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The novel tool of cell reprogramming for applications in molecular medicine

differentiated into every tissue and cell type of the human body. Our ability to reprogram cell types has four main implications for medicine: (1) scientists can now take skin or blood cells from patients and ... , Stanford University School of Medicine , Stanford, CA 94305 , USA Recent discoveries in the field of stem cell biology have enabled scientists to Breprogram^ cells from one type to another. For example, it

Exploring the Use of Molecular Biomarkers for Precision Medicine in Age-Related Macular Degeneration

Precision medicine aims to improve patient care by adjusting medication to each patient’s individual needs. Age-related macular degeneration (AMD) is a heterogeneous eye disease in which several ... Genetics, Donders Institute for Brain , Cognition and Behaviour , Radboud University Medical Center , Nijmegen , The Netherlands 1 & Anneke I. den Hollander Precision medicine aims to improve patient care

Berlin Wild—and the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch

Medical Faculty and the Max Delbrück Center for Molecular Medicine , Lindenbergerweg 80, 13125 Berlin , Germany 1 Friedrich C. Luft With this title, one thinks of Berlin in the roaring 1920s, or perhaps ... for Molecular Medicine (MDC) in Berlin-Buch. As a matter of fact, Regine Witkowski later chauffeured me back to my room in BerlinBuch in her Wartburg. The four geneticists explained to me that the

The microbiome in health and disease: a new role of microbes in molecular medicine

the context of an individual host genome with an individual lifestyle and environment. In the present issue of the Journal of Molecular Medicine, several important aspects of current research around ... opportunities for the preservation of health and cure of disease. In any case, these are exciting times for microbiology within molecular medicine that herald a new dimension in the concepts of precision medicine

Platelet-rich plasma therapy and reproductive medicine

, with a brief history of its applications in research and clinical therapies. Despite its widespread uses in medicine, the mechanisms through which PRP exerts its regenerative effects are only postulated ... microcirculation in some way.^ As the authors hypothesized, these observations had profound implications for short- and long-term preservation of organs. In regenerative medicine research, multipotent mesenchymal

New additions to the cancer precision medicine toolkit

medicine. Two such open source tools, published recently in Genome Medicine, provide important advances to address the clinical cancer genomics data interpretation bottleneck. The data paradox in clinical ... cancer genomics As the genomic characterization of cancers transitions from a pure research endeavor to a means of providing clinically relevant information for cancer medicine, interpreting the data from

Study on the interaction between active components from traditional Chinese medicine and plasma proteins

Traditional Chinese medicine (TCM), as a unique form of natural medicine, has been used in Chinese traditional therapeutic systems over two thousand years. Active components in Chinese herbal ... components in herbal medicine, an analysis of condition changes of drug binding may promote the understanding of the molecular mechanisms involved and clinical relevance about them. Several factors have

Towards precision medicine; a new biomedical cosmology

Precision Medicine has become a common label for data-intensive and patient-driven biomedical research. Its intended future is reflected in endeavours such as the Precision Medicine Initiative in the ... medicine combines population research with various forms of molecular mapping, giving rise to big data. Thus, it is expected to involve various transformations on the level of vocabularies and labels

Highlights of the 30th Annual Congress of the EANM, Vienna 2017: “Yes we can – make nuclear medicine great again”

scientific and featured sessions, CME sessions, and plenary lectures. These lectures were devoted to nuclear medicine imaging and therapy, including hybrid imaging and molecular life sciences. Additionally ... book, published as volume 44, supplement 2 of the European Journal of Nuclear Medicine and Molecular Imaging in October 2017. EANM 2017; Annual congress; Abstracts; Highlights; Nuclear medicine

Correction to: Molecular Imaging of Inflammation in Ischemic Heart Disease

Molecular Imaging Program at Stanford (MIPS), Stanford University , 300 Pasteur Drive, Stanford, CA 94305 , USA 1 Department of Radiology, Stanford University , 300 Pasteur Drive, Stanford, CA 94305 , USA 2 ... Department of Medicine, Division of Cardiovascular Medicine, Stanford University , 300 Pasteur Drive, Stanford, CA 94305 , USA 3 Patricia K. Nguyen 4 Cardiology Section, Veterans Affairs Palo Alto Health Care

The microbiome in precision medicine: the way forward

Microbiology, Baylor College of Medicine , Houston, TX 77030 , USA Novel associations between the human microbiome and health and disease are routinely emerging, and important host-microbiome interactions are ... integrated with other 'omics' data sets to enhance precision medicine. The microbiome is a key component of precision medicine The prospect of individualized medical therapies that are customized for maximal

Integrated approach for identifying and evaluating the quality of Marsdenia tenacissima in the medicine market

evaluate the quality of M. tenacissima in the medicine market. ... M. tenacissima in the medicine market. - Data Availability Statement: All relevant data are within the paper and its Supporting Information file. Funding: This research work was supported by

Serum galactomannan antigen as a prognostic and diagnostic marker for invasive aspergillosis in heterogeneous medicine ICU patient population

Objective This study was conducted to get a complete clinical and mycological picture of invasive aspergillosis (IA) in respiratory medicine ICU of a tertiary care hospital. Patients From the cohort ... 0 1 0 Department of Microbiology, All India Institute of Medical Sciences , New Delhi , India , 2 Department of Pulmonary Medicine and Sleep Disorders, All India Institute of Medical Sciences , New

Bridging the gap between informatics and medicine upon medical school entry: Implementing a course on the Applicative Use of ICT

, "Applicative Use of Information and Communication Technologies (ICT) in Medicine," upon medical school entry. The Faculty of Medicine, University of Belgrade, introduced a curriculum reform in 2014 that included ... of Medicine, University of Belgrade, Belgrade, Serbia, 2 Department for Internal Medicine, Mayo Clinic , Rochester , United States of America, 3 Center for Information and Communication Technologies

Diseases and Molecular Diagnostics: A Step Closer to Precision Medicine

The current advent of molecular technologies together with a multidisciplinary interplay of several fields led to the development of genomics, which concentrates on the detection of pathogenic events ... medicine; in 1995, the Association for Molecular Pathology (AMP) was formed to give it structure. In 1999, the AMP co-founded The Journal of Medical Diagnostics; Informa Healthcare launched Expert Reviews in

The history of medicine

father of clinical medicine, and Asclepiades of Bithynia, the father of molecular medicine . Review. In Vivo (Brooklyn) . 2009 ; 23 ( 4 ): 507 - 14 . 5. França K , Chacon A , Ledon J , Savas J , Nouri K ... Miller School of Medicine , Miami, FL , USA I swear by Apollo the physician, and Asclepius, and Hygeia and Panacea and all the gods and goddesses as my witnesses . . . (Hippocratic Oath). - Humans have

Precision medicine at the crossroads

There are bioethical, institutional, economic, legal, and cultural obstacles to creating the robust-precompetitive-data resource that will be required to advance the vision of “precision medicine ... to advance the vision of “precision medicine,” the ability to use molecular data to target therapies to patients for whom they offer the most benefit at the least risk. Creation of such an “information

Human genetics special issue on computational molecular medicine

define as computational molecular medicine. Modern sequencing methods have revolutionized the study of Mendelian diseases. Bahlo et al. (2014) review approaches to identifying Mendelian causal variants in ... , USA 1 R. Karchin Department of Oncology, Johns Hopkins Medical Institutions , Baltimore , USA 2 ) Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University

Tissue engineering of skin and regenerative medicine for wound care

skin cell thrapies and discusses the future prospects in cutaneous regeneration. Burns; Cell therapy; Skin substitute; Tissue engineering; Wound closure; Scar; Regenerative medicine Background ... healing, and biomedical engineering constitute the emerging field of regenerative medicine. Contemporary research and regenerative medicine Although great progress has been made in reductions of morbidity

eRAM: encyclopedia of rare disease annotations for precision medicine

obstacle for improving their treatment. Detailed clinical phenotyping is considered as a keystone of deciphering genes and realizing the precision medicine for rare diseases. Here, we preset a standardized ... Language System (UMLS), Human Phenotype Ontology, Orphanet, OMIM, GWAS). eRAM systematically incorporates currently available data on clinical manifestations and molecular mechanisms of rare diseases and