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STAT3, stem cells, cancer stem cells and p63

it is involved in signaling pathways in many different cell types and under a wide variety of conditions. Besides other functions, STAT3 is an important regulator of normal stem cells and cancer stem ... Tyr705 phosphorylation. For example, a correlation was found between Ser727 phosphorylation in the absence of Tyr705 phosphorylation and survival of neuronal stem cells [ 58 ]. Moreover, constitutive

Modeling human early otic sensory cell development with induced pluripotent stem cells

The inner ear represents a promising system to develop cell-based therapies from human induced pluripotent stem cells (hiPSCs). In the developing ear, Notch signaling plays multiple roles in otic ... leading to permanent hearing loss. Over the past few years, stem cell-based therapy approaches aiming to emulate otic development in the production of HCs from stem cells have received substantial interest

Melatonin rescued interleukin 1β-impaired chondrogenesis of human mesenchymal stem cells

marrow mesenchymal stem cells (BMSCs) to regenerate cartilage is an appealing method, but in the case of OA requires chondrogenesis to take place within an inflamed environment. Our previous study showed ... Mesenchymal Stem Cell Chondrogenic Differentiation Medium (Cyagen Biosciences Inc.). Droplets (12.5 μl) were carefully placed in each interior well of a 24-well plate. Cells were allowed to adhere at 37 °C for

Efficient induction of functional ameloblasts from human keratinocyte stem cells

tissue-derived epidermal stem cells are capable of differentiating into enamel-secreting ameloblasts and forming teeth with regenerated enamel when recombined with mouse dental mesenchyme that possesses ... enamel indeed warrants further study. Methods: Cultured human keratinocyte stem cells (hKSCs) were treated with fibroblast growth factor 8 (FGF8) and Sonic hedgehog (SHH) for 18 h or 36 h prior to being

Actin and myosin II modulate differentiation of pluripotent stem cells

Use of stem cell-based therapies in tissue engineering and regenerative medicine is hindered by efficient means of directed differentiation. For pluripotent stem cells, an initial critical ... motor during spontaneous differentiation of embryonic stem cells in embryoid bodies. We found that inhibiting either actin polymerization or actin-myosin interactions led to a decrease in differentiation

Human stem cells express pannexins

investigated in induced pluripotent stem cells derived from human cord blood endothelial cells (hCBiPS2), in hematopoietic stem cell-derived induced pluripotent stem cells (HSC_F1285_T-iPS2) and in human ... embryonic stem cells (HES-3). The expression of pannexin (Panx) 1-3 mRNAs was analyzed in all three undifferentiated stem cell lines. Stem cells then underwent undirected differentiation into embryoid bodies

Human nail stem cells are retained but hypofunctional during aging

The nail is a continuous skin appendage. Cells located around the nails, which display coordinated homeostatic dynamics and release a flow of stem cells in response to regeneration, have been ... mice. However, very few studies regarding human nail stem cells exist in the literature. Using specimens isolated from humans, we detected an unreported population of cells within the basal layer of

Specific markers and properties of synovial mesenchymal stem cells in the surface, stromal, and perivascular regions

Department of Cartilage Regeneration, Tokyo Medical and Dental University , Tokyo , Japan Background: Synovial mesenchymal stem cells (MSCs) are an attractive cell source for cartilage and meniscus ... the three regions. Background Mesenchymal stem cells (MSCs) are an attractive cell source for cell therapies. These cells participate in tissue homoeostasis, remodeling, and repair by ensuring

Early passaging of mesenchymal stem cells does not instigate significant modifications in their immunological behavior

& Therapeutics, University of Manitoba , Winnipeg , Canada Background: Bone marrow-derived allogeneic mesenchymal stem cells (MSCs) from young healthy donors are immunoprivileged and their clinical application ... cells; Lipidomics; Proteomics; Immunoprivilege; Bioenergetics; Passage; Apoptosis Background Bone marrow (BM)-derived mesenchymal stem cells (MSCs) are attractive candidates for cell therapy since these

Adipose-derived stem cells (MYSTEM® EVO Technology) as a treatment for complex transsphincteric anal fistula

fibrin glue is considered a valid technique in selected patients. A new frontier in the treatment of perianal fistulas is the application of adipose tissue-derived stem cells (ADSCs). There are many ... sources of adult stem cells including the bone marrow, but the discovery of ADSCs paved the way for their large-scale use [ 1 ]. They can be easily obtained from adipose tissue with minimally invasive

Cell Cycle Regulation of Stem Cells by MicroRNAs

target transcripts that directly or indirectly coordinate the cell cycle progression of stem cells. Moreover, previous studies have shown that altered expression levels of miRNAs can contribute to ... regulation. However, the precise mechanism underlying miRNAmediated regulation of cell cycle in stem cells is still incompletely understood. In this review, we discuss current knowledge of miRNAs regulatory

Stem cells in the treatment of central nervous system disease

cells as therapeutic interventions in CNS disease. First, a randomised-controlled trial of intravenous mesenchymal stem cells as an immunomodulatory therapy to reduce inflammatory mediated neural damage ... research using stem cells for immunomodulation and brain repair in multiple sclerosis. - Stem cells are dividing cells that exhibit potency (ability to subdivide into multiple different cells types) and

Stem cells in toxicological research

Appli- cation of Mouse Embryonic Stem Cell Test to Detect Gender- Specific Effect of Chemicals: A Supplementary Tool for Embryo- toxicity Prediction. Chem Res Toxicol Stem cells in toxicological ... invested to improve in vitro systems with stem cells for toxicity testing (Liu et al. 2017; Godoy et al. 2013, 2016; Chen et al. 2017; Cheng et al. 2016; Hammad 2013; Hammad et al. 2017). This field of

Biochemical profiling of rat embryonic stem cells grown on electrospun polyester fibers using synchrotron infrared microspectroscopy

extracellular matrix and could be combined with growth factors and different types of exogenous uncommitted cells [10] or homing factors to stimulate endogenous stem cell migration towards the injury site [11 ... spinal cord repair . Biomaterials . 2008 ; 29 : 1198 - 206 . 18. Xu X-Y , Li X-T , Peng S-W , Xiao J-F , Liu C , Fang G , et al. The behaviour of neural stem cells on polyhydroxyalkanoate nanofiber

Platelet-rich plasma enhances the proliferation of human adipose stem cells through multiple signaling pathways

(PRP) is an autologous blood product that contains a high concentration of several growth factors. Platelet-derived growth factor (PDGF)-BB is a potential mitogen for human adipose-derived stem cells ... . Background Human adipose-derived stem cells (hASCs) were first isolated from human adipose tissue and identified by Zuk et al. in 2001 [ 1 ]. These cells can differentiate toward multiple lineages, such as

Human adipose-derived stem cells inhibit bioactivity of keloid fibroblasts

identified. As multipotent stem cells, human adipose-derived stem cells (ADSCs) may show the possibility for curing diseases such as fibrosis. This study sought to explore the potential role of human ADSCs in ... significantly inhibited keloid fibroblast-related bioactivities. Adipose-derived stem cells; Keloid fibroblasts; Conditioned medium Background A keloid caused by any traumatic stimulus is characterized by

Immunoisolation of stem cells by simultaneous encapsulation and PEGylation

Today, cell therapy is known as an important tool in the treatment of chronic diseases where cells lose their normal function. Immunoisolation systems using microencapsulation or PEGylation have been ... study was to investigate a combination of microencapsulation and PEGylation methods in coating mouse embryonic stem cells (mESCs) to determine its effect in reducing the host's immune response. Therefore

Dental pulp stem cells used to deliver the anticancer drug paclitaxel

behavior as a delivery tool in cancer therapy is essential for evaluating their future clinical potential. Previous in-vivo studies proved the use of mesenchymal stem cells (MSCs) for local delivery of the ... commonest anticancer drug, paclitaxel (PTX). Dental pulp is a relatively abundant noninvasive source of MSCs. We assess dental pulp stem cells (DPSCs), for the first time, as anticancer drug carriers

Human amnion-derived mesenchymal stem cells alleviate lung injury induced by white smoke inhalation in rats

determine the protective effects of human amnion-derived mesenchymal stem cells (hAMSCs) against WSI-induced lung injury in rats. Methods: hAMSCs were injected into rats via the tail vein 4 h after WSI. At 1 ... inhalation; Human amnion-derived mesenchymal stem cells; Lung injury; Cell-based therapy Background Smoke pots and smoke bombs, which are widely used in fire drills or retreats, can produce white smoke

Development of a Novel Large Animal Model to Evaluate Human Dental Pulp Stem Cells for Articular Cartilage Treatment

PurposeChondral lesion is a pathology with high prevalence, reaching as much as 63% of general population and 36% among athletes. The ability of human Dental Pulp Stem Cells (DPSCs) to differentiate ... Stem Cells (DPSCs) to differentiate into chondroblasts in vitro suggests that this stem cell type may be useful for tissue bioengineering. However, we have yet to identify a study of large animal models