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Characterisation of North American Brucella isolates from marine mammals

Conceptualization: Adrian M. Whatmore. Investigation: Claire Dawson, Jakub Muchowski, Lorraine L. Perrett, Emma Stubberfield, Mark Koylass. Project administration: Adrian M. Whatmore. Resources: Geoffrey Foster ... , Nicholas J. Davison, Christine Quance, Inga F. Sidor, Cara L. Field, Judy St. Leger. Visualization: Claire Dawson, Jakub Muchowski, Emma Stubberfield. Writing ± original draft: Adrian M. Whatmore

The Change of a Medically Important Genus: Worldwide Occurrence of Genetically Diverse Novel Brucella Species in Exotic Frogs

The genus Brucella comprises various species of both veterinary and human medical importance. All species are genetically highly related to each other, sharing intra-species average nucleotide identities (ANI) of > 99%. Infections occur among various warm-blooded animal species, marine mammals, and humans. Until recently, amphibians had not been recognized as a host for Brucella. ...

Brucella genomics as we enter the multi-genome era

The genus Brucella includes species considered among the worlds most important zoonotic pathogens, with brucellosis remaining a significant problem in large parts of the world. Over the last decade a number of Brucella genomes have been fully sequenced providing new insights into this relatively poorly understood group of organisms. In the forthcoming months and years, the ...

Development and assessment of multiplex high resolution melting assay as a tool for rapid single-tube identification of five Brucella species

Background The zoonosis brucellosis causes economically significant reproductive problems in livestock and potentially debilitating disease of humans. Although the causative agent, organisms from the genus Brucella, can be differentiated into a number of species based on phenotypic characteristics, there are also significant differences in genotype that are concordant with ...

Relationships between emm and multilocus sequence types within a global collection of Streptococcus pyogenes

Background The M type-specific surface protein antigens encoded by the 5' end of emm genes are targets of protective host immunity and attractive vaccine candidates against infection by Streptococcus pyogenes, a global human pathogen. A history of genetic change in emm was evaluated for a worldwide collection of > 500 S. pyogenes isolates that were defined for genetic background by ...

Characterisation of the genetic diversity of Brucella by multilocus sequencing

Adrian M Whatmore 0 Lorraine L Perrett 0 Alastair P MacMillan 0 0 Address: Department of Statutory and Exotic Bacterial Diseases , Veterinary Laboratories Agency, Addlestone, Surrey, KT15 3NB , UK

Rapid identification of Brucella isolates to the species level by real time PCR based single nucleotide polymorphism (SNP) analysis

Smith 0 Adrian M Whatmore 0 0 Address: Division of Statutory and Exotic Bacteria, Veterinary Laboratories Agency , Addlestone , UK Background: Brucellosis, caused by members of the genus Brucella

Phenotypic and molecular characterisation of Brucella isolates from marine mammals

Background Bacteria of the genus Brucella are the causative organisms of brucellosis in animals and man. Previous characterisation of Brucella strains originating from marine mammals showed them to be distinct from the terrestrial species and likely to comprise one or more new taxa. Recently two new species comprising Brucella isolates from marine mammals, B. pinnipedialis and B. ...

Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis

Background Streptococcus uberis, a Gram positive bacterial pathogen responsible for a significant proportion of bovine mastitis in commercial dairy herds, colonises multiple body sites of the cow including the gut, genital tract and mammary gland. Comparative analysis of the complete genome sequence of S. uberis strain 0140J was undertaken to help elucidate the biology of this ...

Rapid Evolution of Virulence and Drug Resistance in the Emerging Zoonotic Pathogen Streptococcus suis

Background Streptococcus suis is a zoonotic pathogen that infects pigs and can occasionally cause serious infections in humans. S. suis infections occur sporadically in human Europe and North America, but a recent major outbreak has been described in China with high levels of mortality. The mechanisms of S. suis pathogenesis in humans and pigs are poorly understood. ...