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The novel tool of cell reprogramming for applications in molecular medicine

differentiated into every tissue and cell type of the human body. Our ability to reprogram cell types has four main implications for medicine: (1) scientists can now take skin or blood cells from patients and ... , Stanford University School of Medicine , Stanford, CA 94305 , USA Recent discoveries in the field of stem cell biology have enabled scientists to Breprogram^ cells from one type to another. For example, it

Berlin Wild—and the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch

Medical Faculty and the Max Delbrück Center for Molecular Medicine , Lindenbergerweg 80, 13125 Berlin , Germany 1 Friedrich C. Luft With this title, one thinks of Berlin in the roaring 1920s, or perhaps ... for Molecular Medicine (MDC) in Berlin-Buch. As a matter of fact, Regine Witkowski later chauffeured me back to my room in BerlinBuch in her Wartburg. The four geneticists explained to me that the

Genomics in neurodevelopmental disorders: an avenue to personalized medicine

disorder2. In addition, the clinical heterogeneity of NDDs make diagnosing a lengthy and costly process, complicating the quest for personalized medicine. However, the identification of bona fide genetic risk ... cell models to study patient-specific genetic mutations. Finally, we discuss successful examples of translational research creating an evidence-based framework of how personalized medicine can advance

The microbiome in health and disease: a new role of microbes in molecular medicine

the context of an individual host genome with an individual lifestyle and environment. In the present issue of the Journal of Molecular Medicine, several important aspects of current research around ... opportunities for the preservation of health and cure of disease. In any case, these are exciting times for microbiology within molecular medicine that herald a new dimension in the concepts of precision medicine

Tradition and Perspectives of Arab Herbal Medicine: A Review

Complementary and Alternative Medicine (CAM), including herbal medicine, are popular in the general population worldwide. Parallel to the increasing interest in ‘modern’ CAM therapies and the ... therapies and the historical importance of Arab medicine, there is also a similar trend in research activities dealing with the efficacy and safety of medicinal plants in our region. Historical and current

Respiratory Medicine at McMaster University, Hamilton, Ontario: 1968 To 2013

first Chairman of the Department of Medicine. Moran Campbell, already a world figure in respiratory medicine and physiology, arrived at McMaster in September 1968, and he invited Norman Jones to be ... Can Respir J Respiratory medicine at McMaster University, Hamilton, Ontario: 1968 to 2013 Norman L Jones FRCPC 0 Paul M O'Byrne MB FRCPC FRSC 0 0 Department of Medicine, Michael G DeGroote School

Exploring the Use of Molecular Biomarkers for Precision Medicine in Age-Related Macular Degeneration

Precision medicine aims to improve patient care by adjusting medication to each patient’s individual needs. Age-related macular degeneration (AMD) is a heterogeneous eye disease in which several ... Genetics, Donders Institute for Brain , Cognition and Behaviour , Radboud University Medical Center , Nijmegen , The Netherlands 1 & Anneke I. den Hollander Precision medicine aims to improve patient care

Ayurvedic Medicine for the Treatment of Dementia: Mechanistic Aspects

Ayurvedic medicine is a personalized system of traditional medicine native to India and the Indian subcontinent. It is based on a holistic view of treatment which promotes and supports equilibrium in ... verification of their claimed pharmacological and therapeutic effects. The purpose of this review is to outline the molecular mechanisms, signal transduction processes, and sites of action of some Ayurvedic

Current Status of Canine Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Veterinary Medicine

Stem cell therapy has prompted the expansion of veterinary medicine both experimentally and clinically, with the potential to contribute to contemporary treatment strategies for various diseases and ... , Republic of Korea 3Department of Veterinary Surgery, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea 4Department of Veterinary Obstetrics and Theriogenology, College of Veterinary

Use of Chinese Herbal Medicine Improves Chemotherapy-Induced Thrombocytopenia among Gynecological Cancer Patients: An Observational Study

· View at ScopusL.-D. Liang, T. He, T.-W. Du, Y.-G. Fan, D.-S. Chen, and Y. Wang, “GinsenosideRg5 induces apoptosis and DNA damage in human cervical cancer cells,” Molecular Medicine Reports, vol. 11, no ... Chein-Shuo Yeh,6 Jong-Hwei S. Pang,4 Jian-Tai Qiu,3,5 Hung-Hsueh Chou,3,5 Lan-Yan Yang,5,7 and Yu-Bin Pan7 1Division of Chinese Internal Medicine, Center for Traditional Chinese Medicine, Chang Gung

Constructing a DNA barcode reference library for southern herbs in China: A resource for authentication of southern Chinese medicine

Southern Chinese Medicine (SCM) is an important sect of Traditional Chinese Medicine (TCM) with its own special cultural style. Species identification is essential for TCM quality control because ... Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, and China Academy of Chinese Medical Sciences Guangdong Branch, China Academy of Chinese Medical Sciences , Guangzhou

Platelet-rich plasma therapy and reproductive medicine

, with a brief history of its applications in research and clinical therapies. Despite its widespread uses in medicine, the mechanisms through which PRP exerts its regenerative effects are only postulated ... microcirculation in some way.^ As the authors hypothesized, these observations had profound implications for short- and long-term preservation of organs. In regenerative medicine research, multipotent mesenchymal

Applying ADDIE Model to Ideate Precision Medicine in a Polytechnic Biomedical Science Programme

and bewildered as precision medicine is becoming increasingly important. Using the ADDIE model as the instructional design model, this paper describes the roadmap for creating a molecular techniques ... the roadmap for creating a molecular techniques module within a diploma programme that percolates with the concept of precision medicine. 1. Introduction As the implications of genetics and genomics

Investigation of the anti-TB potential of selected propolis constituents using a molecular docking approach

important role in medicine and continue to provide some inspiring templates for drug design. Propolis, a substance naturally-produced by bees upon collection of plant resins, is used in folk medicine for its ... medicine for its beneficial anti-TB activity. In this study, we used a molecular docking approach to investigate the interactions between selected propolis constituents and four ‘druggable’ proteins involved

Human genetics special issue on computational molecular medicine

define as computational molecular medicine. Modern sequencing methods have revolutionized the study of Mendelian diseases. Bahlo et al. (2014) review approaches to identifying Mendelian causal variants in ... , USA 1 R. Karchin Department of Oncology, Johns Hopkins Medical Institutions , Baltimore , USA 2 ) Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University

A Proteomic Approach for the Diagnosis of ‘Oketsu’ (blood stasis), a Pathophysiologic Concept of Japanese Traditional (Kampo) Medicine

‘Oketsu’ is a pathophysiologic concept in Japanese traditional (Kampo) medicine, primarily denoting blood stasis/stagnant syndrome. Here we have explored plasma protein biomarkers and/or diagnostic ... concepts and efficacy of Kampo medicine(s) in terms of molecular biology. In the present study, we have investigated the expression of plasma protein in patients in the ‘Oketsu’ state by using a proteomics

Pet genomics medicine runs wild

dogs and cats to benefit human health might be lost. Ultimately, people will become more distrustful of science and medicine. Global spending on pets has grown by 14% over the past 5 years (see ‘Animal ... phenotypes.)A cheek swab is all that’s needed for a genetic test.Credit: Elise Amendola/AP/REX/ShutterstockNo such careful reassessment has occurred in veterinary medicine. Many of the 200 tests offered by

Towards precision medicine; a new biomedical cosmology

Precision Medicine has become a common label for data-intensive and patient-driven biomedical research. Its intended future is reflected in endeavours such as the Precision Medicine Initiative in the ... medicine combines population research with various forms of molecular mapping, giving rise to big data. Thus, it is expected to involve various transformations on the level of vocabularies and labels

New additions to the cancer precision medicine toolkit

medicine. Two such open source tools, published recently in Genome Medicine, provide important advances to address the clinical cancer genomics data interpretation bottleneck. The data paradox in clinical ... cancer genomics As the genomic characterization of cancers transitions from a pure research endeavor to a means of providing clinically relevant information for cancer medicine, interpreting the data from

Decoction of Chinese Herbal Medicine Fuzheng Kang-Ai Induces Lung Cancer Cell Apoptosis via STAT3/Bcl-2/Caspase-3 Pathway

Decoction of Chinese herbal medicine (CHM) Fuzheng Kang-Ai (FZKA for short) has been applied as adjuvant treatment strategy in advanced lung cancer patients for decades. We previously showed that ... Sunny Hann1,4 1Department of Oncology, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510120, China