, 28% [95% CI 22–34] of researchers (10 surveys, 2180 respondents) felt that this practice was ‘never’, 24% [95% CI 22–27] ‘rarely’, 25% [95% CI 23–28] ‘sometimes’, 13% [95% CI 9–17] ‘most of the time ... of the justification ‘always justified’ Review item 3a 28% [95% CI 22–34] (2180 respondents in 10 surveys) Review item 3a 24% [95% CI 22–27] (2180 respondents in 10 surveys) Review item 3a 25% [95
Breast cancer is a major health concern, and its accurate diagnosis and management depend on identifying its histological type and biological subtype. Semaphorin-3A (SEMA3A) is a membrane protein ... cores cut before. Then, slides were baked for at 60 min in 60 °C. A Semaphorin 3A, clone EPR19367 was used to demonstrate expression of the secreted protein. Deparaffinization, rehydration and heat
ALPHABETICAL INDEX OF AUTHORS
diazepines (3a–d) or with 2-aminophenol to offer oxazepine (4a–d). The structure of the synthesized compounds was confirmed via melting points, elemental analyses, and different spectroscopic techniques ... anticancer potential. Our results showed that, diazepine (3a) and oxazepine (4a) offered the highest binding energy against the target OMPA/ exo‑1,3‑beta‑glucanase proteins and exhibited the potent
evaluation of lung microbiome. To address this issue, we established a classical acute lung injury (ALI) mice model by intratracheal instillation of lipopolysaccharides (LPS). We found that the bacterial DNA ... controversial which specimen type is preferred for the evaluation of lung microbiome. Methods and results To address this issue, we established a classical acute lung injury (ALI) mice model by intratracheal
Acute lung injury (ALI) remains a high mortality rate with dramatic lung inflammation and alveolar epithelial cell death. Although fatty acid β-oxidation (FAO) impairment has been implicated in the ... roles in lipopolysaccharide (LPS)‑induced ALI remains unclear. Accordingly, we focused on exploring the effect of CPT1A in the context of ALI and the underlying mechanisms. We found that overexpression of
This article discusses the third instalment of Ali Smith’s Seasonal Quartet, a work whose complex multi-voiced narrative addresses various important issues including the role of art in the ... contemporary world. The authors of the article employ two theoretical frameworks, Bakhtin’s theory of dialogism and Vermeulen and van den Akker’s studies on metamodernism, to argue that Smith adopts a dialogical
position 3 and 7 were synthesized and screened for cytotoxic activity utilizing 60 different human cancer cell lines. Furthermore, compounds 3a,b,c,e that revealed potent broad-spectrum anticancer activity ... arrest at the G2-M phase. Moreover, the mechanism of action was determined by determining the topoisomerase inhibitory activity and the molecular modeling study. Compounds 3a,b,c,e showed broad spectrum
Acute lung injury (ALI) as well as its more severe form, acute respiratory distress syndrome (ARDS), frequently leads to an uncontrolled inflammatory response. N6-methyladenosine (m6A) modification ... -methyladenosine (m6A) modification was associated with the progression of several inflammatory diseases. However, the role of methyltransferase-like 14 (METTL14)-mediated m A methylation in ALI/ARDS remains 6 6
In pneumonia, the deficient or delayed pathogen clearance can lead to pathogen proliferation and subsequent overactive immune responses, inducing acute lung injury (ALI). While screening human genome ... analyzed by quantitative mass spectrometry (MS, Fig. 3a). As shown in Fig. 3b, the exosomal proteomic profile of the BALF from the E. coli-induced ALI model was partially different and partially overlapped
Acute lung injury (ALI) represents an aetiologically diverse form of pulmonary damage. Part of the assessment and diagnosis of ALI depends on skilled observer-based scoring of brightfield microscopy ... treatment/therapy. Acute lung injury (ALI) is a form of respiratory failure in which acute inflammation yields disturbances in the endothelial and epithelial barriers, and in its most severe form, manifests
apoptosis, proliferation ability, ROS and inflammatory cytokines level. Bioinformatics and luciferase report analysis confirmed that both miR-22-3p and TRPM7 were downstream targets of circ-Gatad1 ... luciferase reporter analysis confirmed that miR-22-3p inhibited luciferase activity in wild-type cells, but not in mutated cell lines (Fig. 3A and B), suggesting that miR-22-3p was the target of circ-Gatad1
contributions AF: Conceptualisation, Writing– original draft. RA, RG: Writing– review & editing. MM: Writing– review & editing, Formal Analysis. UP: Supervision, Writing– original draft. All authors have read and ... approved the final version of the manuscript. Funding Not applicable. Data availability Not applicable. Declarations Education, Implementation and Team Task Force Chair. All other authors declare that
Malaria-associated acute lung injury (MA-ALI) is a well-recognized clinical complication of severe, complicated malaria that is partly driven by sequestrations of infected red blood cells (iRBCs) on ... experimental MA-ALI mice following GsMTx4 treatment. As shown in Fig. 3A, no obvious morphological abnormality or pathological change was observed in lung tissue in the Naive or GsMTx4 group. Following
Sepsis-induced acute lung injury (ALI) accounts for about 40% of ALI, accompanied by alveolar epithelial injury. The study aimed to reveal the role of circular RNA_0114428 (circ_0114428) in sepsis ... lung injury model [ 22, 23 ]. Based on this model, this work explored the role of circ_0114428 in sepsis-induced ALI, and found that circ_0114428 knockdown protected against LPS-caused lung cell damage
) produced 1-((aryldiazenyl) cyanoacetyl piperidines (3a–d). To create the derivatives of 4-(phenyldiazenyl)-5-(piperidin-1-yl)-1H-pyrazol-3-amine (5a), the propane nitriles (3a–d) were condensed with ... , which was conducted using the AATCC method, revealed that some of the compounds (3a-d) and (4a-d) had impressive antibacterial capabilities against the researched +ve and gram −ve bacteria. For eight
This study aims to the function of miR-22 original mesenchymal stem cells (MSC) on osteosarcoma (OS) proliferation, migration and invasion. Bio-informatics analysis including GEO2R analysis, Gene ... , integration analysis were used to confirmed the target genes (miR‑22, Twist1, CADM1) in OS. RT‑qPCR and western blotting confirmed the different expression of miR‑22, Twist1, CADM1 in OS tissues, MG63 and Saos
During the progression of acute lung injury (ALI), oxidative stress and inflammatory responses always promote each other. The datasets analyzed in this research were acquired from the Gene Expression ... expressed genes (DEGs) were selected with |log2FC| > 1 and p < 0.05 (Fig. 3a). Among them, 69 genes were up-regulated and 2 genes were down-regulated in the ALI samples. Heat map of the expression of up- and
Cronjé et al. Cell Communication and Signaling (2024) 22:180 https://doi.org/10.1186/s12964-024-01534-9 Cell Communication and Signaling Open Access EDITORIAL New trends in cell death: overview ... on May 19–22 (https://celldeath-apoptosis.org) with “New Trends in Cell Death” as the main meeting theme. This was the 29th anniversary of the ICDS Society, a group that was started in 1994 at
