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Search: authors:"Akiyoshi Hirayama"

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Reliability of plasma polar metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry

of the Tsuruoka Metabolomic Cohort Study team for their commitment to the project. Author Contributions Conceptualization: Sei Harada, Akiyoshi Hirayama, Toru Takebayashi. Data curation: Sei Harada ... , Akiyoshi Hirayama, Masahiro Sugimoto, Toru Takebayashi. Formal analysis: Sei Harada, Timothy M. D. Ebbels. Funding acquisition: Sei Harada, Paul Elliott, Masaru Tomita, Tomoyoshi Soga, Toru Takebayashi

Metabolic Profiling of Total Physical Activity and Sedentary Behavior in Community-Dwelling Men

Objective Physical activity is known to be preventive against various non-communicable diseases. We investigated the relationship between daily physical activity level and plasma metabolites using a targeted metabolomics approach in a population-based study. Methods A total of 1,193 participants (male, aged 35 to 74 years) with fasting blood samples were selected from the...

Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles

Advanced Biosciences, Keio University, 246-2 Mizukami Kakuganji, Tsuruoka Yamagata 997-0052, JapanMasahiro Sugimoto, Akiyoshi Hirayama & Tomoyoshi SogaCellular Function Imaging Team, Division of Bio-function ... , JapanYasuyoshi Watanabe AuthorsSearch for Emi Yamano in:Nature Research journals • PubMed • Google ScholarSearch for Masahiro Sugimoto in:Nature Research journals • PubMed • Google ScholarSearch for Akiyoshi

Metabolomic profiling reveals novel biomarkers of alcohol intake and alcohol-induced liver injury in community-dwelling men

Objective Metabolomics is a promising approach to the identification of biomarkers in plasma. Here, we performed a population-based, cross-sectional study to identify potential biomarkers of alcohol intake and alcohol-induced liver injury by metabolomic profiling using capillary electrophoresis-mass spectrometry (CE-MS). Methods Fasting plasma samples were collected from 896...

Dynamic Simulation and Metabolome Analysis of Long-Term Erythrocyte Storage in Adenine–Guanosine Solution

Although intraerythrocytic ATP and 2,3-bisphophoglycerate (2,3-BPG) are known as direct indicators of the viability of preserved red blood cells and the efficiency of post-transfusion oxygen delivery, no current blood storage method in practical use has succeeded in maintaining both these metabolites at high levels for long periods. In this study, we constructed a mathematical...

Metabolomic study of Chilean biomining bacteria Acidithiobacillus ferrooxidans strain Wenelen and Acidithiobacillus thiooxidans strain Licanantay

In this study, we present the first metabolic profiles for two bioleaching bacteria using capillary electrophoresis coupled with mass spectrometry. The bacteria, Acidithiobacillus ferrooxidans strain Wenelen (DSM 16786) and Acidithiobacillus thiooxidans strain Licanantay (DSM 17318), were sampled at different growth phases and on different substrates: the former was grown with...

Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles

Saliva is a readily accessible and informative biofluid, making it ideal for the early detection of a wide range of diseases including cardiovascular, renal, and autoimmune diseases, viral and bacterial infections and, importantly, cancers. Saliva-based diagnostics, particularly those based on metabolomics technology, are emerging and offer a promising clinical strategy...

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

Okada 0 Wado Akamatsu 0 Masato Koike Naoko Kuzumaki 0 Hideki Hayakawa Tomoko Nihira Tetsuro Kobayashi Manabu Ohyama Shigeto Sato Masashi Takanashi Manabu Funayama Akiyoshi Hirayama Tomoyoshi Soga Takako