The risk for autoimmunity and subsequently type 1 diabetes is 10-fold higher in children with a first-degree family history of type 1 diabetes (FDR children) than in children in the general ... general population (GP children). We analyzed children with high-risk HLA genotypes (n = 4,573) in the longitudinal TEDDY birth cohort to determine how much of the divergent risk is attributable to genetic
associated with increased risk for all-cause mortality and death from CVD, coronary heart disease, and cerebral infarction in general East Asian populations, as in Western populations. - S and ... risk for cardiovascular disease (CVD) in general populations has been reported, mainly from Western countries (310). There have been only a few studies regarding the associations between HbA1c and CVD
OBJECTIVE To evaluate the utility of GAD antibodies (GADAs) and islet antigen-2 antibodies (IA-2As) in prediction of type 1 diabetes over 27 years in the general population and to assess the 6-year ... predictive value of 100% (95% CI 59 -100). CONCLUSIONS - One-time screening for GADAs and IA-2As in the general childhood population in Finland would identify 60% of those individuals who will develop type 1
many formulations of insulin to effectively manage the metabolic abnormalities for people with diabetes. However, the affordability of medications in general, and for insulin specifically, is currently ... not entirely clear but are due in part to the complexity of drug pricing in general and of insulin pricing in particular. As the price of insulin continues to rise, individuals with diabetes are often
hyperfiltration in the general middle-aged population. ... general middle-aged population. RESEARCH DESIGN AND METHODS-A total of 1,560 individuals, aged 50-62 years without diabetes, were included in the Renal Iohexol Clearance Survey in Troms 6 (RENIS-T6). GFR
OBJECTIVE Mortality is increased in patients with hereditary hemochromatosis, in individuals from the general population with increased transferrin saturation (TS), and also in patients with type 1 ... recommended targeted screening for TS in specialized diabetes clinics. Whether mortality is also increased in individuals from the general population with diabetes and increased TS is unknown. In two Danish
glucose tolerance and to a higher risk of type 2 diabetes. The aim of the current study was to evaluate the association between IGF-I level and insulin resistance in a Danish general population. ... 2 diabetes. In general, the effects of IGF-I in the control of glucose homeostasis is well known. Animal models showed that a deletion of hepatic IGF-I production, resulting in 80% reduced IGF-I
random sample of the general population of Copenhagen, Denmark, was taken as part of the Inter99 study. Included were 6,405 men and women aged 30-65 years at baseline (1999-2001), with 4,296 participating ... has been found in a general population sample (3). Vitamin D deficiency has been linked to increased risk of type 2 diabetes, but the available epidemiological evidence is limited because most studies
ANGPTL2 quartile than in the lowest quartile (hazard ratio, 1.80; 95% CI, 1.14-2.85; P = 0.01). CONCLUSIONSdElevated serum ANGPTL2 levels were positively associated with the development of T2DM in a general ... findings remained substantially unchanged when waist circumference was used instead of BMI in the adjusted models. CONCLUSIONSdIn a prospective study of a cohort of the general Japanese population, we
) transporters A1 (ABCA1) and -G1 (ABCG1). Whether genetic variation in ABCA1 and ABCG1 predicts risk of type 2 diabetes in the general population is unknown. ... predicted risk of type 2 diabetes in the general population. Twenty-seven variants, identified by previous resequencing of both genes, were genotyped in the Copenhagen City Heart Study (CCHS) (n = 10,185
freshly drawn blood, are labor-intensive, and have limited, if any, predictive ability on their own. In general, when autoantibodies are present in combination, at higher titers, at a younger age, and with ... clinical type 1 diabetes has been firmly documented in the first-degree relatives of type 1 diabetes probands of subjects affected with the disease, as well as in subjects in the general population who
than 5% of all patients with type 2 diabetes participate in these networks. Our aim was to study whether general practitioners (GPs) belonging to a DCN adhered more closely to guidelines for diabetes
cancer death. RESEARCH DESIGN AND METHODSdUsing a prospective study with 12 rural Japanese general populations (n = 3,641, mean age, 53.7 years; 33.5% men), we examined the associations between diabetes ... subjects aged ,65 years (HR 2.32; all P , 0.05). CONCLUSIONSdAmong the Japanese general population, diabetes confers an increased risk of all-cause death. Particular attention must be paid to the pronounced
, Department of General Medicine, Azienda Ospedaliera Universitaria Integrata , Verona, Italy ; the 2 Section of Endocrinology and Metabolism, Department of Medicine, University of Verona , Verona, Italy ; the 3
seemed to be additive without synergistic interaction. Therefore, plasma resistin was associated with some tag SNPs around DCN in the general Japanese population. The possibility that human decorin is a ... susceptibility (8). In the general Japanese population, subjects with the G/G genotype of rs1862513 had the highest plasma resistin, followed by those with the C/G and C/C genotypes (9). Rs1862513 explains ;26% of
OBJECTIVE—There is a recognized association among depression, diabetes, and cardiovascular disease. The aim of this study was to examine in a sample representative of the general population whether ... , the groups studied were not representative samples from the general population with metabolic syndrome, being either relatively young (8,9), men only ( 1 0 ) , p r e m e n o p a u s a l w o m e n o n l
' daily lives remains challenging. General practitioners (GPs) are cited as the primary source of information influencing healthy lifestyle decisions, but few studies have evaluated whether GPs' perceived
OBJECTIVE This study investigated the safety and efficacy of sitagliptin (Januvia) for the inpatient management of type 2 diabetes (T2D) in general medicine and surgery patients. ... sitagliptin alone or in combination with basal insulin is safe and effective for the management of hyperglycemia in general medicine and surgery patients with T2D. - I and randomized controlled studies in
severely ill. In this study, we aimed to determine whether hypoglycemic episodes are associated with higher mortality in diabetic patients hospitalized in the general ward. RESEARCH DESIGN AND METHODS This ... patients with diabetes hospitalized in the general ward of a teaching hospital between January 2003 and August 2004. The associations between the number and severity of hypoglycemic (50 mg/dl) episodes and
in that the subjects were not of the general population, because they had enrolled for weight loss treatment (13) or volunteered to participate in other studies (15). The present large-scale ... . Importantly, based on a screening policy, the subjects in this study are generally regarded to be representative of the general population. The results of our study are subject to limitation. SAD and TAD were