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Soluble bone-derived osteopontin promotes migration and stem-like behavior of breast cancer cells

Breast cancer is a leading cause of cancer death in women, with the majority of these deaths caused by metastasis to distant organs. The most common site of breast cancer metastasis is the bone, which has been shown to provide a rich microenvironment that supports the migration and growth of breast cancer cells. Additionally, growing evidence suggests that breast cancer cells that ...

Aldehyde dehydrogenase as a marker and functional mediator of metastasis in solid tumors

- & Alison L. Allan Introduction Metastasis is a life-threatening systemic condition, with ninety percent of all cancer deaths resulting from cancer cell dissemination from the primary tumor to distant

Deletion of the thrombin cleavage domain of osteopontin mediates breast cancer cell adhesion, proteolytic activity, tumorgenicity, and metastasis

David Goodale Carl O Postenka Alison L Allan 0 0 Department of Anatomy & Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario , (1151 Richmond Street), London Ontario