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The novel tool of cell reprogramming for applications in molecular medicine

differentiated into every tissue and cell type of the human body. Our ability to reprogram cell types has four main implications for medicine: (1) scientists can now take skin or blood cells from patients and ... , Stanford University School of Medicine , Stanford, CA 94305 , USA Recent discoveries in the field of stem cell biology have enabled scientists to Breprogram^ cells from one type to another. For example, it

Berlin Wild—and the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch

Medical Faculty and the Max Delbrück Center for Molecular Medicine , Lindenbergerweg 80, 13125 Berlin , Germany 1 Friedrich C. Luft With this title, one thinks of Berlin in the roaring 1920s, or perhaps ... for Molecular Medicine (MDC) in Berlin-Buch. As a matter of fact, Regine Witkowski later chauffeured me back to my room in BerlinBuch in her Wartburg. The four geneticists explained to me that the

The microbiome in health and disease: a new role of microbes in molecular medicine

the context of an individual host genome with an individual lifestyle and environment. In the present issue of the Journal of Molecular Medicine, several important aspects of current research around ... opportunities for the preservation of health and cure of disease. In any case, these are exciting times for microbiology within molecular medicine that herald a new dimension in the concepts of precision medicine

Precision medicine at the crossroads

There are bioethical, institutional, economic, legal, and cultural obstacles to creating the robust-precompetitive-data resource that will be required to advance the vision of “precision medicine ... to advance the vision of “precision medicine,” the ability to use molecular data to target therapies to patients for whom they offer the most benefit at the least risk. Creation of such an “information

Diseases and Molecular Diagnostics: A Step Closer to Precision Medicine

The current advent of molecular technologies together with a multidisciplinary interplay of several fields led to the development of genomics, which concentrates on the detection of pathogenic events ... medicine; in 1995, the Association for Molecular Pathology (AMP) was formed to give it structure. In 1999, the AMP co-founded The Journal of Medical Diagnostics; Informa Healthcare launched Expert Reviews in

The history of medicine

father of clinical medicine, and Asclepiades of Bithynia, the father of molecular medicine . Review. In Vivo (Brooklyn) . 2009 ; 23 ( 4 ): 507 - 14 . 5. França K , Chacon A , Ledon J , Savas J , Nouri K ... Miller School of Medicine , Miami, FL , USA I swear by Apollo the physician, and Asclepius, and Hygeia and Panacea and all the gods and goddesses as my witnesses . . . (Hippocratic Oath). - Humans have

Cancer chemoprevention and therapy using chinese herbal medicine

Traditional Chinese medicine (TCM) plays an indispensable role in cancer prevention and treatment. Chinese herbal medicine (CHM) is a key component of TCM and has been practiced for thousands of ... contributors 1 Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine , No.110, Ganhe Road, Hongkou District

The limited application of stem cells in medicine: a review

review of the current role of stem cells in medicine in the context of political, ethical and scientific limitations, which draws on the findings of like-minded reviews and research papers. The research ... question this paper seeks to address is a simple one: why has such a promising area of regenerative medicine as of present yielded such a limited impact? Through a comprehensive review of the state of the

Transcriptome assembly strategies for precision medicine

, dynamic and diverse, transcriptome assembly is playing an increasingly important role in precision medicine research to dissect the molecular mechanisms of the human diseases. ... , Wayne State University , Detroit, MI 48202 , USA Background: Precision medicine approach holds great promise to tailored diagnosis, treatment and prevention. Individuals can be vastly different in their

Human genetics special issue on computational molecular medicine

define as computational molecular medicine. Modern sequencing methods have revolutionized the study of Mendelian diseases. Bahlo et al. (2014) review approaches to identifying Mendelian causal variants in ... , USA 1 R. Karchin Department of Oncology, Johns Hopkins Medical Institutions , Baltimore , USA 2 ) Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University

Mechanisms in Medicine

This paper begins by developing a causal theory of mechanisms in medicine, and illustrates the theory with the example of the mechanism of the disease anthrax as elucidated by Koch. The causal ... sciences, such as molecular biology and molecular medicine, the claim ‘‘C causes E’’ is impoverished compared to the claim that ‘‘this mechanism produces this phenomenon.’’ Knowledge of a mechanism in the

Neoadjuvant Chemotherapy for Hypopharyngeal Squamous Cell Carcinoma and Personalized Medicine in Head and Neck Cancer

important to progress the field, while further developments are made in elucidating molecular markers of tumor behavior and targeted therapeutics that will further enhance our ability to provide the optimal

Special collection of bioinformatics in the era of precision medicine

, USA 1 Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University , Atlanta, GA 30322 , USA Precision medicine advocates for the practice of customized disease ... treatment and prevention such that all clinical decisions are made based on the characteristics of individual patients. The precision medicine framework has been enthusiastically endorsed by the health care

Renaissance, reinvention, or rhetoric: mitochondria in reproductive medicine 2017

-the-role-of-scientific-culture-in-modernsociety/) Recalling the milestones from 2017 could focus on any number of topics in reproductive medicine, ranging from gametes to stem cells to the two-headed ... headlines designed for professional and public consumption. Yet another subject dominating the field of reproductive medicine in 2017 was that of the mitochondrion. To this end, JARG features several

Precision medicine for all? Challenges and opportunities for a precision medicine approach to critical illness

All of medicine aspires to be precise, where a greater understanding of individual data will lead to personalized treatment and improved outcomes. Prompted by specific examples in oncology, the field ... , Department of Critical Care Medicine, University of Pittsburgh School of Medicine , Pittsburgh, PA , USA 1 Department of Critical Care Medicine, University of Pittsburgh School of Medicine , 3550 Terrace

Molecular Enrichment for Qualitative Molecular Pathogen Detection in Food

Reliable detection of low levels of pathogenic microbial contaminants is one of the most important prerequisites to guarantee safe food production. In this work, the use of molecular enrichment (ME ... , Department of Veterinary Public Health and Food Science, University of Veterinary Medicine , Veterinärplatz 1, 1210 Vienna , Austria 1 Christian Doppler Laboratory for Monitoring of Microbial Contaminants

Prospects for using risk scores in polygenic medicine

individual is designated ‘at risk’ through environmental risk factors or prodromal symptoms. However, substantial challenges exist before the PRS can be used in precision medicine. Polygenic medicine will ... . Education for clinicians and the public will be necessary to increase understanding and genetic literacy. Organisations such as Genomics England have developed resources to communicate genomic medicine with

Prospects of Molecular Biotechnology in Diagnostics: Step Towards Precision Medicine

best for individual patients. By examining the specifics of the patient and their disease, molecular diagnostics endorses the prospect of personalised medicine. These tests are fruitful in various ... Institute of Medical Sciences , Jodhpur 342005 , India - Molecular diagnostic tools as nucleotide sequences have been extensively utilized through persistent advancement in the molecular biology and

Actionable gene-based classification toward precision medicine in gastric cancer

Background Intertumoral heterogeneity represents a significant hurdle to identifying optimized targeted therapies in gastric cancer (GC). To realize precision medicine for GC patients, an actionable ... enrichment, enhanced depth of coverage, and reduced cost [ 14 ]. Thus, a clinically useful molecular classification based on targeted gene panel sequencing should help to realize precision medicine for GC

151 years Berliner Klinische Wochenschrift and the 20th anniversary of the Journal of Molecular Medicine

Delbrück Center for Molecular Medicine in the Helmholtz Association , Robert-Rössle Straße 10, 13125 Berlin , Germany We are very proud that the Journal of Molecular Medicine (J Mol Med) celebrates its ... Center for Molecular Medicine (MDC) in BerlinBuch, Germany, and the journal was renamed the Journal of Molecular Medicine (J Mol Med) [1]. Since 1995, J Mol Med has been successful in bringing together