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Urbanization, environment and pharmaceuticals: advancing comparative physiology, pharmacology and toxicology

assays originally developed to address historical chemical stressors. Because pharmacology and toxicology information is more readily available for these contaminants of emerging concern than other ... immediately clear how useful pre-clinical pharmacology and toxicology information could be to assist ecologically focused efforts. Therapeutics had long been used (e.g. as positive controls) during basic and

Comparative Risk Assessment of Formulation Changes in Generic Drug Products: A Pharmacology/Toxicology Perspective

-based comparative safety evaluation procedure for generic drugs and discusses representative case studies from a pharmacologytoxicology perspective. For consideration by generic drug industry ... with risk evaluation of generic drugs. Further, we provide specific insights into the generic drug review process from a pharmacologytoxicology perspective and discuss these in light of the excipients

Comparative Risk Assessment of Formulation Changes in Generic Drug Products: A Pharmacology/Toxicology Perspective

-based comparative safety evaluation procedure for generic drugs and discusses representative case studies from a pharmacologytoxicology perspective. For consideration by generic drug industry ... evaluation of generic drugs. Further, we provide specific insights into the generic drug review process from a pharmacologytoxicology perspective and discuss these in light of the excipients, impurities, and

Renal Aspects of Peptic Ulcer Pharmacology

undergoes ex tremely rnpid dc -cstcrificmion to the hiulog1cally active metabol ite, 1111~0proswl ,1cid, priur to or during ah~orpRenal aspects of peptic ulcer pharmacology t ion. No LrnchangL·d d rug 1s

Model reduction in mathematical pharmacology

agent based modelling. The approach provides a straightforward means to construct simplified Quantitative Systems Pharmacology models that still provide significant insight into the mechanisms of drug ... . Mathematical pharmacology; Model reduction; Systems pharmacology; PBPK Introduction Within the past decade quantitative systems pharmacology (QSP) has emerged as a novel discipline proposing the use of

BMC Pharmacology and Toxicology reviewer acknowledgement 2015

Contributing reviewers The editors of BMC Pharmacology and Toxicology would like to thank all our reviewers who have contributed to the journal in Volume 16 (2015). ... , United Kingdom 1 Saskia De Wildt Netherlands 2 Bart Crielaard Netherlands The editors of BMC Pharmacology and Toxicology would like to thank all our reviewers who have contributed to the journal in Volume

Special issue: mathematical pharmacology

der Graaf PH , Benson N , Peletier LA ( 2016 ) Topics in mathematical pharmacology . J Dyn Diff Equat 28 : 1337 - 1356 2. Dokoumetzidis A , Iliadis A , Macheras P ( 2001 ) Nonlinear dynamics and chaos

Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situations

of quantitative understanding about the dynamics of pharmacological drug–target interactions in biological systems. In this study, a quantitative systems pharmacology (QSP) approach is applied to ... processes simultaneously interacting at different levels of biological organization. Quantitative systems pharmacology (QSP) bears the promise to significantly support pharmaceutical development programs

Pharmacology and toxicology of the novel investigational agent Cantrixil (TRX-E-002-1)

mice dosed at clinical concentrations. TRX-E-002-1 toxicology was evaluated in GLP-compliant MTD and 28-day repeat-dose studies in rats and dogs. Results In vitro TRX-E-002-1 has potent cytotoxic ... pancreatic cancer. Conclusions In animals, this clinical formulation and route of administration of Cantrixil demonstrated acceptable activity, safety pharmacology, genotoxicity and toxicology profile and

A network pharmacology-based approach to analyse potential targets of traditional herbal formulas: An example of Yu Ping Feng decoction

therapeutic effects at the level of molecular biology. By taking a classic herbal formula (Yu Ping Feng decoction, YPF) as an example, this study developed a novel network pharmacology based method to identify ... called network pharmacology (NP). In recent years, NP has been proposed as a promising approach for understanding herbal formulas1,2 and predicting potential new drugs or targets3,4,5. To some extent, NP

BMC Pharmacology and Toxicology reviewer acknowledgement 2014

Contributing reviewers The editors of BMC Pharmacology and Toxicology would like to thank all of our reviewers who have contributed to the journal in Volume 15 (2014).

A systems pharmacology model for inflammatory bowel disease

Pharmacometrics & Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy and Nutrition, University of Navarra , Pamplona, Spain, 2 IdiSNA , Navarra Institute for Health ... [ 32 ]. More recently, the R package SPIDDOR (Systems Pharmacology for effIcient Drug Development On R) among others, has implemented new types of regulatory interactions and perturbations within the

A network pharmacology approach to determine the synergetic mechanisms of herb couple for treating rheumatic arthritis

A network pharmacology approach to determine the synergetic mechanisms of herb couple for treating rheumatic arthritis Xi-xi Xu,1 Jian-ping Bi,2 Li Ping,3 Ping Li,1 Fei Li1,4 1State Key Laboratory of ... incisum K.C. Ting ex H.T (CN). Methods: A network pharmacology approach integrating prediction of ingredients, target exploration, network construction, module partition and pathway analysis was used

Ecotoxicology and toxicology: problems and decisions

toxic exposure, or food toxicology and lead to insidious biological effects that indirectly affect health and disease risk. The propensity of a metal to be accumulated by living organisms depends on the

A review of the pharmacology and clinical efficacy of brivaracetam

A review of the pharmacology and clinical efficacy of brivaracetam Pavel Klein,1 Anyzeila Diaz,2 Teresa Gasalla,3 John Whitesides4 1Mid-Atlantic Epilepsy and Sleep Center, Bethesda, MD, USA ... seen on day 1 of oral use in a significant percentage of patients. Intravenous administration in a 2-minute bolus and 15-minute infusion is well tolerated. Here, we review the pharmacology

Engineering in-vitro stem cell-based vascularized bone models for drug screening and predictive toxicology

bone engineering, coupled with a highthroughput platform for drug screening and toxicology assessment. In the future, bioprinting could represent a suitable on-demand platform for the versatile

The future is now: cutting edge science and understanding toxicology

, Gwangju Institute of Science and Technology , 1 Oryong-Dong, Buk-Gu, Gwangju 61005 , Republic of Korea Introduction In 2016, the scope of Cell Biology and Toxicology was expanded to provide greater ... opinions regarding the future scope of Cell Biology and Toxicology. Current research in cell biology and toxicology and cutting edge science The year 2017 has been an exciting and productive year for Cell

Green Toxicology—Know Early About and Avoid Toxic Product Liabilities

Toxicology uniquely among the life sciences relies largely on methods which are more than 40-years old. Over the last 3 decades with more or less success some additions to and few replacements in ... . As similar thoughts developed in the context of Green Chemistry, the term of Green Toxicology was coined to describe this change in approach. Here, the current developments in the alternative field

Pharmacology and pharmacogenetics of prednisone and prednisolone in patients with nephrotic syndrome

ultimately implement pharmacogenetics in clinical practice. Nephrotic syndrome; Pharmacogenetics; Prednisolone; Prednisone; Glucocorticoids; Pharmacology Introduction Nephrotic syndrome is one of the most

Clinical pharmacology in Stockholm 50 years—report from the jubilee symposium

, Stockholm , Sweden 2 Dr. Margarete Fischer-Bosch Institute, Stuttgart and Division of Clinical Pharmacology, University of Tübingen , Tübingen , Germany 3 Folke Sjöqvist 4 The beginning of clinical