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Potentially inappropriate prescribing in two populations with differing socio-economic profiles: a cross-sectional database study using the PROMPT criteria

Health Services Executive Primary Care Reimbursement 2 scribing Optimally in Middle-aged People's Treatments) 3 Janine A. Cooper 4 HRB Centre for Primary Care Research, Division of Population Health ... ), covering the full population in Northern Ireland and factors associated with PIP, using the PROMPT (PReJanine A. Cooper and Frank Moriarty denotes joint first authorship. - S e r vi c e ( H S E - P C R S

The development of the PROMPT (PRescribing Optimally in Middle-aged People�s Treatments) criteria

Background Whilst multimorbidity is more prevalent with increasing age, approximately 30% of middle-aged adults (45�64 years) are also affected. Several prescribing criteria have been developed to optimise medication use in older people (?65�years) with little focus on potentially inappropriate prescribing (PIP) in middle-aged adults. We have developed a set of explicit...

HIV Lipodystrophy in Participants Randomised to Lopinavir/Ritonavir (LPV/r) +2–3 Nucleoside/Nucleotide Reverse Transcriptase Inhibitors (N(t)RTI) or LPV/r + Raltegravir as Second-Line Antiretroviral Therapy

Objective To compare changes over 48 weeks in body fat, lipids, Metabolic Syndrome and cardiovascular disease risk between patients randomised 1∶1 to lopinavir/ritonavir (r/LPV) plus raltegravir (RAL) compared to r/LPV plus 2–3 nucleoside/nucleotide reverse transcriptase inhibitors (N(t)RTIs) as second-line therapy. Methods Participants were HIV-1 positive (>16 years) failing...

Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction

Introduction Activation of the inflammasome has been implicated in the pathology of various autoinflammatory and autoimmune diseases. While the NLRP3 inflammasome has been linked to arthritis progression, little is known about its synovial regulation or contribution to joint histopathology. Regulators of inflammation activation, such as interleukin (IL)-10, may have the potential...

Effect of Rosiglitazone on Peroxisome Proliferator-Activated Receptor γ Gene Expression in Human Adipose Tissue Is Limited by Antiretroviral Drug-Induced Mitochondrial Dysfunction

common conditions. ROSEY INVESTIGATORS Steering committee: Andrew Carr (St. Vincent’s Hospital, Sydney; coprincipal investigator); David A. Cooper (coprincipal investigator), Dianne Carey, Sean Emery ... ; 143 : 337 - 46 . 21. Mallon PW , Sedwell R , Unemori P , Kelleher A , Cooper DA , Carr A . Methodological considerations in human studies of gene expression in HIV-associated lipodystrophy . Antivir