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Follicular growth after xenotransplantation of cryopreserved/thawed human ovarian tissue in SCID mice: dynamics and molecular aspects

tissue obtained from female cancer patients (n = 11) were xenotransplanted into a subcutaneous neck pouch of 6-week-old ovarectomized SCID mice (n = 33) for 4 (n = 18) and 12 (n = 15) weeks. Result Thirty ... gene expression followed by acceleration of follicular recruitment. - Department of Gynecological Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Anichstr. 35, 6020 Innsbruck

Enzyme/Prodrug Systems for Cancer Gene Therapy

significant progress of different suicide gene therapy protocols in preclinical studies and early clinical trials, none has reached the clinic due to several shortcomings. These include slow prodrug-drug ... emphasis on reporting the results of the recent preclinical and clinical studies. Enzyme prodrug; GDEPT; Suicide gene therapy; Bystander effect; Nitroreductase; Cytosine daminase; Thymidine kinase; Carboxyl

Retroviral vectors and transposons for stable gene therapy: advances, current challenges and perspectives

Gene therapy protocols require robust and long-term gene expression. For two decades, retrovirus family vectors have offered several attractive properties as stable gene-delivery vehicles. These ... , accessed in July, 2016). The first successful gene therapy protocol occurred in the 1990s. In that protocol, two patients with severe combined immunodeficiency (SCID) due to adenosine deaminase (ADA

Intraoperative radiation therapy (IORT) in pancreatic cancer

Despite the important improvements made in the fields of surgery, chemotherapy and radiation therapy, pancreatic cancer remains one of the most lethal malignancies. Improved outcomes with novel ... ) limits the dose of radiation that can be administered to the tumor bed with conventional external beam radiation therapy (EBRT). The intraoperative radiotherapy (IORT) appears to be an ideal therapeutic

Increased Engraftment of Human Short Term Repopulating Hematopoietic Cells in NOD/SCID/IL2rγnull Mice by Lentiviral Expression of NUP98-HOXA10HD

Techniques to expand human hematopoietic stem cells ex-vivo could be beneficial to the fields of clinical hematopoietic stem cell transplantation and gene therapy targeted at hematopoietic stem cells ... sustain or improve the HSC content in grafts maintained in culture and potentially improve the transfer efficiency in gene therapy where HSCs are the main target. Results Lentiviral vector production The

Gene Therapy: A Toolkit for Target Cancer

severe side effects and often prove ineffective at completely eradicating malignant cells. Therefore, a more selective method of targeting tumour cells must be designed. Gene therapy holds great potential ... challenges before they can be used to treat cancer patients on a large scale. Early gene therapy trials such as the SCID-XI trial in 2000 have called into question the safety of gene therapy, particularly the

Fracture Healing Is Delayed in Immunodeficient NOD/scid‑IL2Rγcnull Mice

fracture healing remains poorly understood. Here, we investigated bone healing in NOD/scid-IL2Rγcnull mice, which exhibit severe defects in innate and adaptive immunity, by biomechanical testing

DNA repair kinetics in SCID mice Sertoli cells and DNA-PKcs-deficient mouse embryonic fibroblasts

-deficient (Prkdc scid ) and wild-type Sertoli cells. In nonirradiated mice and Prkdc scid Sertoli cells displayed persistent DSBs foci in around 12 % of cells and a fivefold increase in numbers of these DSB ... deficiency in NHEJ DNA repair which is associated with early cellular senescence and compromised growth (Ahmed et al. 2013; Gu et al. 1997; Nussenzweig et al. 1997) . In contrast, DNA-PKcsdeficient SCID mice

The quest for an effective and safe personalized cell therapy using epigenetic tools

as plasticity and allows cell fate definition and tissue specialization. Fundamental epigenetic mechanisms drive these modifications in gene expression and include DNA methylation, histone ... mechanisms can provide powerful tools to switch cell phenotype and implement cell therapy. Environmentally influenced epigenetic changes have also been associated to many diseases such as cancer and

Neue Hoffnung bei ADA-SCID

Folgeerscheinungen eines Androgen-Überschusses bei Frauen, wie Seborrhoe, fettiges Haar oder Hirsutismus. Nach Informationen von Aristo Pharma Neue Ho nung bei ADA-SCID Ein vollständiger Mangel des Enzyms ... Adenosindesaminase (ADA) führt zum klinischen Bild eines schweren kombinierten Immundefekts (SCID). Bei ADASCID handelt es sich um eine seltene genetische Erkrankung, von der pro Jahr rund 15 Kinder in Europa betro„en

The chasmed gene

Mukherjee, S. The Gene: An intimate history.Scribner, NY.594 pages; ISBN: 978-1-4767-330-0; Price: $20.00. ... failures of genomic research and presents his hopes and doubts about the role of genetics in health and human welfare giving some familiar examples. These include: gene therapy study against Adenosine

The chasmed gene

Mukherjee, S. The Gene: An intimate history.Scribner, NY.594 pages; ISBN: 978-1-4767-330-0; Price: $20.00. ... failures of genomic research and presents his hopes and doubts about the role of genetics in health and human welfare giving some familiar examples. These include: gene therapy study against Adenosine

Stem cells isolated from human dental pulp and amniotic fluid improve skeletal muscle histopathology in mdx/SCID mice

evaluate their contribution in the improvement of the pathological features associated with dystrophic skeletal muscle when intramuscularly injected into mdx/SCID mice, an immune-compromised animal model of ... cell and gene therapies, have been tested over the years. Cell therapy could be used to recover the lack of dystrophin in dystrophic muscles and thus repair the damaged muscle fibers and prevent future

Novel regenerative therapy for acute kidney injury

medicine, however, offers potentially direct AKI therapy through two strategies: cell transplantation and kidney reconstruction. Regarding cell transplantation, several cell types are potential sources ... tissues or secrete paracrine factors that help recovery from the kidney injury. Several cell types have been reported as the source for cell therapy, including hematopoietic stem cells (HSCs), mesenchymal

Efficacy of femtosecond lasers for application of acupuncture therapy

to stimulate acupuncture points. We previously reported suppression of myostatin (Mstn) gene expression in skeletal muscle by means of femtosecond laser (FL) irradiation, after electroacupuncture, in ... , we first analyzed Mstn gene expression and Mstn protein level in the skeletal muscle. We then evaluated phosphorylation of the mammalian target of rapamycin (mTOR) and its downstream target 70-kDa

Teacher Competence in Mindfulness-Based Cognitive Therapy for Depression and Its Relation to Treatment Outcome

As mindfulness-based cognitive therapy (MBCT) becomes an increasingly mainstream approach for recurrent depression, there is a growing need for practitioners who are able to teach MBCT. The ... Disorders (SCID II) . Clinical Psychology & Psychotherapy , 18 ( 1 ), 75 - 79 . doi:10.1002/cpp.693. Mason , O. , & Hargreaves , I. ( 2001 ). A qualitative study of mindfulnessbased cognitive therapy for

Mutation c.256_257delAA in RAG1 Gene in Polish Children with Severe Combined Immunodeficiency: Diversity of Clinical Manifestations

Mutations in RAG1 gene may result in different types of severe combined immunodeficiencies. In this study, we compare clinical symptoms and laboratory findings in four children with identical ... .256_257delAA) in RAG1 gene were detected, both in the heterozygous (Patient 1) or homozygous state (Patient 2, 3 and 4). All of the patients showed clinical features of SCID (severe infections, failure to thrive

mutLBSgeneDB: mutated ligand binding site gene DataBase

that ligand binding residues had a significantly higher mutation rate than other parts of the protein. Here, we built mutLBSgeneDB (mutated Ligand Binding Site gene DataBase) available at http ... incorporating kinases, transcription factors, pharmacological genes, and cancer driver genes. We analyzed LBS mutation information, differential gene expression network, drug response correlation with gene

Bacterial serine protease HtrA as a promising new target for antimicrobial therapy?

regulatory protease which cleaves the anti-sigma factor RseA, while the physiological functions of DegQ are not fully understood [11]. Inactivation of the htrA gene by mutation causes an increased sensitivity ... [20, 21]. The deletion of the htrA gene in C. jejuni led to a defect in E-cadherin shedding and causes impaired transmigration of the bacteria across monolayers of polarized epithelial cells in vitro

Nutrition therapy with high intensity interval training to improve prostate cancer-related fatigue in men on androgen deprivation therapy: a study protocol

Background Cancer-related fatigue is one of the most prevalent, prolonged and distressing side effects of prostate cancer treatment with androgen deprivation therapy. Preliminary evidence suggests ... exercise literature has shown high intensity interval training can improve various aspects of health that are typically impaired with androgen deprivation therapy; however exercise at this intensity is yet