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Analyses of genome wide association data, cytokines, and gene expression in African-Americans with benign ethnic neutropenia

NIH Clinical Center. Author Contributions Conceptualization: Matthew M. Hsieh, Adebowale A. Adeyemo, Edward Ramos, Neil A. Zakai, Mary Cushman, Virginia Howard, Willy A. Flegel, Charles N. Rotimi ... . Funding acquisition: Mary Cushman, Charles N. Rotimi, Griffin P. Rodgers. Methodology: Bashira A. Charles, Matthew M. Hsieh, Adebowale A. Adeyemo, Daniel Shriner, Kyung Chin, Kshitij Srivastava, Neil A

Informed consent and ethical re-use of African genomic data

Rapid advances in human genomic research are increasing the availability of genomic data for secondary analysis. Particularly in the case of vulnerable African populations, ethics and informed consent processes need to be transparent´┐Żboth to ensure participant protection, as well as to share skills and to evolve best practice for informed consent from a shared knowledge base. An...

Genetic Susceptibility to Acute Rheumatic Fever: A Systematic Review and Meta-Analysis of Twin Studies

Background Acute rheumatic fever is considered to be a heritable condition, but the magnitude of the genetic effect is unknown. The objective of this study was to conduct a systematic review and meta-analysis of twin studies of concordance of acute rheumatic fever in order to derive quantitative estimates of the size of the genetic effect. Methods We searched PubMed/MEDLINE, ISI...

Genetic structure in four West African population groups

Background Africa contains the most genetically divergent group of continental populations and several studies have reported that African populations show a high degree of population stratification. In this regard, it is important to investigate the potential for population genetic structure or stratification in genetic epidemiology studies involving multiple African populations...

A genome-wide search replicates evidence of a quantitative trait locus for circulating angiotensin I-converting enzyme (ACE) unlinked to the ACE gene

Background Angiotensin I-converting enzyme (ACE) plays an important role in cardiovascular homeostasis. There is evidence from different ethnic groups that circulating ACE levels are influenced by a quantitative trait locus (QTL) at the ACE gene on chromosome 17. The finding of significant residual familial correlations in different ethnic groups, after accounting for this QTL...

Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele

Adebowale A. Adeyemo Cameron Palmer Yan Meng Muredach Reilly Michael G. Shlipak David Siscovick Michele K. Evans Charles N. Rotimi Michael F. Flessner Michael Ko ttgen L. Adrienne Cupples Caroline S. Fox 0

Genome-wide association of anthropometric traits in African- and African-derived populations

Sun J. Kang Charleston W.K. Chiang Cameron D. Palmer Bamidele O. Tayo Guillaume Lettre Johannah L. Butler Rachel Hackett Adebowale A. Adeyemo Candace Guiducci Ilze Berzins Thutrang T. Nguyen Tao Feng

A Genome-Wide Search for Type 2 Diabetes Susceptibility Genes in West Africans: The Africa America Diabetes Mellitus (AADM) Study

Charles N. Rotimi Guanjie Chen Adebowale A. Adeyemo Paulette Furbert-Harris Debra Guass Jie Zhou Kate Berg Olufemi Adegoke Albert Amoah Samuel Owusu Joseph Acheampong Kofi Agyenim-Boateng Benjamin A