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Impact of the heavy-quark matching scales in PDF fits

We investigate the impact of displaced heavy-quark matching scales in a global fit. The heavy-quark matching scale \(\mu _{m}\) determines at which energy scale \(\mu \) the QCD theory transitions from \(N_{F}\) to \(N_{F}+1\) in the variable flavor number scheme (VFNS) for the evolution of the parton distribution functions (PDFs) and strong coupling \(\alpha _S(\mu )\). We study ...

The impact of cardiovascular risk factors on cardiac structure and function: Insights from the UK Biobank imaging enhancement study

. Cooper, Jose Miguel Paiva, Filip Zemrak, Kenneth Fung, Elena Lukaschuk, Valentina Carapella, Young Jin Kim. Methodology: Steffen E. Petersen, Mihir M. Sanghvi, Nay Aung, Jackie A. Cooper. Project ... & editing: Steffen E. Petersen, Mihir M. Sanghvi, Nay Aung, Jackie A. Cooper, Jose Miguel Paiva, Filip Zemrak, Kenneth Fung, Elena Lukaschuk, Aaron M. Lee, Valentina Carapella, Young Jin Kim, Stefan K

Prevalence of self-reported comorbidities in HIV positive and HIV negative men who have sex with men over 55 years—The Australian Positive & Peers Longevity Evaluation Study (APPLES)

: Kathy Petoumenos, Jennifer Hoy, Mark Bloch, David J. Templeton, David Baker, Michelle Giles, Matthew G. Law, David A. Cooper. Formal analysis: Kathy Petoumenos, Robin Huang, Matthew G. Law. 11 / 14 ... Funding acquisition: Kathy Petoumenos, David A. Cooper. Investigation: Kathy Petoumenos, Robin Huang, Jennifer Hoy, Mark Bloch, David J. Templeton, David Baker, Michelle Giles, Matthew G. Law, David A

Prompt neutrino fluxes in the atmosphere with PROSA parton distribution functions

Effects on atmospheric prompt neutrino fluxes of present uncertainties affecting the nucleon composition are studied by using the PROSA fit to parton distribution functions (PDFs). The PROSA fit extends the precision of the PDFs to low x, which is the kinematic region of relevance for high-energy neutrino production, by taking into account LHCb data on charm and bottom ...

UK clinical guideline for the prevention and treatment of osteoporosis

Great Britain ( 2000 ) Update on pharmacological interventions and an algorithm for management . Royal College of Physicians, London 3. Compston J , Cooper A , Cooper C , Francis R , Kanis JA , Marsh D ... 50 years in the UK . Maturitas 62 : 105 - 108 4. Compston J , Bowring C , Cooper A , Cooper C , Davies C , Francis R , Kanis JA , Marsh D , McCloskey EV , Reid DM , Selby P , National Osteoporosis

Pre-operative anaemia is associated with total morbidity burden on days 3 and 5 after cardiac surgery: a cohort study

Background Pre-operative anaemia is associated with mortality and red blood cell (RBC) transfusion requirement after cardiac surgery. However, the effect on post-operative total morbidity burden (TMB) is unknown. We explored the effect of pre-operative anaemia on post-operative TMB. Methods Data were drawn from the Cardiac Post-Operative Morbidity Score (C-POMS) development study ...

Genetic dissection of sorghum grain quality traits using diverse and segregating populations

Key message Coordinated association and linkage mapping identified 25 grain quality QTLs in multiple environments, and fine mapping of the Wx locus supports the use of high-density genetic markers in linkage mapping. Abstract There is a wide range of end-use products made from cereal grains, and these products often demand different grain characteristics. Fortunately, cereal crop ...

Hell and High Water: Diminished Septic System Performance in Coastal Regions Due to Climate Change

Climate change may affect the ability of soil-based onsite wastewater treatment systems (OWTS) to treat wastewater in coastal regions of the Northeastern United States. Higher temperatures and water tables can affect treatment by reducing the volume of unsaturated soil and oxygen available for treatment, which may result in greater transport of pathogens, nutrients, and biochemical ...

Survey of Physicians’ Understanding of Specific Risks Associated with Retigabine

. A. Cooper, and M. Stender were involved in concept and study design, data analysis, and data interpretation; A. Kowalczyk provided operational oversight. All authors have reviewed and approved the

Reality Monitoring and Metamemory in Adults with Autism Spectrum Conditions

Studies of reality monitoring (RM) often implicate medial prefrontal cortex (mPFC) in distinguishing internal and external information, a region linked to autism-related deficits in social and self-referential information processing, executive function, and memory. This study used two RM conditions (self-other; perceived-imagined) to investigate RM and metamemory in adults with ...

Potentially inappropriate prescribing in two populations with differing socio-economic profiles: a cross-sectional database study using the PROMPT criteria

Health Services Executive Primary Care Reimbursement 2 scribing Optimally in Middle-aged People's Treatments) 3 Janine A. Cooper 4 HRB Centre for Primary Care Research, Division of Population Health ... ), covering the full population in Northern Ireland and factors associated with PIP, using the PROMPT (PReJanine A. Cooper and Frank Moriarty denotes joint first authorship. - S e r vi c e ( H S E - P C R S

The descriptive epidemiology of accelerometer-measured physical activity in older adults

Background Objectively measured physical activity between older individuals and between populations has been poorly described. We aimed to describe and compare the variation in accelerometry data in older UK (EPIC-Norfolk) and American (NHANES) adults. Methods Physical activity was measured by uniaxial accelerometry in 4,052 UK (49–91 years) and 3459 US older adults (49–85 years). ...

Tipranavir/Ritonavir (500/200 mg and 500/100 mg) Was Virologically Non-Inferior to Lopinavir/Ritonavir (400/100 mg) at Week 48 in Treatment-Naïve HIV-1-Infected Patients: A Randomized, Multinational, Multicenter Trial

Ritonavir-boosted tipranavir (TPV/r) was evaluated as initial therapy in treatment-naïve HIV-1-infected patients because of its potency, unique resistance profile, and high genetic barrier. Trial 1182.33, an open-label, randomized trial, compared two TPV/r dose combinations versus ritonavir-boosted lopinavir (LPV/r). Eligible adults, who had no prior antiretroviral therapy were ...

GEneSTATION 1.0: a synthetic resource of diverse evolutionary and functional genomic data for studying the evolution of pregnancy-associated tissues and phenotypes

Mammalian gestation and pregnancy are fast evolving processes that involve the interaction of the fetal, maternal and paternal genomes. Version 1.0 of the GEneSTATION database ( integrates diverse types of omics data across mammals to advance understanding of the genetic basis of gestation and pregnancy-associated phenotypes and to accelerate the translation ...

Comprehensive Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Evaluation of Once-Daily Efavirenz 400 and 600 mg in Treatment-Naïve HIV-Infected Patients at 96 Weeks: Results of the ENCORE1 Study

and Pfizer; David A. Cooper has received honoraria and research grant support from Gilead Sciences, Merck Research Laboratories and Bristol–Myers Squibb; and Sean Emery has received research grant

Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment

A newer generation of anti-cancer drugs targeting underlying somatic genetic driver events have resulted in high single-agent or single-pathway response rates in selected patients, but few patients achieve complete responses and a sizeable fraction of patients relapse within a year. Thus, there is a pressing need for identification of combinations of targeted agents which induce ...

Correction: Raltegravir Non-Inferior to Nucleoside Based Regimens in SECOND-LINE Therapy with Lopinavir/Ritonavir over 96 Weeks: A Randomised Open Label Study for the Treatment Of HIV-1 Infection

. Sohn Hedy Teppler Boris Renjifo Jean-Michel Molina Sean Emery David A. Cooper SECOND-LINE - The group author, SECOND-LINE, was omitted from the author byline and should be listed as the fifteenth

Impact of heavy-flavour production cross sections measured by the LHCb experiment on parton distribution functions at low x

:10.1007/ JHEP01(2010)109 11. A. Cooper-Sarkar , P. Mertsch , S. Sarkar , JHEP 1108 , ( 2011 ) 042 arXiv:1106.3723. doi:10.1007/ JHEP08(2011)042 12. L. Pasquali , M.H. Reno , I. Sarcevic , Phys. Rev. D 59

Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress

Two insults often underlie a variety of eye diseases including glaucoma, optic atrophy, and retinal degeneration—defects in mitochondrial function and aberrant Rhodopsin trafficking. Although mitochondrial defects are often associated with oxidative stress, they have not been linked to Rhodopsin trafficking. In an unbiased forward genetic screen designed to isolate mutations that ...