Phosphorylation-dependent protein ubiquitylation and degradation provides an irreversible mechanism to terminate protein kinase signaling. Here, we report that mammary epithelial cells require cullin-5–RING–E3-ubiquitin-ligase complexes (Cul5-CRLs) to prevent transformation by a Src–Cas signaling pathway. Removal of Cul5 stimulates growth-factor-independent growth and migration, ...
Meghan E. Maurer 1 Jonathan A. Cooper ) 0 0 Division of Basic Sciences, Fred Hutchinson Cancer Research Center , 1100 Fairview Avenue N, Seattle, WA 98109, USA 1 Molecular and Cellular Biology
Meghan E. Maurer 0 Jonathan A. Cooper ) 0 0 Division of Basic Sciences and Molecular and Cellular Biology Program, Fred Hutchinson Cancer Research Center , 1100 Fairview Ave N, Seattle, WA, 98109
Andrea N. Ladd 0 Thomas A. Cooper ) 0 0 Department of Pathology, Baylor College of Medicine , One Baylor Plaza, Houston, TX 77030 , USA - Embryonic lethal abnormal vision (ELAV) type RNA binding
R. A. Cooper 0 I. D. Bowen 0 D. Lloyd 0 0 Departments of Microbiology and Zoology, University College , Newport Road, Cardiff, CFi 3NR, Wales The acid -nitrophenyl phosphatase of homogenates of ... . caeca is discussed in view of the inability to detect eleven other latent acid hydrolases in cell-free homogenates. THE PROPERTIES AND SUBCELLULAR ROSEMARY A. COOPER,* I. D. BOWENf AND D. LLOYD