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Lung Cancer Stem Cells

Lung cancer remains a major cause of cancer-related lethality because of high incidence and recurrence in spite of significant advances in staging and therapies. Recent data indicates that stem cells ... that stem cells situated throughout the airways may initiate cancer formation. These putative stem cells maintain protumorigenic characteristics including high proliferative capacity, multipotent

Stem Cells and Cancer in the Liver

Disease Markers 0278-0240 Stem cells and cancer in the liver Hideki Taniguchi 0 1 Tetsuhiro Chiba 1 0 Research Unit for Organ Regeneration, Center for Developmental Biology, Institute of Physical ... presence of somatic stem cells, which have high proliferative capacity, multipotency (capacity to differentiate into multiple mature cells with different functions) and self-renewal capacity (capacity to

Vinexin family (SORBS) proteins regulate mechanotransduction in mesenchymal stem cells

The stiffness of extracellular matrix (ECM) directs the differentiation of mesenchymal stem cells (MSCs) through the transcriptional co-activators Yes-associated protein (YAP) and transcriptional ... . For instance, cells migrate more rapidly on rigid substrates as a short-term response. Mesenchymal stem cells (MSCs) preferentially differentiate into adipocytes on soft substrates, whereas they

Stem Cells in Cartilage Diseases and Repair 2018

cartilage has little ability for repairing itself due to the lack of blood supply, nerves, and lymphangion [1]. The aim of this special issue is to understand the role of the stem cells in cartilage diseases ... and regeneration. It has been demonstrated that stem cells play a critical role in tissue regeneration. For more efficient repair of cartilage, the regenerative medicine provides a variety of trials

The osteopontin-CD44 axis in hepatic cancer stem cells regulates IFN signaling and HCV replication

signaling in cancer stem cells (CSCs) positive for epithelial cell adhesion molecule (EpCAM) and CD44. We show that the EpCAM+/CD44+ CSCs show marked HCV replication when compared to EpCAM−/CD44− cells. In ... in lymphocyte activation, hematopoietic differentiation, inflammation, bacterial infection, and cancer18. Recent work has identified CD44 as the most common marker for cancer stem cells (CSCs) in

Circulating Stem Cells in Physiology and Pathology - Recent Studies Published in Stem Cell Reviews and Reports

Mariusz Z. Ratajczak Article First Online: 07 August 2018 180 Downloads Hematopoietic stem cells (HSC) are untired travelers and a small number of these cells circulate under steady ... . Circulating stem cells also show a circadian rhythm of circulation with the peak in the morning hours and nadir at night. Recently, evidence has accumulated that not only HSC but also other types of stem cells

TGF-β Inhibitor SB431542 Promotes the Differentiation of Induced Pluripotent Stem Cells and Embryonic Stem Cells into Mesenchymal-Like Cells

Due to their potential for tissue engineering applications and ability to modulate the immune system and reduce inflammation, mesenchymal stem cells (MSCs) have been explored as a promising option ... associated with the use of this type of cell that limit their applications. Several studies have been exploring the possibility to produce mesenchymal stem cells from pluripotent stem cells (PSCs). The aim of

Characterization of induced tissue-specific stem cells from pancreas by a synthetic self-replicative RNA

Induced pluripotent stem (iPS) cells have significant implications for overcoming most of the ethical issues associated with embryonic stem (ES) cells. Furthermore, our recent study demonstrated the ... demonstrated the generation of induced tissue-specific stem (iTS) cells by transient overexpression of the reprogramming factors using a plasmid combined with tissue-specific selection. In this study, we were

Generation and Applications of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells with fibroblast-like morphology and isolated from the bone marrow via plastic adhesion. Their multipotency and immunoregulatory properties make MSCs ... circumvented by the derivation of MSCs from pluripotent stem cells. In this paper, we review methods that induce and characterize MSCs derived from induced pluripotent stem cells (iPSCs) and introduce MSC

Cancer stem cells as targets for DC-based immunotherapy of colorectal cancer

The therapy of colorectal cancer (CRC) patients is often unsuccessful because of the presence of cancer stem cells (CSCs) resistant to conventional approaches. Dendritic cells (DC)-based protocols ... CRC development, effectiveness of the therapy remains unsatisfactory because of cancer recurrence and metastases. Cancer stem cells (CSCs) were showed to be responsible for metastasis, recurrence

STAT3, stem cells, cancer stem cells and p63

it is involved in signaling pathways in many different cell types and under a wide variety of conditions. Besides other functions, STAT3 is an important regulator of normal stem cells and cancer stem ... Tyr705 phosphorylation. For example, a correlation was found between Ser727 phosphorylation in the absence of Tyr705 phosphorylation and survival of neuronal stem cells [ 58 ]. Moreover, constitutive

Interrupted reprogramming into induced pluripotent stem cells does not rejuvenate human mesenchymal stromal cells

products. MSCs can be rejuvenated by reprogramming into induced pluripotent stem cells (iPSCs), which is associated with complete erasure of age- and senescence-associated DNA methylation (DNAm) patterns ... pluripotent stem cells (iPSCs) may help to overcome at least some of these limitations3,4. iPSCs can be expanded infinitively without any signs of replicative senescence. Subsequently, iPSC-derived MSCs (iMSCs

Transmission Mechanism of Lewy Body-Like α-Synucleinopathies in Dopaminergic Neurons Derived from Human Induced Pluripotent Stem Cells

pluripotent stem cells (hiPSC) in an in vitro human cellular and molecular PD model and in vivo mouse PD model for dopaminergic neuron transplantation. ... ://doi.org/10.1038/nm1747 Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: 861

Foxc2 and BMP2 Induce Osteogenic/Odontogenic Differentiation and Mineralization of Human Stem Cells from Apical Papilla

osteo-/odontogenic differentiation and mineralization of stem cells from apical papilla (SCAP) is still uncertain. In this research, overexpression of Foxc2 gene significantly improved the proliferation ... , engineering and material methods, and suitable biochemical and physicochemical factors to regenerate biological dentin. Human stem cells from apical papilla (SCAP) are considered to be suitable seed cells for

Perspective: bidirectional exosomal transport between cancer stem cells and their fibroblast-rich microenvironment during metastasis formation

Carcinomas are complex structures composed of hierarchically organized distinct cell populations such as cancer stem cells and non-stem (bulk) cancer cells. Their genetic/epigenetic makeup and the ... RNA, which cooperatively support metastatic tumor spread. Here, we briefly overview potential links between cancer stem cells and the exosome-mediated fibroblast-enriched metastatic niche formation to

Current Status of Canine Umbilical Cord Blood-Derived Mesenchymal Stem Cells in Veterinary Medicine

conditions for which limited or no therapeutic options are presently available. Although the application of various types of stem cells, such as bone marrow-derived mesenchymal stem cells (BM-MSCs), adipose ... cells; nonetheless, isolation of mesenchymal stem cells (MSCs) from UCB presents technical challenges. Although MSCs have been isolated from UCB of diverse species such as human, equine, sheep, goat, and

Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cells

Cancer stem cells (CSCs) are a small population of resistant cells inhabiting the tumors. Although comprising only nearly 3% of the tumor mass, these cells were demonstrated to orchestrate ... populations that can either be the direct product of cells with different cellular or embryonic origins, or a byproduct of the asymmetric division of stem-like cells. In agreement, cancer-committed stem-like

Osteogenic Differentiation of Human Mesenchymal Stem cells in a 3D Woven Scaffold

hydroxyapatite powder by melt spinning. Subsequently, scaffolds of these fibers were fabricated by 3D weaving. The differentiation of human mesenchymal stem cells (hMSCs) in vitro was studied on the 3D scaffolds ... bioactive PLA-hydroxyapatite (PLA/HA) composite fibers and evaluate its performance as a bone growth platform in vitro using bone marrow derived human mesenchymal stem cells (hMSCs). Weaving was selected as a

Effect of Functionalized Carbon Nanotubes and their Citric Acid Polymerization on Mesenchymal Stem Cells In Vitro

The effects of acid-functionalized and polycitric acid- (PCA-) polymerized carbon nanotubes (CNTs) in contact with the extracellular membrane of mesenchymal stem cells (MSC), a genetically unmodified ... applications [17, 27, 28, 30, 32]. Although in cell therapy, mesenchymal stem cells (MSCs) cultured on scaffolding are a real option in the field of tissue engineering [33] for generate or repair of new tissue

Human stem cells express pannexins

investigated in induced pluripotent stem cells derived from human cord blood endothelial cells (hCBiPS2), in hematopoietic stem cell-derived induced pluripotent stem cells (HSC_F1285_T-iPS2) and in human ... embryonic stem cells (HES-3). The expression of pannexin (Panx) 1-3 mRNAs was analyzed in all three undifferentiated stem cell lines. Stem cells then underwent undirected differentiation into embryoid bodies