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Soluble bone-derived osteopontin promotes migration and stem-like behavior of breast cancer cells

Breast cancer is a leading cause of cancer death in women, with the majority of these deaths caused by metastasis to distant organs. The most common site of breast cancer metastasis is the bone, which has been shown to provide a rich microenvironment that supports the migration and growth of breast cancer cells. Additionally, growing evidence suggests that breast cancer cells...

Aldehyde dehydrogenase as a marker and functional mediator of metastasis in solid tumors

- & Alison L. Allan Introduction Metastasis is a life-threatening systemic condition, with ninety percent of all cancer deaths resulting from cancer cell dissemination from the primary tumor to distant

The Role of Cancer Stem Cells in the Organ Tropism of Breast Cancer Metastasis: A Mechanistic Balance between the “Seed” and the “Soil”?

, London, ON, Canada N6A 4V2 Received 15 July 2011; Accepted 19 September 2011 Academic Editor: Lalita Shevde Copyright © 2012 Jenny E. Chu and Alison L. Allan. This is an open access article

Circulating Tumor Cell Analysis: Technical and Statistical Considerations for Application to the Clinic

, London Health Sciences Centre, London, ON, Canada N6A 5W9 Received 30 April 2009; Accepted 15 September 2009 Academic Editor: Vassilis Georgoulias Copyright © 2010 Alison L. Allan and Michael Keeney

Deletion of the thrombin cleavage domain of osteopontin mediates breast cancer cell adhesion, proteolytic activity, tumorgenicity, and metastasis

David Goodale Carl O Postenka Alison L Allan 0 0 Department of Anatomy & Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario , (1151 Richmond Street), London Ontario