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55 papers found.
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Minority race and male sex as risk factors for non-beneficial gastrostomy tube placements after stroke

. Cooper, Rebecca F. Gottesman. Writing ± review & editing: Roland Faigle, Joseph A. Carrese, Lisa A. Cooper, Victor C. Urrutia, Rebecca F. Gottesman. 10 / 12 11 / 12 1. Feigin VL , Lawes CM , Bennett DA ... , Rebecca F. Gottesman. Project administration: Roland Faigle. Supervision: Rebecca F. Gottesman. Writing ± original draft: Roland Faigle. Conceptualization: Roland Faigle, Joseph A. Carrese, Lisa A

Prospective association between handgrip strength and cardiac structure and function in UK adults

. Sanghvi, Jackie A. Cooper, Elena Lukaschuk, Murray A. Mittleman, Steffen E. Petersen. Funding acquisition: Steffen E. Petersen. Investigation: Sebastian E. Beyer, Nay Aung, Murray A. Mittleman ... . Methodology: Mihir M. Sanghvi, Jackie A. Cooper, Jose Miguel Paiva, Aaron M. Lee, Valentina Carapella, Murray A. Mittleman, Soren Brage, Steffen E. Petersen. Project administration: Steffen E. Petersen

HIV dynamics linked to memory CD4+ T cell homeostasis

nonRAL regimen. (PDF) Author Contributions Conceptualization: John M. Murray, Sean Emery, David A. Cooper, Anthony D. Kelleher. Data curation: John Zaunders, William J. Hey-Nguyen, Kersten K. Koelsch ... , Anthony D. Kelleher. Formal analysis: John M. Murray, William J. Hey-Nguyen, Kersten K. Koelsch. Funding acquisition: Sean Emery, David A. Cooper, Anthony D. Kelleher. 11 / 14 Investigation: John M

Prevalence of self-reported comorbidities in HIV positive and HIV negative men who have sex with men over 55 years—The Australian Positive & Peers Longevity Evaluation Study (APPLES)

: Kathy Petoumenos, Jennifer Hoy, Mark Bloch, David J. Templeton, David Baker, Michelle Giles, Matthew G. Law, David A. Cooper. Formal analysis: Kathy Petoumenos, Robin Huang, Matthew G. Law. 11 / 14 ... Funding acquisition: Kathy Petoumenos, David A. Cooper. Investigation: Kathy Petoumenos, Robin Huang, Jennifer Hoy, Mark Bloch, David J. Templeton, David Baker, Michelle Giles, Matthew G. Law, David A

The impact of cardiovascular risk factors on cardiac structure and function: Insights from the UK Biobank imaging enhancement study

. Cooper, Jose Miguel Paiva, Filip Zemrak, Kenneth Fung, Elena Lukaschuk, Valentina Carapella, Young Jin Kim. Methodology: Steffen E. Petersen, Mihir M. Sanghvi, Nay Aung, Jackie A. Cooper. Project ... & editing: Steffen E. Petersen, Mihir M. Sanghvi, Nay Aung, Jackie A. Cooper, Jose Miguel Paiva, Filip Zemrak, Kenneth Fung, Elena Lukaschuk, Aaron M. Lee, Valentina Carapella, Young Jin Kim, Stefan K

Hell and High Water: Diminished Septic System Performance in Coastal Regions Due to Climate Change

Climate change may affect the ability of soil-based onsite wastewater treatment systems (OWTS) to treat wastewater in coastal regions of the Northeastern United States. Higher temperatures and water tables can affect treatment by reducing the volume of unsaturated soil and oxygen available for treatment, which may result in greater transport of pathogens, nutrients, and biochemical ...

Predicting Cortical Dark/Bright Asymmetries from Natural Image Statistics and Early Visual Transforms

The nervous system has evolved in an environment with structure and predictability. One of the ubiquitous principles of sensory systems is the creation of circuits that capitalize on this predictability. Previous work has identified predictable non-uniformities in the distributions of basic visual features in natural images that are relevant to the encoding tasks of the visual ...

Uveal Melanoma Cells Utilize a Novel Route for Transendothelial Migration

Uveal melanoma arises in the eye, and it spreads to distant organs in almost half of patients, leading to a fatal outcome. To metastasize, uveal melanoma cells must transmigrate into and out of the microvasculature, crossing the monolayer of endothelial cells that separates the vessel lumen from surrounding tissues. We investigated how human uveal melanoma cells cross the ...

Role of Cortactin Homolog HS1 in Transendothelial Migration of Natural Killer Cells

Natural Killer (NK) cells perform many functions that depend on actin assembly, including adhesion, chemotaxis, lytic synapse assembly and cytolysis. HS1, the hematopoietic homolog of cortactin, binds to Arp2/3 complex and promotes actin assembly by helping to form and stabilize actin filament branches. We investigated the role of HS1 in transendothelial migration (TEM) by NK ...

Tipranavir/Ritonavir (500/200 mg and 500/100 mg) Was Virologically Non-Inferior to Lopinavir/Ritonavir (400/100 mg) at Week 48 in Treatment-Naïve HIV-1-Infected Patients: A Randomized, Multinational, Multicenter Trial

Ritonavir-boosted tipranavir (TPV/r) was evaluated as initial therapy in treatment-naïve HIV-1-infected patients because of its potency, unique resistance profile, and high genetic barrier. Trial 1182.33, an open-label, randomized trial, compared two TPV/r dose combinations versus ritonavir-boosted lopinavir (LPV/r). Eligible adults, who had no prior antiretroviral therapy were ...

How Accurate Is MOLLI T1 Mapping In Vivo? Validation by Spin Echo Methods

T1 mapping is a promising quantitative tool for assessing diffuse cardiomyopathies. The purpose of this study is to quantify in vivo accuracy of the Modified Look-Locker Inversion Recovery (MOLLI) cardiac T1 mapping sequence against the spin echo gold standard, which has not been done previously. T1 accuracy of MOLLI was determined by comparing with the gold standard inversion ...

Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress

Two insults often underlie a variety of eye diseases including glaucoma, optic atrophy, and retinal degeneration—defects in mitochondrial function and aberrant Rhodopsin trafficking. Although mitochondrial defects are often associated with oxidative stress, they have not been linked to Rhodopsin trafficking. In an unbiased forward genetic screen designed to isolate mutations that ...

You Turn Me Cold: Evidence for Temperature Contagion

Introduction During social interactions, our own physiological responses influence those of others. Synchronization of physiological (and behavioural) responses can facilitate emotional understanding and group coherence through inter-subjectivity. Here we investigate if observing cues indicating a change in another's body temperature results in a corresponding temperature change in ...

Clinical Utility of a Coronary Heart Disease Risk Prediction Gene Score in UK Healthy Middle Aged Men and in the Pakistani Population

Background Numerous risk prediction algorithms based on conventional risk factors for Coronary Heart Disease (CHD) are available but provide only modest discrimination. The inclusion of genetic information may improve clinical utility. Methods We tested the use of two gene scores (GS) in the prospective second Northwick Park Heart Study (NPHSII) of 2775 healthy UK men (284 cases), ...

Effect of the PPARG2 Pro12Ala Polymorphism on Associations of Physical Activity and Sedentary Time with Markers of Insulin Sensitivity in Those with an Elevated Risk of Type 2 Diabetes

Background Peroxisome proliferator-activated receptor gamma (PPARγ) is an important regulator of metabolic health and a common polymorphism in the PPAR-γ2 gene (PPARG2) may modify associations between lifestyle behaviour and health. Objective To investigate whether the PPARG2 Pro12Ala genotype modifies the associations of sedentary behaviour and moderate-to-vigorous intensity ...

HLA Alleles Association with Changes in Bone Mineral Density in HIV-1-Infected Adults Changing Treatment to Tenofovir-Emtricitabine or Abacavir-Lamivudine

Background There are limited data regarding the influence of human leukocyte antigen (HLA) polymorphisms on reduced bone mineral density (BMD). We investigated the relationship between HLA supertypes and BMD in HIV-infected adults changing their existing treatment to tenofovir-emtricitabine (TDF-FTC) or abacavir-lamivudine (ABC-3TC) in the STEAL study. Methods Lumbar spine and ...

Correction: Raltegravir Non-Inferior to Nucleoside Based Regimens in SECOND-LINE Therapy with Lopinavir/Ritonavir over 96 Weeks: A Randomised Open Label Study for the Treatment Of HIV-1 Infection

. Sohn Hedy Teppler Boris Renjifo Jean-Michel Molina Sean Emery David A. Cooper SECOND-LINE - The group author, SECOND-LINE, was omitted from the author byline and should be listed as the fifteenth

Moving Away from Ritonavir, Abacavir, Tenofovir, and Efavirenz (RATE) - Agents That Concern Prescribers and Patients: A Feasibility Study and Call for a Trial

Objectives Regimens sparing RATE (ritonavir, abacavir, tenofovir, efavirienz) agents might have better long-term safety. We conducted a feasibility exercise to assess the potential for a randomised trial evaluating RATE-sparing regimens. Design Observational. Methods We first calculated RATE-sparing options available to an average patient receiving RATE agents. We reviewed ...

HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days—Implications for HIV Remission

HIV infection can be effectively controlled by anti-retroviral therapy (ART) in most patients. However therapy must be continued for life, because interruption of ART leads to rapid recrudescence of infection from long-lived latently infected cells. A number of approaches are currently being developed to ‘purge’ the reservoir of latently infected cells in order to either eliminate ...