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Urbanization, environment and pharmaceuticals: advancing comparative physiology, pharmacology and toxicology

assays originally developed to address historical chemical stressors. Because pharmacology and toxicology information is more readily available for these contaminants of emerging concern than other ... immediately clear how useful pre-clinical pharmacology and toxicology information could be to assist ecologically focused efforts. Therapeutics had long been used (e.g. as positive controls) during basic and

Comparative Risk Assessment of Formulation Changes in Generic Drug Products: A Pharmacology/Toxicology Perspective

-based comparative safety evaluation procedure for generic drugs and discusses representative case studies from a pharmacologytoxicology perspective. For consideration by generic drug industry ... with risk evaluation of generic drugs. Further, we provide specific insights into the generic drug review process from a pharmacologytoxicology perspective and discuss these in light of the excipients

Comparative Risk Assessment of Formulation Changes in Generic Drug Products: A Pharmacology/Toxicology Perspective

-based comparative safety evaluation procedure for generic drugs and discusses representative case studies from a pharmacologytoxicology perspective. For consideration by generic drug industry ... evaluation of generic drugs. Further, we provide specific insights into the generic drug review process from a pharmacologytoxicology perspective and discuss these in light of the excipients, impurities, and

Site-specific protein-polymer conjugate micelles with dramatically enhanced pharmacology

remarkably enhanced pharmacology. J Am Chem Soc, 2018, 140: 10435–10438CrossRefGoogle Scholar Copyright information © Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018

Renal Aspects of Peptic Ulcer Pharmacology

undergoes ex tremely rnpid dc -cstcrificmion to the hiulog1cally active metabol ite, 1111~0proswl ,1cid, priur to or during ah~orpRenal aspects of peptic ulcer pharmacology t ion. No LrnchangL·d d rug 1s

BMC Pharmacology and Toxicology reviewer acknowledgement 2015

Contributing reviewers The editors of BMC Pharmacology and Toxicology would like to thank all our reviewers who have contributed to the journal in Volume 16 (2015). ... , United Kingdom 1 Saskia De Wildt Netherlands 2 Bart Crielaard Netherlands The editors of BMC Pharmacology and Toxicology would like to thank all our reviewers who have contributed to the journal in Volume

Pharmacology and toxicology of the novel investigational agent Cantrixil (TRX-E-002-1)

mice dosed at clinical concentrations. TRX-E-002-1 toxicology was evaluated in GLP-compliant MTD and 28-day repeat-dose studies in rats and dogs. Results In vitro TRX-E-002-1 has potent cytotoxic ... pancreatic cancer. Conclusions In animals, this clinical formulation and route of administration of Cantrixil demonstrated acceptable activity, safety pharmacology, genotoxicity and toxicology profile and

Model reduction in mathematical pharmacology

agent based modelling. The approach provides a straightforward means to construct simplified Quantitative Systems Pharmacology models that still provide significant insight into the mechanisms of drug ... . Mathematical pharmacology; Model reduction; Systems pharmacology; PBPK Introduction Within the past decade quantitative systems pharmacology (QSP) has emerged as a novel discipline proposing the use of

Special issue: mathematical pharmacology

der Graaf PH , Benson N , Peletier LA ( 2016 ) Topics in mathematical pharmacology . J Dyn Diff Equat 28 : 1337 - 1356 2. Dokoumetzidis A , Iliadis A , Macheras P ( 2001 ) Nonlinear dynamics and chaos

Toxicology and Tributaries in Texas

- From March 11–15, 2018 thousands of toxicologists will converge on the Henry B. Gonzalez Convention Center in San Antonio, Texas for the 57th Annual Meeting of the Society of Toxicology. It is impressive

BMC Pharmacology and Toxicology reviewer acknowledgement 2014

Contributing reviewers The editors of BMC Pharmacology and Toxicology would like to thank all of our reviewers who have contributed to the journal in Volume 15 (2014).

Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situations

of quantitative understanding about the dynamics of pharmacological drug–target interactions in biological systems. In this study, a quantitative systems pharmacology (QSP) approach is applied to ... processes simultaneously interacting at different levels of biological organization. Quantitative systems pharmacology (QSP) bears the promise to significantly support pharmaceutical development programs

A network pharmacology-based approach to analyse potential targets of traditional herbal formulas: An example of Yu Ping Feng decoction

therapeutic effects at the level of molecular biology. By taking a classic herbal formula (Yu Ping Feng decoction, YPF) as an example, this study developed a novel network pharmacology based method to identify ... called network pharmacology (NP). In recent years, NP has been proposed as a promising approach for understanding herbal formulas1,2 and predicting potential new drugs or targets3,4,5. To some extent, NP

A systems pharmacology model for inflammatory bowel disease

Pharmacometrics & Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy and Nutrition, University of Navarra , Pamplona, Spain, 2 IdiSNA , Navarra Institute for Health ... [ 32 ]. More recently, the R package SPIDDOR (Systems Pharmacology for effIcient Drug Development On R) among others, has implemented new types of regulatory interactions and perturbations within the

Ecotoxicology and toxicology: problems and decisions

toxic exposure, or food toxicology and lead to insidious biological effects that indirectly affect health and disease risk. The propensity of a metal to be accumulated by living organisms depends on the

Systems Pharmacology Dissection of Traditional Chinese Medicine Wen-Dan Decoction for Treatment of Cardiovascular Diseases

the molecular mechanisms is still ambiguous. In this study, a system pharmacology approach was developed to reveal the underlying molecular mechanisms of a clinically effective herb formula (Wen-Dan ... of Wen-Dan Decoction on CVD is promising, its pharmacological actions have not been fully revealed. By integrating systems biology and pharmacology, systems pharmacology provides a new approach to

Antitumor Mechanisms of Curcumae Rhizoma Based on Network Pharmacology

medications remain unclear [3]. Consequently, it is difficult to dissect the antitumor mechanisms of Curcumae Rhizoma. Network pharmacology, first proposed by Hopkins in 2007 [4], is an approach to drug design ... from a network perspective and in this sense shares the holistic perspective of TCM [2, 3, 6]. Network pharmacology has been increasingly applied to exploring the pharmacological mechanisms of TCM

A network pharmacology approach to determine the synergetic mechanisms of herb couple for treating rheumatic arthritis

A network pharmacology approach to determine the synergetic mechanisms of herb couple for treating rheumatic arthritis Xi-xi Xu,1 Jian-ping Bi,2 Li Ping,3 Ping Li,1 Fei Li1,4 1State Key Laboratory of ... incisum K.C. Ting ex H.T (CN). Methods: A network pharmacology approach integrating prediction of ingredients, target exploration, network construction, module partition and pathway analysis was used

A review of the pharmacology and clinical efficacy of brivaracetam

A review of the pharmacology and clinical efficacy of brivaracetam Pavel Klein,1 Anyzeila Diaz,2 Teresa Gasalla,3 John Whitesides4 1Mid-Atlantic Epilepsy and Sleep Center, Bethesda, MD, USA ... seen on day 1 of oral use in a significant percentage of patients. Intravenous administration in a 2-minute bolus and 15-minute infusion is well tolerated. Here, we review the pharmacology

Principles of Pharmacology and Toxicology Also Govern Effects of Chemicals on the Endocrine System

The present debate on chemicals with Hormonal activity, often termed ‘endocrine disruptors’, is highly controversial and includes challenges of the present paradigms used in toxicology and in hazard ... their concerns regarding the proposed inappropriate regulation. The letter was signed by numerous researchers and teachers in pharmacology and toxicology. Many of them also have been active in advisory