The mitochondrial network constantly changes and remodels its shape to face the cellular energy demand. In human cells, mitochondrial fusion is regulated by the large, evolutionarily conserved GTPases Mfn1 and Mfn2, which are embedded in the mitochondrial outer membrane, and by OPA1, embedded in the mitochondrial inner membrane. In contrast, the soluble dynamin-related GTPase...
. Daniela Corda & Alberto Luini These authors jointly supervised this work Alessandro Pagliuso Present address: Institut Pasteur, Unité des Interactions Bactéries-Cellules, Département de Biologie ... , Centre for Advanced Biomaterials for Health Care at CRIB, Largo Barsanti e Matteucci 53, Naples 80125, ItalyFabio Formiggini AuthorsSearch for Alessandro Pagliuso in:Nature Research journals • PubMed