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Pre-operative anaemia is associated with total morbidity burden on days 3 and 5 after cardiac surgery: a cohort study

Background Pre-operative anaemia is associated with mortality and red blood cell (RBC) transfusion requirement after cardiac surgery. However, the effect on post-operative total morbidity burden (TMB) is unknown. We explored the effect of pre-operative anaemia on post-operative TMB. Methods Data were drawn from the Cardiac Post-Operative Morbidity Score (C-POMS) development study ...

Survey of Physicians’ Understanding of Specific Risks Associated with Retigabine

. A. Cooper, and M. Stender were involved in concept and study design, data analysis, and data interpretation; A. Kowalczyk provided operational oversight. All authors have reviewed and approved the

UK clinical guideline for the prevention and treatment of osteoporosis

Great Britain ( 2000 ) Update on pharmacological interventions and an algorithm for management . Royal College of Physicians, London 3. Compston J , Cooper A , Cooper C , Francis R , Kanis JA , Marsh D ... 50 years in the UK . Maturitas 62 : 105 - 108 4. Compston J , Bowring C , Cooper A , Cooper C , Davies C , Francis R , Kanis JA , Marsh D , McCloskey EV , Reid DM , Selby P , National Osteoporosis

Reality Monitoring and Metamemory in Adults with Autism Spectrum Conditions

Studies of reality monitoring (RM) often implicate medial prefrontal cortex (mPFC) in distinguishing internal and external information, a region linked to autism-related deficits in social and self-referential information processing, executive function, and memory. This study used two RM conditions (self-other; perceived-imagined) to investigate RM and metamemory in adults with ...

The descriptive epidemiology of accelerometer-measured physical activity in older adults

Background Objectively measured physical activity between older individuals and between populations has been poorly described. We aimed to describe and compare the variation in accelerometry data in older UK (EPIC-Norfolk) and American (NHANES) adults. Methods Physical activity was measured by uniaxial accelerometry in 4,052 UK (49–91 years) and 3459 US older adults (49–85 years). ...

Potentially inappropriate prescribing in two populations with differing socio-economic profiles: a cross-sectional database study using the PROMPT criteria

Health Services Executive Primary Care Reimbursement 2 scribing Optimally in Middle-aged People's Treatments) 3 Janine A. Cooper 4 HRB Centre for Primary Care Research, Division of Population Health ... ), covering the full population in Northern Ireland and factors associated with PIP, using the PROMPT (PReJanine A. Cooper and Frank Moriarty denotes joint first authorship. - S e r vi c e ( H S E - P C R S

Comprehensive Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Evaluation of Once-Daily Efavirenz 400 and 600 mg in Treatment-Naïve HIV-Infected Patients at 96 Weeks: Results of the ENCORE1 Study

and Pfizer; David A. Cooper has received honoraria and research grant support from Gilead Sciences, Merck Research Laboratories and Bristol–Myers Squibb; and Sean Emery has received research grant

Clinical Utility of a Coronary Heart Disease Risk Prediction Gene Score in UK Healthy Middle Aged Men and in the Pakistani Population

Background Numerous risk prediction algorithms based on conventional risk factors for Coronary Heart Disease (CHD) are available but provide only modest discrimination. The inclusion of genetic information may improve clinical utility. Methods We tested the use of two gene scores (GS) in the prospective second Northwick Park Heart Study (NPHSII) of 2775 healthy UK men (284 cases), ...

You Turn Me Cold: Evidence for Temperature Contagion

Introduction During social interactions, our own physiological responses influence those of others. Synchronization of physiological (and behavioural) responses can facilitate emotional understanding and group coherence through inter-subjectivity. Here we investigate if observing cues indicating a change in another's body temperature results in a corresponding temperature change in ...

Effect of the PPARG2 Pro12Ala Polymorphism on Associations of Physical Activity and Sedentary Time with Markers of Insulin Sensitivity in Those with an Elevated Risk of Type 2 Diabetes

Background Peroxisome proliferator-activated receptor gamma (PPARγ) is an important regulator of metabolic health and a common polymorphism in the PPAR-γ2 gene (PPARG2) may modify associations between lifestyle behaviour and health. Objective To investigate whether the PPARG2 Pro12Ala genotype modifies the associations of sedentary behaviour and moderate-to-vigorous intensity ...

Post-diagnostic prescriptions for low-dose aspirin and breast cancer-specific survival: a nested case-control study in a breast cancer cohort from the UK Clinical Practice Research Datalink

Practice Research Datalink Liam J Murray 0 1 Janine A Cooper Carmel M Hughes Des G Powe Chris R Cardwell 1 0 Centre of Excellence for Public Health (NI), Queen's University Belfast, Institute of Clinical

Osmoregulatory bicarbonate secretion exploits H+-sensitive haemoglobins to autoregulate intestinal O2 delivery in euryhaline teleosts

Marine teleost fish secrete bicarbonate (HCO3 −) into the intestine to aid osmoregulation and limit Ca2+ uptake by carbonate precipitation. Intestinal HCO3 − secretion is associated with an equimolar transport of protons (H+) into the blood, both being proportional to environmental salinity. We hypothesized that the H+-sensitive haemoglobin (Hb) system of seawater teleosts could be ...

Impact of heavy-flavour production cross sections measured by the LHCb experiment on parton distribution functions at low x

:10.1007/ JHEP01(2010)109 11. A. Cooper-Sarkar , P. Mertsch , S. Sarkar , JHEP 1108 , ( 2011 ) 042 arXiv:1106.3723. doi:10.1007/ JHEP08(2011)042 12. L. Pasquali , M.H. Reno , I. Sarcevic , Phys. Rev. D 59

The development of the PROMPT (PRescribing Optimally in Middle-aged People�s Treatments) criteria

Background Whilst multimorbidity is more prevalent with increasing age, approximately 30% of middle-aged adults (45�64 years) are also affected. Several prescribing criteria have been developed to optimise medication use in older people (?65�years) with little focus on potentially inappropriate prescribing (PIP) in middle-aged adults. We have developed a set of explicit prescribing ...

Cerebrospinal Fluid Exposure of Efavirenz and Its Major Metabolites When Dosed at 400 mg and 600 mg Once Daily: A Randomized Controlled Trial

Background. The optimal penetration of antiretroviral agents into the central nervous system may be a balance between providing adequate drug exposure to inhibit human immunodeficiency virus (HIV) replication while avoiding concentrations associated with neuronal toxicities. Methods. Cerebrospinal fluid (CSF) exposure of efavirenz and the metabolites 7-hydroxy (7OH) and 8-hydroxy ...

Differences in the Direction of Change of Cerebral Function Parameters Are Evident over Three Years in HIV-Infected Individuals Electively Commencing Initial cART

from Abbott, Boehringer-Ingelheim, Bristol-Myers Squibb, GlaxoSmithKline, Merck Sharp and Dohme, Roche, IDS, Bayer Schering and Merck Serono. David A. Cooper has received honoraria, consultancies and

Free Protein S Level as a Risk Factor for Coronary Heart Disease and Stroke in a Prospective Cohort Study of Healthy United Kingdom Men

Laboratories, Department of Medicine, Royal Free and University College Medical School, University of London, London, United Kingdom (Gie Ken-Dror, Jackie A. Cooper, Steve E. Humphries, Fotios Drenos, Helen A

Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction

Introduction Activation of the inflammasome has been implicated in the pathology of various autoinflammatory and autoimmune diseases. While the NLRP3 inflammasome has been linked to arthritis progression, little is known about its synovial regulation or contribution to joint histopathology. Regulators of inflammation activation, such as interleukin (IL)-10, may have the potential ...

Dichotomy in the T-linear resistivity in hole-doped cuprates

N. E. Hussey () R. A. Cooper Xiaofeng Xu Y. Wang I. Mouzopoulou B. Vignolle C. Proust 0 State Key Laboratory for Mesoscopic Physics and School of Physics, Peking University , Beijing 100871