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The novel tool of cell reprogramming for applications in molecular medicine

differentiated into every tissue and cell type of the human body. Our ability to reprogram cell types has four main implications for medicine: (1) scientists can now take skin or blood cells from patients and ... , Stanford University School of Medicine , Stanford, CA 94305 , USA Recent discoveries in the field of stem cell biology have enabled scientists to Breprogram^ cells from one type to another. For example, it

Berlin Wild—and the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch

Medical Faculty and the Max Delbrück Center for Molecular Medicine , Lindenbergerweg 80, 13125 Berlin , Germany 1 Friedrich C. Luft With this title, one thinks of Berlin in the roaring 1920s, or perhaps ... for Molecular Medicine (MDC) in Berlin-Buch. As a matter of fact, Regine Witkowski later chauffeured me back to my room in BerlinBuch in her Wartburg. The four geneticists explained to me that the

The microbiome in health and disease: a new role of microbes in molecular medicine

microbiota transfer may offer new opportunities for the preservation of health and cure of disease. In any case, these are exciting times for microbiology within molecular medicine that herald a new dimension ... , Germany For more than a hundred years, medicine was profoundly influenced by the groundbreaking work of Robert Koch [1] and others demonstrating microbes as causative agents of disease (era Koch 1.0, Table

Interpretation of the Nobel Prize in Physiology or Medicine 2017

decades. The Nobel Prize in Physiology or Medicine this year was awarded jointly to Jeffrey C. Hall, Michael Rosbash, and Michael W. Young “for their discoveries of molecular mechanisms controlling the ... Physiology or Medicine 2017 gave us a mixture of excitement and surprise. Although researchers in circadian rhythm community have been expecting this from the committee of Nobel Prize for quite a few years

The history of medicine

father of clinical medicine, and Asclepiades of Bithynia, the father of molecular medicine . Review. In Vivo (Brooklyn) . 2009 ; 23 ( 4 ): 507 - 14 . 5. França K , Chacon A , Ledon J , Savas J , Nouri K ... Miller School of Medicine , Miami, FL , USA I swear by Apollo the physician, and Asclepius, and Hygeia and Panacea and all the gods and goddesses as my witnesses . . . (Hippocratic Oath). - Humans have

Diseases and Molecular Diagnostics: A Step Closer to Precision Medicine

The current advent of molecular technologies together with a multidisciplinary interplay of several fields led to the development of genomics, which concentrates on the detection of pathogenic events ... medicine; in 1995, the Association for Molecular Pathology (AMP) was formed to give it structure. In 1999, the AMP co-founded The Journal of Medical Diagnostics; Informa Healthcare launched Expert Reviews in

Prospects for using risk scores in polygenic medicine

individual is designated ‘at risk’ through environmental risk factors or prodromal symptoms. However, substantial challenges exist before the PRS can be used in precision medicine. Polygenic medicine will ... . Education for clinicians and the public will be necessary to increase understanding and genetic literacy. Organisations such as Genomics England have developed resources to communicate genomic medicine with

Precision medicine for all? Challenges and opportunities for a precision medicine approach to critical illness

All of medicine aspires to be precise, where a greater understanding of individual data will lead to personalized treatment and improved outcomes. Prompted by specific examples in oncology, the field ... , Department of Critical Care Medicine, University of Pittsburgh School of Medicine , Pittsburgh, PA , USA 1 Department of Critical Care Medicine, University of Pittsburgh School of Medicine , 3550 Terrace

Mechanisms in Medicine

This paper begins by developing a causal theory of mechanisms in medicine, and illustrates the theory with the example of the mechanism of the disease anthrax as elucidated by Koch. The causal ... sciences, such as molecular biology and molecular medicine, the claim ‘‘C causes E’’ is impoverished compared to the claim that ‘‘this mechanism produces this phenomenon.’’ Knowledge of a mechanism in the

Intestinal Stem Cells to Advance Drug Development, Precision, and Regenerative Medicine: A Paradigm Shift in Translational Research

risk factors and drug sensitivity profiles, organoids are a highly relevant screening system for personalized therapy in both human and veterinary medicine. Lastly, and in the context of patient-specific ... , USA 1 Department of Veterinary Clinical Sciences, Iowa State University College of Veterinary Medicine , 50011-1250 Ames, Iowa , USA 2 Department of Biomedical Sciences, Iowa State University College of

Prospects of Molecular Biotechnology in Diagnostics: Step Towards Precision Medicine

best for individual patients. By examining the specifics of the patient and their disease, molecular diagnostics endorses the prospect of personalised medicine. These tests are fruitful in various ... Institute of Medical Sciences , Jodhpur 342005 , India - Molecular diagnostic tools as nucleotide sequences have been extensively utilized through persistent advancement in the molecular biology and

Exosomes in Cardiovascular Medicine

the potential applications of this emerging field to cardiovascular medicine, taking myocardial infarction as our primary example. ... CARDIOVASCULAR DISEASE Biomarkers are a useful diagnostic tool in many areas of cardiovascular medicine. We will here take acute myocardial infarction (AMI) as an example. ST segment elevation myocardial

PMTDS: a computational method based on genetic interaction networks for Precision Medicine Target-Drug Selection in cancer

Background Precision medicine attempts to tailor the right therapy for the right patient. Recent progress in large-scale collection of patents’ tumor molecular profiles in The Cancer Genome Atlas ... 46202 , USA 1 Department of Medical and Molecular Genetics, School of Medicine, Indiana University , Indianapolis, IN 46202 , USA 2 Department of Biomedical Informatics, College of Medicine, Ohio State

From Virus to vector to medicine: Foreword by guest editors

of different diseases. While it had been proposed already long ago, this basic concept represents a modern field of molecular medicine today. Especially during the past decade the field of gene therapy ... Education and Research (ZBAF), Department of Human Medicine, Faculty of Health, University Witten/ Herdecke , Witten , Germany 1 & Anja Ehrhardt 2 & Florian Kreppel 3 Chair for Virology and Microbiology

Human genetics special issue on computational molecular medicine

define as computational molecular medicine. Modern sequencing methods have revolutionized the study of Mendelian diseases. Bahlo et al. (2014) review approaches to identifying Mendelian causal variants in ... , USA 1 R. Karchin Department of Oncology, Johns Hopkins Medical Institutions , Baltimore , USA 2 ) Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University

Topics of nuclear medicine research in Europe

Last year in the European Journal of Nuclear Medicine and Molecular Imaging, we introduced some recent nuclear medicine research conducted in Japan. This was favorably received by European readers in ... European Journal of Nuclear Medicine and Molecular Imaging (EJNMMI), we introduced some recent nuclear medicine research conducted in Japan [ 16 ], which was favorably received by the European readers in

Why the way we look at things in reproductive medicine is changing

- Perceptions in biology and medicine have landed squarely in a high-resolution landscape that seemingly has few boundaries. Progress in biomedical imaging and molecular diagnostics has taken us beyond ... perceptual alignment with disciplines of molecular biology, high-speed data processing, and bioinformatics converge into a new reality of biological systems prompting a new set of questions within which our

Prospects of Molecular Biotechnology in Diagnostics: Step Towards Precision Medicine

best for individual patients. By examining the specifics of the patient and their disease, molecular diagnostics endorses the prospect of personalised medicine. These tests are fruitful in various ... Institute of Medical Sciences , Jodhpur 342005 , India - Molecular diagnostic tools as nucleotide sequences have been extensively utilized through persistent advancement in the molecular biology and

Poetry in Medicine

We are all stressed out to read and understand our medical practice which is so vast and seems monotonous. Amidst so much tension, we can still enjoy our profession if we can narrate the sequence in a different style. Poetry is one way of such expression. Poetry is a combination of knowledge and feeling. Just as we have all read Zachary Cope’s Surgery in Verse which correlates the ...