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16 papers found.
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Whole exome sequencing in neurogenetic odysseys: An effective, cost- and time-saving diagnostic approach

diagnostic yield of our cohort according to phenotype. (TIFF) Author Contributions Conceptualization: Marta CoÂrdoba, Marcelo AndreÂs Kauffman. Data curation: Marta CoÂrdoba, Sergio Alejandro Rodriguez ... CoÂrdoba, Sergio Alejandro Rodriguez-Quiroga, Patricia AnalÂõa Vega, Josefina Perez-Maturo, Marcelo AndreÂs Kauffman. 11 / 13 12. 12 / 13 1. Carmichael N , Tsipis J , Windmueller G , Mandel L , Estrella E

Managing obstructive gastric volvulus: challenges and solutions

Managing obstructive gastric volvulus: challenges and solutions Hector Alejandro Rodriguez-G,1 Andrew S Wright,2–4 Robert B Yates1–3 1Department of Surgery, Center for Esophageal and Gastric Surgery

Unconditional quantile regressions to determine the social gradient of obesity in Spain 1993–2014

Background There is a well-documented social gradient in obesity in most developed countries. Many previous studies have conventionally categorised individuals according to their body mass index (BMI), focusing on those above a certain threshold and thus ignoring a large amount of the BMI distribution. Others have used linear BMI models, relying on mean effects that may mask...

One-view digital breast tomosynthesis as a stand-alone modality for breast cancer detection: do we need more?

Purpose To compare the performance of one-view digital breast tomosynthesis (1v-DBT) to that of three other protocols combining DBT and mammography (DM) for breast cancer detection. Materials and methods Six radiologists, three experienced with 1v-DBT in screening, retrospectively reviewed 181 cases (76 malignant, 50 benign, 55 normal) in two sessions. First, they scored...

Stress sensitivity of a fission yeast strain lacking histidine kinases is rescued by the ectopic expression of Chk1 from Candida albicans

The development of new drugs against the pathogenic yeast Candida albicans is compelling and the evolution of relevant bioassays is important to achieve this goal. Promising drug targets are proteins that lack human counterparts which are true for the His-to-Asp phosphorelay signal transduction systems, important for stress sensing in bacteria, fungi, and plants. In the...

Epidemiology of sepsis in Catalonia: analysis of incidence and outcomes in a European setting

Montserrat Clèries Anna Bosch Carol Lorencio Alejandro Rodriguez Xavier Nuvials Ignacio Martin‑Loeches Antoni Artigas SOCMIC (Catalonian Critical Care Society) Sepsis Working Group Background: Up‑ to‑ date

Lifestyle domains as determinants of wheeze prevalence in urban and rural schoolchildren in Ecuador: cross sectional analysis

Background The acquisition of a modern lifestyle may explain variations in asthma prevalence between urban and rural areas in developing countries. However, the effects of lifestyle on asthma have been investigated as individual factors with little consideration given to the effects of lifestyle as a set of attributes. The aim of the present study was to identify modern lifestyle...

Risk Factors for Soil-Transmitted Helminth Infections during the First 3 Years of Life in the Tropics; Findings from a Birth Cohort

Background Soil-transmitted helminths (STH) infect more than 2 billion humans worldwide, causing significant morbidity in children. There are few data on the epidemiology and risk factors for infection in pre-school children. To investigate risk factors for infection in early childhood, we analysed data prospectively collected in the ECUAVIDA birth cohort in Ecuador. Methods and...

Significant In Vivo Anti-Inflammatory Activity of Pytren4Q-Mn a Superoxide Dismutase 2 (SOD2) Mimetic Scorpiand-Like Mn (II) Complex

Background The clinical use of purified SOD enzymes has strong limitations due to their large molecular size, high production cost and immunogenicity. These limitations could be compensated by using instead synthetic SOD mimetic compounds of low molecular weight. Background/Methodology We have recently reported that two SOD mimetic compounds, the MnII complexes of the polyamines...

Silencing Motifs in the Clr2 Protein from Fission Yeast, Schizosaccharomyces pombe

The fission yeast, Schizosaccharomyces pombe, is a well-established model for heterochromatin formation, but the exact sequence of events for initiation remains to be elucidated. The essential factors involved include RNA transcribed from repeated sequences together with the methyltransferase Clr4. In addition, histone deacetylases, like Clr3, found in the SHREC complex are also...

Effects of the Histone Deacetylase Inhibitor Valproic Acid on Human Pericytes In Vitro

Microvascular pericytes are of key importance in neoformation of blood vessels, in stabilization of newly formed vessels as well as maintenance of angiostasis in resting tissues. Furthermore, pericytes are capable of differentiating into pro-fibrotic collagen type I producing fibroblasts. The present study investigates the effects of the histone deacetylase (HDAC) inhibitor...

Maternal Geohelminth Infections Are Associated with an Increased Susceptibility to Geohelminth Infection in Children: A Case-Control Study

Background Children of mothers infected with soil-transmitted helminths (STH) may have an increased susceptibility to STH infection. Methods and Findings We did a case-control study nested in a birth cohort in Ecuador. Data from 1,004 children aged 7 months to 3 years were analyzed. Cases were defined as children with Ascaris lumbricoides and/or Trichuris trichiura, controls...

Pandemic and post-pandemic Influenza A (H1N1) infection in critically ill patients

Laborda 7 Rosa Granada 6 Juan Bonastre 5 Mar Martn 10 Josu Insausti 9 Angel Arenzana 3 Jose Eugenio Guerrero 13 Ines Navarrete 14 Jesus Bermejo-Martin 11 David Suarez 12 Alejandro Rodriguez 2 for the H 0 4

Impact of Long-Term Treatment with Ivermectin on the Prevalence and Intensity of Soil-Transmitted Helminth Infections

Background Control of soil-transmitted helminth (STH) infections relies on the periodic and long-term administration of anthelmintic drugs to high-risk groups, particularly school-age children living in endemic areas. There is limited data on the effectiveness of long-term periodic anthelmintic treatment on the prevalence of STHs, particularly from operational programmes. The...

Risk factors for asthma and allergy associated with urban migration: background and methodology of a cross-sectional study in Afro-Ecuadorian school children in Northeastern Ecuador (Esmeraldas-SCAALA Study)

Background Asthma and allergic diseases are becoming increasingly frequent in children in urban centres of Latin America although the prevalence of allergic disease is still low in rural areas. Understanding better why the prevalence of asthma is greater in urban migrant populations and the role of risk factors such as life style and environmental exposures, may be key to...