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Short-term Impact of Mass Drug Administration With Dihydroartemisinin Plus Piperaquine on Malaria in Southern Province Zambia: A Cluster-Randomized Controlled Trial

Background. Mass drug administration (MDA) using dihydroartemisinin plus piperaquine (DHAp) represents a potential strategy to clear Plasmodium falciparum infections and reduce the human parasite reservoir. Methods. A cluster-randomized controlled trial in Southern Province, Zambia, was used to assess the short-term impact of 2 rounds of community-wide MDA and household-level ...

The relative contribution of climate variability and vector control coverage to changes in malaria parasite prevalence in Zambia 2006–2012

Background Four malaria indicator surveys (MIS) were conducted in Zambia between 2006 and 2012 to evaluate malaria control scale-up. Nationally, coverage of insecticide-treated nets (ITNs) and indoor residual spraying (IRS) increased over this period, while parasite prevalence in children 1–59 months decreased dramatically between 2006 and 2008, but then increased from 2008 to ...

Incremental impact upon malaria transmission of supplementing pyrethroid-impregnated long-lasting insecticidal nets with indoor residual spraying using pyrethroids or the organophosphate, pirimiphos methyl

Background Long-lasting, insecticidal nets (LLINs) and indoor residual spraying (IRS) are the most widely accepted and applied malaria vector control methods. However, evidence that incremental impact is achieved when they are combined remains limited and inconsistent. Methods Fourteen population clusters of approximately 1000 residents each in Zambia’s Luangwa and Nyimba ...

Assessing the effectiveness of household-level focal mass drug administration and community-wide mass drug administration for reducing malaria parasite infection prevalence and incidence in Southern Province, Zambia: study protocol for a community randomized controlled trial

Finn 0 Victor Chalwe Mukalwa Kamuliwo Busiku Hamainza Hawela Moonga Adam Bennett Josh Yukich 0 Joseph Keating 0 Richard W. Steketee John M. Miller 0 Center for Applied Malaria Research and Evaluation

Comparison of a mobile phone-based malaria reporting system with source participant register data for capturing spatial and temporal trends in epidemiological indicators of malaria transmission collected by community health workers in rural Zambia

Background Timeliness, completeness, and accuracy are key requirements for any surveillance system to reliably monitor disease burden and guide efficient resource prioritization. Evidence that electronic reporting of malaria cases by community health workers (CHWs) meet these requirements remains limited. Methodology Residents of two adjacent rural districts in Zambia were provided ...

Community Coverage with Insecticide-Treated Mosquito Nets and Observed Associations with All-Cause Child Mortality and Malaria Parasite Infections

Development, Tulane School of Public Health and Tropical Medicine, New Orleans, LA, E-mails: and . Adam Bennett, Malaria Elimination Initiative, Global Health Group, University of California, San Francisco, CA

Costs and cost-effectiveness of a large-scale mass testing and treatment intervention for malaria in Southern Province, Zambia

Hamainza Adam Bennett Duncan Earle Mulakwa Kamuliwo Richard W Steketee Thomas P Eisele 0 John M Miller 0 Center for Applied Malaria Research and Evaluation, Tulane University School of Public Health and

Population-Wide Malaria Testing and Treatment with Rapid Diagnostic Tests and Artemether-Lumefantrine in Southern Zambia: A Community Randomized Step-Wedge Control Trial Design

, Syracuse University David B Falk College of Sport and Human Dynamics, Syracuse, NY, E-mail: dalarsen@ syr.edu. Adam Bennett, Malaria Elimination Initiative, Global Health Group, University of California, San

A qualitative study of perceptions of a mass test and treat campaign in Southern Zambia and potential barriers to effectiveness

Background A mass test and treat campaign (MTAT) using rapid diagnostic tests (RDTs) and artemether-lumefantrine (AL) was conducted in Southern Zambia in 2012 and 2013 to reduce the parasite reservoir and progress towards malaria elimination. Through this intervention, community health workers (CHWs) tested all household members with rapid diagnostic tests (RDTs) and provided ...

Coverage and system efficiencies of insecticide-treated nets in Africa from 2000 to 2017

L Moyes Andrew J Tatem Michael Lynch Cristin A Fergus Joshua Yukich Adam Bennett Thomas P Eisele Jan Kolaczinski Richard E Cibulskis Simon I Hay Peter W Gething - Stay current on the latest in life ... . Weiss, Bonnie Mappin, Ursula Dalrymple, Ewan Cameron, Donal Bisanzio, David L. Smith, Catherine L. Moyes, Andrew J. Tatem, Michael Lynch, Cristin A. Fergus, Joshua Yukich, Adam Bennett, Thomas P. Eisele

Spatial-Temporal Variation and Primary Ecological Drivers of Anopheles sinensis Human Biting Rates in Malaria Epidemic-Prone Regions of China

Background Robust malaria vector surveillance is essential for optimally selecting and targeting vector control measures. Sixty-two vector surveillance sites were established between 2005 and 2008 by the national malaria surveillance program in China to measure Anopheles sinensis human biting rates. Using these data to determine the primary ecological drivers of malaria vector ...

Planning long lasting insecticide treated net campaigns: should households’ existing nets be taken into account?

Background Mass distribution of long-lasting insecticide treated bed nets (LLINs) has led to large increases in LLIN coverage in many African countries. As LLIN ownership levels increase, planners of future mass distributions face the challenge of deciding whether to ignore the nets already owned by households or to take these into account and attempt to target individuals or ...

Measuring Coverage in MNCH: Accuracy of Measuring Diagnosis and Treatment of Childhood Malaria from Household Surveys in Zambia

Background To assess progress in the scale-up of rapid diagnostic tests and artemisinin-based combination therapies (ACTs) across Africa, malaria control programs have increasingly relied on standardized national household surveys to determine the proportion of children with a fever in the past 2 wk who received an effective antimalarial within 1–2 d of the onset of fever. Here, ...

Mapping Malaria Transmission Intensity in Malawi, 2000–2010

Control and Prevention and the Malaria Alert Center, University of Malawi College of Medicine. Authors addresses: Adam Bennett, Center for Applied Malaria Research and Evaluation, Department of Global

Monitoring, characterization and control of chronic, symptomatic malaria infections in rural Zambia through monthly household visits by paid community health workers

Background Active, population-wide mass screening and treatment (MSAT) for chronic Plasmodium falciparum carriage to eliminate infectious reservoirs of malaria transmission have proven difficult to apply on large national scales through trained clinicians from central health authorities. Methodology Fourteen population clusters of approximately 1,000 residents centred around health ...

Mass drug administration for the control and elimination of Plasmodium vivax malaria: an ecological study from Jiangsu province, China

Background Recent progress in malaria control has caused renewed interest in mass drug administration (MDA) as a potential elimination strategy but the evidence base is limited. China has extensive experience with MDA, but it is not well documented. Methods An ecological study was conducted to describe the use of MDA for the control and elimination of Plasmodium vivax in Jiangsu ...

Household Possession and Use of Insecticide-Treated Mosquito Nets in Sierra Leone 6 Months after a National Mass-Distribution Campaign

Background In November 2010, Sierra Leone distributed over three million long-lasting insecticide-treated nets (LLINs) with the objective of providing protection from malaria to individuals in all households in the country. Methods We conducted a nationally representative survey six months after the mass distribution campaign to evaluate its impact on household insecticide-treated ...

Estimating Plasmodium falciparum Transmission Rates in Low-Endemic Settings Using a Combination of Community Prevalence and Health Facility Data

As some malaria control programs shift focus from disease control to transmission reduction, there is a need for transmission data to monitor progress. At lower levels of transmission, it becomes increasingly more difficult to measure precisely, for example through entomological studies. Many programs conduct regular cross sectional parasite prevalence surveys, and have access to ...

A quasi-experimental evaluation of an interpersonal communication intervention to increase insecticide-treated net use among children in Zambia

John M Miller Adam Bennett 0 David A Larsen 0 Busiku Hamainza Cynthia Changufu Nicholas Shiliya Thomas P Eisele 0 0 Department of Global Health Systems and Development, Tulane University School of Public

Reductions in Artemisinin-Based Combination Therapy Consumption after the Nationwide Scale up of Routine Malaria Rapid Diagnostic Testing in Zambia

International Development (DFID). Authors addresses: Joshua O. Yukich, Adam Bennett, Joseph Keating, and Thomas P. Eisele, Tulane University School of Public Health and Tropical Medicine, Department of Global