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Structural, optical, and magnetic study of Ni-doped TiO2 nanoparticles synthesized by sol–gel method

In this research, the effects of transition metal (Ni) doping to metal-oxide nanoparticles (TiO2) were studied. Various weight ratios (5, 10, 15, and 20%) of Ni-to-TiO2 nanoparticles were synthesized using the sol–gel technique. These doped nanoparticles were prepared using titanium butoxide and nickel nitrate as precursors and methanol as a solvent. The effects of Ni doping to...

A Potent Inhibitor of Phosphoinositide 3-Kinase (PI3K) and Mitogen Activated Protein (MAP) Kinase Signalling, Quercetin (3, 3', 4', 5, 7-Pentahydroxyflavone) Promotes Cell Death in Ultraviolet (UV)-B-Irradiated B16F10 Melanoma Cells

Ultraviolet (UV) radiation–induced skin damage contributes strongly to the formation of melanoma, a highly lethal form of skin cancer. Quercetin (Qu), the most widely consumed dietary bioflavonoid and well known inhibitor of phosphoinositide 3-kinase (PI3K) and mitogen activated protein (MAP) kinase signalling, has been reported to be chemopreventive in several forms of non...

Disruption of the methyltransferase-like 23 gene METTL23 causes mild autosomal recessive intellectual disability

We describe the characterization of a gene for mild nonsyndromic autosomal recessive intellectual disability (ID) in two unrelated families, one from Austria, the other from Pakistan. Genome-wide single nucleotide polymorphism microarray analysis enabled us to define a region of homozygosity by descent on chromosome 17q25. Whole-exome sequencing and analysis of this region in an...

Molecular evidence for the association ofCucumber mosaic virus causing mosaic and leaf deformation ofPisum sativum in Western Uttar Pradesh, India

Cucumber mosaic virus associated with the mosaic, leaf deformation and stunting ofPisum sativum was identified as a member of subgroup IB on the basis of the capsid protein gene sequence.

Towards a comprehensive structural variation map of an individual human genome

Background Several genomes have now been sequenced, with millions of genetic variants annotated. While significant progress has been made in mapping single nucleotide polymorphisms (SNPs) and small (<10 bp) insertion/deletions (indels), the annotation of larger structural variants has been less comprehensive. It is still unclear to what extent a typical genome differs from the...