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Comparison of strain parameters in dyssynchronous heart failure between speckle tracking echocardiography vendor systems

Although mechanical dyssynchrony parameters derived by speckle tracking echocardiography (STE) may predict response to cardiac resynchronization therapy (CRT), comparability of parameters derived with different STE vendors is unknown. In the MARC study, echocardiographic images of heart failure patients obtained before CRT implantation were prospectively analysed with vendor ...

Comparison of strain parameters in dyssynchronous heart failure between speckle tracking echocardiography vendor systems

Although mechanical dyssynchrony parameters derived by speckle tracking echocardiography (STE) may predict response to cardiac resynchronization therapy (CRT), comparability of parameters derived with different STE vendors is unknown. In the MARC study, echocardiographic images of heart failure patients obtained before CRT implantation were prospectively analysed with vendor ...

Cardiac Resynchronization in Mild Heart Failure: All Issues Resolved?

Editorial to Cardiac Resynchronization Therapy in Patients with Mild Heart Failure: A Systematic Review Meta-Analysis of Randomized Controlled Trials by Ronghui Tu et al. Alexander H. Maass 0

Atrial Remodeling Is Directly Related to End-Diastolic Left Ventricular Pressure in a Mouse Model of Ventricular Pressure Overload

Background Atrial fibrillation (AF) is often preceded by underlying cardiac diseases causing ventricular pressure overload. Objective It was our aim to investigate the progression of atrial remodeling in a small animal model of ventricular pressure overload and its association with induction of AF. Methods Male mice were subjected to transverse aortic constriction (TAC) or sham ...

The Plk1 Inhibitor BI 2536 Temporarily Arrests Primary Cardiac Fibroblasts in Mitosis and Generates Aneuploidy In Vitro

BI 2536 is a new anti-mitotic drug that targets polo-like kinase 1 (Plk1) and is currently under clinical development for cancer therapy. The effect of this drug on cancer cells has been extensively investigated, but information about the effects on primary dividing cells and differentiated non-dividing cells is scarce. We have investigated the effects of this drug on primary ...