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Mass spectrometry in epidemiological studies: What are the key considerations?

, The Netherlands 1 & Abbas Dehghan The incursion of ''-omics'' (e.g. genomics, epi-genomics, transcriptomics and metabolomics) in epidemiological studies has revolutionized the practice of epidemiology ... epidemiological studies flourish once again. Compliance with ethical standards Conflict of interest Abbas Dehghan has received consultancy and research support from Metagenics Inc. (outside the scope of this

Novel inflammatory markers for incident pre-diabetes and type 2 diabetes: the Rotterdam Study

insulin therapy start. Inflammatory markers; Phase-specific; Pre- diabetes; Type 2 diabetes; Insulin therapy; Novel; IL13; IL17; EN-RAGE - & Abbas Dehghan There is increasing evidence that inflammation ... manuscript. Abbas Dehghan is supported by NWO Grant (veni, 916.12.154) and the EUR Fellowship. Maryam Kavousi is supported by the ZonMw Grant (VENI 91616079). Compliance with ethical standards Conflict of

Serum magnesium and the risk of prediabetes: a population-based cohort study

Aims/hypothesis Previous studies have found an association between serum magnesium and incident diabetes; however, this association may be due to reverse causation, whereby diabetes may induce urinary magnesium loss. In contrast, in prediabetes (defined as impaired fasting glucose), serum glucose levels are below the threshold for urinary magnesium wasting and, hence, unlikely to ...

Serum dehydroepiandrosterone levels are associated with lower risk of type 2 diabetes: the Rotterdam Study

Dehghan 0 Oscar H. Franco 0 0 Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC , Rotterdam , the Netherlands Aims/hypothesis Previous literature documents

Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study

the study participants, the staff from the Rotterdam Study, and the participating general practitioners and pharmacists. The authors Kim VE Braun, Trudy Voortman, Oscar H Franco, and Abbas Dehghan work

Serum dehydroepiandrosterone levels are associated with lower risk of type 2 diabetes: the Rotterdam Study

Aims/hypothesis Previous literature documents controversial results for the impact of dehydroepiandrosterone (DHEA) in glucose metabolism. We aimed to assess the associations between serum levels of DHEA and its main derivatives DHEA sulphate (DHEAS) and androstenedione, as well as the ratio of DHEAS to DHEA, and risk of type 2 diabetes. Methods We used data on serum levels of ...

Thyroid function and risk of type 2 diabetes: a population-based prospective cohort study

Background The association of thyroid function with risk of type 2 diabetes remains elusive. We aimed to investigate the association of thyroid function with incident diabetes and progression from prediabetes to diabetes in a population-based prospective cohort study. Methods We included 8452 participants (mean age 65 years) with thyroid function measurement, defined by ...

ADAMTS13 activity as a novel risk factor for incident type 2 diabetes mellitus: a population-based cohort study

Aims/hypothesis ADAMTS13 is a protease that breaks down von Willebrand factor (VWF) multimers into smaller, less active particles. VWF has been associated with an increased risk of incident type 2 diabetes mellitus. Here, we determine whether ADAMTS13 activity and VWF antigen are associated with incident diabetes. Methods This study included 5176 participants from the Rotterdam ...

The clinical value of metabolic syndrome and risks of cardiometabolic events and mortality in the elderly: the Rotterdam study

Background To evaluate the clinical value of metabolic syndrome based on different definitions [American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI), International Diabetes Federation (IDF) and European Group for the Study of Insulin Resistance (EGIR)] in middle-aged and elderly populations. Methods We studied 8643 participants from the Rotterdam study ...

Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation

Background Genome-wide association studies (GWAS) have identified multiple genetic loci for C-reactive protein (CRP) and lipids, of which some overlap. We aimed to identify genetic pleiotropy among CRP and lipids in order to better understand the shared biology of chronic inflammation and lipid metabolism. Results In a bivariate GWAS, we combined summary statistics of published ...

LOng-term follow-up after liVE kidney donation (LOVE) study: a longitudinal comparison study protocol

Background The benefits of live donor kidney transplantation must be balanced against the potential harm to the donor. Well-designed prospective studies are needed to study the long-term consequences of kidney donation. Methods The “LOng-term follow-up after liVE kidney donation” (LOVE) study is a single center longitudinal cohort study on long-term consequences after living kidney ...

Polyunsaturated Fatty Acids and Serum C-Reactive Protein: The Rotterdam Study

. ACKNOWLEDGMENTS Author affiliations: Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands (Taulant Muka, Jessica C. Kiefte-de Jong, Albert Hofman, Abbas Dehghan, Oscar H

Tobacco smoking is associated with DNA methylation of diabetes susceptibility genes

Netherlands 2 Abbas Dehghan 3 Department of Genetics, University of Groningen, University Medical Centre Groningen , Groningen , the Netherlands Aims/hypothesis Tobacco smoking, a risk factor for diabetes, is

DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

Background Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade inflammation may reveal novel pathways or therapeutic targets for inflammation. Results We performed a meta-analysis of epigenome-wide association studies (EWAS) of ...

Heritabilities, proportions of heritabilities explained by GWAS findings, and implications of cross-phenotype effects on PR interval

Electrocardiogram (ECG) measurements are a powerful tool for evaluating cardiac function and are widely used for the diagnosis and prediction of a variety of conditions, including myocardial infarction, cardiac arrhythmias, and sudden cardiac death. Recently, genome-wide association studies (GWASs) identified a large number of genes related to ECG parameter variability, ...

Vitamin D and C-Reactive Protein: A Mendelian Randomization Study

, Switzerland, sponsored the Vitamin D serum analyses. Abbas Dehghan is supported by NWO grant (veni, 916.12.154) and the EUR Fellowship. O.H. Franco works in ErasmusAGE, a center for aging research across the

The Association between Metabolic Syndrome, Bone Mineral Density, Hip Bone Geometry and Fracture Risk: The Rotterdam Study

The association between metabolic syndrome (MS) and bone health remains unclear. We aimed to study the association between MS and hip bone geometry (HBG), femoral neck bone mineral density (FN-BMD), and the risk of osteoporosis and incident fractures. Data of 2040 women and 1510 men participants in the third visit (1997–1999) of the Rotterdam Study (RSI-3), a prospective population ...

Tobacco smoking is associated with methylation of genes related to coronary artery disease

Background Tobacco smoking, a risk factor for coronary artery disease (CAD), is known to modify DNA methylation. We hypothesized that tobacco smoking modifies methylation of the genes identified for CAD by genome-wide association study (GWAS). Results We selected genomic regions based on 150 single-nucleotide polymorphisms (SNPs) identified in the largest GWAS on CAD. We ...

Thyroid function and age-related macular degeneration: a prospective population-based cohort study - the Rotterdam Study

Background In animal models, lack of thyroid hormone is associated with cone photoreceptor preservation, while administration of high doses of active thyroid hormone leads to deterioration. The association between thyroid function and age-related macular degeneration (AMD) has not been investigated in the general population. Methods Participants of age ≥55 years from the Rotterdam ...

Pleiotropy among Common Genetic Loci Identified for Cardiometabolic Disorders and C-Reactive Protein

would also like to thank all the members of the CHARGE Inflammation Working Group: Abbas Dehghan, Jose Dupuis, Maja Barbalic, Joshua C Bis, Gudny Eiriksdottir, Chen Lu, Niina Pellikka, Henri Wallaschofski ... Working Group Abbas Dehghan, MD, PhD, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, Netherlands (E-mail: ). Conceived and designed the experiments: SL AD. Performed the experiments: SL AD