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STAT3, stem cells, cancer stem cells and p63

it is involved in signaling pathways in many different cell types and under a wide variety of conditions. Besides other functions, STAT3 is an important regulator of normal stem cells and cancer stem ... Tyr705 phosphorylation. For example, a correlation was found between Ser727 phosphorylation in the absence of Tyr705 phosphorylation and survival of neuronal stem cells [ 58 ]. Moreover, constitutive

Efficient induction of functional ameloblasts from human keratinocyte stem cells

tissue-derived epidermal stem cells are capable of differentiating into enamel-secreting ameloblasts and forming teeth with regenerated enamel when recombined with mouse dental mesenchyme that possesses ... enamel indeed warrants further study. Methods: Cultured human keratinocyte stem cells (hKSCs) were treated with fibroblast growth factor 8 (FGF8) and Sonic hedgehog (SHH) for 18 h or 36 h prior to being

Human nail stem cells are retained but hypofunctional during aging

The nail is a continuous skin appendage. Cells located around the nails, which display coordinated homeostatic dynamics and release a flow of stem cells in response to regeneration, have been ... mice. However, very few studies regarding human nail stem cells exist in the literature. Using specimens isolated from humans, we detected an unreported population of cells within the basal layer of

Human stem cells express pannexins

investigated in induced pluripotent stem cells derived from human cord blood endothelial cells (hCBiPS2), in hematopoietic stem cell-derived induced pluripotent stem cells (HSC_F1285_T-iPS2) and in human ... embryonic stem cells (HES-3). The expression of pannexin (Panx) 1-3 mRNAs was analyzed in all three undifferentiated stem cell lines. Stem cells then underwent undirected differentiation into embryoid bodies

Adipose-derived stem cells (MYSTEM® EVO Technology) as a treatment for complex transsphincteric anal fistula

fibrin glue is considered a valid technique in selected patients. A new frontier in the treatment of perianal fistulas is the application of adipose tissue-derived stem cells (ADSCs). There are many ... sources of adult stem cells including the bone marrow, but the discovery of ADSCs paved the way for their large-scale use [ 1 ]. They can be easily obtained from adipose tissue with minimally invasive

Specific markers and properties of synovial mesenchymal stem cells in the surface, stromal, and perivascular regions

Department of Cartilage Regeneration, Tokyo Medical and Dental University , Tokyo , Japan Background: Synovial mesenchymal stem cells (MSCs) are an attractive cell source for cartilage and meniscus ... the three regions. Background Mesenchymal stem cells (MSCs) are an attractive cell source for cell therapies. These cells participate in tissue homoeostasis, remodeling, and repair by ensuring

Early passaging of mesenchymal stem cells does not instigate significant modifications in their immunological behavior

& Therapeutics, University of Manitoba , Winnipeg , Canada Background: Bone marrow-derived allogeneic mesenchymal stem cells (MSCs) from young healthy donors are immunoprivileged and their clinical application ... cells; Lipidomics; Proteomics; Immunoprivilege; Bioenergetics; Passage; Apoptosis Background Bone marrow (BM)-derived mesenchymal stem cells (MSCs) are attractive candidates for cell therapy since these

Cell Cycle Regulation of Stem Cells by MicroRNAs

target transcripts that directly or indirectly coordinate the cell cycle progression of stem cells. Moreover, previous studies have shown that altered expression levels of miRNAs can contribute to ... regulation. However, the precise mechanism underlying miRNAmediated regulation of cell cycle in stem cells is still incompletely understood. In this review, we discuss current knowledge of miRNAs regulatory

Biochemical profiling of rat embryonic stem cells grown on electrospun polyester fibers using synchrotron infrared microspectroscopy

extracellular matrix and could be combined with growth factors and different types of exogenous uncommitted cells [10] or homing factors to stimulate endogenous stem cell migration towards the injury site [11 ... spinal cord repair . Biomaterials . 2008 ; 29 : 1198 - 206 . 18. Xu X-Y , Li X-T , Peng S-W , Xiao J-F , Liu C , Fang G , et al. The behaviour of neural stem cells on polyhydroxyalkanoate nanofiber

Platelet-rich plasma enhances the proliferation of human adipose stem cells through multiple signaling pathways

(PRP) is an autologous blood product that contains a high concentration of several growth factors. Platelet-derived growth factor (PDGF)-BB is a potential mitogen for human adipose-derived stem cells ... . Background Human adipose-derived stem cells (hASCs) were first isolated from human adipose tissue and identified by Zuk et al. in 2001 [ 1 ]. These cells can differentiate toward multiple lineages, such as

Stem cells in the treatment of central nervous system disease

cells as therapeutic interventions in CNS disease. First, a randomised-controlled trial of intravenous mesenchymal stem cells as an immunomodulatory therapy to reduce inflammatory mediated neural damage ... research using stem cells for immunomodulation and brain repair in multiple sclerosis. - Stem cells are dividing cells that exhibit potency (ability to subdivide into multiple different cells types) and

Nitric oxide balances osteoblast and adipocyte lineage differentiation via the JNK/MAPK signaling pathway in periodontal ligament stem cells

periodontal tissue are of mesenchymal origin; thus, investigating the regulatory mechanisms underlying the fate of periodontal ligament stem cells could be beneficial for application in periodontal tissue ... regeneration. Nitric oxide (NO) regulates many biological processes in developing embryos and adult stem cells. The present study was designed to investigate the effects of NO on the function of human

Dental pulp stem cells used to deliver the anticancer drug paclitaxel

behavior as a delivery tool in cancer therapy is essential for evaluating their future clinical potential. Previous in-vivo studies proved the use of mesenchymal stem cells (MSCs) for local delivery of the ... commonest anticancer drug, paclitaxel (PTX). Dental pulp is a relatively abundant noninvasive source of MSCs. We assess dental pulp stem cells (DPSCs), for the first time, as anticancer drug carriers

Strontium ranelate-induced anti-adipocytic effects are involved in negative regulation of autophagy in rat bone marrow mesenchymal stem cells

effects and mechanism of SrRN on adipocytic differentiation from bone marrow mesenchymal stem cells (BMMSCs) remain limited. Methods The cytoactivity of BMMSCs was analyzed by CCK-8 and annexin V-FITC/PI ... analyzed by western blotting, as were proteins related with autophagy and differentiation signaling pathways. Results SrRN had no influence on the vatility of BMMSCs (bone marrow mesenchymal stem cells) and

Evaluation of the effects of ascorbic acid on metabolism of human mesenchymal stem cells

, Yamaguchi 755-8505 , Japan 2 Center for Regenerative Medicine, Yamaguchi University School of Medicine , Minami Kogushi 1-1-1, Ube, Yamaguchi 755-8505 , Japan Background: Mesenchymal stem cells (MSCs) are ... in regenerative medicine. Ascorbic acid; Mesenchymal stem cell; Meztabolome; Transcriptome; Extracellular matrix; Hypoxia Background Mesenchymal stem cells (MSCs) have the ability to differentiate

Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors

approach has limitations in terms of the necessity of immunosuppressive drugs and the availability of matching donors [ 3, 4 ]. Generation of pancreatic β cells from human pluripotent stem cells (hPSCs ... ) has recently attracted much attention. hPSCs, including human embryonic stem cells (hESCs) and human induced PSCs (hiPSCs) can provide an unlimited supply of pancreatic β cells in vitro, which have

Human adipose-derived stem cells inhibit bioactivity of keloid fibroblasts

identified. As multipotent stem cells, human adipose-derived stem cells (ADSCs) may show the possibility for curing diseases such as fibrosis. This study sought to explore the potential role of human ADSCs in ... significantly inhibited keloid fibroblast-related bioactivities. Adipose-derived stem cells; Keloid fibroblasts; Conditioned medium Background A keloid caused by any traumatic stimulus is characterized by

Immunoisolation of stem cells by simultaneous encapsulation and PEGylation

Today, cell therapy is known as an important tool in the treatment of chronic diseases where cells lose their normal function. Immunoisolation systems using microencapsulation or PEGylation have been ... study was to investigate a combination of microencapsulation and PEGylation methods in coating mouse embryonic stem cells (mESCs) to determine its effect in reducing the host's immune response. Therefore

Gas5 is an essential lncRNA regulator for self-renewal and pluripotency of mouse embryonic stem cells and induced pluripotent stem cells

partially proved in embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Methods: In the current study, we investigated mouse ESC (mESC) self-renewal, differentiation, and proliferation in ... emerging regulators in embryonic stem cells (ESCs) [ 4 ]. Several regulatory lncRNAs for pluripotency have been identified in ESCs based on their specific expression pattern [ 5 ]. From recent studies

Highly efficient methods to obtain homogeneous dorsal neural progenitor cells from human and mouse embryonic stem cells and induced pluripotent stem cells

First Affiliated Hospital of Zhengzhou University , Zhengzhou, Henan 450052 , China Background: Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have been widely used to generate ... ability to derive and differentiate human and mouse embryonic stem cells (hESCs and mESCs) into dorsal telencephalic neural progenitor cells (NPCs) has become a useful tool to study early neural development