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Search: authors:"Aliaksandr A. Yarmishyn"

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Expression profiling of cell-intrinsic regulators in the process of differentiation of human iPSCs into retinal lineages

BackgroundDifferentiation of human induced pluripotent stem cells (hiPSCs) into retinal lineages offers great potential for medical application. Therefore, it is of crucial importance to know the key intrinsic regulators of differentiation and the specific biomarker signatures of cell lineages.MethodsIn this study, we used microarrays to analyze transcriptomes of terminally...

MicroRNA-142-3p is involved in regulation of MGMT expression in glioblastoma cells

MicroRNA-142-3p is involved in regulation of MGMT expression in glioblastoma cells Yi-Yen Lee,1,2,* Aliaksandr A Yarmishyn,3,4,* Mong-Lien Wang,3,4 Hsiao-Yun Chen,4,5 Shih-Hwa Chiou,3–5 Yi-Ping Yang

HOXD-AS1 is a novel lncRNA encoded in HOXD cluster and a marker of neuroblastoma progression revealed via integrative analysis of noncoding transcriptome

Background Long noncoding RNAs (lncRNAs) constitute a major, but poorly characterized part of human transcriptome. Recent evidence indicates that many lncRNAs are involved in cancer and can be used as predictive and prognostic biomarkers. Significant fraction of lncRNAs is represented on widely used microarray platforms, however they have usually been ignored in cancer studies...

Role of genomic architecture in the expression dynamics of long noncoding RNAs during differentiation of human neuroblastoma cells

Background Mammalian genomes are extensively transcribed producing thousands of long non-protein-coding RNAs (lncRNAs). The biological significance and function of the vast majority of lncRNAs remain unclear. Recent studies have implicated several lncRNAs as playing important roles in embryonic development and cancer progression. LncRNAs are characterized with different genomic...