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Search: authors:"Alexander Negoda"

3 papers found.
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Conformational change of the extracellular parts of the CFTR protein during channel gating

Cystic fibrosis can be treated by potentiators, drugs that interact directly with the cystic fibrosis transmembrane conductance regulator (CFTR) Cl− channel to increase its open probability. These substances likely target key conformational changes occurring during channel opening and closing, however, the molecular bases of these conformational changes, and their susceptibility...

Changes in lipid membranes may trigger amyloid toxicity in Alzheimer's disease

, Zoya Leonenko. Formal analysis: Elizabeth Drolle, Alexander Negoda, Keely Hammond, Evgeny Pavlov. Funding acquisition: Evgeny Pavlov, Zoya Leonenko. Investigation: Elizabeth Drolle, Alexander Negoda ... , Keely Hammond, Evgeny Pavlov, Zoya Leonenko. Methodology: Alexander Negoda, Evgeny Pavlov, Zoya Leonenko. Project administration: Zoya Leonenko. Resources: Evgeny Pavlov, Zoya Leonenko. Software

Modulation of mitochondrial ion transport by inorganic polyphosphate - essential role in mitochondrial permeability transition pore

Inorganic polyphosphate (polyP) is a biopolymer of phosphoanhydride-linked orthophosphate residues. PolyP is involved in multiple cellular processes including mitochondrial metabolism and cell death. We used artificial membranes and isolated mitochondria to investigate the role of the polyP in mitochondrial ion transport and in activation of PTP. Here, we found that polyP can...