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Aligning organisational priorities and implementation science for cancer research

The challenge of implementing evidence into routine clinical practice is well recognised and implementation science offers theories, models and frameworks to promote investigation into delivery of ... implementation science for cancer research Stephanie Best1*, Karin Thursky2, Mark Buzza3, Marlena Klaic4, Sanne Peters4, Lisa Guccione5, Alison Trainer5 and Jillian Francis6 Abstract Background The challenge of

A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration

://shiny.rcc.uq.edu.au/TDP-map/). We identified distinct protein subsets enriched for diverse biological pathways with temporal alterations in protein abundance, including increases in protein folding factors prior to ... stages of ALS and FTLD progression and suggest that protein folding factors could be protective in neurodegenerative diseases. Dysfunction of RNA-binding proteins (RBPs) is implicated in several

What motivates people to defend science: Evidence from the 2017 March for science

The 2017 March for Science was an international march organized in response to concerns over the Trump administration’s misuse of science that drew unprecedented numbers of supporters as well as ... University of Pennsylvania, Penn Center for Science , Sustainability, and the Media, Philadelphia , Pennsylvania, United States of America, 2 George Mason University, Center for Climate Change Communication

Between the Lines: Integrating the Science of Reading and the Science of Behavior to Improve Reading Outcomes for Australian Children

contributions of the science of reading and science of behavior to our collective knowledge regarding reading development and effective reading instruction, and how this knowledge is currently being used in the ... the science of reading and science of behavior, are discussed. Learning to read is a vital skill for a successful life in a contemporary, informationbased society (Benton & Noyelle, 1992) and is

Controlled experiment finds no detectable citation bump from Twitter promotion

relevance, importance or quality and are therefore both tweeted about more and cited more. The authors of this study are leading science communicators on Twitter from several life science disciplines, with ... , College of Environmental Science and Forestry, Syracuse, NY, United States of America, 5 School of Earth and Environment, University of Canterbury, Christchurch, New Zealand, 6 Department of Earth and

Targeting the COMMD4–H2B protein complex in lung cancer

, QLD 4102 , Australia 2 Princess Alexandra Hospital , 199 Ipswich Road, Woolloongabba, QLD 4102 , Australia 3 Department of Computer Science and Engineering, Manipal Institute ARTICLE BACKGROUND: Lung ... biological functions including copper homoeostasis, NF-κB pathway regulation, protein trafficking and cell proliferation [ 25–27 ]. We have recently shown that COMMD4 is a promising NSCLC prognostic marker

The role of pregnancy associated plasma protein-A in triple negative breast cancer: a promising target for achieving clinical benefits

Pregnancy associated plasma protein-A (PAPP-A) plays an integral role in breast cancer (BC), especially triple negative breast cancer (TNBC). This subtype accounts for the most aggressive BC ... available. PAPP-A is a protein that is highly elevated during pregnancy. Frequently, higher PAPP-A expression is detected in tumors than in healthy tissues. The increase in expression coincides with increased

Electrostatic switch mechanisms of membrane protein trafficking and regulation

Lipid-protein interactions are normally classified as either specific or general. Specific interactions refer to lipid binding to specific binding sites within a membrane protein, thereby modulating

Correction: The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus

protein sets with ageing” and blue should instead indicate "Decreased protein sets with ageing". Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and

Two-Ways thinking and Two-Eyed Seeing as ways of implementing Indigenous perspectives in the science education curriculum

A groundswell to include Indigenous Knowledge in the school science curriculum has led to the inclusion of Aboriginal and Torres Strait Islander Histories and Cultures (generally known as Indigenous ... Cultures (generally known as Indigenous perspectives) in the overall Australian Curriculum (AC) and the Australian Curriculum: Science (ACS). However, the experiences in other countries, their states and

Global perspectives of the impact of the COVID-19 pandemic on learning science in higher education

lessons of COVID-19 and to use this knowledge to shape the future of learning science in higher education. In this study, we examined the experiences of instructors and students to ERI in three universities ... Learning in Engineering Sciences, Stockholm, Sweden, 5 School of Medical Science, Faculty of Medicine and Health, The University of Sydney , Sydney, New South Wales , Australia , 6 School of Life and

Towards a pan marsupial sero-immunological tool in the demanding field of wildlife serology: Marsupial immunoglobulin-binding capability with protein A/G, protein L and anti-kangaroo antibody

, including protein A/G and protein L, with the largest range of Australian marsupial species so far, including 32 species representing three major marsupial orders. Immunoglobulin-binding capability was ... Melbourne , Werribee, Victoria , Australia , 2 Asia-Pacific Centre for Animal Health, Melbourne Veterinary School, Faculty of Science, The University of Melbourne , Parkville, Victoria , Australia 1 Editor

What is the power of a genomic multidisciplinary team approach? A systematic review of implementation and sustainability

a significant impact on management, and was acceptable for adoption by a wide variety of subspecialists. Only one study utilized an implementation science based approach. The genomic MDT approach ... gaps remain in health systems readiness for this collaborative model, and there is a lack of implementation science based research especially addressing the cost, sustainability, scale up, and equity of

Early Career Innovations in Science Education Research: Introduction to the Special Issue

Science education research has typically been aligned with a collection of familiar topics and ideas. However, the field, like many others, is becoming ever more varied as it responds to a range of

The evolving landscape of sea-level rise science from 1990 to 2021

As sea-level rise (SLR) accelerates due to climate change, its multidisciplinary field of science has similarly expanded, from 41 articles published in 1990 to 1475 articles published in 2021, and ... , USA 4 Department of Environmental Science and Policy, Rosenstiel School of Marine , Atmospheric , & Earth Science, University of Miami , Miami, FL , USA 5 Department of Earth and Environment, Boston

The cytoprotective co-chaperone, AtBAG4, supports increased nodulation and seed protein content in chickpea without yield penalty

, QLD , Australia 1 School of Biology and Environmental Science, Queensland University of Technology , Brisbane, QLD , Australia 2 School of Agriculture and Food Sciences, University of Queensland ... world’s third most important grain legume with a global value of approximately 4.7 billion USD annually and an excellent source of plant-based protein, minerals, vitamins, and dietary fibre1. Drought and

Clothing and the Discovery of Science

In addition to natural curiosity, science is characterized by a number of psychological processes and perceptions. Among the psychological features, scientific enquiry relates to uncovering—or ... speculative theoretical model is presented, suggesting the evolution of science reflects psychological repercussions of wearing clothes. Specifically, the natural world is perceived as hidden due to the

Scientific eminence and scientific hierarchy: bibliometric prediction of fellowship in the Australian Academy of Science

in the Australian Academy of Sciences (AAS). Based on ideas of a hierarchy of the sciences, the study also examined whether researchers from natural science fields were advantaged in achieving AAS ... advantaged in achieving AAS fellowship relative to researchers from fields toward the social science end of the hierarchy. In a comprehensive sample of top global researchers, the composite index and its

Global spatial dataset of mangrove genus distribution in seaward and riverine margins

hydrodynamic models. Data may be of interest to researchers in coastal engineering, marine science, wetland ecology and blue carbon. ... Science and SCOPUS. The search was conducted on and before 1st November 2022. Search criteria. Topic search criteria included the following terms: (‘country name’) AND (‘mangrove + zonation’ OR ‘mangrove

Progress with the Learning Health System 2.0: a rapid review of Learning Health Systems’ responses to pandemics and climate change

/Zurynski-Braithwaite’s LHS framework: Science and Informatics, Patient-Clinician Partnerships, Continuous Learning Culture, Incentives, and Structure and Governance. The search yielded 182 unique ... Healthcare Resilience and Implementation Science, Australian Institute of Health Innovation, Macquarie University , 75 Talavera Road, North Ryde 2113, Sydney , Australia 1 NHMRC Partnership Centre for Health