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Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes

Bonder, Lude Franke, M. Arfan Ikram, Sonja Kunze, Allan F. McRae, Martina MuÈller-Nurasyid, Annette Peters, P. Eline Slagboom, John M. Starr, David-Alexandre TreÂgoueÈt, Andre G. Uitterlinden, Marleen M

Predicting gene targets from integrative analyses of summary data from GWAS and eQTL studies for 28 human complex traits

0 Jacob Gratten Allan F. McRae Naomi R. Wray Jian Yang 0 Equal contributors Queensland Brain Institute, University of Queensland , Brisbane, Queensland , Australia Genome-wide association studies

Seasonal Effects on Gene Expression

methods. Anita Goldinger wrote the manuscript and carried out the data analysis. Anita Goldinger and Joseph E. Powell conceived and supervised the study design. Anjali K. Henders, Allan F McRae and Grant W ... . Montogomery were involved in the generation of the data used for the study. Joseph E. Powell, Allan F. McRae and Konstatin Shakhbazov provided input on statistical analysis. All authors read, revised, and

Case-Control Association Testing of Common Variants from Sequencing of DNA Pools

While genome-wide association studies (GWAS) have been successful in identifying a large number of variants associated with disease, the challenge of locating the underlying causal loci remains. Sequencing of case and control DNA pools provides an inexpensive method for assessing all variation in a genomic region surrounding a significant GWAS result. However, individual variants ...

Contribution of genetic variation to transgenerational inheritance of DNA methylation

Background Despite the important role DNA methylation plays in transcriptional regulation, the transgenerational inheritance of DNA methylation is not well understood. The genetic heritability of DNA methylation has been estimated using twin pairs, although concern has been expressed whether the underlying assumption of equal common environmental effects are applicable due to ...

Congruence of Additive and Non-Additive Effects on Gene Expression Estimated from Pedigree and SNP Data

There is increasing evidence that heritable variation in gene expression underlies genetic variation in susceptibility to disease. Therefore, a comprehensive understanding of the similarity between relatives for transcript variation is warranted—in particular, dissection of phenotypic variation into additive and non-additive genetic factors and shared environmental effects. We ...

DNA methylation age of blood predicts all-cause mortality in later life

Background DNA methylation levels change with age. Recent studies have identified biomarkers of chronological age based on DNA methylation levels. It is not yet known whether DNA methylation age captures aspects of biological age. Results Here we test whether differences between people’s chronological ages and estimated ages, DNA methylation age, predict all-cause mortality in ...

Congenital Sensorineural Deafness in Australian Stumpy-Tail Cattle Dogs Is an Autosomal Recessive Trait That Maps to CFA10

Background Congenital sensorineural deafness is an inherited condition found in many dog breeds, including Australian Stumpy-tail Cattle Dogs (ASCD). This deafness is evident in young pups and may affect one ear (unilateral) or both ears (bilateral). The genetic locus/loci involved is unknown for all dog breeds. The aims of this study were to determine incidence, inheritance ...

The Brisbane Systems Genetics Study: Genetical Genomics Meets Complex Trait Genetics

There is growing evidence that genetic risk factors for common disease are caused by hereditary changes of gene regulation acting in complex pathways. Clearly understanding the molecular genetic relationships between genetic control of gene expression and its effect on complex diseases is essential. Here we describe the Brisbane Systems Genetics Study (BSGS), a family-based study ...

Replicated effects of sex and genotype on gene expression in human lymphoblastoid cell lines

The expression level for 15 887 transcripts in lymphoblastoid cell lines from 19 monozygotic twin pairs (10 male, 9 female) were analysed for the effects of genotype and sex. On an average, the effect of twin pairs explained 31% of the variance in normalized gene expression levels, consistent with previous broad sense heritability estimates. The effect of sex on gene expression ...

Clustered Coding Variants in the Glutamate Receptor Complexes of Individuals with Schizophrenia and Bipolar Disorder

Current models of schizophrenia and bipolar disorder implicate multiple genes, however their biological relationships remain elusive. To test the genetic role of glutamate receptors and their interacting scaffold proteins, the exons of ten glutamatergic ‘hub’ genes in 1304 individuals were re-sequenced in case and control samples. No significant difference in the overall number of ...