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Search: authors:"Alexandre Iannello"

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A forward genetic screen reveals novel independent regulators of ULBP1, an activating ligand for natural killer cells

Recognition and elimination of tumor cells by the immune system is crucial for limiting tumor growth. Natural killer (NK) cells become activated when the receptor NKG2D is engaged by ligands that are frequently upregulated in primary tumors and on cancer cell lines. However, the molecular mechanisms driving NKG2D ligand expression on tumor cells are not well defined. Using a ...

HIV-1 causes an imbalance in the production of interleukin-18 and its natural antagonist in HIV-infected individuals: Implications for enhanced viral replication

Background. Concentrations of interleukin (IL)-18 increase in the circulation of human immunodeficiency virus (HIV)-infected persons. However, nothing is known concerning the regulation of IL-18-binding protein (IL-18BP), which neutralizes IL-18 in vivo. This issue is addressed in the present study. Methods. Serum samples obtained from healthy subjects and HIV-infected patients ...