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Associations of body mass index and waist circumference with: energy intake and percentage energy from macronutrients, in a cohort of australian children

Background It is evident from previous research that the role of dietary composition in relation to the development of childhood obesity remains inconclusive. Several studies investigating the relationship between body mass index (BMI), waist circumference (WC) and/or skin fold measurements with energy intake have suggested that the macronutrient composition of the diet (protein...

Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth

Despite two decades of research, the major function of FBP-family KH domain proteins during animal development remains controversial. The literature is divided between RNA processing and transcriptional functions for these single stranded nucleic acid binding proteins. Using Drosophila, where the three mammalian FBP proteins (FBP1-3) are represented by one ortholog, Psi, we...

Effective advocacy strategies for influencing government nutrition policy: a conceptual model

Influencing public policy change can be difficult and complex, particularly for those with limited power and resources. For any one issue there may be several groups, including the commercial sector and public health advocates advocating from different policy perspectives. However, much of the public health advocacy literature and tools available for those wanting to improve...

Emergence of Brucella suis in dogs in New South Wales, Australia: clinical findings and implications for zoonotic transmission

Background Animal reservoirs of brucellosis constitute an ongoing threat to human health globally, with foodborne, occupational and recreational exposures creating opportunities for transmission. In Australia and the United States, hunting of feral pigs has been identified as the principal risk factor for human brucellosis due to Brucella suis. Following increased reports of...

Optimization of Non-Thermal Plasma Treatment in an In Vivo Model Organism

Non-thermal plasma is increasingly being recognized for a wide range of medical and biological applications. However, the effect of non-thermal plasma on physiological functions is not well characterized in in vivo model systems. Here we use a genetically amenable, widely used model system, Drosophila melanogaster, to develop an in vivo system, and investigate the role of non...

Physical activities of Patients with adolescent idiopathic scoliosis (AIS): preliminary longitudinal case–control study historical evaluation of possible risk factors

To our knowledge there are no publications that have evaluated physical activities in relation to the etiopathogenesis of adolescent idiopathic scoliosis (AIS) other than sports scolioses. In a preliminary longitudinal case–control study, mother and child were questioned and the children examined by one observer. The aim of the study was to examine possible risk factors for AIS...

Reconstitution of immune cell in liver and lymph node of adult- and newborn-engrafted humanized mice

work was supported by grants from the CIHR to Ali Ashkar. Amanda Lee is a recipient of a CIHR Vanier Scholarship (2013–2016). Ali Ashkar is a recipient of a CIHR Tier 1 Canada Research Chair. Funding ... This work was supported by grants from CIHR to Ali Ashkar. Amanda Lee is a recipient of a CIHR Vanier Scholarship (2013–2016). Ali Ashkar is a recipient of a CIHR Tier 1 Canada Research Chair

Testing the price and affordability of healthy and current (unhealthy) diets and the potential impacts of policy change in Australia

Background Price and affordability of foods are important determinants of health. Targeted food pricing policies may help improve population diets. However, methods producing comparable data to inform relevant policy decisions are lacking in Australia and globally. The objective was to develop and pilot standardised methods to assess the price, relative price and affordability of...

The Ecdysone receptor constrains wingless expression to pattern cell cycle across the Drosophila wing margin in a cyclin B-dependent manner

Background Ecdysone triggers transcriptional changes via the ecdysone receptor (EcR) to coordinate developmental programs of apoptosis, cell cycle and differentiation. Data suggests EcR affects cell cycle gene expression indirectly and here we identify Wingless as an intermediary factor linking EcR to cell cycle. Results We demonstrate EcR patterns cell cycle across the...

Use of low-dose oral theophylline as an adjunct to inhaled corticosteroids in preventing exacerbations of chronic obstructive pulmonary disease: study protocol for a randomised controlled trial

Background Chronic obstructive pulmonary disease (COPD) is associated with high morbidity, mortality, and health-care costs. An incomplete response to the anti-inflammatory effects of inhaled corticosteroids is present in COPD. Preclinical work indicates that ‘low dose’ theophylline improves steroid responsiveness. The Theophylline With Inhaled Corticosteroids (TWICS) trial...

Using systems science to understand the determinants of inequities in healthy eating

Health, Australian Capital Territory Health, HCF, and the HCF Research Foundation. Author Contributions Conceptualization: Sharon Friel, Melanie Pescud, Eleanor Malbon, Amanda Lee, Robert Carter. Data ... , Eleanor Malbon, Amanda Lee, Robert Carter, Joanne Greenfield, Megan Cobcroft, Jane Potter, Lucie Rychetnik, Beth Meertens. Methodology: Sharon Friel, Eleanor Malbon. Project administration: Sharon Friel