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Mechanical phenotyping of K562 cells by the Micropipette Aspiration Technique allows identifying mechanical changes induced by drugs

Mechanical properties of living cells can be used as reliable markers of their state, such as the presence of a pathological state or their differentiation phase. The mechanical behavior of cells depends on the organization of their cytoskeletal network and the main contribution typically comes from the actomyosin contractile system, in both suspended and adherent cells. In the...

Persistence of bacterial indicators and zoonotic pathogens in contaminated cattle wastes

Background Manure can provide a favourable environment for pathogens’ survival. De-contamination may be conducted by extended storage, until field conditions are suitable for application to land as source of agricultural nutrients. Results The hygienic evaluation of manure and slurry coming from a plant that collects cattle livestock wastes from a big slaughterhouse was carried...

Clinical evaluation of a nutraceutical diet as an adjuvant to pharmacological treatment in dogs affected by Keratoconjunctivitis sicca

Background Canine keratoconjunctivitis sicca (cKCS) is an inflammatory eye condition related to a deficiency in the tear aqueous fraction. Etiopathogenesis of such disease is substantially multifactorial, combining the individual genetic background with environmental factors that contribute to the process of immunological tolerance disruption and, as a consequence, to the...

Jurassic surgery and immunity enhancement by alkyglycerols of shark liver oil

Background Shark liver oil (SLO) contains both alkylglycerols (AKG) and squalene and is an ancient remedy among the fishermen on the west coast of Norway and Sweden. Literature reports showed that alkyglycerols enhance Fc–receptor mediated phagocytosis, increase humoral immune response and delay hypersensitivity reactions. Methods On this background we performed an open...

Clinical evaluation of an antiinflammatory and antioxidant diet effect in 30 dogs affected by chronic otitis externa: preliminary results

Sciences, University of Naples Federico II , Naples , Italy 2 Sara Centenaro 3 Alessandro Di Cerbo 4 Department of Science, University of Basilicata , Potenza , Italy 5 School of Biosciences and Veterinary ... efficacy of a combined therapy with drugs and a specific nutraceutical diet. Nutraceutical diet; Otitis externa; Symptoms intensity decrease; Antiinflammatory and antioxidant activities - Alessandro Di

A preliminary study of painless and effective transdermal botulinum toxin A delivery by jet nebulization for treatment of primary hyperhidrosis

A preliminary study of painless and effective transdermal botulinum toxin A delivery by jet nebulization for treatment of primary hyperhidrosis Tommaso Iannitti,1,2 Beniamino Palmieri,3 Anna Aspiro,3 Alessandro Di Cerbo2,3 1School of Biomedical Sciences, University of Leeds, Leeds, UK; 2Poliambulatorio del Secondo Parere, Modena, Italy; 3Department of Surgery and Surgical...

In Vitro Effects of Some Botanicals with Anti-Inflammatory and Antitoxic Activity

the scientific community. Authors’ Contributions Gianandrea Guidetti, Alessandro Di Cerbo, Angela Giovazzino, and Valentina Rubino contributed equally to this work. References P. J. Delves and I. M

Onco-epidemiology of domestic animals and targeted therapeutic attempts: perspectives on human oncology

The spontaneous tumor biology has been investigated with the support of animalists using animals as a preclinical model allowing translation of results in clinical practice. This review provides an insight into the field of comparative oncology. Evidence shows that companion animal health care is impressively growing in terms of development of new therapies and diagnostic tools...

An immune-modulating diet increases the regulatory T cells and reduces T helper 1 inflammatory response in Leishmaniosis affected dogs treated with standard therapy

Background Clinical appearance and evolution of Canine Leishmaniosis (CL) are the consequence of complex interactions between the parasite and the genetic and immunological backgrounds. We investigated the effect of an immune-modulating diet in CL. Dogs were treated with anti- Leishmania pharmacological therapy combined with standard diet (SD Group) or with the immune-modulating...

An Antioxidant Dietary Supplement Improves Brain-Derived Neurotrophic Factor Levels in Serum of Aged Dogs: Preliminary Results

Cerbo,3 Sergio Canello,2 Gianandrea Guidetti,2 Filippo Fiore,1 and Raffaella Cocco1 1Department of Veterinary Medicine, Pathology and Veterinary Clinic Section, Via Vienna 2, 07100 Sassari, Italy

Comparison of the effects of hyaluronidase and hyaluronic acid on probiotics growth

Background Hyaluronic acid has several clinical applications. Recent evidences suggested antimicrobial properties against several pathogens. The aim of the present survey was to evaluate the effect of hyaluronic acid, alone or in combination with hyaluronidase, on protechnological or probiotic strains. Results The role of hyaluronic acid and hyaluronidase on in vitro growth rate...