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Measuring and Improving Physician Knowledge of Safety Risks Using Traditional and Online Methods in Pharmacovigilance

& Alexander Liede 3 Center for Observational Research, Amgen Inc. , Thousand Oaks, CA , USA 4 Adelphi Research , Macclesfield , UK Background Traditional methods for assessing prescriber knowledge can take

Preferences for breast cancer risk reduction among BRCA1/BRCA2 mutation carriers: a discrete-choice experiment

Purpose Unaffected women who carry BRCA1 or BRCA2 mutations face difficult choices about reducing their breast cancer risk. Understanding their treatment preferences could help us improve patient counseling and inform drug trials. The objective was to explore preferences for various risk-reducing options among women with germline BRCA1/2 mutations using a discrete-choice...

Burden of symptoms associated with development of metastatic bone disease in patients with breast cancer

Purpose Women with breast cancer frequently develop painful bone metastases. This retrospective study was designed to longitudinally characterize patterns of patient-reported symptoms among patients with breast cancer relative to the diagnosis of bone metastases. Methods Patient records were identified from the Oncology Services Comprehensive Electronic Records (OSCER) database...

Prevalence and Penetrance of BRCA1 and BRCA2 Gene Mutations in Unselected Ashkenazi Jewish Women With Breast Cancer

, Roxana Moslehi, Joanne Honeyford, Alexander Liede, Gordon Glendon, Jean-Se ́bastien Brunet, Steven Narod Background: Approximately 2.0%– 2.5% of Ashkenazi Jewish women carry one of three founding