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Diagnostic utility of whole body Dixon MRI in multiple myeloma: A multi-reader study

: Timothy J. P. Bray, Kannan Rajesparan, Farzana Rahman, Priya Narayanan, Sahar Naaseri, Alan Bainbridge, Margaret A. Hall-Craggs. Methodology: Timothy J. P. Bray, Saurabh Singh, Arash Latifoltojar, Andre ... Lopes, Alan Bainbridge, Margaret A. Hall-Craggs. Project administration: Alan Bainbridge, Shonit Punwani, Margaret A. Hall-Craggs. Resources: Alan Bainbridge, Margaret A. Hall-Craggs. Software: Timothy

Whole-body MRI quantitative biomarkers are associated significantly with treatment response in patients with newly diagnosed symptomatic multiple myeloma following bortezomib induction

Objectives To evaluate whole-body MRI (WB-MRI) parameters significantly associated with treatment response in multiple myeloma (MM). Methods Twenty-one MM patients underwent WB-MRI at diagnosis and after two cycles of chemotherapy. Scans acquired at 3.0 T included T2, diffusion-weighted-imaging (DWI) and mDixon pre- and post-contrast. Twenty focal lesions (FLs) matched on DWI and...

Modelling Blood Flow and Metabolism in the Preclinical Neonatal Brain during and Following Hypoxic-Ischaemia

Hypoxia-ischaemia (HI) is a major cause of neonatal brain injury, often leading to long-term damage or death. In order to improve understanding and test new treatments, piglets are used as preclinical models for human neonates. We have extended an earlier computational model of piglet cerebral physiology for application to multimodal experimental data recorded during episodes of...

Neonatal Encephalopathic Cerebral Injury in South India Assessed by Perinatal Magnetic Resonance Biomarkers and Early Childhood Neurodevelopmental Outcome

Although brain injury after neonatal encephalopathy has been characterised well in high-income countries, little is known about such injury in low- and middle-income countries. Such injury accounts for an estimated 1 million neonatal deaths per year. We used magnetic resonance (MR) biomarkers to characterise perinatal brain injury, and examined early childhood outcomes in South...