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Transcriptional profiling of PBMCs unravels B cell mediated immunopathogenic imprints of HCV vasculitis

Contributions Conceptualization: Shyamasundaran Kottilil. Data curation: Shyamasundaran Kottilil. Formal analysis: Benjamin Emmanuel, Shyamasundaran Kottilil. Investigation: Cheol-Woo Kim, Alison Murphy, Xi

Genome sequencing of the extinct Eurasian wild aurochs, Bos primigenius, illuminates the phylogeography and evolution of cattle

A. McGettigan 0 Matthew D. Teasdale 7 Ceiridwen J. Edwards 6 Amanda J. Lohan 1 Alison Murphy 1 Martin Braud 5 Mark T. Donoghue 5 Yuan Liu 9 Andrew T. Chamberlain 8 Kévin Rue-Albrecht 0 Steven

A Complete Mitochondrial Genome Sequence from a Mesolithic Wild Aurochs (Bos primigenius)

Background The derivation of domestic cattle from the extinct wild aurochs (Bos primigenius) has been well-documented by archaeological and genetic studies. Genetic studies point towards the Neolithic Near East as the centre of origin for Bos taurus, with some lines of evidence suggesting possible, albeit rare, genetic contributions from locally domesticated wild aurochsen across...

Inhibiting TGF-β signaling restores immune surveillance in the SMA-560 glioma model

Transforming growth factor-β (TGF-β) is a proinvasive and immunosuppressive cytokine that plays a major role in the malignant phenotype of gliomas. One novel strategy of disabling TGF-β activity in gliomas is to disrupt the signaling cascade at the level of the TGF-β receptor I (TGF-βRI) kinase, thus abrogating TGF-β-mediated invasiveness and immune suppression. SX-007, an orally...