socioeconomic statuses. Our findings challenge a long-standing conjecture in human geography and highlight how urban design can both prevent and facilitate encounters among diverse individuals. ... studies of human mobility across many different areas including COVID-19 modelling51, political polarization39 and consumer preference tracking52. All data provided by SafeGraph were stored on a secure
modelling of prehistoric human mobility in Tibet. In this study, we developed an integrated high-resolution geospatial model and network analysis that simulates and correlates subsistence-based mobility and ... prehistory. We seek to understand how the geospatial patterning of interactions—modelled as a mobility network between agrarian zones and highland pastures—correlates with the evident geography of human
mean fire interval but without Native American landuse proxies28. Stambaugh et al.20 used regression to model historical fire return interval from FSRs in Missouri versus terrain roughness, human ... American geography to FSRs for the eastern US, Great Lakes, and central PA. We then assessed whether climate, terrain, and distance-based Native American landuse proxies were correlated with historical fire
Human milk oligosaccharides (HMOs) impact neonate immunity and health outcomes. However, the environmental factors influencing HMO composition remain understudied. This study examined the
the accelerated nature of bone loss on the ISS. This prompts the question, how does the lack of load due to zero-gravity propagate to bone-forming cells, human fetal osteoblasts (hFOBs), altering their ... pSMAD2/3 activated by TGF-β in human embryonic stem cells to regulate stem-cell self-renewal11, but the cytoplasmic function of YAP/TAZ on SMAD is controversial and may be cell type dependent12,13. YAP
, analyze, and reference. Since 2019, we have been maintaining the Allen Ancient DNA Resource (AADR), which aims to provide an up-to-date, curated version of the world’s published ancient human DNA data ... , Boston, MA, 02115, USA. 2Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. 3Howard Hughes Medical Institute, Boston, MA, 02115, USA. 4Department of Human Evolutionary Biology, Harvard
The genetic basis of human facial variation and craniofacial birth defects remains poorly understood. Distant-acting transcriptional enhancers control the fine-tuned spatiotemporal expression of ... genetic basis of human facial variation and craniofacial birth defects remains poorly understood. Distant-acting transcriptional enhancers control the fine-tuned spatiotemporal expression of genes during
NASA uses a continuous risk management process to seek out new knowledge of spaceflight-induced risk to human health and performance. The evidence base that informs the risk assessments in this ... that span disciplines, including engineering, medicine, food and nutrition, and many other life sciences. The Human System Risk Board (HSRB) at NASA is responsible for assessing risk to astronauts and
theories to refugee network dynamics—, potentially furthering theoretical development with respect to both network theory and theories on human mobility. ... Introduction Refugee and migrant movements represent the most fundamental [ 1 ] and most extreme reactions to natural and human-induced change. When viewed together, these movements form complex networks—with
BYU Studies Quarterly Volume 61 Issue 4 Article 10 2022 Human Sacrifice Stephen O. Smoot John Gee Kerry Muhlestein John S. Thompson Follow this and additional works at: https ... ://scholarsarchive.byu.edu/byusq Part of the Mormon Studies Commons, and the Religious Education Commons Recommended Citation Smoot, Stephen O.; Gee, John; Muhlestein, Kerry; and Thompson, John S. (2022) "Human Sacrifice
and after spaceflight. The Human System Risk Board (HSRB) at NASA Johnson Space Center is responsible for setting the official risk posture for each of the human system risks and determining—based on ... diagramming for assessing human system risk in spaceflight Check for updates 1234567890():,; 1234567890():,; Erik Antonsen 1 , Robert J. Reynolds 2, Jacqueline Charvat 2, Erin Connell3, Avalon Monti Devan
identity of the cardiac cell types that develop the human heart. This approach also provided a spatial mapping of individual cells that enables illumination of their organization into cellular communities ... . Interrogating cell-cell interactions within these communities using in vivo conditional genetic mouse models and in vitro human pluripotent stem cell systems revealed multicellular signalling pathways that
The human cerebellum is engaged in a broad array of tasks related to motor coordination, cognition, language, attention, memory, and emotional regulation. A detailed cerebellar atlas can facilitate ... considerably larger surface area and intricately folded pattern of the human cerebellar cortex, in comparison to other mammals32,33, indicate its potential relevance to cognitive performance. Recent years have
Working Dogs have shown an extraordinary ability to utilize olfaction for victim recovery efforts. Although instrumental analysis has chemically characterized odor volatiles from various human ... remains unclear what perceptually constitutes human scent (HS) for dogs. This may be in part due to the lack of methodology and equipment to train and evaluate HS perception. The aims of this research were
Human locomotion is controlled by spinal neuronal networks of similar properties, function, and organization to those described in animals. Transspinal stimulation affects the spinal locomotor ... their control on stepping8–10. Human CPGs have been a black box for decades, giving rise to great debates regarding their existence and function11. Direct evidence in humans is difficult, but the
and processes. The primary cell types in the human placenta are the trophoblasts: cytotrophoblasts (CTs), syncytiotrophoblasts (STs), and extravillous trophoblasts (EVTs). CTs represent undifferentiated ... trophoblast lineage differentiation are not fully understood in part due to ethical and practical limitations to access to and utilize early human placenta. Since human TSCs can differentiate into various
Vaccine priming immunogens that activate germline precursors for broadly neutralizing antibodies (bnAbs) have promise for development of precision vaccines against major human pathogens. In a ... development by heterologous boosting. In this approach, the precursor frequency and binding affinity are critically important and depend on human genetic characteristics. The IAVI G001 phase 1 clinical trial of
establish generalizable and robust decoders for threat and safety in the human brain. Results Decoding threat and safe cues based on patterns of the ‘threat circuit’ First, we used activation patterns of the ... many high-level aspects of human cognition, including attentional processes, cognitive control, and conscious awareness41. external datasets with different experimental paradigms (summarized in
explain how these techniques offer unprecedented precision and versatility for modifying the human genome. Third, we introduce the current delivery systems used to deploy precise genome-editing components ... (2024)9:47 INTRODUCTION Among the approximately 25,000 annotated genes in the human genome, over 3000 mutations have been identified in connection with diseases, and ongoing research is revealing
negative regulator of human MMR. ... regulator of human DNA mismatch repair Demin Du1†, Yueyan Yang2†, Yuanyuan Zhang1, Guanxiong Wang1, Liying Chen1, Xiaowei Guan1*, Lene Juel Rasmussen3* and Dekang Liu1* † Demin Du and Yueyan Yang are
