase while maintaining encoded gene function

sequences replicable by Qβ replicase while maintaining the encoded gene function. ... [10], and complex gene regulatory networks have been developed using these reconstituted systems [ 11,12 ]. Another important biological function is the replication of genetic information as DNA or

A Convenient In Vivo Model Using Small Interfering RNA Silencing to Rapidly Assess Skeletal Gene Function

target gene on the local skeletal environment. In this model, 160-g male Sprague-Dawley rats were treated for 1–2 weeks. The left tibia received intraosseous injection of a parathyroid hormone 1 receptor ... disrupted, these in vitro assays do not always reflect what occurs in vivo. A simple and rapid model is crucial to study the impact of one target gene, cytokine or signaling pathway on bone function. In

The deleterious effects of human erythropoietin gene driven by the rabbit whey acidic protein gene promoter in transgenic rabbits

) Erythropoietin: structure, control of production and function . Physiol Rev 72 , 449 - 489 Lathe R , Vilotte JL , Clark AJ ( 1987 ) Plasmid and bacteriophage vectors for excision of intact inserts . Gene 57 , 193 ... , 6, rue Alexandre-Cabanel, 75015 Paris, France Summary ― Human erythropoietin (EPO) gene and cDNA associated with the rabbit whey acidic protein (WAP) gene promoter were used to tentatively

Genetic risk for neurodegenerative disorders, and its overlap with cognitive ability and physical function

Neurodegenerative disorders are associated with impaired cognitive function and worse physical health outcomes. This study aims to test whether polygenic risk for Alzheimer’s disease, Amyotrophic

Genetic analysis of phytoene synthase 1 (Psy1) gene function and regulation in common wheat

responded to Psy1 down-regulation. The aspartate rich domain (DXXXD) was important for PSY1 function, and conserved nucleotides adjacent to the domain influenced YPC by regulating gene expression, enzyme ... = 0.8) [6, 9]. To date, several studies have focused on homology-based cloning of Psy1 and QTL analysis, whereas gene function and regulation remain to be determined. © The Author(s). 2016 Open Access

Investigating essential gene function in Mycobacterium tuberculosis using an efficient CRISPR interference system

Despite many methodological advances that have facilitated investigation of Mycobacterium tuberculosis pathogenesis, analysis of essential gene function in this slow-growing pathogen remains ... work, CRISPR interference provides an efficient approach to investigate essential gene function that may be particularly useful in characterizing genes of unknown function and potential targets for novel

Transmembrane domain dependent inhibitory function of FcγRIIB

FcγRIIB, the only inhibitory IgG Fc receptor, functions to suppress the hyper-activation of immune cells. Numerous studies have illustrated its inhibitory function through the ITIM motif in the ... FcγRIIB is also indispensable for its inhibitory function. Indeed, recent epidemiological studies revealed that a non-synonymous single nucleotide polymorphism (rs1050501) within the TM domain of FcγRIIB

Ligand Similarity Complements Sequence, Physical Interaction, and Co-Expression for Gene Function Prediction

the boost in guilt-by-association gene function prediction when the networks are combined and describe underlying properties that can be further exploited. ... whether adding the ligand similarity network improves gene function prediction using a guilt-by-association predictor of Gene Ontology annotations. Results Calculating ligand-based similarities We

Protoplast transformation as a potential platform for exploring gene function in Verticillium dahliae

difficult to control once the plant is infected. Although Agrobacterium tumefaciens-mediated transformation (ATMT) has been widely used for gene screening, a quick and easy method has been needed to ... been ideal because it is simple and fast [20]. RNA interference (RNAi) is an effective tool to investigate gene function in various organisms [ 21–24 ]. In filamentous fungi, plasmid constructs

Methylation of L1RE1, RARB, and RASSF1 function as possible biomarkers for the differential diagnosis of lung cancer

combination with either RARB or RASSF1 could function as biomarkers for separating lung cancer and non-cancerous tissue and could be useful for samples of limited size such as biopsies. ... methylation is an early event in carcinogenesis and considered as one of the possible alterations that underlie the hallmarks of cancer [1±3]. Therefore, gene-specific methylation changes and their assessment

The SAV1322 gene from Staphylococcus aureus: genomic and proteomic approaches to identification and characterization of gene function

identified. The histidine kinase/response regulator SAV1321/SAV1322 in the S. aureus shares considerable homology with the TCRS DesKR in Bacillus subtilis. However, a function for the SAV1322 locus has not yet

Pathogenic adaptations of Colletotrichum fungi revealed by genome wide gene family evolutionary analyses

gene content variations among 13 Colletotrichum and 11 non-Colletotrichum genomes by gene function annotation, OrthoMCL grouping and CAFE analysis. The results provided a global evolutionary picture of ... broad host range species is made up of individual host-limited forms. A C. fructicola strain isolated from strawberry, Nara-gc5, has been genome sequenced [ 13 ], providing a reference for gene function

Determination of an effective scoring function for RNA–RNA interactions with a physics-based double-iterative method

RNA–RNA interactions play fundamental roles in gene and cell regulation. Therefore, accurate prediction of RNA–RNA interactions is critical to determine their complex structures and understand the ... derived scoring function, which is referred to as DITScoreRR, was evaluated on an RNA-RNA docking benchmark of 60 test cases and compared with three other scoring functions. It was shown that for bound

PARP10 (ARTD10) modulates mitochondrial function

) Controls Adipogenic Gene Expression and Adipocyte Function . Mol Endocrinol . 2012 ; 26 ( 1 ): 79 ±86 https://doi. org/10.1210/me.2011-1163 PMID: 22053002 56. Erener S , Mirsaidi A , Hesse M , Tiaden AN ... performed with the qPCRBIO SyGreen Lo-ROX Supermix (PCR Biosystems, London, UK) using a Light-Cycler 480 system (Roche Applied Science, Basel, Switzerland). Gene expression was normalized to the geometric

Ezh2 promotes clock function and hematopoiesis independent of histone methyltransferase activity in zebrafish

EZH2 is a subunit of polycomb repressive complex 2 (PRC2) that silences gene transcription via H3K27me3 and was shown to be essential for mammalian liver circadian regulation and hematopoiesis ... function . J. Biol. Chem ., 281 , 21209 - 21215 . 27. Tang ,Q., Cheng, B. , Xie , M. , Chen , Y. , Zhao , J. , Zhou , X. and Chen , L. ( 2017 ) Circadian clock gene Bmal1 inhibits tumorigenesis and increases

Using hybrid transcription factors to study gene function in rice

in heterologous protein and/or cellular environment [24], supporting a hypothesis that the transcription regulatory domains function independent of other functional domains of TF proteins. However ... transcription factors to identify gene functions. A, The distribution of cloned TFs in different gene families. B, Schematic presentations of the HTF constructs. The detailed vector maps and sequences are

Nestin-expressing progenitor cells: function, identity and therapeutic implications

the study of Nestin+ cells and their progeny, their function and elusive nature in nervous system and bone marrow, and their potential mechanistic role and promising therapeutic value in preclinical ... + cells are present, further supporting that Nestin function is indeed complex and cell-specific. Later, a second Nestin−/− mouse model was generated by gene targeting, where the regions deleted included

Functional variation in a key defense gene structures herbivore communities and alters plant performance

effects. We studied the consequences of varying the expression of a single biosynthetic gene in jasmonate (JA) defense hormones, which are essential for defense against herbivores but constrain plant growth ... explanatory power for linking intraspecific diversity to effects at other organizational levels by indicating focal measurements based on knowledge of gene function, as well as pointing to specific gene

Zebrafish as a model for kidney function and disease

regularly interspaced short palindromic repeat (CRISPR)-Cas9 system can be easily employed in the zebrafish to study gene function and the consequences of its absence/modification. Zebrafish have long been ... mutagenesis in the embryo to alter gene function and assessing phenotypes as a starting point to find the causative gene [ 10 ]. Zebrafish screens are feasible and were first used to identify genes involved