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Urbanization, environment and pharmaceuticals: advancing comparative physiology, pharmacology and toxicology

assays originally developed to address historical chemical stressors. Because pharmacology and toxicology information is more readily available for these contaminants of emerging concern than other ... immediately clear how useful pre-clinical pharmacology and toxicology information could be to assist ecologically focused efforts. Therapeutics had long been used (e.g. as positive controls) during basic and

Comparative Risk Assessment of Formulation Changes in Generic Drug Products: A Pharmacology/Toxicology Perspective

-based comparative safety evaluation procedure for generic drugs and discusses representative case studies from a pharmacologytoxicology perspective. For consideration by generic drug industry ... with risk evaluation of generic drugs. Further, we provide specific insights into the generic drug review process from a pharmacologytoxicology perspective and discuss these in light of the excipients

Comparative Risk Assessment of Formulation Changes in Generic Drug Products: A Pharmacology/Toxicology Perspective

-based comparative safety evaluation procedure for generic drugs and discusses representative case studies from a pharmacologytoxicology perspective. For consideration by generic drug industry ... evaluation of generic drugs. Further, we provide specific insights into the generic drug review process from a pharmacologytoxicology perspective and discuss these in light of the excipients, impurities, and

Model reduction in mathematical pharmacology

agent based modelling. The approach provides a straightforward means to construct simplified Quantitative Systems Pharmacology models that still provide significant insight into the mechanisms of drug ... . Mathematical pharmacology; Model reduction; Systems pharmacology; PBPK Introduction Within the past decade quantitative systems pharmacology (QSP) has emerged as a novel discipline proposing the use of

Special issue: mathematical pharmacology

der Graaf PH , Benson N , Peletier LA ( 2016 ) Topics in mathematical pharmacology . J Dyn Diff Equat 28 : 1337 - 1356 2. Dokoumetzidis A , Iliadis A , Macheras P ( 2001 ) Nonlinear dynamics and chaos

BMC Pharmacology and Toxicology reviewer acknowledgement 2015

Contributing reviewers The editors of BMC Pharmacology and Toxicology would like to thank all our reviewers who have contributed to the journal in Volume 16 (2015). ... , United Kingdom 1 Saskia De Wildt Netherlands 2 Bart Crielaard Netherlands The editors of BMC Pharmacology and Toxicology would like to thank all our reviewers who have contributed to the journal in Volume

Pharmacology and toxicology of the novel investigational agent Cantrixil (TRX-E-002-1)

mice dosed at clinical concentrations. TRX-E-002-1 toxicology was evaluated in GLP-compliant MTD and 28-day repeat-dose studies in rats and dogs. Results In vitro TRX-E-002-1 has potent cytotoxic ... pancreatic cancer. Conclusions In animals, this clinical formulation and route of administration of Cantrixil demonstrated acceptable activity, safety pharmacology, genotoxicity and toxicology profile and

A systems pharmacology model for inflammatory bowel disease

Pharmacometrics & Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy and Nutrition, University of Navarra , Pamplona, Spain, 2 IdiSNA , Navarra Institute for Health ... [ 32 ]. More recently, the R package SPIDDOR (Systems Pharmacology for effIcient Drug Development On R) among others, has implemented new types of regulatory interactions and perturbations within the

Engineering in-vitro stem cell-based vascularized bone models for drug screening and predictive toxicology

bone engineering, coupled with a highthroughput platform for drug screening and toxicology assessment. In the future, bioprinting could represent a suitable on-demand platform for the versatile

Ecotoxicology and toxicology: problems and decisions

toxic exposure, or food toxicology and lead to insidious biological effects that indirectly affect health and disease risk. The propensity of a metal to be accumulated by living organisms depends on the

Pharmacology and pharmacogenetics of prednisone and prednisolone in patients with nephrotic syndrome

ultimately implement pharmacogenetics in clinical practice. Nephrotic syndrome; Pharmacogenetics; Prednisolone; Prednisone; Glucocorticoids; Pharmacology Introduction Nephrotic syndrome is one of the most

BMC Pharmacology and Toxicology reviewer acknowledgement 2014

Contributing reviewers The editors of BMC Pharmacology and Toxicology would like to thank all of our reviewers who have contributed to the journal in Volume 15 (2014).

The future is now: cutting edge science and understanding toxicology

, Gwangju Institute of Science and Technology , 1 Oryong-Dong, Buk-Gu, Gwangju 61005 , Republic of Korea Introduction In 2016, the scope of Cell Biology and Toxicology was expanded to provide greater ... opinions regarding the future scope of Cell Biology and Toxicology. Current research in cell biology and toxicology and cutting edge science The year 2017 has been an exciting and productive year for Cell

Green Toxicology—Know Early About and Avoid Toxic Product Liabilities

Toxicology uniquely among the life sciences relies largely on methods which are more than 40-years old. Over the last 3 decades with more or less success some additions to and few replacements in ... . As similar thoughts developed in the context of Green Chemistry, the term of Green Toxicology was coined to describe this change in approach. Here, the current developments in the alternative field

Clinical pharmacology in Stockholm 50 years—report from the jubilee symposium

, Stockholm , Sweden 2 Dr. Margarete Fischer-Bosch Institute, Stuttgart and Division of Clinical Pharmacology, University of Tübingen , Tübingen , Germany 3 Folke Sjöqvist 4 The beginning of clinical

In Vitro Safety Pharmacology Profiling of Topical α-Adrenergic Agonist Treatments for Erythema of Rosacea

patients. Brimonidine and oxymetazoline are both topical a-adrenergic agonists. Objectives The objective of this in vitro safety pharmacology study was to compare the potential safety profiles of brimonidine ... -inflammatory (ex vivo human skin model and in vivo inflammation model) properties of brimonidine have previously been demonstrated [ 6 ]. The objective of this in vitro safety pharmacology study was to

Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion

with the recommendations on experimental design and analysis in pharmacology [ 45 ]. Data are presented as group average ± SEM except for in vitro studies where SD is indicated. Statistical analysis ... recruitment profile To develop a molecular understanding of the differential pharmacology observed for AZD9977, the X-ray structures of MR LBD with mutations Cys808Ser and Cys910Ser in complex with AZD9977 and

Abstracts from the Joint Meeting of the International Society for NeuroVirology (ISNV) and the Society on NeuroImmune Pharmacology (SNIP) April 10-14, 2018, Chicago, Illinois, USA

122 Okinawa Institute of Science and Technology, Neuronal Rhythms in Movement Unit , Okinawa , Japan 123 Department of Pharmacology & Toxicology, Virginia Commonwealth University , Richmond, VA , USA ... Pharmacology, Georgetown University , Washington, DC , USA 5 Department of Neuroscience, Georgetown University , Washington, DC , USA 6 P8 The role of neuronal cytoskeleton in NeuroAIDS Valeria Avdoshina 7

Carbon nanotubes exhibit fibrillar pharmacology in primates

for pharmacokinetic and safety toxicology profiles. Here, we examined intravenous administration of fCNT in cynomolgus monkeys (S8±S10 Figs). Our first goal was to establish that the pharmacology that ... , 5 Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center , New York , New York, United States of America, 6 Department of Pharmacology, Weill Cornell Medicine , New York , New York

Automated recording of home cage activity and temperature of individual rats housed in social groups: The Rodent Big Brother project

occurring behavioral effects, extending beyond the capabilities of routine observational tests and conventional monitoring equipment. It has numerous potential applications including safety pharmacology ... temperature. Furthermore, in addition to toxicology and safety pharmacology, the technology has potential applications across the entire spectrum of behavioral neuroscience and drug discovery: behavioral