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Mass spectrometry in epidemiological studies: What are the key considerations?

and such a revolution will let the investments that have made in epidemiological studies flourish once again. Compliance with ethical standards Conflict of interest Abbas Dehghan has received

The association between serum uric acid and the incidence of prediabetes and type 2 diabetes mellitus: The Rotterdam Study

Heemst of Erasmus University Medical Center for their invaluable contribution to the collection and organization of the Conceptualization: Niels van der Schaft, Abbas Dehghan. Data curation: Niels van ... der Schaft, Ke-xin Wen. Formal analysis: Niels van der Schaft, Adela Brahimaj, Abbas Dehghan. Funding acquisition: Oscar H. Franco. Investigation: Niels van der Schaft. Methodology: Niels van der

Age at natural menopause and risk of type 2 diabetes: a prospective cohort study

Aims/hypothesis In this study, we aimed to examine the association between age at natural menopause and risk of type 2 diabetes, and to assess whether this association is independent of potential mediators. Methods We included 3639 postmenopausal women from the prospective, population-based Rotterdam Study. Age at natural menopause was self-reported retrospectively and was...

Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk

Brñnne, Cristen J. Willer, Markku Laakso, Lars Wallentin, Paul W. Franks, Veikko Salomaa, Abbas Dehghan, Thomas Meitinger, Nilesh J. Samani. Formal analysis: Ingrid Brñnne, Christina Willenborg. Funding

Serum dehydroepiandrosterone levels are associated with lower risk of type 2 diabetes: the Rotterdam Study

Dehghan 0 Oscar H. Franco 0 0 Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC , Rotterdam , the Netherlands Aims/hypothesis Previous literature documents

Novel inflammatory markers for incident pre-diabetes and type 2 diabetes: the Rotterdam Study

Department of Neurology, Erasmus University Medical Center , Rotterdam , The Netherlands 2 & Abbas Dehghan 3 Harvard School of Public Health , Boston, MA , USA The immune response involved in each phase of ... had any role in design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. Abbas Dehghan is supported by

Serum dehydroepiandrosterone levels are associated with lower risk of type 2 diabetes: the Rotterdam Study

Dehghan 0 Oscar H. Franco 0 0 Division of Reproductive Medicine, Department of Obstetrics and Gynaecology, Erasmus MC , Rotterdam , the Netherlands Aims/hypothesis Previous literature documents

Thyroid function and risk of type 2 diabetes: a population-based prospective cohort study

Background The association of thyroid function with risk of type 2 diabetes remains elusive. We aimed to investigate the association of thyroid function with incident diabetes and progression from prediabetes to diabetes in a population-based prospective cohort study. Methods We included 8452 participants (mean age 65 years) with thyroid function measurement, defined by thyroid...

Serum magnesium and the risk of prediabetes: a population-based cohort study

Aims/hypothesis Previous studies have found an association between serum magnesium and incident diabetes; however, this association may be due to reverse causation, whereby diabetes may induce urinary magnesium loss. In contrast, in prediabetes (defined as impaired fasting glucose), serum glucose levels are below the threshold for urinary magnesium wasting and, hence, unlikely to...

The clinical value of metabolic syndrome and risks of cardiometabolic events and mortality in the elderly: the Rotterdam study

Background To evaluate the clinical value of metabolic syndrome based on different definitions [American Heart Association/National Heart, Lung and Blood Institute (AHA/NHLBI), International Diabetes Federation (IDF) and European Group for the Study of Insulin Resistance (EGIR)] in middle-aged and elderly populations. Methods We studied 8643 participants from the Rotterdam study...

Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation

Background Genome-wide association studies (GWAS) have identified multiple genetic loci for C-reactive protein (CRP) and lipids, of which some overlap. We aimed to identify genetic pleiotropy among CRP and lipids in order to better understand the shared biology of chronic inflammation and lipid metabolism. Results In a bivariate GWAS, we combined summary statistics of published...

Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study

the study participants, the staff from the Rotterdam Study, and the participating general practitioners and pharmacists. The authors Kim VE Braun, Trudy Voortman, Oscar H Franco, and Abbas Dehghan work

The Role of DNA Methylation and Histone Modifications in Neurodegenerative Diseases: A Systematic Review

Importance Epigenetic modifications of the genome, such as DNA methylation and histone modifications, have been reported to play a role in neurodegenerative diseases (ND) such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). Objective To systematically review studies investigating epigenetic marks in AD or PD. Methods Eleven bibliographic databases (, Medline...

ADAMTS13 activity as a novel risk factor for incident type 2 diabetes mellitus: a population-based cohort study

Aims/hypothesis ADAMTS13 is a protease that breaks down von Willebrand factor (VWF) multimers into smaller, less active particles. VWF has been associated with an increased risk of incident type 2 diabetes mellitus. Here, we determine whether ADAMTS13 activity and VWF antigen are associated with incident diabetes. Methods This study included 5176 participants from the Rotterdam...

Polyunsaturated Fatty Acids and Serum C-Reactive Protein: The Rotterdam Study

. ACKNOWLEDGMENTS Author affiliations: Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands (Taulant Muka, Jessica C. Kiefte-de Jong, Albert Hofman, Abbas Dehghan, Oscar H

LOng-term follow-up after liVE kidney donation (LOVE) study: a longitudinal comparison study protocol

Background The benefits of live donor kidney transplantation must be balanced against the potential harm to the donor. Well-designed prospective studies are needed to study the long-term consequences of kidney donation. Methods The “LOng-term follow-up after liVE kidney donation” (LOVE) study is a single center longitudinal cohort study on long-term consequences after living...

Heritabilities, proportions of heritabilities explained by GWAS findings, and implications of cross-phenotype effects on PR interval

Electrocardiogram (ECG) measurements are a powerful tool for evaluating cardiac function and are widely used for the diagnosis and prediction of a variety of conditions, including myocardial infarction, cardiac arrhythmias, and sudden cardiac death. Recently, genome-wide association studies (GWASs) identified a large number of genes related to ECG parameter variability...

Tobacco smoking is associated with DNA methylation of diabetes susceptibility genes

Netherlands 2 Abbas Dehghan 3 Department of Genetics, University of Groningen, University Medical Centre Groningen , Groningen , the Netherlands Aims/hypothesis Tobacco smoking, a risk factor for diabetes, is

Vitamin D and C-Reactive Protein: A Mendelian Randomization Study

, Switzerland, sponsored the Vitamin D serum analyses. Abbas Dehghan is supported by NWO grant (veni, 916.12.154) and the EUR Fellowship. O.H. Franco works in ErasmusAGE, a center for aging research across the

The Association between Metabolic Syndrome, Bone Mineral Density, Hip Bone Geometry and Fracture Risk: The Rotterdam Study

The association between metabolic syndrome (MS) and bone health remains unclear. We aimed to study the association between MS and hip bone geometry (HBG), femoral neck bone mineral density (FN-BMD), and the risk of osteoporosis and incident fractures. Data of 2040 women and 1510 men participants in the third visit (1997–1999) of the Rotterdam Study (RSI-3), a prospective...