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Tetrazine ligation for chemical proteomics

Determining small molecule—target protein interaction is essential for the chemical proteomics. One of the most important keys to explore biological system in chemical proteomics field is finding

Proteomics of Staphylococcus aureus biofilm matrix in a rat model of orthopedic implant-associated infection

Immun . 2011 ; 79 : 3476 ± 3491 . 10.1128/IAI.00179-11 PMID: 21646455 23. Wang W , Jeffery CJ . An analysis of surface proteomics results reveals novel candidates for intracellular ... , Krut O . Proteomics-based identification of anchorless cell wall proteins as vaccine candidates against Staphylococcus aureus . Infect Immun . 2009 ; 77 : 2719 ± 2729 . https://doi. org/10.1128/IAI.00617

Proteomics in asthma: the clinicians were right after all, were not they?

asthma (defined solely by chest tightness). The authors threw in sophisticated proteomics of induced-sputum supernatant, using reversephase HPLC/tandem mass spectrometry (MS/MS). The normalized data were ... proteomics-driven groups of subjects as defined by PCA and PLS-DA. Not unexpectedly, there were significant differences between patients with asthma and controls revealing differential expression of 23 amongst

Bayesian inference for biomarker discovery in proteomics: an analytic solution

This paper addresses the question of biomarker discovery in proteomics. Given clinical data regarding a list of proteins for a set of individuals, the tackled problem is to extract a short subset of ... ; Proteomics; Biomarker 1 Introduction It is now generally recognized that protein expression analysis is crucial in explaining the changes that occur as a part of disease pathogenesis [1, 2]. In this context

Urinary Proteomics in Predicting Heart Transplantation Outcomes (uPROPHET)—Rationale and database description

Objectives Urinary Proteomics in Predicting Heart Transplantation Outcomes (uPROPHET; NCT03152422) aims: (i) to construct new multidimensional urinary proteomic (UP) classifiers that after heart ... ], renal impairment [8±10], acute coronary syndromes [ 11 ], and even 5-year adverse cardiovascular and cardiac outcomes [ 12 ]. The urinary PROteomics in Predicting HEart Transplantation outcomes

Targeted proteomics reveals promising biomarkers of disease activity and organ involvement in antineutrophil cytoplasmic antibody-associated vasculitis

Targeted proteomics, which involves quantitative analysis of targeted proteins using selected reaction monitoring (SRM) mass spectrometry, has emerged as a new methodology for discovery of clinical

Quantitative proteomics in A30P*A53T α-synuclein transgenic mice reveals upregulation of Sel1l

model is a useful model for analyzing the pathological cascade from aggregated α-synuclein to motor disturbance. Proteomics is a powerful methodology to investigate how protein expression is affected in

Quantitative proteomics analysis reveals the tolerance of wheat to salt stress in response to Enterobacter cloacae SBP-8

]. The development of proteomics tools has greatly facilitated the application of plant protein analysis to investigate plant-rhizobacteria interaction. Many of the plant proteins expressed in response to ... wheat plant would give us insights into the molecular mechanism of salt tolerance. The use of proteomic tools and technologies has facilitated the application of proteomics in the characterization of

Potential urine proteomics biomarkers for primary nephrotic syndrome

study, we suggest that urine proteomics could be a non-invasive and clinically available tool to discriminate MCD from MN and FSGS. ... nephropathy; Nephrotic syndrome; Urine proteomics - Background Nephrotic syndrome (NS) is a nonspecific kidney disorder that can affect individuals of any age, and accounts for about 15% of cases of end-stage

Microwave & magnetic proteomics of macrophages from patients with HIV-associated cognitive impairment

quantitative proteomics study exploring the changes in protein abundance of macrophages isolated from patients with HACI. Further studies are warranted to determine if these proteins may be target candidates for ... , University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico, 2 Department of Chemistry, University of Puerto Rico, Rio Piedras Campus, San Juan, Puerto Rico, 3 RCMI Translational Proteomics

The prediction of late-onset preeclampsia: Results from a longitudinal proteomics study

abundance of 1,125 proteins was measured using an aptamers-based proteomics technique. Protein abundance in normal pregnancies was modeled using linear mixed-effects models to estimate mean abundance as a ... its reagents that allowed the abundance of 1,125 proteins to be profiled [138±140]. Proteomics profiling services were provided by Somalogic, Inc. (Boulder, CO, USA) in December 2014. The serum samples

Proteomics analysis reveals a dynamic diurnal pattern of photosynthesis-related pathways in maize leaves

(iTRAQ)-based proteomics analysis was performed to reveal the dynamic pattern of proteins related to photosynthetic reactions. Steady, single-peak and double-peak protein expression patterns were ... mechanism contributes to highly efficient photosynthesis in maize leaves. To understand the molecular basis of this process, an isobaric tag for relative and absolute quantitation (iTRAQ)-based proteomics

Protein signatures of molecular pathways in non-small cell lung carcinoma (NSCLC): comparison of glycoproteomics and global proteomics

spectrometry (MS) technology featuring proteomics and glycoproteomics to analyze six primary lung SqCCs and eleven ADCs, and we compared the expression level of proteins and glycoproteins in tumors using

Differential cellular responses associated with oxidative stress and cell fate decision under nitrate and phosphate limitations in Thalassiosira pseudonana: Comparative proteomics

of harvest under different cultural conditions. Here, an iTRAQ-LC-MS/MS proteomics approach was used to evaluate relative protein abundances in T. pseudonana cultivated under nitrate or phosphate ... those associated with oxidative stress, cell viability and cell death. This integration of quantitative proteomics provides an in-depth view of cellular metabolic activity associated with ROS production

Shotgun proteomics of the barley seed proteome

differentially abundant seed proteins between the two-rowed Conrad and six-rowed Lacey cultivars. Conclusion This study paves the way for the use of a top-down gel-free proteomics strategy in barley for ... analyzed using 2-DE combined with mass spectrometry which led to the identification of hundreds of proteins [9]. Some of the recent advances in the proteomics field such as shotgun proteomics have not been

Prediction of adjuvant chemotherapy response in triple negative breast cancer with discovery and targeted proteomics

many patients still suffer from a relapse. The main objective of this study was to identify proteomics-based biomarkers that predict the response to standard adjuvant chemotherapy, so that patients at ... Fresno Vara 1 2 0 Proteomics Unit, Center of Genomics Regulation (CRG), Barcelona Institute of Science and Technology (BIST) , Barcelona , Spain , 4 Proteomics Unit, Universitat Pompeu Fabra (UPF

Proteomics in India: the clinical aspect

Proteomics has emerged as a highly promising bioanalytical technique in various aspects of applied biological research. In Indian academia, proteomics research has grown remarkably over the last

A novel workflow combining plaque imaging, plaque and plasma proteomics identifies biomarkers of human coronary atherosclerotic plaque disruption

proteomics analysis by liquid chromatography tandem mass spectrometry (LC–MS/MS). We discovered five novel, plaque-enriched proteins (lipopolysaccharide binding protein, Annexin A5, eukaryotic translocation ... atherosclerosis; Plaque rupture; Proteomics; Biomarkers - Background Atherosclerotic plaque rupture is the culprit event which underpins a majority of acute vascular syndromes such as acute myocardial infarction

iTRAQ-Based Proteomics Reveals Novel Biomarkers for Idiopathic Pulmonary Fibrosis

expressed serum proteins would facilitate the development of biomarkers for IPF diagnosis and prognosis. Proteomics tools allow the high throughput studies of protein expression, and thereby enables the ... applied to IPF, proteomics analysis offers various advantages [ 18, 19 ]. In particular, proteomics indicates the effective existence of functional proteins in studied samples. In addition, high

Identification of novel biomarker and therapeutic target candidates for acute intracerebral hemorrhage by quantitative plasma proteomics

) were prospectively enrolled, and their plasma samples were obtained. The TMT-LC–MS/MS-based proteomics approach was used to quantify the differential proteome across plasma samples, and the results were ... potential pathological mechanism and therapeutic targets underlying ICH. Biomarkers; Acute intracerebral hemorrhage; Proteomics - Background Intracerebral hemorrhage (ICH) caused by ruptured cerebral blood