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Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice

D. Parnell 6 John C. Mathers 5 Igor Bendik 4 Lorraine Brennan 9 Carlos Celis-Morales 5 8 Elisa Cirillo 1 Hannelore Daniel 2 Brenda de Kok 1 Ahmed El-Sohemy 10 Susan J. Fairweather-Tait Rosalind

Disclosure of Genetic Information and Change in Dietary Intake: A Randomized Controlled Trial

Background Proponents of consumer genetic tests claim that the information can positively impact health behaviors and aid in chronic disease prevention. However, the effects of disclosing genetic information on dietary intake behavior are not clear. Methods A double-blinded, parallel group, 2∶1 online randomized controlled trial was conducted to determine the short- and long-term...

A randomized trial of genetic information for personalized nutrition

Daiva E. Nielsen 0 Ahmed El-Sohemy 0 0 D. E. Nielsen A. El-Sohemy (&) Department of Nutritional Sciences , Room 350, University of Toronto, 150 College St , Toronto , ON M5S 3E2, Canada Personal ... a grant from the Advanced Foods and Materials Network (AFMNet). Ahmed El-Sohemy holds a Canada Research Chair in Nutrigenomics. The authors would like to thank Maria Tassone for her assistance with

Ethnicity, sex, FADS genetic variation, and hormonal contraceptive use influence delta-5- and delta-6-desaturase indices and plasma docosahexaenoic acid concentration in young Canadian adults: a cross-sectional study

Background There is great interest in the relationship between polyunsaturated fatty acids and health. Yet, the combinatory effect of factors such as sex, ethnicity, genetic polymorphisms and hormonal contraceptives (HC) on the concentrations of these fatty acids is unknown. Therefore, we sought to determine the effects of FADS polymorphisms, and HC use in females, on aggregate...

ABO Genotype, ‘Blood-Type’ Diet and Cardiometabolic Risk Factors

Background The ‘Blood-Type’ diet advises individuals to eat according to their ABO blood group to improve their health and decrease risk of chronic diseases such as cardiovascular disease. However, the association between blood type-based dietary patterns and health outcomes has not been examined. The objective of this study was to determine the association between ‘blood-type...

Comprehensive Profiling of Plasma Fatty Acid Concentrations in Young Healthy Canadian Adults

Circulating fatty acids (FA) are associated with a multitude of chronic diseases. However, a major gap in establishing such relationships is the lack of accepted fatty acid reference ranges representing healthy individuals. Data on validated FA reference ranges would provide a better understanding of study baseline measures and aid in the evaluation and interpretation of...

Effects of 9cis,11trans and 10trans,12cis CLA on osteoclast formation and activity from human CD14+ monocytes

Advanced Foods and Materials Network. Ilana Platt is a recipient of a Natural Sciences and Engineering Research Council of Canada Postgraduate Scholarship. Ahmed El-Sohemy holds a Canada Research Chair in

Genetic Variation in Putative Salt Taste Receptors and Salt Taste Perception in Humans

The objective of this study was to determine whether single nucleotide polymorphisms (SNPs) in the SCNN1A (3), SCNN1B (12), SCNN1G (6), and TRPV1 (10) genes affect salt taste perception. Participants were men (n = 28) and women (n = 67) from the Toronto Nutrigenomics and Health study aged 21–31 years. Taste thresholds were determined using a 3-alternative forced-choice staircase...

Association between circulating ascorbic acid, α-tocopherol, 25-hydroxyvitamin D, and plasma cytokine concentrations in young adults: a cross-sectional study

Background Inflammation and oxidative stress are associated with the development of numerous chronic diseases. Circulating ascorbic acid, α-tocopherol, and 25-hydroxyvitamin D (25(OH)D) may help reduce concentrations of pro-inflammatory cytokines through their antioxidant and anti-inflammatory properties. These micronutrients may act synergistically, and they may have different...

Novel Effects of Hormonal Contraceptive Use on the Plasma Proteome

-Sohemy 0 Rizwan Hasan Khan, Aligarh Muslim University, India 0 1 Department of Nutritional Sciences, Faculty of Medicine, University of Toronto , Toronto, Ontario , Canada , 2 Institute of Food, Nutrition

Plasma concentration of cis9trans11 CLA in males and females is influenced by SCD1 genetic variations and hormonal contraceptives: a cross-sectional study

Background The conjugated linoleic acid isomer cis9trans11 CLA can be endogenously synthesized from trans vaccenic acid (C18:1 t11) via desaturation at the delta 9 position catalyzed by the stearoyl-CoA desaturase 1 (SCD1), also known as delta-9 desaturase (D9D). Diet, hormonal regulation of gene expression and single nucleotide polymorphisms (SNPs) have been implicated in...

Ethnic- and sex-specific associations between plasma fatty acids and markers of insulin resistance in healthy young adults

Background Although evidence indicates that fatty acids (FA) can affect insulin resistance (IR), not all FA contribute equally to the process. Indeed, monounsaturated FA (MUFA) and polyunsaturated FA (PUFA) are reported to reduce IR, whereas saturated FA (SFA) and trans FA appear to increase IR. However, it is not yet clear how individual FA are associated with markers of IR, and...

Vitamin C Deficiency in a Population of Young Canadian Adults

Toronto , Toronto, Ontario , Canada ( Leah Cahill, Ahmed El-Sohemy); and Dalla Lana School of Public Health Sciences, University of Toronto , Toronto, Ontario , Canada ( Paul N. Corey). This work was

Comparison of body mass index and waist circumference as predictors of cardiometabolic health in a population of young Canadian adults

Background This study aimed to investigate whether waist circumference (WC) or body mass index (BMI) is a better predictor of blood lipid concentrations among young men and women from different ethnocultural groups. Methods Participants were 1181 healthy men (n = 358) and women (n = 823) aged 20-29 years taken from the cross-sectional Toronto Nutrigenomics and Health Study...

Genetic polymorphisms of innate immunity-related inflammatory pathways and their association with factors related to type 2 diabetes

Background Type 2 diabetes mellitus (T2DM) has been linked to a state of pre-clinical chronic inflammation resulting from abnormalities in the innate immune pathway. Serum levels of pro-inflammatory cytokines and acute-phase proteins, collectively known as 'inflammatory network', are elevated in the pre-, or early, stages of T2DM and increase with disease progression. Genetic...

Inhibition of N-methyl-N-nitrosourea- and 7,12-dimethylbenz[a] anthracene-induced rat mammary tumorigenesis by dietary cholesterol is independent of Ha-ras mutations

Ahmed El-Sohemy 0 Michael C.Archer 0 0 Department of Nutritional Sciences, Faculty of Medicine, University of Toronto , FitzGerald Building, 150 College Street, Toronto M5S 3E2 , Canada 1To whom

The Micronutrient Genomics Project: a community-driven knowledge base for micronutrient research

Micronutrients influence multiple metabolic pathways including oxidative and inflammatory processes. Optimum micronutrient supply is important for the maintenance of homeostasis in metabolism and, ultimately, for maintaining good health. With advances in systems biology and genomics technologies, it is becoming feasible to assess the activity of single and multiple micronutrients...