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Role of stem cells in cancer therapy and cancer stem cells: a review

For over 30 years, stem cells have been used in the replenishment of blood and immune systems damaged by the cancer cells or during treatment of cancer by chemotherapy or radiotherapy. Apart from

Stem Cells: Potential Cures or Abortion Lures?

promising technology is making rapid gains." 2 They defend the acquisition of stem cells from aborted fetuses or from the fertilization of a human egg in a test tube, because of the cells' unique ability to ... repair tissue,3 which holds much promise for new treatments and potential cures. Essentially, this article will explore the scientific and moral debate enveloped in the use of fetal stem cells in medical

Lung Cancer Stem Cells

Lung cancer remains a major cause of cancer-related lethality because of high incidence and recurrence in spite of significant advances in staging and therapies. Recent data indicates that stem cells ... that stem cells situated throughout the airways may initiate cancer formation. These putative stem cells maintain protumorigenic characteristics including high proliferative capacity, multipotent

Racial Disparities in the Allocation of Stem Cells

Care L. 179 (2002) Available at: Follow this and additional works at; http; //via; library; depaul; edu/jhcl DISPARITIES IN THE ALLOCATION STEM CELLS Andrea Flynn* INTRODUCTION On August 9, 2001 ... , President Bush announced that the federal government would fund research on the 64 stem cell lines that meet certain criteria.' These stem cells must come from an embryo that was created for reproductive

The Utility of Embryonic Stem Cells

tility of E m br yonic Stem Cells Gary R. Wright Recommended Citation - The U Cells Article 3 Follow this and additional works at: The Utility of ... Embryonic Stem Cells by The author is the Physician Ethicist of St. Vincent Hospitals and Health Services, Indianapolis, IN He is a former Fellow of the Maclean Center for Clinical Medical Ethics at the

Stem Cells and the Culture Wars

cannot be reduced merely to a disagreement as to the efficacy of embryonic stem cells versus adult stem cells. The debate is really a recapitulation of the fundamental conflict about the dignity and indeed ... will subsequently be implanted. In 1998, scientists succeeded in isolating and growing human stem cells in the laboratory. These stem cells have the potential to develop into any of the different cell

Understanding the colon cancer stem cells and perspectives on treatment

An area of research that has been recently gaining attention is the relationship between cancer stem cell (CSC) biology and chemo-resistance in colon cancer patients. It is well recognized that tumor ... against CSCs. Cancer stem cells; Chemoresistance; Colon cancer - Introduction Colorectal cancer (CRC) is the third leading cause of cancer death worldwide, and the 5-year relative survival rate is only 8

The Generation, Exploitation and Future of Induced Pluripotent Stem Cells

induced pluripotent stem (iPS) cells, subsequent validation, and application of which are reviewed. The experiments investigated here aim to demonstrate the capacity of iPS cells to replace the ethically ... Biochemistry Commons, Cell Biology Commons, Laboratory and Basic Science Recommended Citation - hTe Ge Cells neration, Exploitation and Future of Induced Pluripotent Stem Cover Page Footnote Special thanks

The Ethics of Using Animal Stem Cells

Stem cell research is highly debated in fields of bioethics. This project examines the often-overlooked issue of using animal versus human stem cells. Stem cells can either be cultivated from ... cells can either be cultivated from embryonic cells, which are undifferentiated and pluripotent, or they are cultivated from adult stem cells, which normally replace worn out or damaged cells

Alternatives to Embryonic Stem Cells and Cloning: A Brief Scientific Overview

Advances in recent years have begun to elucidate the distinct mechanisms that maintain embryonic stem cells (ESCs) undifferentiated, self-renewing, and pluripotent. One of the "grails" of therapeutic ... human tissues into a cell with several properties of embryonic stem cells, including self renewal and pluripotency. 1 These reports demonstrate that much of the "grail" has now been found, albeit with

Stem Cells and Cancer in the Liver

Disease Markers 0278-0240 Stem cells and cancer in the liver Hideki Taniguchi 0 1 Tetsuhiro Chiba 1 0 Research Unit for Organ Regeneration, Center for Developmental Biology, Institute of Physical ... presence of somatic stem cells, which have high proliferative capacity, multipotency (capacity to differentiate into multiple mature cells with different functions) and self-renewal capacity (capacity to

Exosomes Derived from miR-214-Enriched Bone Marrow-Derived Mesenchymal Stem Cells Regulate Oxidative Damage in Cardiac Stem Cells by Targeting CaMKII

Cardiac stem cells (CSCs) have emerged as one of the most promising stem cells for cardiac protection. Recently, exosomes from bone marrow-derived mesenchymal stem cells (BMSCs) have been found to ... cardiac stem cells (CSCs) [1–3], and preclinical and clinical studies have provided abundant evidence for the ability of CSCs to improve cardiac function [4–8]. Despite this impressive cardiac repair

Stem Cells in Dentistry: Types of Intra- and Extraoral Tissue-Derived Stem Cells and Clinical Applications

Stem cells are undifferentiated cells, capable of renewing themselves, with the capacity to produce different cell types to regenerate missing tissues and treat diseases. Oral facial tissues have

Keratinocyte stem cells are more resistant to UVA radiation than their direct progeny

The epidermis undergoes constant renewal during its lifetime. This is possible due to a special population of keratinocyte stem cells (KSCs) located at the basal layer. These cells are surrounded by ... cells of origin, surprisingly few studies have addressed the specific responses of these cells to UV radiation. In this study, we showed for the first time that keratinocyte stem cells were more resistant

Stem Cells in Cartilage Diseases and Repair 2018

cartilage has little ability for repairing itself due to the lack of blood supply, nerves, and lymphangion [1]. The aim of this special issue is to understand the role of the stem cells in cartilage diseases ... and regeneration. It has been demonstrated that stem cells play a critical role in tissue regeneration. For more efficient repair of cartilage, the regenerative medicine provides a variety of trials

Between Scylla and Charybdis: Patentability and Morality Related to Human Embryonic Stem Cells

Cells." Intellectual Property Brief 6 , no. 1 (2015): 53-97 The patentability of inventions related to Human Embryonic Stem Cells (HESC) is challenged by the morality provision of various nations ... application......81 INTRODUCTION Inventions related to Human Embryonic Stem Cells (HESC) as a patentable subject matter are in considerable flux.2 In most circumstances, 2. See Amanda Odell West, The Absence

Generation and Applications of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells with fibroblast-like morphology and isolated from the bone marrow via plastic adhesion. Their multipotency and immunoregulatory properties make MSCs ... circumvented by the derivation of MSCs from pluripotent stem cells. In this paper, we review methods that induce and characterize MSCs derived from induced pluripotent stem cells (iPSCs) and introduce MSC

TGF-β Inhibitor SB431542 Promotes the Differentiation of Induced Pluripotent Stem Cells and Embryonic Stem Cells into Mesenchymal-Like Cells

Due to their potential for tissue engineering applications and ability to modulate the immune system and reduce inflammation, mesenchymal stem cells (MSCs) have been explored as a promising option ... associated with the use of this type of cell that limit their applications. Several studies have been exploring the possibility to produce mesenchymal stem cells from pluripotent stem cells (PSCs). The aim of

Cell line-based xenograft mouse model of paediatric glioma stem cells mirrors the clinical course of the patient

stem cell (GSC) lines derived from paediatric GBM were orthotopically transplanted into immunodeficient mice. Overall survival data were collected and histological analysis of the resulting neoplasias ... contrast to PDTX models, where a small portion of a heterogeneous tumour containing unknown numbers of cancer stem cells (25) results in large variabilities between animals and an uneven engraftment rate (26

Vinexin family (SORBS) proteins regulate mechanotransduction in mesenchymal stem cells

The stiffness of extracellular matrix (ECM) directs the differentiation of mesenchymal stem cells (MSCs) through the transcriptional co-activators Yes-associated protein (YAP) and transcriptional ... . For instance, cells migrate more rapidly on rigid substrates as a short-term response. Mesenchymal stem cells (MSCs) preferentially differentiate into adipocytes on soft substrates, whereas they